EA201290601A1 - Новые бензойные производные пирролопиридина - Google Patents

Новые бензойные производные пирролопиридина

Info

Publication number
EA201290601A1
EA201290601A1 EA201290601A EA201290601A EA201290601A1 EA 201290601 A1 EA201290601 A1 EA 201290601A1 EA 201290601 A EA201290601 A EA 201290601A EA 201290601 A EA201290601 A EA 201290601A EA 201290601 A1 EA201290601 A1 EA 201290601A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrropolyridine
benzoa
derivatives
new
compounds
Prior art date
Application number
EA201290601A
Other languages
English (en)
Inventor
Жером Амодру
Бенаисса Бубиа
Фабрис Гиллье
Оливия Пупардин-Оливье
Original Assignee
Лабораториз Фурнье С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораториз Фурнье С.А. filed Critical Лабораториз Фурнье С.А.
Publication of EA201290601A1 publication Critical patent/EA201290601A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к соединениям формулыв которой А, Су, R1, R2, R3, R4, R5, R6, R7 и R8 являются такими, как определено в описании. Соединения по изобретению являются модуляторами ядерных рецепторов NURR-1.
EA201290601A 2010-01-08 2011-01-07 Новые бензойные производные пирролопиридина EA201290601A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1050113A FR2955110A1 (fr) 2010-01-08 2010-01-08 Nouveaux derives de type pyrrolopyridine benzoique
PCT/FR2011/050023 WO2011083278A1 (fr) 2010-01-08 2011-01-07 Nouveaux derives de type pyrrolopyridine benzoique

Publications (1)

Publication Number Publication Date
EA201290601A1 true EA201290601A1 (ru) 2012-12-28

Family

ID=42124595

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290601A EA201290601A1 (ru) 2010-01-08 2011-01-07 Новые бензойные производные пирролопиридина

Country Status (22)

Country Link
US (1) US8546385B2 (ru)
EP (1) EP2521727B1 (ru)
JP (1) JP2013516448A (ru)
KR (1) KR20120123042A (ru)
CN (1) CN102753552A (ru)
AR (1) AR079842A1 (ru)
AU (1) AU2011204518A1 (ru)
BR (1) BR112012016844A2 (ru)
CA (1) CA2785876A1 (ru)
DK (1) DK2521727T3 (ru)
EA (1) EA201290601A1 (ru)
ES (1) ES2478191T3 (ru)
FR (1) FR2955110A1 (ru)
HK (1) HK1178893A1 (ru)
MX (1) MX2012007968A (ru)
PL (1) PL2521727T3 (ru)
PT (1) PT2521727E (ru)
SA (1) SA111320080B1 (ru)
TW (1) TWI473806B (ru)
UY (1) UY33166A (ru)
WO (1) WO2011083278A1 (ru)
ZA (1) ZA201204863B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102347368B1 (ko) 2020-11-03 2022-01-07 (주)케이메디켐 신규한 아자인돌 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025611A1 (en) 1996-12-13 1998-06-18 Rhône-Poulenc Rorer Pharmaceuticals Inc. Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
ATE482945T1 (de) * 1998-05-26 2010-10-15 Chugai Pharmaceutical Co Ltd Heterozyklische indolderivate und mono- oder diazaindol-derivate
GB0119911D0 (en) 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
JP4845730B2 (ja) 2003-07-17 2011-12-28 プレキシコン，インコーポレーテッド Ｐｐａｒ活性化合物
US8455489B2 (en) 2003-11-10 2013-06-04 Exelixis, Inc. Substituted pyrimidine compositions and methods of use
FR2890072A1 (fr) * 2005-09-01 2007-03-02 Fournier S A Sa Lab Nouveaux composesde pyrrolopyridine
FR2903106B1 (fr) 2006-07-03 2010-07-30 Sanofi Aventis Utilisations de 2-benzoyl-imidazopyridines en therapeutique
FR2903107B1 (fr) 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2903105A1 (fr) 2006-07-03 2008-01-04 Sanofi Aventis Sa Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
CA2674087A1 (en) 2007-02-16 2008-08-21 Memory Pharmaceuticals Corporation 6' substituted compounds having 5-ht6 receptor affinity
US20100022581A1 (en) 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity

Also Published As

Publication number Publication date
ZA201204863B (en) 2013-09-25
EP2521727B1 (fr) 2014-03-19
US20120302560A1 (en) 2012-11-29
EP2521727A1 (fr) 2012-11-14
TWI473806B (zh) 2015-02-21
WO2011083278A1 (fr) 2011-07-14
CA2785876A1 (fr) 2011-07-14
CN102753552A (zh) 2012-10-24
TW201144307A (en) 2011-12-16
MX2012007968A (es) 2012-08-03
AU2011204518A1 (en) 2012-07-26
PT2521727E (pt) 2014-06-25
JP2013516448A (ja) 2013-05-13
PL2521727T3 (pl) 2014-08-29
US8546385B2 (en) 2013-10-01
FR2955110A1 (fr) 2011-07-15
KR20120123042A (ko) 2012-11-07
HK1178893A1 (en) 2013-09-19
AR079842A1 (es) 2012-02-22
BR112012016844A2 (pt) 2018-05-08
DK2521727T3 (da) 2014-06-16
SA111320080B1 (ar) 2014-06-23
UY33166A (es) 2011-08-31
ES2478191T3 (es) 2014-07-18

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