EA201100230A1 - Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой - Google Patents

Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой

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Publication number
EA201100230A1
EA201100230A1 EA201100230A EA201100230A EA201100230A1 EA 201100230 A1 EA201100230 A1 EA 201100230A1 EA 201100230 A EA201100230 A EA 201100230A EA 201100230 A EA201100230 A EA 201100230A EA 201100230 A1 EA201100230 A1 EA 201100230A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
acceptable acid
ivabradin
new method
pharmaceutical acceptable
Prior art date
Application number
EA201100230A
Other languages
English (en)
Other versions
EA019373B1 (ru
Inventor
Жан-Луи Пегльон
Паскаль Кэньяр
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA201100230A1 publication Critical patent/EA201100230A1/ru
Publication of EA019373B1 publication Critical patent/EA019373B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Способ синтеза ивабрадина формулы (I)и его аддитивных солей с фармацевтически приемлемой кислотой.
EA201100230A 2010-02-17 2011-02-15 Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой EA019373B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1000657A FR2956401B1 (fr) 2010-02-17 2010-02-17 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
EA201100230A1 true EA201100230A1 (ru) 2011-08-30
EA019373B1 EA019373B1 (ru) 2014-03-31

Family

ID=42133409

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100230A EA019373B1 (ru) 2010-02-17 2011-02-15 Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой

Country Status (36)

Country Link
US (1) US8278440B2 (ru)
EP (1) EP2364972B1 (ru)
JP (1) JP5306387B2 (ru)
KR (1) KR101310683B1 (ru)
CN (3) CN102161642B (ru)
AR (1) AR080178A1 (ru)
AU (1) AU2011200403B2 (ru)
BR (1) BRPI1100169A2 (ru)
CA (1) CA2731315C (ru)
CL (1) CL2011000297A1 (ru)
CY (1) CY1113338T1 (ru)
DK (1) DK2364972T3 (ru)
EA (1) EA019373B1 (ru)
ES (1) ES2396042T3 (ru)
FR (1) FR2956401B1 (ru)
GE (1) GEP20135737B (ru)
HK (3) HK1162021A1 (ru)
HR (1) HRP20120955T1 (ru)
JO (1) JO2854B1 (ru)
MA (1) MA32681B1 (ru)
ME (1) ME01464B (ru)
MX (1) MX2011001465A (ru)
MY (1) MY147697A (ru)
NZ (1) NZ590883A (ru)
PE (1) PE20120576A1 (ru)
PL (1) PL2364972T3 (ru)
PT (1) PT2364972E (ru)
RS (1) RS52529B (ru)
SA (1) SA111320199B1 (ru)
SG (1) SG173961A1 (ru)
SI (1) SI2364972T1 (ru)
TW (1) TWI395738B (ru)
UA (1) UA106208C2 (ru)
UY (1) UY33211A (ru)
WO (1) WO2011101558A1 (ru)
ZA (1) ZA201100964B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950343B1 (fr) * 2009-09-18 2011-11-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN102566619B (zh) * 2012-02-07 2013-12-25 宁波市镇海华泰电器厂 噪声式水温控制装置
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
US7008958B2 (en) * 2002-05-21 2006-03-07 Bristol-Myers Squibb Company 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
TW200817334A (en) * 2005-02-07 2008-04-16 Servier Lab New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
ES2381771T3 (es) * 2006-11-30 2012-05-31 Cadila Healthcare Limited Procedimiento para la preparación de hidrocloruro de ivabradina
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
RU2473544C2 (ru) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций
CN101544605A (zh) * 2008-03-24 2009-09-30 北京深蓝海生物医药科技有限公司 伊伐布雷定及其药学上可接受的加成盐的制备方法
FR2932800B1 (fr) 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP2367782B1 (en) 2008-12-22 2013-02-13 KRKA, D.D., Novo Mesto Process for preparation of ivabradine

Also Published As

Publication number Publication date
UA106208C2 (ru) 2014-08-11
CN103265491A (zh) 2013-08-28
PT2364972E (pt) 2012-10-02
HK1183488A1 (en) 2013-12-27
SA111320199B1 (ar) 2014-05-21
MY147697A (en) 2013-01-07
TW201144287A (en) 2011-12-16
KR20110095210A (ko) 2011-08-24
AR080178A1 (es) 2012-03-21
EP2364972B1 (fr) 2012-09-19
JP5306387B2 (ja) 2013-10-02
CN102161642B (zh) 2014-03-19
CN102161642A (zh) 2011-08-24
CL2011000297A1 (es) 2012-02-17
CA2731315A1 (fr) 2011-08-17
KR101310683B1 (ko) 2013-09-24
DK2364972T3 (da) 2013-01-07
EA019373B1 (ru) 2014-03-31
UY33211A (ru) 2011-07-29
GEP20135737B (en) 2013-01-25
JO2854B1 (en) 2015-03-15
CY1113338T1 (el) 2016-06-22
RS52529B (en) 2013-04-30
HK1162021A1 (en) 2012-08-17
JP2011168590A (ja) 2011-09-01
SG173961A1 (en) 2011-09-29
SI2364972T1 (sl) 2012-12-31
AU2011200403A1 (en) 2011-09-01
MX2011001465A (es) 2011-08-30
ZA201100964B (en) 2011-10-26
EP2364972A1 (fr) 2011-09-14
CN103232360B (zh) 2014-05-21
CN103265491B (zh) 2015-01-21
HK1183295A1 (en) 2013-12-20
MA32681B1 (fr) 2011-10-02
WO2011101558A1 (fr) 2011-08-25
PL2364972T3 (pl) 2013-01-31
FR2956401B1 (fr) 2012-02-03
BRPI1100169A2 (pt) 2012-07-31
CA2731315C (fr) 2013-03-26
PE20120576A1 (es) 2012-05-12
CN103232360A (zh) 2013-08-07
FR2956401A1 (fr) 2011-08-19
HRP20120955T1 (hr) 2012-12-31
TWI395738B (zh) 2013-05-11
ES2396042T3 (es) 2013-02-18
AU2011200403B2 (en) 2015-02-19
NZ590883A (en) 2012-01-12
ME01464B (me) 2014-04-20
US20110201805A1 (en) 2011-08-18
US8278440B2 (en) 2012-10-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU