DK2158194T3 - Derivater af 7-alkynyl-1,8-naphtyridoner, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf - Google Patents

Derivater af 7-alkynyl-1,8-naphtyridoner, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf

Info

Publication number: DK2158194T3
Authority: DK; Denmark
Prior art keywords: naphtyridones; alkynyl; derivatives; preparation; therapeutic use
Prior art date: 2007-06-13

Application number

DK08826271.2T

Other languages

English (en)

Inventor

Cort Gary Mc

Antoine Alam

Francoise Bono

Olivier Duclos

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-13

Filing date

2008-06-11

Publication date

2011-09-12

2008-06-11 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-09-12 Application granted granted Critical

2011-09-12 Publication of DK2158194T3 publication Critical patent/DK2158194T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

DK08826271.2T 2007-06-13 2008-06-11 Derivater af 7-alkynyl-1,8-naphtyridoner, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf DK2158194T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0704193A FR2917413B1 (fr)	2007-06-13	2007-06-13	Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
PCT/FR2008/000794 WO2009007536A2 (fr)	2007-06-13	2008-06-11	Dérivés de 7 -alkynyl-1,8-naphthyridones, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
DK2158194T3 true DK2158194T3 (da)	2011-09-12

Family

ID=38961501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08826271.2T DK2158194T3 (da)	2007-06-13	2008-06-11	Derivater af 7-alkynyl-1,8-naphtyridoner, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf

Country Status (29)

Country	Link
US (2)	US8263614B2 (da)
EP (1)	EP2158194B1 (da)
JP (1)	JP5346337B2 (da)
KR (1)	KR20100019507A (da)
CN (1)	CN101815715B (da)
AR (1)	AR066955A1 (da)
AT (1)	ATE509923T1 (da)
AU (1)	AU2008274100B2 (da)
BR (1)	BRPI0813809B1 (da)
CA (1)	CA2690349C (da)
CO (1)	CO6150157A2 (da)
CY (1)	CY1111748T1 (da)
DK (1)	DK2158194T3 (da)
EA (1)	EA016552B1 (da)
ES (1)	ES2366629T3 (da)
FR (1)	FR2917413B1 (da)
HK (1)	HK1143590A1 (da)
HR (1)	HRP20110550T1 (da)
IL (1)	IL202677A (da)
IN (1)	IN2009KN04279A (da)
MA (1)	MA31674B1 (da)
ME (1)	ME00957B (da)
MX (1)	MX2009013514A (da)
MY (1)	MY146939A (da)
NZ (1)	NZ581883A (da)
PL (1)	PL2158194T3 (da)
PT (1)	PT2158194E (da)
SI (1)	SI2158194T1 (da)
WO (1)	WO2009007536A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2917412B1 (fr) *	2007-06-13	2009-08-21	Sanofi Aventis Sa	Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
EP2649997B1 (en) *	2007-12-10	2019-01-23	Sunesis Pharmaceuticals, Inc.	(+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome
FR2933700B1 (fr)	2008-07-08	2010-07-30	Sanofi Aventis	Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2952934B1 (fr)	2009-11-23	2012-06-22	Sanofi Aventis	Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2954943B1 (fr) *	2010-01-07	2013-03-01	Sanofi Aventis	Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique
FR2955109B1 (fr) *	2010-01-08	2012-09-07	Sanofi Aventis	Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
EP2582682B1 (en) *	2010-06-17	2015-01-14	Cytokinetics, Inc.	Mitotic kinesin inhibitors for use in the treatmetnof pulmonary arterial hypertension
WO2013072882A1 (en) *	2011-11-18	2013-05-23	Actelion Pharmaceuticals Ltd	2 -amino- 1, 8 -naphthyridine-3 -carboxamide derivatives as antimicrobial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0841927B1 (en)	1995-08-02	2004-01-28	Darwin Discovery Limited	Quinolones and their therapeutic use
KR20010005830A (ko)	1998-01-29	2001-01-15	도리이 신이치로	타입 ⅳ 포스포디에스테라제 억제활성을 지닌 1-사이클로알킬-1,8-나프틸리딘-4-온 유도체
DE19826050A1 (de) *	1998-06-12	1999-12-16	Bayer Ag	Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
BR0209485A (pt)	2001-05-08	2004-07-06	Schering Ag	Antranilamidapiridinamidas seletivas como inibidores vegfr-2 e vegfr-3
ATE303384T1 (de)	2001-05-24	2005-09-15	Merck Frosst Canada Inc	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
US7148357B2 (en)	2002-07-31	2006-12-12	Schering Ag	VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
JP2008501628A (ja) *	2004-06-02	2008-01-24	武田薬品工業株式会社	インドール誘導体およびがんの治療用途
FR2917412B1 (fr) *	2007-06-13	2009-08-21	Sanofi Aventis Sa	Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique

2007
- 2007-06-13 FR FR0704193A patent/FR2917413B1/fr not_active Expired - Fee Related
2008
- 2008-06-11 EP EP08826271A patent/EP2158194B1/fr active Active
- 2008-06-11 AR ARP080102478A patent/AR066955A1/es unknown
- 2008-06-11 AT AT08826271T patent/ATE509923T1/de active
- 2008-06-11 CN CN200880020155.4A patent/CN101815715B/zh active Active
- 2008-06-11 PL PL08826271T patent/PL2158194T3/pl unknown
- 2008-06-11 WO PCT/FR2008/000794 patent/WO2009007536A2/fr active Application Filing
- 2008-06-11 EA EA201070010A patent/EA016552B1/ru not_active IP Right Cessation
- 2008-06-11 JP JP2010511681A patent/JP5346337B2/ja active Active
- 2008-06-11 AU AU2008274100A patent/AU2008274100B2/en active Active
- 2008-06-11 PT PT08826271T patent/PT2158194E/pt unknown
- 2008-06-11 CA CA2690349A patent/CA2690349C/fr active Active
- 2008-06-11 ES ES08826271T patent/ES2366629T3/es active Active
- 2008-06-11 BR BRPI0813809-5A patent/BRPI0813809B1/pt active IP Right Grant
- 2008-06-11 MY MYPI20095317A patent/MY146939A/en unknown
- 2008-06-11 ME MEP-2009-334A patent/ME00957B/me unknown
- 2008-06-11 IN IN4279KON2009 patent/IN2009KN04279A/en unknown
- 2008-06-11 NZ NZ581883A patent/NZ581883A/en not_active IP Right Cessation
- 2008-06-11 MX MX2009013514A patent/MX2009013514A/es active IP Right Grant
- 2008-06-11 DK DK08826271.2T patent/DK2158194T3/da active
- 2008-06-11 KR KR1020097025902A patent/KR20100019507A/ko active IP Right Grant
- 2008-06-11 SI SI200830319T patent/SI2158194T1/sl unknown
2009
- 2009-12-04 US US12/631,130 patent/US8263614B2/en active Active
- 2009-12-10 IL IL202677A patent/IL202677A/en not_active IP Right Cessation
- 2009-12-11 CO CO09142107A patent/CO6150157A2/es unknown
2010
- 2010-01-12 MA MA32509A patent/MA31674B1/fr unknown
- 2010-10-28 HK HK10110153.0A patent/HK1143590A1/xx not_active IP Right Cessation
2011
- 2011-07-25 HR HR20110550T patent/HRP20110550T1/hr unknown
- 2011-08-09 CY CY20111100763T patent/CY1111748T1/el unknown
2012
- 2012-06-01 US US13/486,414 patent/US8586602B2/en active Active

Also Published As

Publication number	Publication date
ATE509923T1 (de)	2011-06-15
IL202677A0 (en)	2010-06-30
EP2158194B1 (fr)	2011-05-18
WO2009007536A8 (fr)	2010-01-07
US20100144782A1 (en)	2010-06-10
WO2009007536A3 (fr)	2009-03-19
CN101815715A (zh)	2010-08-25
AU2008274100A1 (en)	2009-01-15
FR2917413B1 (fr)	2009-08-21
CA2690349C (fr)	2015-11-24
FR2917413A1 (fr)	2008-12-19
CN101815715B (zh)	2014-10-08
AU2008274100B2 (en)	2013-07-11
US8586602B2 (en)	2013-11-19
EA016552B1 (ru)	2012-05-30
PL2158194T3 (pl)	2011-10-31
PT2158194E (pt)	2011-08-17
IN2009KN04279A (da)	2015-08-28
JP5346337B2 (ja)	2013-11-20
US20120238598A1 (en)	2012-09-20
CY1111748T1 (el)	2015-10-07
BRPI0813809B1 (pt)	2021-05-25
IL202677A (en)	2014-12-31
CO6150157A2 (es)	2010-04-20
WO2009007536A2 (fr)	2009-01-15
JP2010529179A (ja)	2010-08-26
EA201070010A1 (ru)	2010-06-30
MX2009013514A (es)	2010-01-27
NZ581883A (en)	2011-05-27
BRPI0813809A2 (pt)	2020-02-04
AR066955A1 (es)	2009-09-23
MY146939A (en)	2012-10-15
US8263614B2 (en)	2012-09-11
MA31674B1 (fr)	2010-09-01
SI2158194T1 (sl)	2011-10-28
ME00957B (me)	2012-06-20
CA2690349A1 (fr)	2009-01-15
KR20100019507A (ko)	2010-02-18
ES2366629T3 (es)	2011-10-24
EP2158194A2 (fr)	2010-03-03
HRP20110550T1 (hr)	2011-09-30
HK1143590A1 (en)	2011-01-07

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