EA201001252A1 - Способ получения производных 3,6-дигидро-1,3,5-триазина - Google Patents

Способ получения производных 3,6-дигидро-1,3,5-триазина

Info

Publication number
EA201001252A1
EA201001252A1 EA201001252A EA201001252A EA201001252A1 EA 201001252 A1 EA201001252 A1 EA 201001252A1 EA 201001252 A EA201001252 A EA 201001252A EA 201001252 A EA201001252 A EA 201001252A EA 201001252 A1 EA201001252 A1 EA 201001252A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazine
dihydro
producing derivatives
formula
compound
Prior art date
Application number
EA201001252A
Other languages
English (en)
Other versions
EA017062B1 (ru
Inventor
Маттиас Хельмрайх
Майк Бранднер
Original Assignee
Поксел Сас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Поксел Сас filed Critical Поксел Сас
Publication of EA201001252A1 publication Critical patent/EA201001252A1/ru
Publication of EA017062B1 publication Critical patent/EA017062B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Способ получения соединений формулы Iв которой R, R, R, R, Rи Rимеют значения, указанные в п.1 формулы изобретения, который включает реакцию между соединением формулы IIв которой R, R, R, Rимеют значения, указанные ранее, и соединением формулы IIIв которой R, Rимеют значения, указанные ранее.
EA201001252A 2008-02-02 2009-01-15 Способ получения производных 3,6-дигидро-1,3,5-триазина EA017062B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008007314A DE102008007314A1 (de) 2008-02-02 2008-02-02 Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten
PCT/EP2009/000212 WO2009095159A1 (de) 2008-02-02 2009-01-15 Verfahren zur herstellung von 3, 6-dihydro-l, 3, 5-triazinderivaten aus metformin- und paraldehydderivaten

Publications (2)

Publication Number Publication Date
EA201001252A1 true EA201001252A1 (ru) 2010-12-30
EA017062B1 EA017062B1 (ru) 2012-09-28

Family

ID=40459622

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001252A EA017062B1 (ru) 2008-02-02 2009-01-15 Способ получения производных 3,6-дигидро-1,3,5-триазина

Country Status (24)

Country Link
US (1) US8461331B2 (ru)
EP (1) EP2240456B1 (ru)
JP (1) JP5542066B2 (ru)
KR (1) KR101553568B1 (ru)
CN (1) CN101932566B (ru)
AR (1) AR070329A1 (ru)
AT (1) ATE519752T1 (ru)
AU (1) AU2009210293B2 (ru)
BR (1) BRPI0907052B8 (ru)
CA (1) CA2713236C (ru)
CY (1) CY1111837T1 (ru)
DE (1) DE102008007314A1 (ru)
DK (1) DK2240456T3 (ru)
EA (1) EA017062B1 (ru)
ES (1) ES2368116T3 (ru)
HR (1) HRP20110644T1 (ru)
IL (1) IL206816A (ru)
MX (1) MX2010008282A (ru)
PL (1) PL2240456T3 (ru)
PT (1) PT2240456E (ru)
RS (1) RS51968B (ru)
SI (1) SI2240456T1 (ru)
WO (1) WO2009095159A1 (ru)
ZA (1) ZA201006211B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2646422T3 (pl) 2010-12-01 2015-12-31 Poxel Rozdział enancjomerów pochodnych triazyny z zastosowaniem kwasu winowego
US11617754B2 (en) 2017-10-02 2023-04-04 Poxel Sa Methods of treating heart failure with preserved ejection fraction
KR20200130281A (ko) 2018-06-06 2020-11-18 메타반트 사이언시스 게엠베하 당뇨병과 만성 신장 질환을 갖는 대상체를 치료하는 방법
CN112218623A (zh) 2018-06-14 2021-01-12 博希尔公司 用于治疗糖尿病的包含三嗪衍生物的薄膜包衣片剂
CN109655544B (zh) * 2018-12-25 2022-08-12 广东华南药业集团有限公司 一种盐酸二甲双胍及其制剂的质量控制方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1537604A (fr) 1966-09-26 1968-08-23 Sandoz Sa Procédé de préparation de biguanides
GB1250531A (ru) * 1969-01-01 1971-10-20
DE2117015A1 (de) 1971-04-02 1972-10-26 Schering Ag 1,2-Biguanide
SU458538A1 (ru) * 1973-06-14 1975-01-30 Уфимский Нефтяной Институт Способ совместного получени 1,3диеновых углеводородов и гексаметилентетрамина
JPH061779A (ja) * 1992-02-06 1994-01-11 Wakamoto Pharmaceut Co Ltd ベンズオキサジノン誘導体
US5767294A (en) * 1993-02-17 1998-06-16 Hoechst Celanese Corporation Process for the production of trioxane from formaldehyde
US5627282A (en) * 1996-01-03 1997-05-06 Yukong Limited Process for the preparation of optically pure 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid and its derivatives
FR2804113B1 (fr) * 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
AU2003289375A1 (en) * 2002-12-17 2004-07-09 Hamari Chemicals, Ltd Novel 2,4-diamino-1,3,5-triazine derivative
CN100551916C (zh) * 2002-12-17 2009-10-21 浜理药品工业株式会社 新的2,4-二氨基-1,3,5-三嗪衍生物
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
TWI410413B (zh) * 2006-04-26 2013-10-01 Sumitomo Seika Chemicals Preparation method of methylene disulfonate compound

Also Published As

Publication number Publication date
ATE519752T1 (de) 2011-08-15
HRP20110644T1 (hr) 2011-10-31
IL206816A0 (en) 2010-12-30
EP2240456A1 (de) 2010-10-20
PT2240456E (pt) 2011-09-27
CN101932566A (zh) 2010-12-29
EA017062B1 (ru) 2012-09-28
BRPI0907052B1 (pt) 2020-09-24
US8461331B2 (en) 2013-06-11
PL2240456T3 (pl) 2011-11-30
CA2713236C (en) 2016-03-22
BRPI0907052A2 (pt) 2015-07-07
DK2240456T3 (da) 2011-09-26
CN101932566B (zh) 2013-04-10
EP2240456B1 (de) 2011-08-10
WO2009095159A1 (de) 2009-08-06
JP5542066B2 (ja) 2014-07-09
ES2368116T3 (es) 2011-11-14
SI2240456T1 (sl) 2012-01-31
KR101553568B1 (ko) 2015-09-16
AU2009210293B2 (en) 2013-05-23
BRPI0907052B8 (pt) 2021-05-25
KR20100103698A (ko) 2010-09-27
CY1111837T1 (el) 2015-10-07
AR070329A1 (es) 2010-03-31
DE102008007314A1 (de) 2009-08-06
MX2010008282A (es) 2010-11-30
ZA201006211B (en) 2011-05-25
JP2011510940A (ja) 2011-04-07
CA2713236A1 (en) 2009-08-06
RS51968B (en) 2012-02-29
AU2009210293A1 (en) 2009-08-06
IL206816A (en) 2013-02-28
US20110118463A1 (en) 2011-05-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM