EA201000883A1 - Производные индолинона и способ их получения - Google Patents
Производные индолинона и способ их полученияInfo
- Publication number
- EA201000883A1 EA201000883A1 EA201000883A EA201000883A EA201000883A1 EA 201000883 A1 EA201000883 A1 EA 201000883A1 EA 201000883 A EA201000883 A EA 201000883A EA 201000883 A EA201000883 A EA 201000883A EA 201000883 A1 EA201000883 A1 EA 201000883A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- indolinona
- production
- hydrogen atom
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
В заявке описаны особые производные индолинона, а именно соединения формулыв которой Rобозначает атом водорода или Cl-CH-CO-rpynny, a Rи Rкаждый обозначает атом водорода или Rи Rвместе представляют собой-группу, при условии, что, если Rобозначает атом водорода, то Rи Rвместе представляют собой-группу, а также способ их получения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122123 | 2007-12-03 | ||
PCT/EP2008/066581 WO2009071524A2 (en) | 2007-12-03 | 2008-12-02 | Indolinone derivatives and process for their manufacture |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201000883A1 true EA201000883A1 (ru) | 2010-12-30 |
EA016196B1 EA016196B1 (ru) | 2012-03-30 |
Family
ID=40718253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000883A EA016196B1 (ru) | 2007-12-03 | 2008-12-02 | Производные индолинона и способ их получения |
Country Status (36)
Country | Link |
---|---|
US (1) | US8067617B2 (ru) |
EP (1) | EP2229360B1 (ru) |
JP (2) | JP5933924B2 (ru) |
KR (2) | KR101676261B1 (ru) |
CN (1) | CN101883755B (ru) |
AR (1) | AR069531A1 (ru) |
AU (1) | AU2008333287B2 (ru) |
BR (1) | BRPI0819991B1 (ru) |
CA (1) | CA2705490C (ru) |
CL (1) | CL2008003599A1 (ru) |
CO (1) | CO6210751A2 (ru) |
CY (1) | CY1123333T1 (ru) |
DK (1) | DK2229360T3 (ru) |
EA (1) | EA016196B1 (ru) |
EC (1) | ECSP10010195A (ru) |
ES (1) | ES2818993T3 (ru) |
HK (1) | HK1145682A1 (ru) |
HR (1) | HRP20201480T1 (ru) |
HU (1) | HUE051550T2 (ru) |
IL (1) | IL205348A (ru) |
LT (1) | LT2229360T (ru) |
MA (1) | MA31989B1 (ru) |
MX (1) | MX2010005557A (ru) |
MY (1) | MY148574A (ru) |
NZ (1) | NZ585798A (ru) |
PE (1) | PE20091445A1 (ru) |
PL (1) | PL2229360T3 (ru) |
PT (1) | PT2229360T (ru) |
RS (1) | RS60818B1 (ru) |
SI (1) | SI2229360T1 (ru) |
TN (1) | TN2010000248A1 (ru) |
TW (1) | TWI432415B (ru) |
UA (1) | UA97872C2 (ru) |
UY (1) | UY31506A1 (ru) |
WO (1) | WO2009071524A2 (ru) |
ZA (1) | ZA201002723B (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
WO2012068441A2 (en) | 2010-11-19 | 2012-05-24 | Ratiopharm Gmbh | Intedanib salts and solid state forms thereof |
CN103787949A (zh) * | 2012-10-31 | 2014-05-14 | 韩冰 | 一类保护移植器官的化合物及其用途 |
US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
US20140342772A1 (en) * | 2013-09-12 | 2014-11-20 | Bandwidth.Com, Inc. | Predictive Caching of IP Data |
CN104262232B (zh) * | 2014-09-09 | 2016-05-04 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
CN105712923A (zh) * | 2014-12-03 | 2016-06-29 | 江苏先声药业有限公司 | 一种尼达尼布杂质及其制备方法与应用 |
WO2016178064A1 (en) | 2015-05-06 | 2016-11-10 | Suven Life Sciences Limited | Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof |
CN105001143A (zh) * | 2015-07-24 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种制备高纯度乙磺酸尼达尼布的方法 |
WO2017077551A2 (en) | 2015-11-03 | 2017-05-11 | Mylan Laboratories Limited | An amorphous nintedanib esylate and solid dispersion thereof |
WO2017198202A1 (zh) * | 2016-05-19 | 2017-11-23 | 上海诚妙医药科技有限公司 | 尼达尼布的新晶型及其制备方法及其用途 |
CN106543069A (zh) * | 2016-09-20 | 2017-03-29 | 北京万全德众医药生物技术有限公司 | 6‑甲氧基羰基‑2‑氧代二氢吲哚的制备 |
CN108610308A (zh) * | 2016-12-09 | 2018-10-02 | 上海奥博生物医药技术有限公司 | 一锅法制备尼达尼布中间体的方法 |
CN106841495B (zh) * | 2017-04-21 | 2018-05-11 | 常州佳德医药科技有限公司 | 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法 |
WO2019048974A1 (en) * | 2017-09-06 | 2019-03-14 | Glenmark Pharmaceuticals Limited | PROCESS FOR PREPARING NINTEDANIB |
WO2019097112A1 (en) | 2017-11-17 | 2019-05-23 | Fermion Oy | Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib |
CN110746378B (zh) * | 2018-12-03 | 2021-11-05 | 江苏豪森药业集团有限公司 | 一种胺基中间体的制备方法 |
CN111377845A (zh) * | 2018-12-27 | 2020-07-07 | 江苏先声药业有限公司 | 3-(二甲氨基(苯基)亚甲基)-2-氧化吲哚-6-羧酸甲酯及其制备方法与应用 |
CN111662223B (zh) * | 2019-03-08 | 2023-07-14 | 四川科伦药物研究院有限公司 | 二氢吲哚酮衍生物及其中间体的制备方法 |
CA3191013A1 (en) * | 2020-08-07 | 2022-02-10 | Bdr Lifesciences Private Limited | An improved highly efficient process for the prepration of nintedanib and pharmaceutically acceptable salt thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4876863A (ru) * | 1972-01-22 | 1973-10-16 | ||
US6469181B1 (en) * | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
YU21301A (sh) * | 1998-09-25 | 2003-04-30 | Boehringer Ingelheim Pharama Gmbh. & Co. Kg. | Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdk |
US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
UA75054C2 (ru) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Замещенные в положении 6 индолиноны, их получение и их применение как лекарственного средства |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
WO2008056634A1 (fr) * | 2006-11-06 | 2008-05-15 | Theravalues Corporation | Nouveau dérivé d'hydroxyindole |
WO2009071523A1 (en) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Process for the manufacture of an indolinone derivative |
PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
-
2008
- 2008-12-01 PE PE2008002005A patent/PE20091445A1/es not_active Application Discontinuation
- 2008-12-01 UY UY31506A patent/UY31506A1/es not_active Application Discontinuation
- 2008-12-02 PT PT88575030T patent/PT2229360T/pt unknown
- 2008-12-02 SI SI200832138T patent/SI2229360T1/sl unknown
- 2008-12-02 TW TW097146808A patent/TWI432415B/zh not_active IP Right Cessation
- 2008-12-02 PL PL08857503T patent/PL2229360T3/pl unknown
- 2008-12-02 JP JP2010535407A patent/JP5933924B2/ja active Active
- 2008-12-02 MY MYPI2010002337A patent/MY148574A/en unknown
- 2008-12-02 AR ARP080105254A patent/AR069531A1/es unknown
- 2008-12-02 CN CN2008801190684A patent/CN101883755B/zh active Active
- 2008-12-02 CL CL2008003599A patent/CL2008003599A1/es unknown
- 2008-12-02 DK DK08857503.0T patent/DK2229360T3/da active
- 2008-12-02 ES ES08857503T patent/ES2818993T3/es active Active
- 2008-12-02 KR KR1020107012251A patent/KR101676261B1/ko active IP Right Grant
- 2008-12-02 HU HUE08857503A patent/HUE051550T2/hu unknown
- 2008-12-02 RS RS20201116A patent/RS60818B1/sr unknown
- 2008-12-02 CA CA2705490A patent/CA2705490C/en active Active
- 2008-12-02 US US12/745,788 patent/US8067617B2/en active Active
- 2008-12-02 LT LTEP08857503.0T patent/LT2229360T/lt unknown
- 2008-12-02 EP EP08857503.0A patent/EP2229360B1/en active Active
- 2008-12-02 BR BRPI0819991-4A patent/BRPI0819991B1/pt active IP Right Grant
- 2008-12-02 NZ NZ585798A patent/NZ585798A/en unknown
- 2008-12-02 WO PCT/EP2008/066581 patent/WO2009071524A2/en active Application Filing
- 2008-12-02 MX MX2010005557A patent/MX2010005557A/es active IP Right Grant
- 2008-12-02 UA UAA201007864A patent/UA97872C2/ru unknown
- 2008-12-02 KR KR1020157026969A patent/KR101712810B1/ko active IP Right Grant
- 2008-12-02 AU AU2008333287A patent/AU2008333287B2/en active Active
- 2008-12-02 EA EA201000883A patent/EA016196B1/ru not_active IP Right Cessation
-
2010
- 2010-04-19 ZA ZA2010/02723A patent/ZA201002723B/en unknown
- 2010-04-26 IL IL205348A patent/IL205348A/en active IP Right Grant
- 2010-05-21 EC EC2010010195A patent/ECSP10010195A/es unknown
- 2010-06-01 TN TN2010000248A patent/TN2010000248A1/fr unknown
- 2010-06-03 CO CO10067260A patent/CO6210751A2/es active IP Right Grant
- 2010-07-01 MA MA32974A patent/MA31989B1/fr unknown
- 2010-12-23 HK HK10112055.5A patent/HK1145682A1/xx not_active IP Right Cessation
-
2014
- 2014-10-27 JP JP2014218112A patent/JP6044025B2/ja active Active
-
2020
- 2020-09-08 CY CY20201100845T patent/CY1123333T1/el unknown
- 2020-09-16 HR HRP20201480TT patent/HRP20201480T1/hr unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ BY KZ |