EA200970642A1 - Трициклическое соединение и его фармацевтическое применение - Google Patents

Трициклическое соединение и его фармацевтическое применение

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Publication number
EA200970642A1
EA200970642A1 EA200970642A EA200970642A EA200970642A1 EA 200970642 A1 EA200970642 A1 EA 200970642A1 EA 200970642 A EA200970642 A EA 200970642A EA 200970642 A EA200970642 A EA 200970642A EA 200970642 A1 EA200970642 A1 EA 200970642A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituent
optionally
group
atom
tricyclic compound
Prior art date
Application number
EA200970642A
Other languages
English (en)
Inventor
Осаму Утикава
Тацуки Койке
Такафуми Такаи
Ясутака Хоаси
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA200970642A1 publication Critical patent/EA200970642A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Abstract

Настоящее изобретение предоставляет соединение, представленное формулойгде Rпредставляет собой углеводородную группу, необязательно имеющую заместитель(и), аминогруппу, необязательно имеющую заместитель(и), гидроксигруппу, необязательно имеющую заместитель, или гетероциклическую группу, необязательно имеющую заместитель(и), Rпредставляет собой атом водорода или углеводородную группу, необязательно имеющую заместитель(и), Rпредставляет собой атом водорода, атом галогена, углеводородную группу, необязательно имеющую заместитель(и), аминогруппу, необязательно имеющую заместитель(и), гидроксигруппу, необязательно имеющую заместитель, или меркаптогруппу, необязательно имеющую заместитель, каждый из Xa, Xb, Xc и Xd представляет собой атом углерода или атом азота, при условии, что любой один или любые два из Ха, Xb, Хс и Xd, представляет(ют) собой атом(ы) азота, m равно от 0 до 2 и каждое из колец А-С представляет собой кольцо, необязательно имеющее заместитель(и), или его соль, которое применимо в качестве средства для профилактики или лечения заболеваний, связанных с действием мелатонина и т.п.
EA200970642A 2006-12-28 2007-12-27 Трициклическое соединение и его фармацевтическое применение EA200970642A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006356344 2006-12-28
PCT/JP2007/075159 WO2008084717A1 (ja) 2006-12-28 2007-12-27 三環性化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
EA200970642A1 true EA200970642A1 (ru) 2009-12-30

Family

ID=39608611

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970642A EA200970642A1 (ru) 2006-12-28 2007-12-27 Трициклическое соединение и его фармацевтическое применение

Country Status (11)

Country Link
US (1) US8247429B2 (ru)
EP (1) EP2098513B1 (ru)
JP (1) JP5291470B2 (ru)
KR (1) KR20090095666A (ru)
CN (1) CN101622233A (ru)
AU (1) AU2007342806A1 (ru)
BR (1) BRPI0722057A2 (ru)
CA (1) CA2674045A1 (ru)
EA (1) EA200970642A1 (ru)
MX (1) MX2009007058A (ru)
WO (1) WO2008084717A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
WO2012109695A1 (en) * 2011-02-16 2012-08-23 Casal Y Galzov Ramon Ernesto Drug compositions for the treatment of insomnia
US8986283B2 (en) 2011-05-18 2015-03-24 Solo-Dex, Llc Continuous anesthesia nerve conduction apparatus, system and method thereof
CA2835354C (en) 2011-05-18 2020-08-25 Solodex Llc Continuous anesthesia nerve conduction apparatus, system and method
US10399961B2 (en) 2015-10-27 2019-09-03 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
KR20180100627A (ko) 2016-01-08 2018-09-11 다케다 야쿠힌 고교 가부시키가이샤 섬망의 예방 또는 치료제
EP3400939B1 (en) 2016-01-08 2022-03-16 Takeda Pharmaceutical Company Limited Prophylactic or therapeutic agent for autism spectrum disorder

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008466A1 (en) 1994-09-12 1996-03-21 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds, their production and use
JP3908798B2 (ja) * 1994-09-12 2007-04-25 武田薬品工業株式会社 ベンゾシクロアルケン類、その製造法および剤
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
JP2884153B2 (ja) * 1996-03-08 1999-04-19 武田薬品工業株式会社 三環性化合物、その製造法および剤
NZ330656A (en) 1996-03-08 1999-06-29 Takeda Chemical Industries Ltd Tricyclic compounds, their production and use
FR2773798B1 (fr) * 1998-01-16 2001-02-02 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2007148808A (ja) 2005-11-28 2007-06-14 Hitachi Ltd 金融・証券コラボレーション方法
AR061478A1 (es) * 2006-06-19 2008-08-27 Takeda Pharmaceutical Compuesto triciclico y composicion farmaceutica
EP2100895B1 (en) 2006-12-08 2012-03-07 Takeda Pharmaceutical Company Limited Tricyclic compound and medical use thereof

Also Published As

Publication number Publication date
MX2009007058A (es) 2009-07-10
US20100010038A1 (en) 2010-01-14
CN101622233A (zh) 2010-01-06
US8247429B2 (en) 2012-08-21
EP2098513B1 (en) 2015-01-21
WO2008084717A1 (ja) 2008-07-17
BRPI0722057A2 (pt) 2014-04-01
EP2098513A1 (en) 2009-09-09
AU2007342806A1 (en) 2008-07-17
JP5291470B2 (ja) 2013-09-18
JPWO2008084717A1 (ja) 2010-04-30
KR20090095666A (ko) 2009-09-09
CA2674045A1 (en) 2008-07-17
EP2098513A4 (en) 2010-12-01

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