WO2008084717A1 - 三環性化合物およびその医薬用途 - Google Patents

三環性化合物およびその医薬用途 Download PDF

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Publication number
WO2008084717A1
WO2008084717A1 PCT/JP2007/075159 JP2007075159W WO2008084717A1 WO 2008084717 A1 WO2008084717 A1 WO 2008084717A1 JP 2007075159 W JP2007075159 W JP 2007075159W WO 2008084717 A1 WO2008084717 A1 WO 2008084717A1
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optionally substituted
hydrocarbon group
atom
pharmaceutical use
respectively represent
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PCT/JP2007/075159
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English (en)
French (fr)
Inventor
Osamu Uchikawa
Tatsuki Koike
Takafumi Takai
Yasutaka Hoashi
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Takeda Pharmaceutical Company Limited
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Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to MX2009007058A priority Critical patent/MX2009007058A/es
Priority to EP07860381.8A priority patent/EP2098513B1/en
Priority to AU2007342806A priority patent/AU2007342806A1/en
Priority to US12/448,366 priority patent/US8247429B2/en
Priority to CA002674045A priority patent/CA2674045A1/en
Priority to BRPI0722057-0A2A priority patent/BRPI0722057A2/pt
Priority to EA200970642A priority patent/EA200970642A1/ru
Priority to JP2008553074A priority patent/JP5291470B2/ja
Publication of WO2008084717A1 publication Critical patent/WO2008084717A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　本発明は、メラトニンの作用と関連した疾患の予防・治療剤として有用な、式 〔式中、Ｒ１は、置換基を有していてもよい炭化水素基、置換基を有していてもよいアミノ、置換基を有していてもよいヒドロキシ、または置換基を有していてもよい複素環基、Ｒ２は、水素原子または置換基を有していてもよい炭化水素基、Ｒ３は、水素原子、ハロゲン原子、置換基を有していてもよい炭化水素基、置換基を有していてもよいアミノ、置換基を有していてもよいヒドロキシ、または置換基を有していてもよいメルカプト、Ｘａ、Ｘｂ、ＸｃおよびＸｄは、炭素原子または窒素原子（ただし、Ｘａ、Ｘｂ、ＸｃおよびＸｄのいずれか一または二は窒素原子である。）、ｍは０～２、環Ａ～Ｃはそれぞれ置換基を有していてもよい環を示す。〕で表される化合物またはその塩などを提供する。
PCT/JP2007/075159 2006-12-28 2007-12-27 三環性化合物およびその医薬用途 WO2008084717A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX2009007058A MX2009007058A (es) 2006-12-28 2007-12-27 Compuesto triciclico y uso farmaceutico del mismo.
EP07860381.8A EP2098513B1 (en) 2006-12-28 2007-12-27 Tricyclic compound and pharmaceutical use thereof
AU2007342806A AU2007342806A1 (en) 2006-12-28 2007-12-27 Tricyclic compound and pharmaceutical use thereof
US12/448,366 US8247429B2 (en) 2006-12-28 2007-12-27 Tricyclic compound and pharmaceutical use thereof
CA002674045A CA2674045A1 (en) 2006-12-28 2007-12-27 Tricyclic compound and pharmaceutical use thereof
BRPI0722057-0A2A BRPI0722057A2 (pt) 2006-12-28 2007-12-27 Composto, prodroga, composição farmacêutica, método para prevenir ou tratar distúrbio do sono, e, uso do composto.
EA200970642A EA200970642A1 (ru) 2006-12-28 2007-12-27 Трициклическое соединение и его фармацевтическое применение
JP2008553074A JP5291470B2 (ja) 2006-12-28 2007-12-27 三環性化合物およびその医薬用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-356344 2006-12-28
JP2006356344 2006-12-28

Publications (1)

Publication Number Publication Date
WO2008084717A1 true WO2008084717A1 (ja) 2008-07-17

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PCT/JP2007/075159 WO2008084717A1 (ja) 2006-12-28 2007-12-27 三環性化合物およびその医薬用途

Country Status (11)

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US (1) US8247429B2 (ja)
EP (1) EP2098513B1 (ja)
JP (1) JP5291470B2 (ja)
KR (1) KR20090095666A (ja)
CN (1) CN101622233A (ja)
AU (1) AU2007342806A1 (ja)
BR (1) BRPI0722057A2 (ja)
CA (1) CA2674045A1 (ja)
EA (1) EA200970642A1 (ja)
MX (1) MX2009007058A (ja)
WO (1) WO2008084717A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
WO2017119455A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 自閉症スペクトラム障害の予防または治療剤
WO2017119456A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 せん妄の予防または治療剤

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012109695A1 (en) * 2011-02-16 2012-08-23 Casal Y Galzov Ramon Ernesto Drug compositions for the treatment of insomnia
US8986283B2 (en) 2011-05-18 2015-03-24 Solo-Dex, Llc Continuous anesthesia nerve conduction apparatus, system and method thereof
CA3065357C (en) 2011-05-18 2023-04-25 Solodex Llc Continuous anesthesia nerve conduction apparatus, system and method
EP3368529B1 (en) 2015-10-27 2022-04-06 Boehringer Ingelheim International GmbH Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08134030A (ja) * 1994-09-12 1996-05-28 Takeda Chem Ind Ltd ベンゾシクロアルケン類、その製造法および剤
WO1997032871A1 (en) 1996-03-08 1997-09-12 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
JPH10287665A (ja) * 1996-03-08 1998-10-27 Takeda Chem Ind Ltd 三環性化合物、その製造法および剤
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
JP2002509130A (ja) * 1998-01-16 2002-03-26 アディール エ コンパニー 新しい三環系化合物、その製造方法及びこれらを含む医薬組成物
WO2007148808A1 (en) * 2006-06-19 2007-12-27 Takeda Pharmaceutical Company Limited Tricyclic compound and pharmaceutical use thereof

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
WO1996008466A1 (en) 1994-09-12 1996-03-21 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds, their production and use
JP2007148808A (ja) 2005-11-28 2007-06-14 Hitachi Ltd 金融・証券コラボレーション方法
ATE548371T1 (de) 2006-12-08 2012-03-15 Takeda Pharmaceutical Tricyclische verbindung und deren medizinische verwendung

Patent Citations (6)

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JPH08134030A (ja) * 1994-09-12 1996-05-28 Takeda Chem Ind Ltd ベンゾシクロアルケン類、その製造法および剤
WO1997032871A1 (en) 1996-03-08 1997-09-12 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
JPH10287665A (ja) * 1996-03-08 1998-10-27 Takeda Chem Ind Ltd 三環性化合物、その製造法および剤
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
JP2002509130A (ja) * 1998-01-16 2002-03-26 アディール エ コンパニー 新しい三環系化合物、その製造方法及びこれらを含む医薬組成物
WO2007148808A1 (en) * 2006-06-19 2007-12-27 Takeda Pharmaceutical Company Limited Tricyclic compound and pharmaceutical use thereof

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See also references of EP2098513A4
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
WO2017119455A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 自閉症スペクトラム障害の予防または治療剤
WO2017119456A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 せん妄の予防または治療剤
US10759768B2 (en) 2016-01-08 2020-09-01 Takeda Pharmaceutical Company Limited Prophylactic or therapeutic agent for autism spectrum disorder
US11173147B2 (en) 2016-01-08 2021-11-16 Takeda Pharmaceutical Company Limited Prophylactic or therapeutic agent for delirium

Also Published As

Publication number Publication date
KR20090095666A (ko) 2009-09-09
EP2098513A1 (en) 2009-09-09
AU2007342806A1 (en) 2008-07-17
JP5291470B2 (ja) 2013-09-18
JPWO2008084717A1 (ja) 2010-04-30
CN101622233A (zh) 2010-01-06
US20100010038A1 (en) 2010-01-14
BRPI0722057A2 (pt) 2014-04-01
MX2009007058A (es) 2009-07-10
EP2098513A4 (en) 2010-12-01
EP2098513B1 (en) 2015-01-21
US8247429B2 (en) 2012-08-21
CA2674045A1 (en) 2008-07-17
EA200970642A1 (ru) 2009-12-30

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