WO2008084717A1 - 三環性化合物およびその医薬用途 - Google Patents
三環性化合物およびその医薬用途 Download PDFInfo
- Publication number
- WO2008084717A1 WO2008084717A1 PCT/JP2007/075159 JP2007075159W WO2008084717A1 WO 2008084717 A1 WO2008084717 A1 WO 2008084717A1 JP 2007075159 W JP2007075159 W JP 2007075159W WO 2008084717 A1 WO2008084717 A1 WO 2008084717A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- hydrocarbon group
- atom
- pharmaceutical use
- respectively represent
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2009007058A MX2009007058A (es) | 2006-12-28 | 2007-12-27 | Compuesto triciclico y uso farmaceutico del mismo. |
EP07860381.8A EP2098513B1 (en) | 2006-12-28 | 2007-12-27 | Tricyclic compound and pharmaceutical use thereof |
AU2007342806A AU2007342806A1 (en) | 2006-12-28 | 2007-12-27 | Tricyclic compound and pharmaceutical use thereof |
US12/448,366 US8247429B2 (en) | 2006-12-28 | 2007-12-27 | Tricyclic compound and pharmaceutical use thereof |
CA002674045A CA2674045A1 (en) | 2006-12-28 | 2007-12-27 | Tricyclic compound and pharmaceutical use thereof |
BRPI0722057-0A2A BRPI0722057A2 (pt) | 2006-12-28 | 2007-12-27 | Composto, prodroga, composição farmacêutica, método para prevenir ou tratar distúrbio do sono, e, uso do composto. |
EA200970642A EA200970642A1 (ru) | 2006-12-28 | 2007-12-27 | Трициклическое соединение и его фармацевтическое применение |
JP2008553074A JP5291470B2 (ja) | 2006-12-28 | 2007-12-27 | 三環性化合物およびその医薬用途 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006-356344 | 2006-12-28 | ||
JP2006356344 | 2006-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008084717A1 true WO2008084717A1 (ja) | 2008-07-17 |
Family
ID=39608611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/075159 WO2008084717A1 (ja) | 2006-12-28 | 2007-12-27 | 三環性化合物およびその医薬用途 |
Country Status (11)
Country | Link |
---|---|
US (1) | US8247429B2 (ja) |
EP (1) | EP2098513B1 (ja) |
JP (1) | JP5291470B2 (ja) |
KR (1) | KR20090095666A (ja) |
CN (1) | CN101622233A (ja) |
AU (1) | AU2007342806A1 (ja) |
BR (1) | BRPI0722057A2 (ja) |
CA (1) | CA2674045A1 (ja) |
EA (1) | EA200970642A1 (ja) |
MX (1) | MX2009007058A (ja) |
WO (1) | WO2008084717A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2253617A1 (de) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
WO2017119455A1 (ja) | 2016-01-08 | 2017-07-13 | 武田薬品工業株式会社 | 自閉症スペクトラム障害の予防または治療剤 |
WO2017119456A1 (ja) | 2016-01-08 | 2017-07-13 | 武田薬品工業株式会社 | せん妄の予防または治療剤 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012109695A1 (en) * | 2011-02-16 | 2012-08-23 | Casal Y Galzov Ramon Ernesto | Drug compositions for the treatment of insomnia |
US8986283B2 (en) | 2011-05-18 | 2015-03-24 | Solo-Dex, Llc | Continuous anesthesia nerve conduction apparatus, system and method thereof |
CA3065357C (en) | 2011-05-18 | 2023-04-25 | Solodex Llc | Continuous anesthesia nerve conduction apparatus, system and method |
EP3368529B1 (en) | 2015-10-27 | 2022-04-06 | Boehringer Ingelheim International GmbH | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08134030A (ja) * | 1994-09-12 | 1996-05-28 | Takeda Chem Ind Ltd | ベンゾシクロアルケン類、その製造法および剤 |
WO1997032871A1 (en) | 1996-03-08 | 1997-09-12 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
JPH10287665A (ja) * | 1996-03-08 | 1998-10-27 | Takeda Chem Ind Ltd | 三環性化合物、その製造法および剤 |
US6034239A (en) | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
JP2002509130A (ja) * | 1998-01-16 | 2002-03-26 | アディール エ コンパニー | 新しい三環系化合物、その製造方法及びこれらを含む医薬組成物 |
WO2007148808A1 (en) * | 2006-06-19 | 2007-12-27 | Takeda Pharmaceutical Company Limited | Tricyclic compound and pharmaceutical use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996008466A1 (en) | 1994-09-12 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds, their production and use |
JP2007148808A (ja) | 2005-11-28 | 2007-06-14 | Hitachi Ltd | 金融・証券コラボレーション方法 |
ATE548371T1 (de) | 2006-12-08 | 2012-03-15 | Takeda Pharmaceutical | Tricyclische verbindung und deren medizinische verwendung |
-
2007
- 2007-12-27 BR BRPI0722057-0A2A patent/BRPI0722057A2/pt not_active IP Right Cessation
- 2007-12-27 EA EA200970642A patent/EA200970642A1/ru unknown
- 2007-12-27 AU AU2007342806A patent/AU2007342806A1/en not_active Abandoned
- 2007-12-27 EP EP07860381.8A patent/EP2098513B1/en not_active Not-in-force
- 2007-12-27 KR KR1020097015731A patent/KR20090095666A/ko not_active Application Discontinuation
- 2007-12-27 JP JP2008553074A patent/JP5291470B2/ja not_active Expired - Fee Related
- 2007-12-27 CA CA002674045A patent/CA2674045A1/en not_active Abandoned
- 2007-12-27 US US12/448,366 patent/US8247429B2/en not_active Expired - Fee Related
- 2007-12-27 WO PCT/JP2007/075159 patent/WO2008084717A1/ja active Application Filing
- 2007-12-27 CN CN200780051883A patent/CN101622233A/zh active Pending
- 2007-12-27 MX MX2009007058A patent/MX2009007058A/es not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08134030A (ja) * | 1994-09-12 | 1996-05-28 | Takeda Chem Ind Ltd | ベンゾシクロアルケン類、その製造法および剤 |
WO1997032871A1 (en) | 1996-03-08 | 1997-09-12 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
JPH10287665A (ja) * | 1996-03-08 | 1998-10-27 | Takeda Chem Ind Ltd | 三環性化合物、その製造法および剤 |
US6034239A (en) | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
JP2002509130A (ja) * | 1998-01-16 | 2002-03-26 | アディール エ コンパニー | 新しい三環系化合物、その製造方法及びこれらを含む医薬組成物 |
WO2007148808A1 (en) * | 2006-06-19 | 2007-12-27 | Takeda Pharmaceutical Company Limited | Tricyclic compound and pharmaceutical use thereof |
Non-Patent Citations (21)
Title |
---|
"Jikken Kagaku Koza (Courses in Experimental Chemistry", vol. 19, pages: 273 - 274 |
"Shin Jikken Kagaku Koza (New Experimental Chemistry Course", vol. 14, pages: 251 - 253 |
"Shin Jikken Kagaku Koza (New Experimental Chemistry Course)", vol. 14, 15 |
"Shin Jikken Kagaku Koza (New Experimental Chemistry Course)", vol. 14, -15 |
ANN. N. Y. ACAD. SCI., vol. 719, 1994, pages 456 - 460 |
CLINICAL EXAMINATIONS, vol. 38, no. 11, 1994, pages 282 - 284 |
IYAKUHIN NO KAIHATSU, DEVELOPMENT OF PHARMACEUTICALS, vol. 7, pages 163 - 198 |
J. CHEM. SOC, vol. 1, 1973, pages 2371 |
J. CHEM. SOC. PERKIN TRANS., vol. 1, 1997, pages 3597 |
J. HETEROCYCLIC CHEM., vol. 21, 1984, pages 1063 |
J. ORG. CHEM, vol. 56, 1991, pages 2866 |
J. ORG. CHEM., vol. 38, 1973, pages 1239 |
J. ORG. CHEM., vol. 58, 1993, pages 3162 |
J. ORG. CHEM., vol. 68, 2003, pages 7119 |
JIKKEN KAGAKU KOZA: "Courses in Experimental Chemistry", vol. 20, THE CHEMICAL SOCIETY OF JAPAN, pages: 353 - 354 |
JIKKEN KAGAKU KOZA: "Courses in Experimental Chemistry", vol. 22, THE CHEMICAL SOCIETY OF JAPAN, pages: 43 - 54 |
JIKKEN KAGAKU KOZA: "New Experimental Chemistry Course", vol. 14, 15, THE CHEMICAL SOCIETY OF JAPAN, pages: 230 - 239 |
MONATSH. CHEM., vol. 105, 1974, pages 196 |
PAKKOI.11H, BIOCHIM BIOPHYS ACTA, vol. 1219, no. 2, 1994, pages 251 - 259 |
See also references of EP2098513A4 |
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2253617A1 (de) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
WO2017119455A1 (ja) | 2016-01-08 | 2017-07-13 | 武田薬品工業株式会社 | 自閉症スペクトラム障害の予防または治療剤 |
WO2017119456A1 (ja) | 2016-01-08 | 2017-07-13 | 武田薬品工業株式会社 | せん妄の予防または治療剤 |
US10759768B2 (en) | 2016-01-08 | 2020-09-01 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for autism spectrum disorder |
US11173147B2 (en) | 2016-01-08 | 2021-11-16 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for delirium |
Also Published As
Publication number | Publication date |
---|---|
KR20090095666A (ko) | 2009-09-09 |
EP2098513A1 (en) | 2009-09-09 |
AU2007342806A1 (en) | 2008-07-17 |
JP5291470B2 (ja) | 2013-09-18 |
JPWO2008084717A1 (ja) | 2010-04-30 |
CN101622233A (zh) | 2010-01-06 |
US20100010038A1 (en) | 2010-01-14 |
BRPI0722057A2 (pt) | 2014-04-01 |
MX2009007058A (es) | 2009-07-10 |
EP2098513A4 (en) | 2010-12-01 |
EP2098513B1 (en) | 2015-01-21 |
US8247429B2 (en) | 2012-08-21 |
CA2674045A1 (en) | 2008-07-17 |
EA200970642A1 (ru) | 2009-12-30 |
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