EA200900662A1 - Лечение синдрома "сухого глаза" с помощью тестостерона и прогестагена - Google Patents

Лечение синдрома "сухого глаза" с помощью тестостерона и прогестагена

Info

Publication number
EA200900662A1
EA200900662A1 EA200900662A EA200900662A EA200900662A1 EA 200900662 A1 EA200900662 A1 EA 200900662A1 EA 200900662 A EA200900662 A EA 200900662A EA 200900662 A EA200900662 A EA 200900662A EA 200900662 A1 EA200900662 A1 EA 200900662A1
Authority
EA
Eurasian Patent Office
Prior art keywords
progestagene
testosterone
treatment
dry eye
eye syndrome
Prior art date
Application number
EA200900662A
Other languages
English (en)
Inventor
Чарльз Дж. Коннор
Чарльз Хэйн
Original Assignee
Саутерн Колледж Ов Оптометри
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саутерн Колледж Ов Оптометри filed Critical Саутерн Колледж Ов Оптометри
Publication of EA200900662A1 publication Critical patent/EA200900662A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Eyeglasses (AREA)

Abstract

Настоящее изобретение относится к композиции и способам лечения заболеваний глаз с помощью композиции, содержащей терапевтически эффективное количество прогестагена, терапевтически эффективное количество прогестагена и фармацевтически приемлемый носитель, причем композиция наносится на пальпебральную часть глаза и/или на поверхность глаза.
EA200900662A 2006-12-05 2007-12-05 Лечение синдрома "сухого глаза" с помощью тестостерона и прогестагена EA200900662A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/634,347 US20080132475A1 (en) 2006-12-05 2006-12-05 Treatment for dry eye
PCT/US2007/086517 WO2008070728A2 (en) 2006-12-05 2007-12-05 Treatment for dry eye using testosterone and progestagen

Publications (1)

Publication Number Publication Date
EA200900662A1 true EA200900662A1 (ru) 2009-12-30

Family

ID=39476533

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200900662A EA200900662A1 (ru) 2006-12-05 2007-12-05 Лечение синдрома "сухого глаза" с помощью тестостерона и прогестагена
EA200900663A EA200900663A1 (ru) 2006-12-05 2007-12-05 Лечение синдрома "сухого глаза"

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200900663A EA200900663A1 (ru) 2006-12-05 2007-12-05 Лечение синдрома "сухого глаза"

Country Status (12)

Country Link
US (3) US20080132475A1 (ru)
EP (2) EP2101785A4 (ru)
JP (2) JP2010511729A (ru)
KR (2) KR20090104813A (ru)
CN (2) CN101636165A (ru)
AU (1) AU2009202711A1 (ru)
BR (2) BRPI0720172A2 (ru)
CA (2) CA2671698A1 (ru)
EA (2) EA200900662A1 (ru)
IL (1) IL199094A0 (ru)
MX (2) MX2009005993A (ru)
WO (2) WO2008070728A2 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10105441B2 (en) * 2007-08-16 2018-10-23 The Schepens Eye Research Institute, Inc. Method for inhibiting or reducing dry eye disease by IL-1Ra
US20100016264A1 (en) * 2007-12-05 2010-01-21 Connor Charles G Treatment for dry eye using testosterone and progestagen
EP2320912B1 (en) * 2008-08-05 2015-01-14 University College Cork-National University of Ireland, Cork Treatment of retinal degeneration
MX344046B (es) 2011-01-26 2016-12-02 Allergan Inc Composicion de androgeno para tratar una afeccion oftalmica.
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP3936133A1 (en) 2011-11-23 2022-01-12 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
MX362185B (es) 2012-07-27 2019-01-08 Glia Llc Composiciones y tratamiento para enfermedades y trastornos del ojo.
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9682032B2 (en) * 2013-03-15 2017-06-20 Glia, Llc Cranial delivery of pharmaceuticals
CA2947767A1 (en) 2014-05-22 2015-11-26 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP3174542A4 (en) 2014-07-29 2018-01-03 TherapeuticsMD, Inc. Transdermal cream
MX2017012708A (es) * 2015-04-03 2018-01-09 Santen Pharmaceutical Co Ltd Agente terapeutico para ojo seco que comprende nandrolona o ester del mismo o metenolona o ester del mismo como un ingrediente activo.
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
BR112018070199A2 (pt) 2016-04-01 2019-01-29 Therapeuticsmd Inc composição farmacêutica de hormônio esteroide
CN110072523A (zh) 2016-09-07 2019-07-30 格利亚有限责任公司 通过脑神经的药理皮肤激活来治疗与神经退行性病症相关的症状
TW202131927A (zh) * 2019-11-13 2021-09-01 美商葛莉亞有限責任公司 睾固酮組合物
WO2023107796A1 (en) * 2021-12-11 2023-06-15 The Regents Of The University Of California Ophthalmic formulations for macular degeneration

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2861920A (en) * 1954-05-04 1958-11-25 Upjohn Co Therapeutic suspensions of steroids containing pvp and/or pva
JPS59184135A (ja) * 1983-04-04 1984-10-19 Teijin Ltd グリセリンピログルタミン酸エステル類を含有する医薬品組成物
US4617299A (en) * 1983-12-19 1986-10-14 Knepper Paul A Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
DE3514724A1 (de) * 1985-04-24 1986-10-30 Albin F. Dr. 4200 Oberhausen Jereb Salbe zur verbeugung und behandlung von augen- und hauterkrankungen
US4914088A (en) * 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
USRE34578E (en) * 1990-05-07 1994-04-05 Lubkin; Virginia Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
ZA912797B (en) * 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
US5688765A (en) * 1992-04-21 1997-11-18 The Schepens Eye Research Institute, Inc. Ocular therapy in Sjogren's syndrome using topically applied androgensor TGF-β
DE69326836T2 (de) * 1992-04-21 2000-02-24 The Schepens Eye Research Institute, Inc. Androgentherapie am auge beim sjögrensyndrom
US5958912A (en) * 1992-04-21 1999-09-28 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β
US6107289A (en) * 1992-04-21 2000-08-22 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β
US5366739A (en) * 1992-08-06 1994-11-22 Deo Corporation Method of ophthalmic drug delivery
DE69328368T2 (de) * 1992-08-28 2000-08-10 Pharmos Corp., New York Emulsionen im submikron-bereich als vehikel zur arzneistoffverabreichung am auge
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
JP2000515523A (ja) * 1996-07-22 2000-11-21 ザ・ビクトリア・ユニバーシティ・オブ・マンチェスター 創傷および線維性障害の治療における性ステロイド機能モジュレーターの使用
AU735944B2 (en) * 1997-02-28 2001-07-19 Minnesota Mining And Manufacturing Company Transdermal device for the delivery of testosterone
US5869090A (en) * 1998-01-20 1999-02-09 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
FR2774587B1 (fr) * 1998-02-09 2000-03-10 Oreal Utilisation d'une microdispersion de cire dans une composition cosmetique ou dermatologique
US6348210B1 (en) * 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
US6117446A (en) * 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
PE20010404A1 (es) * 1999-06-11 2001-04-09 Watson Pharmaceuticals Inc Combinacion de esteroides androgenicos no orales y compuestos estrogenicos y su uso en mujeres
US6569903B2 (en) * 1999-12-07 2003-05-27 Rohto Pharmaceutical Co., Ltd. Ophthalmic compositions
US6630175B1 (en) * 2000-06-29 2003-10-07 Johnson & Johnson Consumer Companies, Inc. Method of reducing eye irritation
WO2002055020A2 (en) * 2000-12-11 2002-07-18 Testocreme Llc Topical testosterone formulations and associated methods
US6659985B2 (en) * 2002-01-30 2003-12-09 Southern College Of Optometry Method to use transdermal administration of androgens to the adnexa of the eye
WO2004045510A2 (en) * 2002-11-15 2004-06-03 Panaseca, Inc. Methods and compositions for alleviating dry eyes
US20060111318A1 (en) * 2003-04-18 2006-05-25 Advanced Medicine Research Institute Agent for treating eye diseases
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
US7960350B2 (en) * 2003-10-24 2011-06-14 Ader Enterprises, Inc. Composition and method for the treatment of eye disease
US20050202097A1 (en) * 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
US20050234018A1 (en) * 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US20060258698A1 (en) * 2005-02-09 2006-11-16 Sreenivasu Mudumba Liquid formulations for treatment of diseases or conditions
US20100016264A1 (en) * 2007-12-05 2010-01-21 Connor Charles G Treatment for dry eye using testosterone and progestagen

Also Published As

Publication number Publication date
WO2008070726A2 (en) 2008-06-12
EA200900663A1 (ru) 2009-12-30
WO2008070726A3 (en) 2008-08-21
EP2101785A2 (en) 2009-09-23
MX2009005994A (es) 2009-12-14
AU2009202711A1 (en) 2009-07-23
BRPI0719918A2 (pt) 2014-03-04
WO2008070728A2 (en) 2008-06-12
US20080132475A1 (en) 2008-06-05
IL199094A0 (en) 2010-03-28
US20210008079A1 (en) 2021-01-14
KR20090104813A (ko) 2009-10-06
EP2101785A4 (en) 2009-12-30
JP2010511729A (ja) 2010-04-15
CA2671698A1 (en) 2008-06-12
CN101636165A (zh) 2010-01-27
CN101636164A (zh) 2010-01-27
MX2009005993A (es) 2009-12-14
EP2124958A4 (en) 2009-12-30
BRPI0720172A2 (pt) 2014-01-07
WO2008070728A3 (en) 2008-08-07
KR20090104814A (ko) 2009-10-06
EP2124958A2 (en) 2009-12-02
US20140113889A1 (en) 2014-04-24
CA2671769A1 (en) 2008-06-12
JP2010511730A (ja) 2010-04-15

Similar Documents

Publication Publication Date Title
EA200900662A1 (ru) Лечение синдрома "сухого глаза" с помощью тестостерона и прогестагена
WO2008070593A3 (en) Variant target binding agents and uses thereof
EA200601746A1 (ru) Применение ротиготина для лечения и предупреждения синдрома "паркинсонизм-плюс"
EA200601648A1 (ru) Глюкозамин и общие пролекарства глюкозамин/противовоспалительный агент, композиции и способы
WO2006091459A3 (en) Compositions and methods for treating vascular permeability
BRPI0813699A2 (pt) Formulações de proteína de fusão glp-1-fc
IL192181A0 (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of mania and bipolar disorder
EP2628486A3 (en) Method for treating bone fracture with anti-sclerostin antibodies
BRPI0506970A (pt) derivados de alfa-aminoamida úteis no tratamento de distúrbios do trato urinário inferior
MXPA05013733A (es) 2-aminobenzotiazoles como agonistas inversos del receptor de cb1.
WO2008075376A8 (en) Polymorphic forms of bortezomib and process for their preparation
WO2007067519A3 (en) The use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
EA200870093A1 (ru) Применение производных бензоконденсированного гетероциклического сульфамида для лечения ожирения
ATE384058T1 (de) Thiazolderivate
MX2009013353A (es) Compuestos activadores de telomerasa y metodos para su uso.
MX2010007584A (es) Inhibidores de proteina cinasa y uso de los mismos.
MX2011012015A (es) Tratamiento de deterioro cognitivo leve y enfermedad de alzheimer.
MX2012012355A (es) Composiciones organicas para tratar enfermedades relacionadas con beta-enac.
DOP2011000055A (es) [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos
WO2008079270A3 (en) Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
EA200700772A1 (ru) Аналоги полиаминов в качестве терапевтических средств для глазных заболеваний
NZ597866A (en) Therapeutic lactams
WO2006101909A3 (en) Combination therapy for treating or preventing diseases
NZ595271A (en) Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
WO2007095609A3 (en) Use of benzo-heteroaryl sulfamide derivatives for the treatment of mania and bipolar disorder