WO2008075376A8 - Polymorphic forms of bortezomib and process for their preparation - Google Patents

Polymorphic forms of bortezomib and process for their preparation Download PDF

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Publication number
WO2008075376A8
WO2008075376A8 PCT/IN2007/000561 IN2007000561W WO2008075376A8 WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8 IN 2007000561 W IN2007000561 W IN 2007000561W WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8
Authority
WO
WIPO (PCT)
Prior art keywords
bortezomib
preparation
polymorphic forms
forms
novel
Prior art date
Application number
PCT/IN2007/000561
Other languages
French (fr)
Other versions
WO2008075376A1 (en
Inventor
Janaki Rama Rao Ravi
Muddasani Pulla Reddy
Bhujanga Rao Adibatla Kali Satya
Nannapaneni Venkaiah Chowdary
Original Assignee
Natco Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Limited filed Critical Natco Pharma Limited
Publication of WO2008075376A1 publication Critical patent/WO2008075376A1/en
Publication of WO2008075376A8 publication Critical patent/WO2008075376A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to two novel and stable polymorphic forms, namely Form I and Form II of bortezomib (1) and processes for the preparation of these forms. Bortezomib is an anti-neoplastic agent used in the treatment of multiple myeloma.
PCT/IN2007/000561 2006-12-18 2007-12-03 Polymorphic forms of bortezomib and process for their preparation WO2008075376A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2348CH2006 2006-12-18
IN2348/CHE/2006 2006-12-18

Publications (2)

Publication Number Publication Date
WO2008075376A1 WO2008075376A1 (en) 2008-06-26
WO2008075376A8 true WO2008075376A8 (en) 2010-04-15

Family

ID=39327992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000561 WO2008075376A1 (en) 2006-12-18 2007-12-03 Polymorphic forms of bortezomib and process for their preparation

Country Status (1)

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WO (1) WO2008075376A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010002836A (en) * 2007-09-12 2010-03-31 Reddys Lab Ltd Dr Bortezomib and process for producing same.
WO2011099018A1 (en) * 2010-02-15 2011-08-18 Hetero Research Foundation Polymorphs of bortezomib
WO2011107912A1 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Polymorphic forms of bortezomib
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
RU2529800C2 (en) 2010-03-18 2014-09-27 ИННОФАРМА, Инк. Stable formulations of bortezomib
CA2813003A1 (en) 2010-10-05 2012-04-12 Fresenius Kabi Usa, Llc Bortezomib formulations stabilised with boric acid
US8497374B2 (en) 2011-05-12 2013-07-30 Scinopharm Taiwan, Ltd. Process for preparing and purifying bortezomib
CA2784240C (en) 2012-03-27 2014-07-08 Innopharma, Inc. Stable bortezomib formulations
NZ630287A (en) * 2012-11-16 2016-07-29 Shilpa Medicare Ltd Crystalline bortezomib process
WO2014097306A1 (en) 2012-12-21 2014-06-26 Natco Pharma Limited Stable and pure polymorphic form of bortezomib
ZA201402789B (en) * 2013-04-16 2015-11-25 Cipla Ltd Process for the preparation of bortezomib mannitol ester
WO2015122702A1 (en) * 2014-02-14 2015-08-20 Kyongbo Pharm. Co., Ltd. Novel crystalline form of bortezomib and preparation method thereof
EP3224263B1 (en) 2014-11-25 2023-05-17 BioXcel LLC Use of ubiquitin-proteasome system inhibitors for treatment of tumors associated with neurofibromatosis type-2
EP3031811A1 (en) 2014-12-09 2016-06-15 Teva Pharmaceuticals Ltd. Malic acid esters of bortezomib
CN110312727A (en) * 2017-02-17 2019-10-08 费森尤斯卡比肿瘤学有限公司 A kind of improved method for preparing borate
JP7263263B2 (en) * 2018-02-01 2023-04-24 日本化薬株式会社 Method for producing bortezomib crystals
CN110642881A (en) * 2019-10-18 2020-01-03 扬子江药业集团上海海尼药业有限公司 Bortezomib crystal form M and preparation method and application thereof
US11964993B2 (en) 2021-07-03 2024-04-23 Shilpa Pharma Lifesciences Limited Crystalline bortezomib process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA012927B1 (en) * 2004-03-30 2010-02-26 Миллениум Фармасьютикалз, Инк. Synthesis of boronic ester and acid compounds
WO2006101535A1 (en) * 2005-03-23 2006-09-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibition of proteasome function to potentiate the proapoptotic and antitumor activity of cytokines

Also Published As

Publication number Publication date
WO2008075376A1 (en) 2008-06-26

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