EA200802181A1 - Избирательные модуляторы андрогеновых рецепторов и способы их применения - Google Patents
Избирательные модуляторы андрогеновых рецепторов и способы их примененияInfo
- Publication number
- EA200802181A1 EA200802181A1 EA200802181A EA200802181A EA200802181A1 EA 200802181 A1 EA200802181 A1 EA 200802181A1 EA 200802181 A EA200802181 A EA 200802181A EA 200802181 A EA200802181 A EA 200802181A EA 200802181 A1 EA200802181 A1 EA 200802181A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bone
- disorder
- promoting
- compounds
- electional
- Prior art date
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- C07—ORGANIC CHEMISTRY
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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Abstract
Изобретение относится к соединениям SARM и к их применению для лечения различных заболеваний или состояний у индивидуума, включая наряду с прочим истощающее мышцы заболевание и/или расстройство или связанное с костями заболевание и/или расстройство.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/861,923 US8008348B2 (en) | 2001-12-06 | 2004-06-07 | Treating muscle wasting with selective androgen receptor modulators |
US10/863,524 US20050038110A1 (en) | 2000-08-24 | 2004-06-09 | Selective androgen receptor modulators and methods of use thereof |
US10/961,380 US20060019931A1 (en) | 2003-10-14 | 2004-10-12 | Treating bone-related disorders with selective androgen receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200802181A1 true EA200802181A1 (ru) | 2009-02-27 |
EA018699B1 EA018699B1 (ru) | 2013-10-30 |
Family
ID=35503640
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200602278A EA011306B8 (ru) | 2004-06-07 | 2005-06-07 | Избирательные модуляторы андрогеновых рецепторов и способы их применения |
EA200802181A EA018699B1 (ru) | 2004-06-07 | 2005-06-07 | Применение соединения селективного модулятора андрогеновых рецепторов |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200602278A EA011306B8 (ru) | 2004-06-07 | 2005-06-07 | Избирательные модуляторы андрогеновых рецепторов и способы их применения |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP1753417B1 (ru) |
JP (2) | JP4201818B2 (ru) |
AT (1) | ATE552235T1 (ru) |
AU (1) | AU2005251781C1 (ru) |
BR (1) | BRPI0511308B8 (ru) |
CA (1) | CA2543827C (ru) |
CY (1) | CY1120469T1 (ru) |
DK (1) | DK2289872T3 (ru) |
EA (2) | EA011306B8 (ru) |
GE (1) | GEP20094851B (ru) |
IL (1) | IL178716A (ru) |
MX (1) | MXPA06013958A (ru) |
PL (2) | PL2289872T3 (ru) |
WO (1) | WO2005120483A2 (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
EA011306B8 (ru) * | 2004-06-07 | 2012-10-30 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Избирательные модуляторы андрогеновых рецепторов и способы их применения |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
ES2453981T3 (es) * | 2005-08-31 | 2014-04-09 | University Of Tennessee Research Foundation | Tratamiento de síntomas de enfermedad renal con moduladores selectivos de receptor de andrógenos (SARM) |
EP2040694A2 (en) * | 2006-07-14 | 2009-04-01 | VIB vzw | Use of ppar-alpha agonists to treat skeletal muscle wasting disorders |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
DK2054049T3 (en) | 2006-08-24 | 2016-08-01 | Univ Tennessee Res Found | SUBSTITUTED ACYLANILIDES AND PROCEDURES FOR USING THEREOF |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
CL2008002313A1 (es) | 2007-08-07 | 2009-05-15 | Takeda Pharmaceuticals Co | Compuesto 4-[(2s, 3s)-2-etil-3-hidroxi-5-oxopirrolidin-1-il]-2-(trifluorometil)benzonitrilo o una de sus sales, modulador del receptor de androgenos; composicion farmaceutica; y uso del compuesto para la prevencion o el tratamiento de hipogonadismo, trastorno del climaterio masculino, debilidad, caquexia , osteoporosis, hipertrofia prostatica y amiotrofia. |
US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
WO2011085385A1 (en) | 2010-01-11 | 2011-07-14 | Gtx, Inc. | Methods of treating meibomian gland dysfunction |
US8987319B2 (en) | 2010-02-04 | 2015-03-24 | Radius Health, Inc. | Selective androgen receptor modulators |
EP2568806B1 (en) | 2010-05-12 | 2016-05-11 | Radius Health, Inc. | Therapeutic regimens |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
AU2011312490B2 (en) | 2010-09-28 | 2015-06-25 | Radius Pharmaceuticals, Inc. | Selective androgen receptor modulators |
CN104754939A (zh) | 2012-07-13 | 2015-07-01 | Gtx公司 | 用选择性雄激素受体调节剂(sarm)治疗雄激素受体(ar)阳性乳癌的方法 |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
CA2878895A1 (en) * | 2012-07-13 | 2014-01-16 | Indiana University Research & Technology Corporation | Compounds for treatment of spinal muscular atrophy |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
RU2019117364A (ru) * | 2014-10-16 | 2019-08-05 | ДжиТиИкс, ИНК. | Способы лечения урологических нарушений с применением селективных модуляторов андрогеновых рецепторов |
EP3474841B1 (en) | 2016-06-22 | 2022-03-16 | Ellipses Pharma Ltd | Ar+ breast cancer treatment methods |
WO2019055687A1 (en) | 2017-09-13 | 2019-03-21 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER CACHEXIA |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE28864T1 (de) * | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
US6995284B2 (en) | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
WO1998053826A1 (en) * | 1997-05-30 | 1998-12-03 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
US20030232792A1 (en) * | 2000-08-24 | 2003-12-18 | Dalton James T. | Selective androgen receptor modulators and methods of use thereof |
US6838484B2 (en) * | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
EA014224B1 (ru) * | 2000-08-24 | 2010-10-29 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Селективные модуляторы андрогенового рецептора и способы их применения |
PT1463497E (pt) * | 2001-12-06 | 2011-12-20 | Gtx Inc | Tratamento do desgaste muscular com moduladores selectivos do receptor de androgénios |
KR20100112659A (ko) * | 2002-02-07 | 2010-10-19 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 조절자를 이용한 양성 전립선 과형성증의 치료 방법 |
GEP20074209B (en) * | 2002-02-28 | 2007-10-10 | , | Multi-substitued selective androgen receptor modulators and methods of use thereof |
US20040087810A1 (en) * | 2002-10-23 | 2004-05-06 | Dalton James T. | Irreversible selective androgen receptor modulators and methods of use thereof |
FI20030958A0 (fi) * | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
CA2535953C (en) * | 2003-10-14 | 2012-07-03 | Gtx, Inc. | Treating bone-related disorders with selective androgen receptor modulators |
EP1631540A4 (en) * | 2003-12-16 | 2006-10-04 | Gtx Inc | PRODRUGS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD OF USE THEREOF |
EA011306B8 (ru) * | 2004-06-07 | 2012-10-30 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Избирательные модуляторы андрогеновых рецепторов и способы их применения |
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IL178716A (en) | 2014-04-30 |
JP4971252B2 (ja) | 2012-07-11 |
DK2289872T3 (en) | 2017-10-09 |
CA2543827C (en) | 2010-03-09 |
BRPI0511308A (pt) | 2007-12-04 |
EP1753417A2 (en) | 2007-02-21 |
EP2289872A2 (en) | 2011-03-02 |
EP1753417B1 (en) | 2012-04-04 |
EP2289872B1 (en) | 2017-08-02 |
GEP20094851B (en) | 2009-12-10 |
CA2543827A1 (en) | 2005-12-22 |
CY1120469T1 (el) | 2019-07-10 |
EA200602278A1 (ru) | 2007-04-27 |
AU2005251781B2 (en) | 2007-09-13 |
BRPI0511308B8 (pt) | 2021-05-25 |
MXPA06013958A (es) | 2007-03-15 |
IL178716A0 (en) | 2007-02-11 |
EA011306B8 (ru) | 2012-10-30 |
PL2289872T3 (pl) | 2017-12-29 |
AU2005251781A1 (en) | 2005-12-22 |
PL1753417T3 (pl) | 2012-09-28 |
BRPI0511308B1 (pt) | 2019-07-02 |
WO2005120483A3 (en) | 2006-08-03 |
ATE552235T1 (de) | 2012-04-15 |
EP2289872A3 (en) | 2013-01-09 |
AU2005251781C1 (en) | 2008-02-21 |
JP4201818B2 (ja) | 2008-12-24 |
EA011306B1 (ru) | 2009-02-27 |
JP2007513980A (ja) | 2007-05-31 |
JP2008266350A (ja) | 2008-11-06 |
EP1753417A4 (en) | 2008-07-09 |
EA018699B1 (ru) | 2013-10-30 |
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