EA200800535A1 - Пептиды и соединения, которые связываются с рецептором - Google Patents

Пептиды и соединения, которые связываются с рецептором

Info

Publication number
EA200800535A1
EA200800535A1 EA200800535A EA200800535A EA200800535A1 EA 200800535 A1 EA200800535 A1 EA 200800535A1 EA 200800535 A EA200800535 A EA 200800535A EA 200800535 A EA200800535 A EA 200800535A EA 200800535 A1 EA200800535 A1 EA 200800535A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor
associate
peptides
connections
tpo
Prior art date
Application number
EA200800535A
Other languages
English (en)
Inventor
Брайан Р. Макдональд
Джеффри Кеннет Уэйс
Эдвард Джон Юрков
Original Assignee
Орто-Макнейл Фармасьютикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37734435&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800535(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Орто-Макнейл Фармасьютикал, Инк. filed Critical Орто-Макнейл Фармасьютикал, Инк.
Publication of EA200800535A1 publication Critical patent/EA200800535A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Пептидные соединения, которые связываются с рецептором тромбопоэтина (с-mpl или TPO-R) и активируют его или каким-либо иным образом действуют как агонисты ТРО.
EA200800535A 2005-08-09 2006-08-03 Пептиды и соединения, которые связываются с рецептором EA200800535A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/200,416 US7723295B2 (en) 2003-08-28 2005-08-09 Peptides and compounds that bind to a receptor
PCT/US2006/030359 WO2007021572A2 (en) 2005-08-09 2006-08-03 Use of peptides that bind to tpo receptor

Publications (1)

Publication Number Publication Date
EA200800535A1 true EA200800535A1 (ru) 2008-08-29

Family

ID=37734435

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800535A EA200800535A1 (ru) 2005-08-09 2006-08-03 Пептиды и соединения, которые связываются с рецептором

Country Status (35)

Country Link
US (1) US7723295B2 (ru)
EP (1) EP1957517B1 (ru)
JP (1) JP2009504650A (ru)
KR (1) KR20080048026A (ru)
CN (1) CN101287749A (ru)
AR (1) AR055114A1 (ru)
AU (1) AU2006280230B2 (ru)
BR (1) BRPI0614647A2 (ru)
CA (1) CA2618958A1 (ru)
CR (1) CR9798A (ru)
CY (1) CY1114032T1 (ru)
DK (1) DK1957517T3 (ru)
EA (1) EA200800535A1 (ru)
EC (1) ECSP088169A (ru)
ES (1) ES2419005T3 (ru)
GT (1) GT200600361A (ru)
HK (1) HK1123811A1 (ru)
HR (1) HRP20130518T1 (ru)
IL (1) IL189361A (ru)
JO (1) JO2859B1 (ru)
MY (1) MY152177A (ru)
NI (1) NI200800040A (ru)
NO (1) NO344405B1 (ru)
NZ (1) NZ565497A (ru)
PE (1) PE20070416A1 (ru)
PL (1) PL1957517T3 (ru)
PT (1) PT1957517E (ru)
RS (1) RS52802B (ru)
SI (1) SI1957517T1 (ru)
SV (1) SV2008002648A (ru)
TW (1) TWI400081B (ru)
UA (1) UA96418C2 (ru)
UY (1) UY29736A1 (ru)
WO (1) WO2007021572A2 (ru)
ZA (1) ZA200802184B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7615533B2 (en) * 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
AU2007208226A1 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
AU2009256465B2 (en) * 2008-06-03 2015-05-14 Janssen Pharmaceutica Nv TPO mimetic peptide for preventing hematological disorder associated with cancer treatment
US9295734B2 (en) 2011-06-23 2016-03-29 Shimadzu Corporation Branched amphipathic block polymer and molecular aggregate and drug delivery system using same
CN111432845B (zh) 2017-07-26 2024-02-06 詹森药业有限公司 保护靶向放射治疗诱导下的血管完整性的方法
CN113660943A (zh) 2019-01-25 2021-11-16 詹森药业有限公司 增强对全身放射/化学暴露反应的对器官和血管损伤的保护、造血恢复以及存活的方法
MA54830A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Procédés d'atténuation des effets toxiques d'agents vésicants et de gaz caustiques
WO2020154585A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments
WO2023056444A1 (en) 2021-10-01 2023-04-06 Janssen Pharmaceutica N.V. Methods of increasing progenitor cell production
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
IT1241395B (it) 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
DK0644771T4 (da) 1992-06-11 2006-12-27 Alkermes Inc Lægemiddelsystem til levering af erythropoietin
JP3401005B2 (ja) * 1992-12-11 2003-04-28 ユニバーシティ オブ フロリダ 有害生物の防除のための材料および方法
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
SG79882A1 (en) 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
NZ281482A (en) 1994-02-14 2000-09-29 Univ Washington The stimulation of erythropoiesis using thrombopoietin and erythropoietin
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
KR100289201B1 (ko) 1994-02-14 2001-05-02 엘. 데이예를 카렌. 조혈 단백질과 그것의 제조를 위한 재료 및 방법
GEP20002180B (en) 1994-03-31 2000-07-25 Amgen Inc Composition and Methods for Stimulating Megakaryocyte Growth and Differentiation
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
AU4163196A (en) 1994-11-30 1996-06-19 Zymogenetics Inc. Low molecular weight thrombopoietin
CA2194070A1 (en) 1995-04-26 1996-10-31 Haruhiko Yokoi Novel polypeptides
PE7898A1 (es) * 1995-06-07 1998-03-05 Glaxo Group Ltd Peptidos compuestos que se ligan al receptor de trombopoietina
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6060052A (en) * 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
ATE350044T1 (de) 1999-09-24 2007-01-15 Smithkline Beecham Corp Thrombopoietinmimetika
AU2002307062A1 (en) 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
KR101183875B1 (ko) 2003-08-28 2012-09-27 오르토-맥네일 파마슈티칼, 인코퍼레이티드 수용체에 결합하는 펩티드 및 화합물

Also Published As

Publication number Publication date
JP2009504650A (ja) 2009-02-05
NI200800040A (es) 2010-11-25
NZ565497A (en) 2011-10-28
RS52802B (en) 2013-10-31
UA96418C2 (ru) 2011-11-10
AU2006280230B2 (en) 2012-11-08
CA2618958A1 (en) 2007-02-22
ECSP088169A (es) 2008-03-26
MY152177A (en) 2014-08-15
UY29736A1 (es) 2006-12-29
EP1957517B1 (en) 2013-03-20
TW200744626A (en) 2007-12-16
PL1957517T3 (pl) 2013-08-30
ES2419005T3 (es) 2013-08-19
SI1957517T1 (sl) 2013-07-31
EP1957517A2 (en) 2008-08-20
US7723295B2 (en) 2010-05-25
JO2859B1 (en) 2015-03-15
TWI400081B (zh) 2013-07-01
GT200600361A (es) 2007-03-14
HRP20130518T1 (hr) 2013-07-31
PT1957517E (pt) 2013-05-28
IL189361A0 (en) 2008-06-05
HK1123811A1 (en) 2009-06-26
DK1957517T3 (da) 2013-04-08
CN101287749A (zh) 2008-10-15
CY1114032T1 (el) 2016-07-27
PE20070416A1 (es) 2007-06-13
AR055114A1 (es) 2007-08-08
ZA200802184B (en) 2009-08-26
NO20081298L (no) 2008-04-23
SV2008002648A (es) 2008-11-28
WO2007021572A3 (en) 2007-06-07
AU2006280230A1 (en) 2007-02-22
NO344405B1 (no) 2019-12-02
WO2007021572A2 (en) 2007-02-22
KR20080048026A (ko) 2008-05-30
US20060040866A1 (en) 2006-02-23
BRPI0614647A2 (pt) 2011-04-12
CR9798A (es) 2008-09-09
IL189361A (en) 2015-11-30

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