EA200702524A1 - Нестероидные модуляторы рецептора прогестерона - Google Patents
Нестероидные модуляторы рецептора прогестеронаInfo
- Publication number
- EA200702524A1 EA200702524A1 EA200702524A EA200702524A EA200702524A1 EA 200702524 A1 EA200702524 A1 EA 200702524A1 EA 200702524 A EA200702524 A EA 200702524A EA 200702524 A EA200702524 A EA 200702524A EA 200702524 A1 EA200702524 A1 EA 200702524A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- receptor modulators
- progesterone receptor
- nonsteroid
- prevention
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Представленное изобретение касается нестероидных модуляторов рецептора прогестерона общей формулы Iспособа их получения, применения модуляторов рецептора прогестерона для получения медикаментов и фармацевтических композиций, содержащих эти соединения. Соединения в соответствии с изобретением пригодны для лечения и профилактики гинекологических расстройств, таких как эндометриоз, леиомиома матки, дисфункциональное кровотечение и дисменорея, и для лечения и профилактики гормонозависимых опухолей и для применения для контроля женской фертильности и для гормонзаместительной терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005030292A DE102005030292A1 (de) | 2005-06-24 | 2005-06-24 | Nichtsteroidale Progesteronrezeptor-Modulatoren |
PCT/EP2006/006531 WO2006136461A2 (en) | 2005-06-24 | 2006-06-22 | Non-steroidal progesterone receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200702524A1 true EA200702524A1 (ru) | 2008-06-30 |
Family
ID=37199176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200702524A EA200702524A1 (ru) | 2005-06-24 | 2006-06-22 | Нестероидные модуляторы рецептора прогестерона |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1902049A2 (ru) |
JP (1) | JP2008543910A (ru) |
KR (1) | KR20080030622A (ru) |
CN (1) | CN101248066A (ru) |
AR (1) | AR054519A1 (ru) |
AU (1) | AU2006261048A1 (ru) |
BR (1) | BRPI0611903A2 (ru) |
CA (1) | CA2611897A1 (ru) |
CR (1) | CR9598A (ru) |
DE (1) | DE102005030292A1 (ru) |
DO (1) | DOP2006000148A (ru) |
EA (1) | EA200702524A1 (ru) |
EC (1) | ECSP078044A (ru) |
GT (1) | GT200600271A (ru) |
IL (1) | IL188021A0 (ru) |
MX (1) | MX2008000072A (ru) |
NO (1) | NO20080440L (ru) |
PE (1) | PE20070125A1 (ru) |
TW (1) | TW200740778A (ru) |
UY (1) | UY29624A1 (ru) |
WO (1) | WO2006136461A2 (ru) |
ZA (1) | ZA200800690B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
DE102007032800A1 (de) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
DE102007058747A1 (de) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
WO2010002075A1 (en) * | 2008-07-02 | 2010-01-07 | Pharmacostech Co., Ltd. | Methods for preparing amide derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19856475A1 (de) * | 1998-11-27 | 2000-05-31 | Schering Ag | Nichtsteroidale Entzündungshemmer |
EP1344776A1 (en) * | 2002-03-11 | 2003-09-17 | Schering Aktiengesellschaft | 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders |
BRPI0412231A (pt) * | 2003-07-01 | 2006-08-22 | Schering Ag | derivados de pentanol substituìdos heterociclicamente, processos para a sua preparação e sua aplicação como inibidores de inflamação |
-
2005
- 2005-06-24 DE DE102005030292A patent/DE102005030292A1/de not_active Ceased
-
2006
- 2006-06-22 CN CNA2006800308707A patent/CN101248066A/zh active Pending
- 2006-06-22 BR BRPI0611903-4A patent/BRPI0611903A2/pt not_active Application Discontinuation
- 2006-06-22 JP JP2008517444A patent/JP2008543910A/ja active Pending
- 2006-06-22 MX MX2008000072A patent/MX2008000072A/es not_active Application Discontinuation
- 2006-06-22 EP EP06762404A patent/EP1902049A2/en not_active Withdrawn
- 2006-06-22 EA EA200702524A patent/EA200702524A1/ru unknown
- 2006-06-22 KR KR1020087001793A patent/KR20080030622A/ko not_active Application Discontinuation
- 2006-06-22 WO PCT/EP2006/006531 patent/WO2006136461A2/en active Application Filing
- 2006-06-22 CA CA002611897A patent/CA2611897A1/en not_active Abandoned
- 2006-06-22 AU AU2006261048A patent/AU2006261048A1/en not_active Abandoned
- 2006-06-23 TW TW095122742A patent/TW200740778A/zh unknown
- 2006-06-26 DO DO2006000148A patent/DOP2006000148A/es unknown
- 2006-06-26 UY UY29624A patent/UY29624A1/es not_active Application Discontinuation
- 2006-06-26 PE PE2006000733A patent/PE20070125A1/es not_active Application Discontinuation
- 2006-06-27 AR ARP060102750A patent/AR054519A1/es unknown
- 2006-06-28 GT GT200600271A patent/GT200600271A/es unknown
-
2007
- 2007-12-10 IL IL188021A patent/IL188021A0/en unknown
- 2007-12-17 CR CR9598A patent/CR9598A/es not_active Application Discontinuation
- 2007-12-21 EC EC2007008044A patent/ECSP078044A/es unknown
-
2008
- 2008-01-23 ZA ZA200800690A patent/ZA200800690B/xx unknown
- 2008-01-23 NO NO20080440A patent/NO20080440L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP078044A (es) | 2008-01-23 |
NO20080440L (no) | 2008-03-25 |
JP2008543910A (ja) | 2008-12-04 |
MX2008000072A (es) | 2008-03-24 |
TW200740778A (en) | 2007-11-01 |
UY29624A1 (es) | 2007-01-31 |
GT200600271A (es) | 2007-02-05 |
PE20070125A1 (es) | 2007-02-14 |
EP1902049A2 (en) | 2008-03-26 |
DOP2006000148A (es) | 2007-07-15 |
KR20080030622A (ko) | 2008-04-04 |
CA2611897A1 (en) | 2006-12-28 |
DE102005030292A1 (de) | 2007-01-11 |
ZA200800690B (en) | 2009-09-30 |
BRPI0611903A2 (pt) | 2010-10-05 |
AU2006261048A1 (en) | 2006-12-28 |
WO2006136461A2 (en) | 2006-12-28 |
WO2006136461A3 (en) | 2007-03-15 |
CN101248066A (zh) | 2008-08-20 |
IL188021A0 (en) | 2008-03-20 |
AR054519A1 (es) | 2007-06-27 |
CR9598A (es) | 2008-04-09 |
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