EA200700871A1 - METHODS OF NEUROPROTECTION - Google Patents

METHODS OF NEUROPROTECTION

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Publication number
EA200700871A1
EA200700871A1 EA200700871A EA200700871A EA200700871A1 EA 200700871 A1 EA200700871 A1 EA 200700871A1 EA 200700871 A EA200700871 A EA 200700871A EA 200700871 A EA200700871 A EA 200700871A EA 200700871 A1 EA200700871 A1 EA 200700871A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
phenyl
alkyl
moreover
formula
Prior art date
Application number
EA200700871A
Other languages
Russian (ru)
Inventor
Рой Е. Тваймэн
Боюй Чжао
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200700871A1 publication Critical patent/EA200700871A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Изобретение направлено на обеспечение нейропротекции, включающей введение пациенту терапевтически эффективного количества соединения, выбранного из группы, состоящей из формулы (I) и формулы (II), или его фармацевтически приемлемой соли или сложного эфирав которых фенил замещен в положении Х атомами галогена числом от одного до пяти, выбранными из группы, состоящей из фтора, хлора, брома и йода; и R, R, R, R, Rи Rнезависимо выбраны из группы, состоящей из водорода и С-С-алкила; причем С-С-алкил в случае необходимости замещен фенилом (причем фенил в случае необходимости замещен заместителями, независимо выбранными из группы, состоящей из галогена, С-С-алкила, С-С-алкокси, амино, нитро и циано).The invention is directed to providing neuroprotection, comprising administering to a patient a therapeutically effective amount of a compound selected from the group consisting of formula (I) and formula (II), or a pharmaceutically acceptable salt or ester thereof, of which phenyl is substituted at position X with halogen atoms from one to five selected from the group consisting of fluorine, chlorine, bromine and iodine; and R, R, R, R, R, and R are independently selected from the group consisting of hydrogen and C — C alkyl; moreover, C-C-alkyl is optionally substituted with phenyl (moreover, phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C-C-alkyl, C-C-alkoxy, amino, nitro and cyano).

EA200700871A 2004-10-15 2005-10-14 METHODS OF NEUROPROTECTION EA200700871A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61940204P 2004-10-15 2004-10-15
US69840305P 2005-07-12 2005-07-12
PCT/US2005/036695 WO2006044472A1 (en) 2004-10-15 2005-10-14 Carbamate compounds for use in treating neurodegenerative disorders

Publications (1)

Publication Number Publication Date
EA200700871A1 true EA200700871A1 (en) 2007-10-26

Family

ID=35840528

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700871A EA200700871A1 (en) 2004-10-15 2005-10-14 METHODS OF NEUROPROTECTION

Country Status (14)

Country Link
EP (1) EP1802294A1 (en)
JP (1) JP2008516961A (en)
KR (3) KR20090130175A (en)
AU (1) AU2005295787A1 (en)
BR (1) BRPI0516112A (en)
CA (1) CA2584854A1 (en)
EA (1) EA200700871A1 (en)
EC (1) ECSP077395A (en)
IL (1) IL182432A0 (en)
MX (1) MX2007004491A (en)
NI (1) NI200700094A (en)
NO (1) NO20072444L (en)
SG (1) SG142306A1 (en)
WO (1) WO2006044472A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
KR20190081385A (en) 2017-12-29 2019-07-09 강원대학교산학협력단 Composition for preventing the ischemia stroke disease containing oxcarbazepine
CN115996905A (en) 2020-08-31 2023-04-21 生物药品解决方案有限公司 Phenylalkyl carbamate compounds for use in preventing or treating neurodegenerative diseases
EP4211125A1 (en) 2020-09-10 2023-07-19 Bio-Pharm Solutions Co., Ltd. Sulfamate derivative compounds for use in treating or alleviating a psychiatric disorder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US20010034365A1 (en) * 1996-01-16 2001-10-25 Choi Yong Moon Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
CZ2002524A3 (en) * 1999-08-20 2002-11-13 Ortho-Mcneil Pharmaceutical, Inc. Composition containing tramadol and anticonvulsants
HUP0303264A3 (en) * 2001-02-27 2012-07-30 Ortho Mcneil Pharm Inc Carbamate compounds for use in preventing and treating neurodegenerative disorders
NZ553813A (en) * 2004-09-16 2010-09-30 Janssen Pharmaceutica Nv Use of 2-phenyl-1, 2-ethanediol-(DI) carbamates for treating epileptogenesis and epilepsy

Also Published As

Publication number Publication date
KR20070085309A (en) 2007-08-27
MX2007004491A (en) 2007-08-08
SG142306A1 (en) 2008-05-28
WO2006044472A1 (en) 2006-04-27
BRPI0516112A (en) 2008-08-26
ECSP077395A (en) 2007-05-30
AU2005295787A1 (en) 2006-04-27
JP2008516961A (en) 2008-05-22
KR20090130175A (en) 2009-12-18
IL182432A0 (en) 2007-09-20
KR20110049901A (en) 2011-05-12
EP1802294A1 (en) 2007-07-04
NO20072444L (en) 2007-06-14
CA2584854A1 (en) 2006-04-27
NI200700094A (en) 2008-02-11

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