EA200501399A1 - Производные бензопирана, которые могут использоваться при лечении воспалительных заболеваний - Google Patents

Производные бензопирана, которые могут использоваться при лечении воспалительных заболеваний

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Publication number
EA200501399A1
EA200501399A1 EA200501399A EA200501399A EA200501399A1 EA 200501399 A1 EA200501399 A1 EA 200501399A1 EA 200501399 A EA200501399 A EA 200501399A EA 200501399 A EA200501399 A EA 200501399A EA 200501399 A1 EA200501399 A1 EA 200501399A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzopirane
derivatives
treatment
inflammatory diseases
compounds
Prior art date
Application number
EA200501399A
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English (en)
Inventor
Джеффри Стивен Картер
Карл Уилльям Эстон
Дэвид Луис Браун
Анджела Депроу
Тереза Флетчер
Э. Энн Хэллинан
Брюс Камерон Хэмпер
Рене Хафф
Джеймс Ричард Мл. Кифер
Франсис Косцик
Стивен Крамер
Субо Лиао
Дэвид Кристофер Лимбург
Синди Людвиг
Джон Майкл Макколл
Джон Роберт Спрингер
Джон Дж. Толли
Лицзюань Джейн Ванг
Ли Син
И Юй
Original Assignee
Фармация Корпорейшн
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Publication date
Application filed by Фармация Корпорейшн filed Critical Фармация Корпорейшн
Publication of EA200501399A1 publication Critical patent/EA200501399A1/ru

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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D493/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к способам и соединениям, которые могут использоваться для лечения состояний, связанных расстройствами, опосредованными циклооксигеназой-2. Конкретно, интересующие соединения представляют собой бензопираны и их аналоги, определенные формулой (1)где Z, X, R, R, Rи Rтакие, как описано в описании.
EA200501399A 2003-03-31 2004-03-26 Производные бензопирана, которые могут использоваться при лечении воспалительных заболеваний EA200501399A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45921503P 2003-03-31 2003-03-31
PCT/IB2004/001113 WO2004087686A2 (en) 2003-03-31 2004-03-26 Benzopyran compounds useful for treating inflammatory conditions

Publications (1)

Publication Number Publication Date
EA200501399A1 true EA200501399A1 (ru) 2006-04-28

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EA200501399A EA200501399A1 (ru) 2003-03-31 2004-03-26 Производные бензопирана, которые могут использоваться при лечении воспалительных заболеваний

Country Status (25)

Country Link
US (1) US7259266B2 (ru)
EP (1) EP1615905A2 (ru)
JP (1) JP2006522098A (ru)
KR (1) KR20060015490A (ru)
CN (1) CN1768050A (ru)
AR (1) AR044207A1 (ru)
AU (1) AU2004226164A1 (ru)
BR (1) BRPI0408388A (ru)
CA (1) CA2520724A1 (ru)
EA (1) EA200501399A1 (ru)
EC (2) ECSP056063A (ru)
IS (1) IS7995A (ru)
MA (1) MA27725A1 (ru)
MX (1) MXPA05010630A (ru)
NL (9) NL1025843C2 (ru)
NO (1) NO20054121L (ru)
OA (1) OA13112A (ru)
PA (1) PA8599601A1 (ru)
PE (1) PE20050012A1 (ru)
RS (1) RS20050744A (ru)
TN (1) TNSN05249A1 (ru)
TW (1) TWI257927B (ru)
UY (1) UY28252A1 (ru)
WO (1) WO2004087686A2 (ru)
ZA (1) ZA200506551B (ru)

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NL1028304C2 (nl) 2005-11-16
TNSN05249A1 (fr) 2007-06-11
NO20054121D0 (no) 2005-09-05
PA8599601A1 (es) 2005-05-24
PE20050012A1 (es) 2005-03-12
NL1025843C2 (nl) 2005-03-01
BRPI0408388A (pt) 2006-03-01
CA2520724A1 (en) 2004-10-14
NL1028306C2 (nl) 2005-11-16
KR20060015490A (ko) 2006-02-17
WO2004087686A2 (en) 2004-10-14
JP2006522098A (ja) 2006-09-28
NL1028303A1 (nl) 2005-03-09
NL1028304A1 (nl) 2005-03-09
MXPA05010630A (es) 2005-12-12
CN1768050A (zh) 2006-05-03
TWI257927B (en) 2006-07-11
NL1028305A1 (nl) 2005-03-09
OA13112A (en) 2006-11-10
NO20054121L (no) 2005-12-20
RS20050744A (en) 2007-08-03
NL1028310C2 (nl) 2005-11-16
TW200510365A (en) 2005-03-16
ECSP056064A (es) 2006-01-27
NL1028310A1 (nl) 2005-03-09
ECSP056063A (es) 2006-01-27
NL1028303C2 (nl) 2005-11-16
NL1028308C2 (nl) 2005-11-16
IS7995A (is) 2005-08-18
NL1028309C2 (nl) 2005-11-16
NL1028307C2 (nl) 2005-11-16
AU2004226164A1 (en) 2004-10-14
NL1028307A1 (nl) 2005-03-09
NL1028306A1 (nl) 2005-03-09
EP1615905A2 (en) 2006-01-18
UY28252A1 (es) 2004-11-08
AR044207A1 (es) 2005-09-07
US20050148777A1 (en) 2005-07-07
NL1025843A1 (nl) 2004-10-01
WO2004087686A3 (en) 2004-12-16
NL1028309A1 (nl) 2005-03-09
ZA200506551B (en) 2006-11-29
NL1028305C2 (nl) 2005-11-16
MA27725A1 (fr) 2006-01-02
US7259266B2 (en) 2007-08-21
NL1028308A1 (nl) 2005-03-09

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