EA200400464A1 - METHODS AND COMPOSITIONS OF NEW TRIAZINE CONNECTIONS - Google Patents
METHODS AND COMPOSITIONS OF NEW TRIAZINE CONNECTIONSInfo
- Publication number
- EA200400464A1 EA200400464A1 EA200400464A EA200400464A EA200400464A1 EA 200400464 A1 EA200400464 A1 EA 200400464A1 EA 200400464 A EA200400464 A EA 200400464A EA 200400464 A EA200400464 A EA 200400464A EA 200400464 A1 EA200400464 A1 EA 200400464A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- present
- compounds
- inhibit
- smooth muscle
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
Abstract
Настоящее изобретение относится к способам и композициям, содержащим соединения, которые лечат физиологические состояния, возникающие из-за воспалительных ответов. В частности, настоящее изобретение направлено на соединения, которые ингибируют или блокируют вызываемую гликированным белком индукцию ассоциированного с передачей сигнала воспалительного ответа в эндотелиальных клетках. Настоящее изобретение относится к соединениям, которые ингибируют пролиферацию гладких мышц. В частности, настоящее изобретение направлено на соединения, которые ингибируют пролиферацию гладкомышечных клеток модуляцией гепарансульфатпротеогликанов, таких как перлекан. Настоящее изобретение далее относится к применению соединений для лечения сосудистых окклюзионных состояний, характеризующихся гладкомышечной пролиферацией, таких как рестеноз и атеросклероз.Отчет о международном поиске был опубликован 2003.12.11.The present invention relates to methods and compositions containing compounds that treat physiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block the glycated protein-induced induction of a signal associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit the proliferation of smooth muscle cells by modulating heparan sulfate proteoglycans, such as perlecan. The present invention further relates to the use of compounds for the treatment of vascular occlusive conditions characterized by smooth muscle proliferation, such as restenosis and atherosclerosis. The international search report was published 2003.12.11.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32414701P | 2001-09-21 | 2001-09-21 | |
PCT/US2002/030177 WO2003024926A2 (en) | 2001-09-21 | 2002-09-23 | Methods and compositions of novel triazine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400464A1 true EA200400464A1 (en) | 2005-02-24 |
EA009728B1 EA009728B1 (en) | 2008-02-28 |
Family
ID=23262298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400464A EA009728B1 (en) | 2001-09-21 | 2002-09-23 | Methods and compositions of novel triazine compounds |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1436266A4 (en) |
JP (1) | JP2005511509A (en) |
KR (1) | KR20040088457A (en) |
CN (1) | CN1578773A (en) |
BR (1) | BR0212895A (en) |
CA (1) | CA2461074A1 (en) |
EA (1) | EA009728B1 (en) |
IL (1) | IL160984A0 (en) |
IS (1) | IS7190A (en) |
MX (1) | MXPA04002680A (en) |
NO (1) | NO20041187L (en) |
NZ (1) | NZ532349A (en) |
PL (1) | PL369600A1 (en) |
RS (1) | RS34004A (en) |
WO (1) | WO2003024926A2 (en) |
ZA (1) | ZA200403009B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7112587B2 (en) | 2001-09-21 | 2006-09-26 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7132423B2 (en) | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7169785B2 (en) | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7173032B2 (en) | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7375222B2 (en) | 2002-02-05 | 2008-05-20 | Astellas Pharma Inc. | 2,4,6-Triamino-1,3,5-triazine derivative |
AU2003253735A1 (en) * | 2002-06-25 | 2004-01-06 | The Center For Blood Research, Inc. | Vacuolins |
US20070161637A1 (en) * | 2003-07-22 | 2007-07-12 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
CN1629157A (en) * | 2003-12-19 | 2005-06-22 | 中国科学院上海药物研究所 | Piperazinyl triazine compounds, preparation method thereof and pharmaceutical composition containing same |
US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
US20100256160A1 (en) * | 2006-11-03 | 2010-10-07 | Nerviano Medical Sciences S.R.L. | Method of administering an antitumor compound |
KR101314869B1 (en) * | 2010-07-29 | 2013-10-04 | 광주과학기술원 | Pharmaceutical Compositions for Treating or Preventing Diabetes Comprising Triazine Compound as an Active Ingredient |
JP5907986B2 (en) * | 2010-11-29 | 2016-04-26 | ガリオン ファーマシューティカルズ インコーポレイテッド | Compounds as respiratory stimulants for the treatment of respiratory control disorders or respiratory control disorders |
US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
WO2017112951A1 (en) | 2015-12-24 | 2017-06-29 | The Regents Of The University Of California | Cftr regulators and methods of use thereof |
EP3672598A4 (en) | 2017-08-24 | 2021-04-28 | The Regents of The University of California | Ocular pharmaceutical compositions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2083568C1 (en) * | 1994-05-05 | 1997-07-10 | Кубанский государственный аграрный университет | Triazinecarboxylic acid salts and agent for presowing treatment of agriculture crop seeds |
DE19531084A1 (en) * | 1995-08-24 | 1997-02-27 | Hoechst Schering Agrevo Gmbh | 2,4-diamino-1,3,5-triazines, process for their preparation and their use as herbicides and plant growth regulators |
PT1037886E (en) * | 1997-12-12 | 2003-09-30 | Abbott Lab | TRIAZINE ANGIOGENESE INHIBITORS |
EP0945447A1 (en) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
DE60043397D1 (en) * | 1999-12-28 | 2010-01-07 | Pharmacopeia Inc | CYTOKINE, PARTICULAR TNF-ALPHA, HEMMER |
AU2002216650A1 (en) * | 2000-10-31 | 2002-05-15 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
-
2002
- 2002-09-23 EP EP02799019A patent/EP1436266A4/en not_active Withdrawn
- 2002-09-23 NZ NZ532349A patent/NZ532349A/en unknown
- 2002-09-23 RS YU34004A patent/RS34004A/en unknown
- 2002-09-23 CA CA002461074A patent/CA2461074A1/en not_active Abandoned
- 2002-09-23 KR KR10-2004-7004179A patent/KR20040088457A/en not_active Application Discontinuation
- 2002-09-23 WO PCT/US2002/030177 patent/WO2003024926A2/en active Application Filing
- 2002-09-23 BR BR0212895-0A patent/BR0212895A/en not_active IP Right Cessation
- 2002-09-23 JP JP2003528774A patent/JP2005511509A/en active Pending
- 2002-09-23 EA EA200400464A patent/EA009728B1/en not_active IP Right Cessation
- 2002-09-23 MX MXPA04002680A patent/MXPA04002680A/en active IP Right Grant
- 2002-09-23 CN CNA028232402A patent/CN1578773A/en active Pending
- 2002-09-23 IL IL16098402A patent/IL160984A0/en unknown
- 2002-09-23 PL PL02369600A patent/PL369600A1/en not_active Application Discontinuation
-
2004
- 2004-03-19 IS IS7190A patent/IS7190A/en unknown
- 2004-03-22 NO NO20041187A patent/NO20041187L/en not_active Application Discontinuation
- 2004-04-20 ZA ZA200403009A patent/ZA200403009B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL369600A1 (en) | 2005-05-02 |
MXPA04002680A (en) | 2004-06-18 |
EP1436266A2 (en) | 2004-07-14 |
IS7190A (en) | 2004-03-19 |
WO2003024926A3 (en) | 2003-12-11 |
NO20041187L (en) | 2004-05-19 |
ZA200403009B (en) | 2007-12-27 |
IL160984A0 (en) | 2004-08-31 |
NZ532349A (en) | 2007-02-23 |
EA009728B1 (en) | 2008-02-28 |
EP1436266A4 (en) | 2004-12-22 |
BR0212895A (en) | 2005-05-10 |
CN1578773A (en) | 2005-02-09 |
JP2005511509A (en) | 2005-04-28 |
CA2461074A1 (en) | 2003-03-27 |
RS34004A (en) | 2006-10-27 |
KR20040088457A (en) | 2004-10-16 |
WO2003024926A2 (en) | 2003-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |