BR0312863A - Derivados de aldeìdo de polietileno glicol - Google Patents

Derivados de aldeìdo de polietileno glicol

Info

Publication number
BR0312863A
BR0312863A BR0312863-6A BR0312863A BR0312863A BR 0312863 A BR0312863 A BR 0312863A BR 0312863 A BR0312863 A BR 0312863A BR 0312863 A BR0312863 A BR 0312863A
Authority
BR
Brazil
Prior art keywords
polyethylene glycol
aldehyde derivatives
glycol aldehyde
compounds
derivatives
Prior art date
Application number
BR0312863-6A
Other languages
English (en)
Other versions
BR0312863B1 (pt
Inventor
Chee-Youb Won
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0312863A publication Critical patent/BR0312863A/pt
Publication of BR0312863B1 publication Critical patent/BR0312863B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/324—Polymers modified by chemical after-treatment with inorganic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2615—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen the other compounds containing carboxylic acid, ester or anhydride groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
    • C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
    • C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen

Abstract

"DERIVADOS DE ALDEìDO DE POLIETILENO GLICOL". A presente invenção refere-se a compostos de aldeídos de polietileno glicol que são proporcionados. Processos de produção e uso desses compostos, bem como intermediários químicos, são também proporcionados.
BRPI0312863-6A 2002-07-24 2003-07-16 derivados de aldeÍdo de polietileno glicol e processo de produÇço dos mesmos. BR0312863B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39819602P 2002-07-24 2002-07-24
PCT/EP2003/007734 WO2004013205A1 (en) 2002-07-24 2003-07-16 Polyethylene glycol aldehyde derivatives

Publications (2)

Publication Number Publication Date
BR0312863A true BR0312863A (pt) 2005-06-14
BR0312863B1 BR0312863B1 (pt) 2013-02-05

Family

ID=31495721

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0312863-6A BR0312863B1 (pt) 2002-07-24 2003-07-16 derivados de aldeÍdo de polietileno glicol e processo de produÇço dos mesmos.

Country Status (28)

Country Link
US (2) US7273909B2 (pt)
EP (1) EP1539857B1 (pt)
JP (1) JP4071238B2 (pt)
KR (1) KR100615753B1 (pt)
CN (1) CN1671769B (pt)
AR (1) AR040607A1 (pt)
AT (1) ATE344289T1 (pt)
AU (1) AU2003250971B2 (pt)
BR (1) BR0312863B1 (pt)
CA (1) CA2493221C (pt)
DE (1) DE60309482T2 (pt)
DK (1) DK1539857T3 (pt)
ES (1) ES2274277T3 (pt)
GT (1) GT200300154A (pt)
HR (1) HRP20050026A2 (pt)
IL (1) IL165920A0 (pt)
JO (1) JO2400B1 (pt)
MX (1) MXPA05000799A (pt)
NO (1) NO336974B1 (pt)
PA (1) PA8577601A1 (pt)
PE (1) PE20040703A1 (pt)
PL (1) PL214871B1 (pt)
PT (1) PT1539857E (pt)
RU (1) RU2288212C2 (pt)
TW (1) TWI276647B (pt)
UY (1) UY27902A1 (pt)
WO (1) WO2004013205A1 (pt)
ZA (1) ZA200410296B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05002632A (es) 2002-09-09 2005-09-20 Nektar Therapeutics Al Corp Metodo para preparar derivados de polimeros solubles en agua que portan un acido carboxilico terminal.
BR0314172A (pt) * 2002-09-09 2005-07-26 Nektar Therapeutics Al Corp Polìmero solúvel em água, composição, forma de hidrato ou acetal, composto,composição, usos do composto e do conjugado, e, processo para preparar o conjugado
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
WO2008051383A2 (en) * 2006-10-19 2008-05-02 Amgen Inc. Use of alcohol co-solvents to improve pegylation reaction yields
WO2008048079A1 (en) * 2006-10-20 2008-04-24 Postech Academy-Industry Foundation Long acting formulation of biopharmaceutical
US8247493B2 (en) * 2007-10-22 2012-08-21 Postech Academy-Industry Foundation Long acting formulation of biopharmaceutical
KR100967833B1 (ko) * 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
JP5766118B2 (ja) * 2008-09-11 2015-08-19 ウェルズ ファーゴ バンク ナショナル アソシエイション ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
CN110251683A (zh) * 2013-06-24 2019-09-20 Abl生物公司 具有改进的稳定性的抗体-药物缀合物及其用途
KR102247701B1 (ko) 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
US11603346B2 (en) 2016-03-07 2023-03-14 Hanmi Pharm. Co., Ltd. Polyethylene glycol derivative and use thereof
US11357861B2 (en) 2017-09-29 2022-06-14 Hanmi Pharm. Co., Ltd Protein complex comprising non-peptidyl polymer-coupled fatty acid derivative compound as linker and preparation method therefor
WO2023111213A1 (en) 2021-12-16 2023-06-22 Rdp Pharma Ag Cell penetrating polypeptides (cpps) and their use in human therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
CH690143A5 (de) * 1995-01-27 2000-05-15 Rieter Automotive Int Ag Lambda/4-Schallabsorber.
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
AU1325400A (en) * 1998-10-26 2000-05-15 University Of Utah Research Foundation Method for preparation of polyethylene glycol aldehyde derivatives
JO2291B1 (en) * 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
KR100488351B1 (ko) * 2001-12-11 2005-05-11 선바이오(주) 신규한 폴리에틸렌글리콜-프로피온알데히드 유도체
WO2003049699A2 (en) 2001-12-11 2003-06-19 Sun Bio, Inc. Novel monofunctional polyethylene glycol aldehydes

Also Published As

Publication number Publication date
PL214871B1 (pl) 2013-09-30
CA2493221C (en) 2008-11-18
RU2288212C2 (ru) 2006-11-27
TWI276647B (en) 2007-03-21
US20070167606A1 (en) 2007-07-19
UY27902A1 (es) 2003-12-31
EP1539857B1 (en) 2006-11-02
ES2274277T3 (es) 2007-05-16
IL165920A0 (en) 2006-01-15
US20040019157A1 (en) 2004-01-29
GT200300154A (es) 2004-03-15
RU2005105568A (ru) 2005-10-20
DE60309482D1 (de) 2006-12-14
PE20040703A1 (es) 2004-10-14
NO336974B1 (no) 2015-12-07
ATE344289T1 (de) 2006-11-15
JP4071238B2 (ja) 2008-04-02
ZA200410296B (en) 2006-07-26
DE60309482T2 (de) 2007-06-28
AU2003250971B2 (en) 2008-04-03
EP1539857A1 (en) 2005-06-15
AR040607A1 (es) 2005-04-13
AU2003250971A1 (en) 2004-02-23
HRP20050026A2 (en) 2006-02-28
CN1671769B (zh) 2010-05-12
TW200416241A (en) 2004-09-01
WO2004013205A1 (en) 2004-02-12
PT1539857E (pt) 2007-01-31
JP2005533913A (ja) 2005-11-10
JO2400B1 (en) 2007-06-17
KR20050025974A (ko) 2005-03-14
US7273909B2 (en) 2007-09-25
PA8577601A1 (es) 2004-02-07
KR100615753B1 (ko) 2006-08-25
NO20050019L (no) 2005-02-23
PL375266A1 (en) 2005-11-28
CN1671769A (zh) 2005-09-21
DK1539857T3 (da) 2007-03-12
MXPA05000799A (es) 2005-04-19
CA2493221A1 (en) 2004-02-12
BR0312863B1 (pt) 2013-02-05

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/07/2003, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)