EA200100947A1 - Жевательные таблетки с высоким содержанием n-ацетилцистеина - Google Patents

Жевательные таблетки с высоким содержанием n-ацетилцистеина

Info

Publication number
EA200100947A1
EA200100947A1 EA200100947A EA200100947A EA200100947A1 EA 200100947 A1 EA200100947 A1 EA 200100947A1 EA 200100947 A EA200100947 A EA 200100947A EA 200100947 A EA200100947 A EA 200100947A EA 200100947 A1 EA200100947 A1 EA 200100947A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acetylcechetine
content
acetylcysteine
weight
chewing tablets
Prior art date
Application number
EA200100947A
Other languages
English (en)
Other versions
EA003878B1 (ru
Inventor
Франко Кастеджини
Алессандро Грассано
Риккардо Барина
Итало Дзулиани
Джованни Гурьери
Original Assignee
Дзамбон Гроуп С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзамбон Гроуп С.П.А. filed Critical Дзамбон Гроуп С.П.А.
Publication of EA200100947A1 publication Critical patent/EA200100947A1/ru
Publication of EA003878B1 publication Critical patent/EA003878B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Описана жевательная таблетка, содержащая 80-95 вес.% N-ацетилцистеина, 0,5-4 вес.% связующего агента от количества N-ацетилцистеина, а также фармацевтически приемлемые наполнители, такие как разбавители, агенты, вызывающие дезинтеграцию, жирные вещества при необязательном присутствии добавки, повышающей текучесть, и слоя пленочного покрытия.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100947A 1999-04-06 2000-03-21 Способ получения жевательной таблетки с высоким содержанием n-ацетилцистеина и таблетка, полученная этим способом EA003878B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000704A IT1311907B1 (it) 1999-04-06 1999-04-06 Compresse deglutibili ad alto contenuto di n-acetilcisteina.
PCT/EP2000/002464 WO2000059500A1 (en) 1999-04-06 2000-03-21 Swallowable tablets with high content of n-acetylcysteine

Publications (2)

Publication Number Publication Date
EA200100947A1 true EA200100947A1 (ru) 2002-04-25
EA003878B1 EA003878B1 (ru) 2003-10-30

Family

ID=11382595

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100947A EA003878B1 (ru) 1999-04-06 2000-03-21 Способ получения жевательной таблетки с высоким содержанием n-ацетилцистеина и таблетка, полученная этим способом

Country Status (15)

Country Link
EP (1) EP1165065B1 (ru)
CN (1) CN1159004C (ru)
AT (1) ATE239463T1 (ru)
AU (1) AU4106800A (ru)
BR (1) BR0008657A (ru)
CA (1) CA2361843C (ru)
CO (1) CO4970828A1 (ru)
DE (1) DE60002570T2 (ru)
DK (1) DK1165065T3 (ru)
EA (1) EA003878B1 (ru)
ES (1) ES2197087T3 (ru)
HU (1) HU228823B1 (ru)
IT (1) IT1311907B1 (ru)
PT (1) PT1165065E (ru)
WO (1) WO2000059500A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
US20060099253A1 (en) * 2004-10-20 2006-05-11 Wyeth Antibiotic product formulation
US7993578B2 (en) 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
NZ595071A (en) * 2009-03-13 2013-01-25 Toyama Chemical Co Ltd Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
US20110014285A1 (en) * 2009-07-15 2011-01-20 Herzenberg Leonore A N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen
IT1399492B1 (it) * 2010-04-13 2013-04-19 Alpex Pharma Sa Composizioni farmaceutiche effervescenti contenenti n-acetilcisteina.
CN102028657B (zh) * 2010-12-02 2012-05-23 海南美兰史克制药有限公司 乙酰半胱氨酸脂质体固体制剂
CN102144978B (zh) * 2011-04-11 2013-03-13 南京正科制药有限公司 一种乙酰半胱氨酸颗粒及其制备工艺
CN102743369A (zh) * 2012-06-19 2012-10-24 苏州朗易生物医药研究有限公司 一种乙酰半胱氨酸的药物组合物及其制备方法
ITMI20130874A1 (it) * 2013-05-29 2014-11-30 Zambon Spa Compresse deglutibili di n-acetilcisteina
CN104784116B (zh) * 2015-04-15 2017-05-24 武汉诺贝药业有限公司 一种n‑乙酰半胱氨酸口服制剂
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
CN110292569B (zh) * 2019-07-15 2021-11-02 广东人人康药业有限公司 一种乙酰半胱氨酸胶囊及其制备方法
CN112843008A (zh) * 2021-02-07 2021-05-28 广东赛康制药厂有限公司 一种乙酰半胱氨酸片及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0315249A1 (en) * 1987-11-02 1989-05-10 Merck & Co. Inc. Phthalazineacetic acid composition and tablet
ES2077757T5 (es) * 1990-10-19 2001-06-01 Spirig Ag Pharmazeutische Prap Preparacion farmaceutica solida con disolucion rapida que contiene la n-acetilcisteina.
ZA963590B (en) * 1995-05-10 1996-11-19 Adcock Ingram Ltd Pharmaceutical composition

Also Published As

Publication number Publication date
CO4970828A1 (es) 2000-11-07
IT1311907B1 (it) 2002-03-20
HUP0200646A2 (hu) 2002-07-29
ITMI990704A1 (it) 2000-10-06
WO2000059500A1 (en) 2000-10-12
CA2361843A1 (en) 2000-10-12
EP1165065B1 (en) 2003-05-07
CN1159004C (zh) 2004-07-28
CA2361843C (en) 2008-10-14
ATE239463T1 (de) 2003-05-15
ES2197087T3 (es) 2004-01-01
CN1345236A (zh) 2002-04-17
AU4106800A (en) 2000-10-23
EP1165065A1 (en) 2002-01-02
DE60002570T2 (de) 2004-02-26
BR0008657A (pt) 2001-12-18
DE60002570D1 (de) 2003-06-12
HU228823B1 (en) 2013-05-28
EA003878B1 (ru) 2003-10-30
PT1165065E (pt) 2003-08-29
DK1165065T3 (da) 2003-09-01

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