EA200000398A1 - Химические соединения - Google Patents

Химические соединения

Info

Publication number
EA200000398A1
EA200000398A1 EA200000398A EA200000398A EA200000398A1 EA 200000398 A1 EA200000398 A1 EA 200000398A1 EA 200000398 A EA200000398 A EA 200000398A EA 200000398 A EA200000398 A EA 200000398A EA 200000398 A1 EA200000398 A1 EA 200000398A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
sor
cor
halogen
salts
Prior art date
Application number
EA200000398A
Other languages
English (en)
Other versions
EA003087B1 (ru
Inventor
Колин Дейвид Элдред
Эндрю Майкл Кеннет Пеннелл
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200000398A1 publication Critical patent/EA200000398A1/ru
Publication of EA003087B1 publication Critical patent/EA003087B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединение формулы (I), где Rпредставляет собой Cалкил, галоген или водород; Rпредставляет собой алкильную группу с прямой или разветвленной цепью, состоящую из 1-6 атомов углерода; при условии, что когда Rпредставляет собой Cалкил, Rявляется Cалкилом, Rне может представлять собой фенил, возможно замещенный одним или более чем одним заместителем, выбранным из галогена, Cалкила, трифторметила, нитро, циано, -COR, -CONRR, -COR, -SOR, -SOR, -SOH, -SONRR, -OR, -NHSOR, -NHCORи -NRR; и его соли и сольваты, в частности его физиологически приемлемые сольваты и соли. Эти соединения являются агонистами к аденозиновому A1-рецептору.Отчет о международном поиске был опубликован 1999.08.19.
EA200000398A 1997-11-08 1998-11-06 Производные аденозина EA003087B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723590.7A GB9723590D0 (en) 1997-11-08 1997-11-08 Chemical compounds
PCT/EP1998/007023 WO1999024451A2 (en) 1997-11-08 1998-11-06 Adenosine a1 receptor agonists

Publications (2)

Publication Number Publication Date
EA200000398A1 true EA200000398A1 (ru) 2000-12-25
EA003087B1 EA003087B1 (ru) 2002-12-26

Family

ID=10821761

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000398A EA003087B1 (ru) 1997-11-08 1998-11-06 Производные аденозина

Country Status (27)

Country Link
US (2) US6544960B1 (ru)
EP (1) EP1030856B1 (ru)
JP (1) JP2001522859A (ru)
KR (1) KR20010031878A (ru)
CN (1) CN1217952C (ru)
AP (1) AP2000001804A0 (ru)
AT (1) ATE273989T1 (ru)
AU (1) AU763414B2 (ru)
BR (1) BR9813989A (ru)
CA (1) CA2309202C (ru)
DE (1) DE69825779T2 (ru)
EA (1) EA003087B1 (ru)
EE (1) EE04499B1 (ru)
ES (1) ES2222619T3 (ru)
GB (1) GB9723590D0 (ru)
HR (1) HRP20000277A2 (ru)
HU (1) HUP0004102A3 (ru)
ID (1) ID24758A (ru)
IL (2) IL135966A0 (ru)
IS (1) IS5479A (ru)
NO (1) NO20002359L (ru)
NZ (1) NZ504336A (ru)
PL (1) PL340873A1 (ru)
SK (1) SK6702000A3 (ru)
TR (1) TR200001937T2 (ru)
WO (1) WO1999024451A2 (ru)
YU (1) YU26800A (ru)

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KR20100113557A (ko) 2008-01-11 2010-10-21 노파르티스 아게 키나제 억제제로서의 피리미딘
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CN101857622B (zh) * 2009-04-07 2014-12-03 中国医学科学院药物研究所 一种腺苷衍生物及其制备方法和应用
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US10174033B2 (en) 2009-12-10 2019-01-08 Institute Of Materia Medica, Chinese Academy Of Medical Sciences N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof
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Also Published As

Publication number Publication date
EP1030856A2 (en) 2000-08-30
IS5479A (is) 2000-05-03
GB9723590D0 (en) 1998-01-07
JP2001522859A (ja) 2001-11-20
KR20010031878A (ko) 2001-04-16
YU26800A (sh) 2002-12-10
WO1999024451A3 (en) 1999-08-19
HUP0004102A2 (hu) 2001-04-28
CA2309202A1 (en) 1999-05-20
TR200001937T2 (tr) 2000-11-21
US6740644B2 (en) 2004-05-25
BR9813989A (pt) 2000-09-26
SK6702000A3 (en) 2001-01-18
ATE273989T1 (de) 2004-09-15
ID24758A (id) 2000-08-03
ES2222619T3 (es) 2005-02-01
DE69825779D1 (de) 2004-09-23
IL135966A (en) 2006-06-11
CN1217952C (zh) 2005-09-07
EE200000283A (et) 2001-08-15
EA003087B1 (ru) 2002-12-26
US6544960B1 (en) 2003-04-08
AU763414B2 (en) 2003-07-24
NZ504336A (en) 2002-11-26
AU1666599A (en) 1999-05-31
DE69825779T2 (de) 2005-08-25
CA2309202C (en) 2008-06-17
EP1030856B1 (en) 2004-08-18
HUP0004102A3 (en) 2002-09-30
NO20002359L (no) 2000-07-05
CN1285844A (zh) 2001-02-28
IL135966A0 (en) 2001-05-20
AP2000001804A0 (en) 2000-06-30
PL340873A1 (en) 2001-03-12
WO1999024451A2 (en) 1999-05-20
NO20002359D0 (no) 2000-05-05
HRP20000277A2 (en) 2000-10-31
US20030158146A1 (en) 2003-08-21
EE04499B1 (et) 2005-06-15

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