EA200000181A1 - Фармацевтические композиции, содержащие витамин d и кальций, их приготовление и терапевтическое применение - Google Patents

Фармацевтические композиции, содержащие витамин d и кальций, их приготовление и терапевтическое применение

Info

Publication number
EA200000181A1
EA200000181A1 EA200000181A EA200000181A EA200000181A1 EA 200000181 A1 EA200000181 A1 EA 200000181A1 EA 200000181 A EA200000181 A EA 200000181A EA 200000181 A EA200000181 A EA 200000181A EA 200000181 A1 EA200000181 A1 EA 200000181A1
Authority
EA
Eurasian Patent Office
Prior art keywords
calcium
preparation
pharmaceutical compositions
compositions containing
therapeutic application
Prior art date
Application number
EA200000181A
Other languages
English (en)
Other versions
EA002492B1 (ru
Inventor
Маурицио Валлери
Алессандро Тозетти
Original Assignee
Менарини Интернэшнл Оперейшнз Люксембург С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Менарини Интернэшнл Оперейшнз Люксембург С.А. filed Critical Менарини Интернэшнл Оперейшнз Люксембург С.А.
Publication of EA200000181A1 publication Critical patent/EA200000181A1/ru
Publication of EA002492B1 publication Critical patent/EA002492B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Представлена фармацевтическая композиция, содержащая витамин D и кальций, включающая связывающее вещество, выбранное из группы, состоящей из: пропиленгликоля, полиэтиленгликоля, имеющего молекулярный вес, находящийся в интервале между 300 и 1500, жидкого парафина или силиконового масла, применимая для лечения пищевого дефицита кальция и витамина D в пожилом возрасте.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000181A 1997-07-30 1998-07-21 Фармацевтическая композиция, содержащая витамин d и кальций, способы ее приготовления и терапевтического применения EA002492B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97FI000184A ITFI970184A1 (it) 1997-07-30 1997-07-30 Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
PCT/EP1998/004567 WO1999006051A1 (en) 1997-07-30 1998-07-21 Pharmaceutical compositions containing vitamin d and calcium, their preparation and therapeutic use

Publications (2)

Publication Number Publication Date
EA200000181A1 true EA200000181A1 (ru) 2000-10-30
EA002492B1 EA002492B1 (ru) 2002-06-27

Family

ID=11352223

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000181A EA002492B1 (ru) 1997-07-30 1998-07-21 Фармацевтическая композиция, содержащая витамин d и кальций, способы ее приготовления и терапевтического применения

Country Status (29)

Country Link
US (1) US7067154B1 (ru)
EP (1) EP0999843B1 (ru)
JP (1) JP4497496B2 (ru)
KR (1) KR100573421B1 (ru)
AT (1) ATE271387T1 (ru)
AU (1) AU8978198A (ru)
BG (1) BG65044B1 (ru)
BR (1) BR9810832B1 (ru)
CA (1) CA2299420C (ru)
CZ (1) CZ297670B6 (ru)
DE (1) DE69825164D1 (ru)
EA (1) EA002492B1 (ru)
EE (1) EE04046B1 (ru)
ES (1) ES2223135T3 (ru)
HK (1) HK1027751A1 (ru)
HU (1) HU226112B1 (ru)
ID (1) ID23504A (ru)
IL (1) IL134268A0 (ru)
IS (1) IS5359A (ru)
IT (1) ITFI970184A1 (ru)
NO (1) NO20000310L (ru)
PL (1) PL189295B1 (ru)
PT (1) PT999843E (ru)
RS (1) RS49703B (ru)
SI (1) SI0999843T1 (ru)
SK (1) SK284873B6 (ru)
TR (1) TR200000261T2 (ru)
UA (1) UA61968C2 (ru)
WO (1) WO1999006051A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040071789A1 (en) * 2002-02-14 2004-04-15 Baron John A Calcium supplementation to reduce prostate cancer risk
ES2192136B1 (es) * 2002-01-04 2005-03-16 Italfarmaco, S.A. Composiciones farmaceuticas para el tratamiento o prevencion de la osteoporosis.
ITFI20030194A1 (it) * 2003-07-17 2005-01-18 Menarini Int Operations Lu Sa Composizione farmaceutiche effervescenti contenenti
WO2005115342A1 (en) 2004-05-24 2005-12-08 Nycomed Pharma As Particulate comprising a calcium-containing compound and a sugar alcohol
DE602005024800D1 (de) 2004-06-01 2010-12-30 Nycomed Pharma As Kaubare, lutschbare und verschluckbare tablette mit einer calciumhaltigen verbindung als wirkstoff
ATE395908T1 (de) 2005-02-03 2008-06-15 Nycomed Pharma As Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung
US8808735B2 (en) 2005-02-03 2014-08-19 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
EP3047847A1 (en) * 2005-10-12 2016-07-27 OPKO Renal, LLC Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
CN102872157A (zh) * 2005-12-07 2013-01-16 奈科明制药有限公司 预先压实的含钙组合物
UA95093C2 (ru) 2005-12-07 2011-07-11 Нікомед Фарма Ас Способ получения кальциесодержащего соединения
MXPA05014091A (es) * 2005-12-20 2007-06-20 Leopoldo De Jesus Espinosa Abdala Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus
CA2835910C (en) * 2007-04-25 2016-06-28 Warner Chilcott Company, Llc Improved vitamin d content uniformity in pharmaceutical dosage forms
PL2358374T3 (pl) 2008-11-17 2014-03-31 Takeda As Ulepszona stabilność rozpuszczania tabletek węglanu wapnia
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
TR200900878A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik formülasyonlar
TR200908237A2 (tr) 2009-11-02 2011-05-23 Bi̇lgi̇ç Mahmut Kalsiyum ve D vitamini içeren farmasötik bileşimler.
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
WO2015020191A1 (ja) * 2013-08-09 2015-02-12 日東薬品工業株式会社 カルシウム剤
CN105166935B (zh) * 2015-09-01 2018-08-31 张伟 一种含有维生素d3的液体制剂及其制备方法
JP2021522299A (ja) 2018-05-02 2021-08-30 フェリング・ベー・フェー 改良製剤
KR102211287B1 (ko) * 2018-12-21 2021-02-03 (주)휴온스 비타민 d 또는 이의 유도체를 포함하는 안정성이 개선된 액상 제제

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2073271A1 (en) * 1969-12-11 1971-10-01 Boivin Jean Calcium salt - vitamin d2 compn - for treatment of decalcification of
ZA813205B (en) * 1980-12-05 1983-03-30 Smith Kline French Lab Dosage units
DK8603837A (ru) * 1985-08-13 1987-02-14
US5624683A (en) * 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
ATE147592T1 (de) * 1990-02-05 1997-02-15 Lifescience Corp Vitamine und mineralien enthaltende nahrungszusätze
EP0730862A1 (en) * 1990-05-16 1996-09-11 Zbigniew Walaszek Formulation containing glucaric acid for the prevention or treatment of non-cancerous cellular hyperproliferation and dietary supplement
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
FR2724844B1 (fr) 1994-09-23 1997-01-24 Innothera Lab Sa Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
IL115241A (en) * 1994-09-26 2000-08-31 American Cyanamid Co Calcium dietary supplement
FR2760639B1 (fr) * 1997-03-14 2000-09-22 Innothera Lab Sa Association therapeutique mineralo-vitaminique sous forme de preparation unitaire liquide buvable

Also Published As

Publication number Publication date
EP0999843A1 (en) 2000-05-17
JP2001511453A (ja) 2001-08-14
EA002492B1 (ru) 2002-06-27
IL134268A0 (en) 2001-04-30
ID23504A (id) 2000-04-27
ITFI970184A1 (it) 1999-01-30
PL189295B1 (pl) 2005-07-29
ATE271387T1 (de) 2004-08-15
KR20010022319A (ko) 2001-03-15
CA2299420C (en) 2009-04-21
DE69825164D1 (de) 2004-08-26
EE04046B1 (et) 2003-06-16
IS5359A (is) 2000-01-24
PT999843E (pt) 2004-11-30
PL338237A1 (en) 2000-10-09
WO1999006051A1 (en) 1999-02-11
HU226112B1 (en) 2008-04-28
SK802000A3 (en) 2000-07-11
HK1027751A1 (en) 2001-01-23
EP0999843B1 (en) 2004-07-21
BR9810832A (pt) 2000-07-25
EE200000054A (et) 2000-10-16
CA2299420A1 (en) 1999-02-11
BG104057A (en) 2000-07-31
BG65044B1 (bg) 2007-01-31
NO20000310D0 (no) 2000-01-21
SK284873B6 (sk) 2006-01-05
TR200000261T2 (tr) 2000-09-21
SI0999843T1 (en) 2005-02-28
US7067154B1 (en) 2006-06-27
AU8978198A (en) 1999-02-22
CZ2000199A3 (cs) 2000-05-17
ES2223135T3 (es) 2005-02-16
HUP0100539A2 (hu) 2001-08-28
CZ297670B6 (cs) 2007-02-28
UA61968C2 (en) 2003-12-15
YU3700A (sh) 2002-11-15
NO20000310L (no) 2000-01-21
KR100573421B1 (ko) 2006-04-26
BR9810832B1 (pt) 2010-11-16
JP4497496B2 (ja) 2010-07-07
RS49703B (sr) 2007-12-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU