EA033102B1 - Pharmaceutic composition with modified delayed and sustained release containing asparaginates - Google Patents

Pharmaceutic composition with modified delayed and sustained release containing asparaginates

Info

Publication number
EA033102B1
EA033102B1 EA201700370A EA201700370A EA033102B1 EA 033102 B1 EA033102 B1 EA 033102B1 EA 201700370 A EA201700370 A EA 201700370A EA 201700370 A EA201700370 A EA 201700370A EA 033102 B1 EA033102 B1 EA 033102B1
Authority
EA
Eurasian Patent Office
Prior art keywords
shell
core
sustained release
potassium
pharmaceutical composition
Prior art date
Application number
EA201700370A
Other languages
Russian (ru)
Other versions
EA201700370A1 (en
Inventor
Андрей Михайлович Гомжин
Михаил Бренер
Дмитрий Сергеевич Олейников
Роман Прокопьевич Савяк
Владимир Григорьевич Тимко
Original Assignee
Общество с ограниченной ответственностью "Фармамед"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "Фармамед" filed Critical Общество с ограниченной ответственностью "Фармамед"
Priority to EA201700370A priority Critical patent/EA033102B1/en
Publication of EA201700370A1 publication Critical patent/EA201700370A1/en
Publication of EA033102B1 publication Critical patent/EA033102B1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to pharmaceutics and more specifically to a process of manufacturing a drug product for regulation of metabolic processes associated with potassium and magnesium deficiency. The drug product may be used in therapy, e.g. in cardiology and in sports medicine. The invention proposes a pharmaceutical composition with delayed and sustained release comprising a mixture of potassium and magnesium salts of asparagine acid presented as racemates and/or isomers thereof and/or a mixture thereof. The pharmaceutical composition represents a solid dosage form characterized by targeted release of the active substance and consisting of a core and a shell as a film coating. Pharmacokinetic benefits consist in lower side effects on the gastric mucosa. This is achieved by applying a specially-composed shell that is soluble in the alkaline intestinal medium, and this is also due to the optimally developed ratio of active ingredients and excipients both in the core and in the shell, namely: filler, disintegrant, anti-friction agent - in the core; release modifier, plasticizer, anti-friction agent and coloring agent - in the shell of the solid dosage form.
EA201700370A 2017-08-21 2017-08-21 Pharmaceutic composition with modified delayed and sustained release containing asparaginates EA033102B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201700370A EA033102B1 (en) 2017-08-21 2017-08-21 Pharmaceutic composition with modified delayed and sustained release containing asparaginates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201700370A EA033102B1 (en) 2017-08-21 2017-08-21 Pharmaceutic composition with modified delayed and sustained release containing asparaginates

Publications (2)

Publication Number Publication Date
EA201700370A1 EA201700370A1 (en) 2019-02-28
EA033102B1 true EA033102B1 (en) 2019-08-30

Family

ID=65443153

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700370A EA033102B1 (en) 2017-08-21 2017-08-21 Pharmaceutic composition with modified delayed and sustained release containing asparaginates

Country Status (1)

Country Link
EA (1) EA033102B1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2207853C1 (en) * 2002-04-04 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Pharmaceutical solid composition eliciting anti- arrhythmic activity and method for its preparing
WO2003074041A1 (en) * 2002-03-07 2003-09-12 Novartis Ag Pharmaceutical compositions
RU2229879C1 (en) * 2003-02-28 2004-06-10 Закрытое акционерное общество "Биоамид" Medicinal agent "asparkam-1" for regulation of metabolic processes and method for its preparing
RU2336076C2 (en) * 2006-06-22 2008-10-20 Закрытое акционерное общество "Биоамид" Peroral medical product for offset of magnesium deficiency in organism
RU2404775C2 (en) * 2005-05-10 2010-11-27 Новартис Аг Pharmaceutical compositions, containing imatinib and release moderator
RU2014105636A (en) * 2014-02-17 2015-08-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук PHARMACEUTICAL COMPOSITIONS WITH PROLONGED RELEASE FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003074041A1 (en) * 2002-03-07 2003-09-12 Novartis Ag Pharmaceutical compositions
RU2207853C1 (en) * 2002-04-04 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Pharmaceutical solid composition eliciting anti- arrhythmic activity and method for its preparing
RU2229879C1 (en) * 2003-02-28 2004-06-10 Закрытое акционерное общество "Биоамид" Medicinal agent "asparkam-1" for regulation of metabolic processes and method for its preparing
RU2404775C2 (en) * 2005-05-10 2010-11-27 Новартис Аг Pharmaceutical compositions, containing imatinib and release moderator
RU2336076C2 (en) * 2006-06-22 2008-10-20 Закрытое акционерное общество "Биоамид" Peroral medical product for offset of magnesium deficiency in organism
RU2014105636A (en) * 2014-02-17 2015-08-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук PHARMACEUTICAL COMPOSITIONS WITH PROLONGED RELEASE FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAYMOND C. ROWE et al. Handbook Pharmaceutical Excipients, Pharmaceutical Press and American Pharmacists Association, 2009, no. 6, p. 185, 404, 517, 525-526, 581, 685, 728, 741 *
Панангин. РЛС он-лайн. 13.07.2015, с. 1-6. Найдено из Интернет: https://www.rlsnat.ru/tn_index_id_2499.htm *

Also Published As

Publication number Publication date
EA201700370A1 (en) 2019-02-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG TJ TM