EA015654B9 - Антитела против бета-амилоидного пептида - Google Patents

Антитела против бета-амилоидного пептида

Info

Publication number
EA015654B9
EA015654B9 EA200801842A EA200801842A EA015654B9 EA 015654 B9 EA015654 B9 EA 015654B9 EA 200801842 A EA200801842 A EA 200801842A EA 200801842 A EA200801842 A EA 200801842A EA 015654 B9 EA015654 B9 EA 015654B9
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies against
beta peptide
antibodies
beta
against amyloid
Prior art date
Application number
EA200801842A
Other languages
English (en)
Other versions
EA200801842A1 (ru
EA015654B1 (ru
Inventor
Стивен Энтони Бербидж
Джонатан Генри Эллис
Сюзанна К. Форд
Фолькер Гермашевски
Умеш Кумар
Карен Луиз Филпотт
Питер Эрнест Соден
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200801842A1 publication Critical patent/EA200801842A1/ru
Publication of EA015654B1 publication Critical patent/EA015654B1/ru
Publication of EA015654B9 publication Critical patent/EA015654B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Раскрыты антитела, которые связывают человеческий β-амилоидный пептид; способы лечения указанными антителами заболеваний или расстройств, отличающихся повышенными уровнями β-амилоида или отложениями β-амилоида; фармацевтические композиции, содержащие указанные антитела; и способы получения антител.
EA200801842A 2006-03-30 2007-03-27 Антитела против бета-амилоидного пептида EA015654B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78758806P 2006-03-30 2006-03-30
PCT/EP2007/052928 WO2007113172A2 (en) 2006-03-30 2007-03-27 Antibodies against amyloid-beta peptide

Publications (3)

Publication Number Publication Date
EA200801842A1 EA200801842A1 (ru) 2009-02-27
EA015654B1 EA015654B1 (ru) 2011-10-31
EA015654B9 true EA015654B9 (ru) 2012-01-30

Family

ID=38284050

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801842A EA015654B9 (ru) 2006-03-30 2007-03-27 Антитела против бета-амилоидного пептида

Country Status (33)

Country Link
US (3) US8227576B2 (ru)
EP (2) EP2177536B1 (ru)
JP (1) JP5103466B2 (ru)
KR (2) KR101263294B1 (ru)
CN (2) CN103539857A (ru)
AR (1) AR060332A1 (ru)
AT (1) ATE451392T1 (ru)
AU (1) AU2007233831B2 (ru)
BR (1) BRPI0709246A2 (ru)
CA (1) CA2647808C (ru)
CR (1) CR10347A (ru)
CY (1) CY1109877T1 (ru)
DE (1) DE602007003703D1 (ru)
DK (2) DK2177536T3 (ru)
EA (1) EA015654B9 (ru)
ES (2) ES2338179T3 (ru)
HK (2) HK1138015A1 (ru)
HR (2) HRP20100115T1 (ru)
IL (1) IL193695A (ru)
JO (1) JO2576B1 (ru)
MA (1) MA30337B1 (ru)
MX (1) MX2008012483A (ru)
MY (1) MY149630A (ru)
NO (1) NO20083793L (ru)
NZ (1) NZ571038A (ru)
PE (1) PE20080181A1 (ru)
PL (2) PL2177536T3 (ru)
PT (2) PT2177536E (ru)
SI (2) SI1996621T1 (ru)
TW (1) TWI385179B (ru)
UA (1) UA94734C2 (ru)
WO (1) WO2007113172A2 (ru)
ZA (1) ZA200807911B (ru)

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CN116348487A (zh) 2020-07-23 2023-06-27 欧萨尔普罗席纳有限公司 抗淀粉样β抗体
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
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Also Published As

Publication number Publication date
DK2177536T3 (da) 2014-07-14
AU2007233831B2 (en) 2013-02-14
EP2177536B1 (en) 2014-06-04
BRPI0709246A2 (pt) 2011-07-12
CA2647808A1 (en) 2007-10-11
US20160024197A1 (en) 2016-01-28
US9193784B2 (en) 2015-11-24
MX2008012483A (es) 2008-10-10
HRP20100115T1 (hr) 2010-04-30
CN103539857A (zh) 2014-01-29
CR10347A (es) 2008-10-29
KR101263294B1 (ko) 2013-06-04
UA94734C2 (ru) 2011-06-10
DK1996621T3 (da) 2010-04-19
KR20080113273A (ko) 2008-12-29
MA30337B1 (fr) 2009-04-01
HK1122311A1 (en) 2009-05-15
JO2576B1 (en) 2011-02-27
SI2177536T1 (sl) 2014-09-30
DE602007003703D1 (de) 2010-01-21
KR20120093400A (ko) 2012-08-22
MY149630A (en) 2013-09-13
US20140050719A1 (en) 2014-02-20
SI1996621T1 (sl) 2010-04-30
WO2007113172A2 (en) 2007-10-11
HK1138015A1 (en) 2010-08-13
PT1996621E (pt) 2010-03-08
CY1109877T1 (el) 2014-09-10
AR060332A1 (es) 2008-06-11
ES2338179T3 (es) 2010-05-04
EP1996621B1 (en) 2009-12-09
US8227576B2 (en) 2012-07-24
ES2484967T3 (es) 2014-08-12
WO2007113172A3 (en) 2007-11-29
ZA200807911B (en) 2009-11-25
HRP20140618T1 (hr) 2014-08-15
JP2009531380A (ja) 2009-09-03
NO20083793L (no) 2008-10-13
IL193695A (en) 2012-05-31
AU2007233831A1 (en) 2007-10-11
CN101415729B (zh) 2013-09-04
NZ571038A (en) 2011-03-31
PL1996621T3 (pl) 2010-05-31
JP5103466B2 (ja) 2012-12-19
IL193695A0 (en) 2011-08-01
PL2177536T3 (pl) 2014-11-28
CA2647808C (en) 2015-11-17
EP2177536A1 (en) 2010-04-21
TWI385179B (zh) 2013-02-11
ATE451392T1 (de) 2009-12-15
TW200815466A (en) 2008-04-01
US20110142824A1 (en) 2011-06-16
PT2177536E (pt) 2014-08-22
EA200801842A1 (ru) 2009-02-27
EP1996621A2 (en) 2008-12-03
EA015654B1 (ru) 2011-10-31
PE20080181A1 (es) 2008-03-16
CN101415729A (zh) 2009-04-22

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