EA015227B1 - Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их Download PDF

Info

Publication number
EA015227B1
EA015227B1 EA200801681A EA200801681A EA015227B1 EA 015227 B1 EA015227 B1 EA 015227B1 EA 200801681 A EA200801681 A EA 200801681A EA 200801681 A EA200801681 A EA 200801681A EA 015227 B1 EA015227 B1 EA 015227B1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
cyclopropyl
compound
pyridin
branched
Prior art date
Application number
EA200801681A
Other languages
English (en)
Russian (ru)
Other versions
EA200801681A1 (ru
Inventor
Соло Голдштейн
Клод Гиллонно
Ив Шартон
Брайан Локхарт
Пьерр Лестаж
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200801681A1 publication Critical patent/EA200801681A1/ru
Publication of EA015227B1 publication Critical patent/EA015227B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA200801681A 2006-01-30 2007-01-30 Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их EA015227B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0600784A FR2896800B1 (fr) 2006-01-30 2006-01-30 Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2007/000170 WO2007085750A1 (fr) 2006-01-30 2007-01-30 Nouveaux composes pyridinylaminoalkylene- et pyridinyloxyalkylene- cyclopropanamines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200801681A1 EA200801681A1 (ru) 2009-02-27
EA015227B1 true EA015227B1 (ru) 2011-06-30

Family

ID=37102591

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801681A EA015227B1 (ru) 2006-01-30 2007-01-30 Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их

Country Status (29)

Country Link
US (1) US20100317698A1 (pt)
EP (1) EP1979321B9 (pt)
JP (1) JP2009525311A (pt)
KR (1) KR101050910B1 (pt)
CN (1) CN101374814B (pt)
AR (1) AR059221A1 (pt)
AT (1) ATE437857T1 (pt)
AU (1) AU2007209235B2 (pt)
BR (1) BRPI0710443A2 (pt)
CA (1) CA2640482C (pt)
CY (1) CY1109477T1 (pt)
DE (1) DE602007001779D1 (pt)
DK (1) DK1979321T3 (pt)
EA (1) EA015227B1 (pt)
ES (1) ES2330899T3 (pt)
FR (1) FR2896800B1 (pt)
GE (1) GEP20105090B (pt)
HK (1) HK1126190A1 (pt)
HR (1) HRP20090523T1 (pt)
MA (1) MA30222B1 (pt)
MY (1) MY149068A (pt)
NO (1) NO20083753L (pt)
PL (1) PL1979321T3 (pt)
PT (1) PT1979321E (pt)
RS (1) RS51065B (pt)
SI (1) SI1979321T1 (pt)
UA (1) UA88116C2 (pt)
WO (1) WO2007085750A1 (pt)
ZA (1) ZA200806399B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009303545A1 (en) * 2008-10-14 2010-04-22 Psychogenics, Inc Nicotinic acetylcholine receptor ligands and the uses thereof
US8975261B2 (en) 2011-05-24 2015-03-10 Merck Sharp & Dohme Corp. Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors
BR112017004334A2 (pt) * 2014-09-05 2018-08-07 Celgene Quanticel Res Inc inibidores de desmetilase específica de lisina-1.
US20180311238A1 (en) * 2017-04-28 2018-11-01 Saniona A/S Selective Agonist Of a6 Containing nAChRs
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075110A1 (en) * 1999-06-07 2000-12-14 Targacept, Inc. Pharmaceutical compositions and methods for use
WO2001070733A2 (en) * 2000-03-21 2001-09-27 Suntory Limited Di-substituted iminoheterocyclic compounds
EP1170281A1 (fr) * 2000-06-27 2002-01-09 Les Laboratoires Servier Nouveaux composés cyclopropaniques 1,1 et 1,2-disubstitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2004078752A1 (en) * 2003-03-05 2004-09-16 Targacept Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889188B1 (fr) * 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinylaminocyclopropanamines polysubstitues, leur procede de preparation et les compositions phamaceutiques qui les contiennent
FR2889187B1 (fr) * 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075110A1 (en) * 1999-06-07 2000-12-14 Targacept, Inc. Pharmaceutical compositions and methods for use
WO2001070733A2 (en) * 2000-03-21 2001-09-27 Suntory Limited Di-substituted iminoheterocyclic compounds
EP1170281A1 (fr) * 2000-06-27 2002-01-09 Les Laboratoires Servier Nouveaux composés cyclopropaniques 1,1 et 1,2-disubstitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2004078752A1 (en) * 2003-03-05 2004-09-16 Targacept Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Also Published As

Publication number Publication date
EA200801681A1 (ru) 2009-02-27
CA2640482A1 (fr) 2007-08-02
EP1979321B1 (fr) 2009-07-29
BRPI0710443A2 (pt) 2011-08-16
MY149068A (en) 2013-07-15
KR101050910B1 (ko) 2011-07-20
UA88116C2 (ru) 2009-09-10
WO2007085750A1 (fr) 2007-08-02
AU2007209235B2 (en) 2011-03-03
PT1979321E (pt) 2009-08-31
ATE437857T1 (de) 2009-08-15
CN101374814A (zh) 2009-02-25
FR2896800A1 (fr) 2007-08-03
US20100317698A1 (en) 2010-12-16
AU2007209235A1 (en) 2007-08-02
KR20080090564A (ko) 2008-10-08
GEP20105090B (en) 2010-10-11
DE602007001779D1 (de) 2009-09-10
CN101374814B (zh) 2011-05-25
SI1979321T1 (sl) 2009-12-31
FR2896800B1 (fr) 2008-04-11
CY1109477T1 (el) 2014-08-13
HRP20090523T1 (hr) 2009-11-30
CA2640482C (fr) 2011-04-19
NO20083753L (no) 2008-10-10
PL1979321T3 (pl) 2009-10-30
DK1979321T3 (da) 2009-11-02
JP2009525311A (ja) 2009-07-09
ZA200806399B (en) 2009-11-25
ES2330899T3 (es) 2009-12-16
EP1979321A1 (fr) 2008-10-15
RS51065B (sr) 2010-10-31
HK1126190A1 (en) 2009-08-28
MA30222B1 (fr) 2009-02-02
EP1979321B9 (fr) 2010-02-17
AR059221A1 (es) 2008-03-19

Similar Documents

Publication Publication Date Title
KR101913619B1 (ko) Gpr-119의 조절제로서의 신규한 화합물
KR20070064375A (ko) 글루타메이트 수용체의 증강제
JP2010527980A (ja) 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物
EA015227B1 (ru) Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их
US20180250277A1 (en) Positive allosteric modulators of nicotinic acetylcholine receptor
TWI458710B (zh) 乙炔基衍生物
EA005185B1 (ru) Новые 1,1- и 1,2-дизамещенные циклопропановые производные, способ их получения и содержащие их фармацевтические композиции
KR20120095481A (ko) Hcn 차단제로서의 아미노-헤테로아릴 유도체
DK2729447T3 (en) POSITIVE ALLOSTERIC MODULATORS OF NICOTIN ACETYL CHOLINE RECEPTOR
AU2006201993A1 (en) New phenylpridinylpiperazine compounds, a process for their preparation and pharmaceutical compositions containing them
US20130005743A1 (en) New positive allosteric modulators of nicotinic acetylcholine receptor
EA011124B1 (ru) Новые многократно замещённые соединения 1,1-пиридиламиноциклопропанамина, способ их получения и фармацевтические композиции, которые их содержат
WO2013071067A1 (en) Phenyl-substituted nicotinic ligands, and methods of use thereof
NZ710003B2 (en) Positive allosteric modulators of nicotinic acetylcholine receptor
OA19541A (en) Positive Allosteric Modulators of Nicotinic Acetylcholine Receptor.
NZ617367B2 (en) Positive allosteric modulators of nicotinic acetylcholine receptor

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU