DOP2016000120A - Nuevos inhibidores de dgat2 - Google Patents
Nuevos inhibidores de dgat2Info
- Publication number
- DOP2016000120A DOP2016000120A DO2016000120A DO2016000120A DOP2016000120A DO P2016000120 A DOP2016000120 A DO P2016000120A DO 2016000120 A DO2016000120 A DO 2016000120A DO 2016000120 A DO2016000120 A DO 2016000120A DO P2016000120 A DOP2016000120 A DO P2016000120A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- new
- dgat2 inhibitors
- dgat2
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DE LA SIGUIENTE FÓRMULA: DONDE R ES H O -CH3; MÉTODOS DE TRATAMIENTO DE PACIENTES PARA HIPERTRIGLICERIDEMIA Y ENFERMEDADES CARDIOVASCULARES QUE INCLUYEN DISLIPIDEMIA Y ATEROSCLEROSIS, Y PROCESOS PARA PREPARAR LOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361908339P | 2013-11-25 | 2013-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2016000120A true DOP2016000120A (es) | 2016-06-15 |
Family
ID=52016867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2016000120A DOP2016000120A (es) | 2013-11-25 | 2016-05-24 | Nuevos inhibidores de dgat2 |
Country Status (24)
Country | Link |
---|---|
US (1) | US9073901B2 (es) |
EP (1) | EP3074381B1 (es) |
JP (1) | JP6155395B2 (es) |
KR (1) | KR20160072252A (es) |
CN (1) | CN105764889B (es) |
AP (1) | AP2016009230A0 (es) |
AR (1) | AR098394A1 (es) |
AU (1) | AU2014353109B2 (es) |
CA (1) | CA2928468A1 (es) |
CL (1) | CL2016001172A1 (es) |
CR (1) | CR20160216A (es) |
DO (1) | DOP2016000120A (es) |
EA (1) | EA201690847A1 (es) |
ES (1) | ES2695302T3 (es) |
HK (1) | HK1223367A1 (es) |
IL (1) | IL245245A0 (es) |
MA (1) | MA39048B1 (es) |
MX (1) | MX2016006665A (es) |
NZ (1) | NZ719444A (es) |
PE (1) | PE20161099A1 (es) |
PH (1) | PH12016500963A1 (es) |
TN (1) | TN2016000146A1 (es) |
TW (1) | TW201609668A (es) |
WO (1) | WO2015077299A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2982267C (en) * | 2015-05-20 | 2019-11-12 | Eli Lilly And Company | Novel dgat2 inhibitors |
AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
TWI771766B (zh) | 2019-10-04 | 2022-07-21 | 美商輝瑞股份有限公司 | 二醯基甘油醯基轉移酶2 抑制劑 |
JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ2阻害剤とアセチル-CoAカルボキシラーゼ阻害剤との組合せ |
WO2021236401A1 (en) | 2020-05-18 | 2021-11-25 | Merck Sharp & Dohme Corp. | Novel diacylglyceride o-acyltransferase 2 inhibitors |
MX2023003842A (es) | 2020-10-08 | 2023-04-14 | Merck Sharp & Dohme Llc | Preparacion de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2. |
US20240092756A1 (en) | 2020-11-20 | 2024-03-21 | 2692372 Ontario, Inc. | Methods and composition for kras modifications |
WO2023026180A1 (en) | 2021-08-26 | 2023-03-02 | Pfizer Inc. | Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1455815A4 (en) | 2001-12-19 | 2006-11-02 | Millennium Pharm Inc | MEMBERS OF THE DIACYLGLYCEROL-ACYLTRANSFERASES FAMILY 2 (DGAT2) AND USES THEREOF |
US20050288213A1 (en) | 2002-07-18 | 2005-12-29 | Macneil Douglas J | Combination therapy for the treatment of obesity |
US7825235B2 (en) | 2003-08-18 | 2010-11-02 | Isis Pharmaceuticals, Inc. | Modulation of diacylglycerol acyltransferase 2 expression |
DK1756084T3 (da) * | 2004-06-04 | 2009-03-23 | Arena Pharm Inc | Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed |
EP1807102A2 (en) | 2004-10-29 | 2007-07-18 | Merck & Co., Inc. | Compositions and methods for the treatment of obesity and sexual dysfunction |
JP5566880B2 (ja) | 2007-04-24 | 2014-08-06 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤としての4,6−二置換アミノピリミジン誘導体 |
JP2013515085A (ja) | 2009-12-22 | 2013-05-02 | ジ・アドミニストレイターズ・オブ・ザ・チユレーン・エデユケーシヨナル・フアンド | 肥満症および糖尿病を治療するための組成物および方法 |
WO2011078102A1 (ja) * | 2009-12-22 | 2011-06-30 | 第一三共株式会社 | 新規フェノキシピリミジン誘導体 |
US20130079345A1 (en) | 2010-03-22 | 2013-03-28 | Bayer Intellectual Property Gmbh | Pharmaceutically active disubstituted triazine derivatives |
AU2012223720A1 (en) * | 2011-03-03 | 2013-09-26 | Vanderbilt University | 6-alkyl-n-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same |
EP2561867A1 (en) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | CDK9 inhibitors in the treatment of midline carcinoma |
EP2562265A1 (en) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | Susceptibility to selective CDK9 inhibitors |
CA2869587A1 (en) | 2012-04-06 | 2013-10-10 | Pfizer Inc. | Diacylglycerol acyltransferase 2 inhibitors |
-
2014
- 2014-11-12 AR ARP140104254A patent/AR098394A1/es unknown
- 2014-11-13 TW TW103139445A patent/TW201609668A/zh unknown
- 2014-11-19 MX MX2016006665A patent/MX2016006665A/es unknown
- 2014-11-19 AP AP2016009230A patent/AP2016009230A0/en unknown
- 2014-11-19 AU AU2014353109A patent/AU2014353109B2/en not_active Ceased
- 2014-11-19 US US14/547,615 patent/US9073901B2/en active Active
- 2014-11-19 KR KR1020167013324A patent/KR20160072252A/ko not_active Application Discontinuation
- 2014-11-19 CN CN201480064300.4A patent/CN105764889B/zh active Active
- 2014-11-19 NZ NZ719444A patent/NZ719444A/en not_active IP Right Cessation
- 2014-11-19 TN TN2016000146A patent/TN2016000146A1/en unknown
- 2014-11-19 EP EP14809734.8A patent/EP3074381B1/en active Active
- 2014-11-19 PE PE2016000674A patent/PE20161099A1/es not_active Application Discontinuation
- 2014-11-19 EA EA201690847A patent/EA201690847A1/ru unknown
- 2014-11-19 ES ES14809734T patent/ES2695302T3/es active Active
- 2014-11-19 MA MA39048A patent/MA39048B1/fr unknown
- 2014-11-19 WO PCT/US2014/066339 patent/WO2015077299A1/en active Application Filing
- 2014-11-19 JP JP2016532611A patent/JP6155395B2/ja not_active Expired - Fee Related
- 2014-11-19 CA CA2928468A patent/CA2928468A1/en not_active Abandoned
-
2016
- 2016-04-20 IL IL245245A patent/IL245245A0/en unknown
- 2016-05-05 CR CR20160216A patent/CR20160216A/es unknown
- 2016-05-16 CL CL2016001172A patent/CL2016001172A1/es unknown
- 2016-05-24 DO DO2016000120A patent/DOP2016000120A/es unknown
- 2016-05-24 PH PH12016500963A patent/PH12016500963A1/en unknown
- 2016-10-06 HK HK16111635.0A patent/HK1223367A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3074381A1 (en) | 2016-10-05 |
US9073901B2 (en) | 2015-07-07 |
CL2016001172A1 (es) | 2016-12-09 |
MA39048B1 (fr) | 2018-04-30 |
AR098394A1 (es) | 2016-05-26 |
CN105764889B (zh) | 2018-01-02 |
US20150148358A1 (en) | 2015-05-28 |
TW201609668A (zh) | 2016-03-16 |
CA2928468A1 (en) | 2015-05-28 |
IL245245A0 (en) | 2016-06-30 |
TN2016000146A1 (en) | 2017-10-06 |
KR20160072252A (ko) | 2016-06-22 |
NZ719444A (en) | 2017-12-22 |
JP6155395B2 (ja) | 2017-06-28 |
WO2015077299A1 (en) | 2015-05-28 |
CN105764889A (zh) | 2016-07-13 |
PH12016500963A1 (en) | 2016-06-20 |
EA201690847A1 (ru) | 2016-09-30 |
AP2016009230A0 (en) | 2016-05-31 |
AU2014353109B2 (en) | 2017-02-02 |
JP2016539115A (ja) | 2016-12-15 |
EP3074381B1 (en) | 2018-07-04 |
MX2016006665A (es) | 2016-07-26 |
MA39048A1 (fr) | 2017-05-31 |
ES2695302T3 (es) | 2019-01-03 |
PE20161099A1 (es) | 2016-10-22 |
AU2014353109A1 (en) | 2016-05-12 |
CR20160216A (es) | 2016-06-27 |
HK1223367A1 (zh) | 2017-07-28 |
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