DK77090D0 - Immunmodulerende azaspiraner - Google Patents

Immunmodulerende azaspiraner

Info

Publication number
DK77090D0
DK77090D0 DK077090A DK77090A DK77090D0 DK 77090 D0 DK77090 D0 DK 77090D0 DK 077090 A DK077090 A DK 077090A DK 77090 A DK77090 A DK 77090A DK 77090 D0 DK77090 D0 DK 77090D0
Authority
DK
Denmark
Prior art keywords
immunomodulatory
azaspirans
azaspiranes
formulae
chem
Prior art date
Application number
DK077090A
Other languages
English (en)
Other versions
DK170042B1 (da
DK77090A (da
Inventor
Alison Mary Badger
David Aaron Schwartz
Elaine Nicholas Cheeseman
Michael John Dimartino
James Woodrow Dorman
Christopher Kevin Mirabelli
Donald Harold Picker
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK77090A publication Critical patent/DK77090A/da
Publication of DK77090D0 publication Critical patent/DK77090D0/da
Application granted granted Critical
Publication of DK170042B1 publication Critical patent/DK170042B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK077090A 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel DK170042B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US10170487 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes
US24422988 1988-09-13
PCT/US1988/003323 WO1989002889A1 (en) 1987-09-28 1988-09-27 Immunomodulatory azaspiranes
US8803323 1988-09-27

Publications (3)

Publication Number Publication Date
DK77090A DK77090A (da) 1990-03-23
DK77090D0 true DK77090D0 (da) 1990-03-23
DK170042B1 DK170042B1 (da) 1995-05-08

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK077090A DK170042B1 (da) 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel

Country Status (24)

Country Link
US (1) US4963557A (da)
EP (1) EP0310321B1 (da)
JP (1) JP2582888B2 (da)
KR (1) KR0166336B1 (da)
CN (1) CN1031618C (da)
AT (1) ATE114463T1 (da)
AU (1) AU619780B2 (da)
CA (1) CA1313189C (da)
CY (1) CY1955A (da)
DE (1) DE3852266T2 (da)
DK (1) DK170042B1 (da)
ES (1) ES2064356T3 (da)
FI (1) FI93006C (da)
GR (1) GR3014931T3 (da)
HK (1) HK1006274A1 (da)
HU (1) HU208809B (da)
IE (1) IE67891B1 (da)
IL (1) IL87908A (da)
MX (1) MX9203765A (da)
NO (1) NO173824C (da)
NZ (1) NZ226354A (da)
PT (1) PT88603B (da)
WO (1) WO1989002889A1 (da)
ZW (1) ZW12388A1 (da)

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US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
JP2675194B2 (ja) * 1990-08-10 1997-11-12 スミスクライン・ビーチャム・コーポレイション 免疫抑制組成物
EP0550595A4 (en) * 1990-09-24 1993-09-08 Smithkline Beecham Corporation Methods
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
AU675633B2 (en) * 1991-12-18 1997-02-13 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
ATE241359T1 (de) * 1993-03-26 2003-06-15 Beth Israel Hospital Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
NZ286951A (en) * 1995-07-13 1998-02-26 Anormed Inc Substituted Under N-n-diethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
AU6637096A (en) * 1995-07-13 1997-02-10 Smithkline Beecham Corporation N,n-dimethyl-8,8-dipropyl-2-azaspiro{4,5}decane-2-propanamin e dimaleate
WO1997002819A1 (en) * 1995-07-13 1997-01-30 Anormed Inc, 2-[2-(dimethylamino)ethyl]-8,8-dipropyl-2-azaspiro[4.5]decane dimaleate
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
AU710542B2 (en) * 1996-05-17 1999-09-23 Anormed Inc. Use of substituted azaspirane in the treatment of asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
US20050250801A1 (en) * 2003-03-10 2005-11-10 Kunwar Shailubhai Method of treating cancer with azaspirane compositions
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
EP1802601A1 (en) * 2004-09-20 2007-07-04 Targacept, Inc. Azaspiroalkene and azapiroalkane compounds with nicotinic cholinergic receptor activity
MX2007011670A (es) 2005-03-23 2007-11-15 Actelion Pharmaceuticals Ltd Derivados de benzo(c) tiofeno hidrogenados como inmunomoduladores.
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CA2635124C (en) 2006-01-24 2014-04-29 Actelion Pharmaceuticals Ltd Novel pyridine derivatives
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GB823338A (en) * 1956-11-07 1959-11-11 Thomae Gmbh Dr K Diquaternary salts of aminoalkyl piperidines
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
US3282947A (en) * 1962-05-17 1966-11-01 Geschickter Fund Med Res Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds
NL124128C (da) * 1963-05-27
US3424755A (en) * 1964-03-09 1969-01-28 Rolf Denss 4-piperidine-p-fluorobutyrophenones and related compounds
US3432499A (en) * 1965-04-02 1969-03-11 Geschickter Fund Med Res Trifluoromethylazaspiranes and azaspirane diones
DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
BE788490A (fr) * 1971-09-08 1973-01-02 Geschickter Fund Med Res Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant
US4468393A (en) * 1982-12-06 1984-08-28 Unimed, Inc. Treatment of arthritis
WO1985005031A1 (en) * 1984-05-09 1985-11-21 The Australian National University A method for the modulation of the immune response
JPH0662407B2 (ja) * 1984-12-25 1994-08-17 株式会社三和化学研究所 安定化された３―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤
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Also Published As

Publication number Publication date
FI93006B (fi) 1994-10-31
HUT57722A (en) 1991-12-30
ATE114463T1 (de) 1994-12-15
IE67891B1 (en) 1996-05-01
IL87908A (en) 1993-02-21
NZ226354A (en) 1991-02-26
AU2533388A (en) 1989-04-18
NO901392L (no) 1990-03-27
FI93006C (fi) 1995-02-10
CN1031618C (zh) 1996-04-24
DE3852266D1 (de) 1995-01-12
NO173824C (no) 1994-02-09
WO1989002889A1 (en) 1989-04-06
EP0310321A2 (en) 1989-04-05
JPH03500290A (ja) 1991-01-24
PT88603A (pt) 1988-10-01
NO173824B (no) 1993-11-01
ES2064356T3 (es) 1995-02-01
FI901530A0 (fi) 1990-03-27
KR0166336B1 (ko) 1999-01-15
US4963557A (en) 1990-10-16
DK170042B1 (da) 1995-05-08
ZW12388A1 (en) 1989-01-04
MX9203765A (es) 1992-07-01
HU208809B (en) 1995-06-28
DK77090A (da) 1990-03-23
IE882929L (en) 1989-03-28
JP2582888B2 (ja) 1997-02-19
AU619780B2 (en) 1992-02-06
EP0310321A3 (en) 1991-02-06
DE3852266T2 (de) 1995-05-18
CN1032437A (zh) 1989-04-19
CY1955A (en) 1997-05-16
HK1006274A1 (en) 1999-02-19
PT88603B (pt) 1992-12-31
NO901392D0 (no) 1990-03-27
GR3014931T3 (en) 1995-05-31
IL87908A0 (en) 1989-03-31
CA1313189C (en) 1993-01-26
KR890701562A (ko) 1989-12-20
HU885889D0 (en) 1991-11-28
EP0310321B1 (en) 1994-11-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired