US4965199A
(en)
*
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
KR910006424B1
(ko)
*
|
1985-08-21 |
1991-08-24 |
인코텍스 비.브이 |
편성브리프(brief) 제조방법
|
US5198349A
(en)
*
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
FI98829C
(fi)
*
|
1986-01-27 |
1997-08-25 |
Chiron Corp |
Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
|
US5595886A
(en)
*
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
US5422260A
(en)
*
|
1986-05-29 |
1995-06-06 |
Genetics Institute, Inc. -Legal Affairs |
Human factor VIII:c muteins
|
US5451521A
(en)
*
|
1986-05-29 |
1995-09-19 |
Genetics Institute, Inc. |
Procoagulant proteins
|
IL84168A0
(en)
*
|
1986-10-15 |
1988-03-31 |
Rorer Int Overseas |
Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same
|
US6060447A
(en)
*
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
EP0690126B1
(en)
*
|
1987-06-12 |
2001-11-28 |
Baxter Aktiengesellschaft |
Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
AU627150B2
(en)
*
|
1987-06-12 |
1992-08-20 |
Immuno Ag |
Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
US5171844A
(en)
*
|
1987-06-12 |
1992-12-15 |
Gist-Brocades N.W. |
Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
FR2619314B1
(fr)
*
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
JPH0387173A
(ja)
*
|
1987-09-10 |
1991-04-11 |
Teijin Ltd |
ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体
|
EP0500734B1
(en)
*
|
1989-11-17 |
1998-02-11 |
Novo Nordisk A/S |
Protein complexes having factor viii:c activity and production thereof
|
US20050209121A1
(en)
*
|
1990-12-05 |
2005-09-22 |
Novozymes A/S |
Proteins with changed epitopes and methods for the production thereof
|
US20060122376A1
(en)
*
|
1991-02-07 |
2006-06-08 |
Chiron Corporation |
Protein complexes having factor VIII:C activity and production thereof
|
US5661008A
(en)
*
|
1991-03-15 |
1997-08-26 |
Kabi Pharmacia Ab |
Recombinant human factor VIII derivatives
|
US5744446A
(en)
*
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
US5888974A
(en)
*
|
1992-04-07 |
1999-03-30 |
Emory University |
Hybrid human/animal factor VIII
|
US6180371B1
(en)
*
|
1996-06-26 |
2001-01-30 |
Emory University |
Modified factor VIII
|
US5364771A
(en)
*
|
1992-04-07 |
1994-11-15 |
Emory University |
Hybrid human/porcine factor VIII
|
US5663060A
(en)
*
|
1992-04-07 |
1997-09-02 |
Emory University |
Hybrid human/animal factor VIII
|
DK53792D0
(da)
*
|
1992-04-24 |
1992-04-24 |
Novo Nordisk As |
Fremgangsmaade til fremstilling af proteiner
|
AU4535893A
(en)
*
|
1992-06-15 |
1994-01-04 |
Regents Of The University Of California, The |
Screening assay for the identification of immunosuppressive drugs
|
US5563045A
(en)
|
1992-11-13 |
1996-10-08 |
Genetics Institute, Inc. |
Chimeric procoagulant proteins
|
EP0710288B1
(en)
*
|
1993-06-10 |
2006-04-05 |
Genetic Therapy, Inc. |
Adenoviral vectors for treatment of hemophilia
|
SE504074C2
(sv)
*
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
AU7254894A
(en)
*
|
1993-07-23 |
1995-02-20 |
Baxter International Inc. |
Activated human factor viii and method of preparation
|
US5576291A
(en)
*
|
1993-09-13 |
1996-11-19 |
Baxter International Inc. |
Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
|
US5874562A
(en)
*
|
1995-06-07 |
1999-02-23 |
Progenitor, Inc. |
Nucleic acid encoding developmentally-regulated endothelial cell locus-1
|
US7041801B1
(en)
|
1995-06-07 |
2006-05-09 |
Vanderbilt University |
Antibodies binding to polypeptides encoded by developmentally-regulated endothelial cell locus-1
|
US5910481A
(en)
*
|
1995-11-13 |
1999-06-08 |
Immuno Ag |
Hybrid proteins with modified activity
|
US20040092442A1
(en)
*
|
1996-04-24 |
2004-05-13 |
University Of Michigan |
Inactivation resistant factor VIII
|
WO1997040145A1
(en)
*
|
1996-04-24 |
1997-10-30 |
The Regents Of The University Of Michigan |
Inactivation resistant factor viii
|
US8183344B2
(en)
*
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
US6458563B1
(en)
*
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
US7560107B2
(en)
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
CA2312291A1
(en)
*
|
1997-12-05 |
1999-06-17 |
The Immune Response Corporation |
Novel vectors and genes exhibiting increased expression
|
US7820796B2
(en)
*
|
1998-03-12 |
2010-10-26 |
Genetics Institute, Llc. |
Methods for producing Factor VIII proteins
|
PT1062244E
(pt)
|
1998-03-12 |
2002-12-31 |
Inst Genetics Llc |
Metodos melhorados para produzir proteinas do factor viii
|
CZ20011021A3
(cs)
|
1998-09-21 |
2001-10-17 |
Genetics Institute, Inc. |
Způsoby tlumení imunitní odpovědi na terapeutické proteiny
|
US6358703B1
(en)
|
1998-12-10 |
2002-03-19 |
Bayer Corporation |
Expression system for factor VIII
|
US6197526B1
(en)
|
1999-01-04 |
2001-03-06 |
Dyax Corp. |
Polypeptides for binding human factor VIII and fragments of human factor VIII
|
US7112438B2
(en)
|
1999-01-04 |
2006-09-26 |
Dyax Corp. |
Binding molecules for human factor VIII and factor VIII-like proteins
|
BR0008405B1
(pt)
|
1999-02-22 |
2014-04-22 |
Baxter Int |
Composição de fator viii formulada sem a adição de albumina, uso de uma composição de fator viii, e, método de liofilizar uma formulação farmacêutica aquosa
|
US6517830B1
(en)
*
|
1999-08-05 |
2003-02-11 |
Emory University |
Compositions and methods for the expression of factor VIII polypeptides and uses therefor
|
JP2005518181A
(ja)
*
|
2001-01-12 |
2005-06-23 |
ジ・アメリカン・ナショナル・レッド・クロス |
第viii因子のヘパラン硫酸プロテオグリカン仲介性クリアランスを低下させるための方法および組成物
|
ES2331909T3
(es)
|
2001-06-14 |
2010-01-20 |
The Scripps Research Institute |
Factor viii estabilizado con enlaces disulfuro modificados geneticamente.
|
MXPA04005079A
(es)
*
|
2001-11-30 |
2004-08-19 |
Univ Emory |
Variantes del dominio c2 del factor viii.
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
CN1767857A
(zh)
|
2003-02-26 |
2006-05-03 |
尼克塔治疗亚拉巴马公司 |
聚合物-因子ⅷ部分共轭物
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
WO2005046583A2
(en)
*
|
2003-10-30 |
2005-05-26 |
Emory University |
Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
PL1750733T3
(pl)
|
2004-05-03 |
2014-05-30 |
Univ Emory |
Sposób podawania świńskiego czynnika krzepnięcia VIII pozbawionego domeny B
|
US20060080848A1
(en)
*
|
2004-10-19 |
2006-04-20 |
Lace Charles R |
Wheel blade sight
|
EP1707634A1
(en)
|
2005-03-29 |
2006-10-04 |
Octapharma AG |
Method for isolation of recombinantly produced proteins
|
EP1739179A1
(en)
|
2005-06-30 |
2007-01-03 |
Octapharma AG |
Serum-free stable transfection and production of recombinant human proteins in human cell lines
|
GB0606190D0
(en)
|
2006-03-28 |
2006-05-10 |
Isis Innovation |
Construct
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
AU2007269233B2
(en)
*
|
2006-06-30 |
2011-06-09 |
Cnj Holdings, Inc. |
Method of producing Factor VIII proteins by recombinant methods
|
FR2913020B1
(fr)
*
|
2007-02-23 |
2012-11-23 |
Biomethodes |
Nouveaux facteurs viii pour le traitement des hemophiles de type a
|
CA2991162A1
(en)
|
2007-12-21 |
2009-07-02 |
Aptevo Biotherapeutics Llc |
Stabilized factor ix formulations containing trehalose
|
EP3255152A1
(en)
*
|
2007-12-27 |
2017-12-13 |
Baxalta GmbH |
Cell culture processes
|
KR100981092B1
(ko)
*
|
2008-02-29 |
2010-09-08 |
고려대학교 산학협력단 |
제8 혈액응고 인자와 폰 빌리 블란트 인자 변이체의 재조합발현 벡터 시스템
|
WO2010045321A2
(en)
|
2008-10-15 |
2010-04-22 |
Baxter International Inc. |
Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
|
MX362028B
(es)
|
2009-02-03 |
2019-01-04 |
Amunix Pharmaceuticals Inc |
Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
|
US9493545B2
(en)
|
2009-02-11 |
2016-11-15 |
Albumedix A/S |
Albumin variants and conjugates
|
US8691211B2
(en)
*
|
2009-03-10 |
2014-04-08 |
Puget Sound Blood Center |
Suppression of immune response to factor VIII in hemophilia A patients
|
AU2010290077C1
(en)
|
2009-08-24 |
2015-12-03 |
Bioverativ Therapeutics Inc. |
Coagulation factor IX compositions and methods of making and using same
|
US8748380B2
(en)
|
2009-10-30 |
2014-06-10 |
Novozymes Biopharma Dk A/S |
Albumin variants
|
ES2880038T3
(es)
|
2009-12-06 |
2021-11-23 |
Bioverativ Therapeutics Inc |
Polipéptidos quiméricos e híbridos de factor VIII-Fc, y métodos de uso de los mismos
|
US8765432B2
(en)
|
2009-12-18 |
2014-07-01 |
Oligasis, Llc |
Targeted drug phosphorylcholine polymer conjugates
|
WO2011095604A1
(en)
|
2010-02-04 |
2011-08-11 |
Octapharma Biopharmaceuticals Gmbh |
Half-life prolongation of proteins
|
US10233228B2
(en)
|
2010-04-09 |
2019-03-19 |
Albumedix Ltd |
Albumin derivatives and variants
|
MX2013000301A
(es)
|
2010-07-09 |
2013-05-09 |
Biogen Idec Hemophilia Inc |
Factores quimericos de coagulacion.
|
WO2012006623A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Systems for factor viii processing and methods thereof
|
EP2635297B1
(en)
|
2010-11-05 |
2019-02-27 |
Baxalta GmbH |
A new variant of antihemophilic factor viii having increased specific activity
|
BRPI1105317A2
(pt)
|
2011-01-24 |
2013-04-30 |
Fundacco Hemoct De Ribeirco Preto |
produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
|
PL2717898T3
(pl)
|
2011-06-10 |
2019-06-28 |
Bioverativ Therapeutics Inc. |
Związki o działaniu prokoagulacyjnym i sposoby ich stosowania
|
RS58578B1
(sr)
|
2011-07-08 |
2019-05-31 |
Bioverativ Therapeutics Inc |
Faktor viii himernih i hibridnih polipeptida i postupci za njihovu upotrebu
|
US10656167B2
(en)
|
2011-07-25 |
2020-05-19 |
Bioverativ Therapeutics Inc. |
Assays to monitor bleeding disorders
|
CA2850579A1
(en)
|
2011-10-18 |
2013-04-25 |
Carsten Horn |
Method for improving the stability of purified factor viii after reconstitution
|
US9393289B2
(en)
|
2011-10-18 |
2016-07-19 |
Csl Behring Gmbh |
Use of sulfated glycosaminoglycans for improving the bioavailability of factor VIII
|
DK2768521T3
(da)
|
2011-10-18 |
2016-10-24 |
Csl Behring Gmbh |
Kombineret anvendelse af et sulfateret glykosamin-glykan og en hyaluronidase til forbedring af bio-rådigheden af Faktor VIII
|
US20140315817A1
(en)
|
2011-11-18 |
2014-10-23 |
Eleven Biotherapeutics, Inc. |
Variant serum albumin with improved half-life and other properties
|
EP3453402B1
(en)
|
2012-01-12 |
2021-07-21 |
Bioverativ Therapeutics Inc. |
Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
|
BR112014017165B1
(pt)
|
2012-01-12 |
2023-05-02 |
Bioverativ Therapeutics Inc |
Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos
|
EP3549953A1
(en)
|
2012-02-15 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Recombinant factor viii proteins
|
ES2771208T3
(es)
|
2012-02-15 |
2020-07-06 |
Bioverativ Therapeutics Inc |
Composiciones de factor VIII y métodos de preparación y uso de las mismas
|
AU2013234299B2
(en)
|
2012-03-16 |
2017-06-22 |
Albumedix Ltd. |
Albumin variants
|
CA2875246A1
(en)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Procoagulant compounds
|
CN104427995A
(zh)
|
2012-06-08 |
2015-03-18 |
比奥根艾迪克Ma公司 |
嵌合凝血因子
|
EP2870250B2
(en)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
CN110054699A
(zh)
|
2012-07-11 |
2019-07-26 |
比奥贝拉蒂治疗公司 |
具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途
|
EP2877202A4
(en)
|
2012-07-25 |
2016-06-01 |
Biogen Ma Inc |
BLOOD FACTOR MONITORING TEST AND USES THEREOF
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
MX2015005363A
(es)
|
2012-11-08 |
2015-11-06 |
Novozymes Biopharma Dk As |
Variantes de albumina.
|
ES2959747T3
(es)
|
2013-02-15 |
2024-02-28 |
Bioverativ Therapeutics Inc |
Gen del factor VIII optimizado
|
LT2968477T
(lt)
|
2013-03-15 |
2020-03-10 |
Bioverativ Therapeutics Inc. |
Faktoriaus viii polipeptido kompozicijos
|
AU2014228938B2
(en)
|
2013-03-15 |
2019-05-02 |
Bioverativ Therapeutics Inc. |
Factor IX polypeptide formulations
|
CN105392495A
(zh)
|
2013-06-28 |
2016-03-09 |
比奥根Ma公司 |
具有xten的凝血酶可裂解连接子和其用途
|
US10947269B2
(en)
|
2013-08-08 |
2021-03-16 |
Bioverativ Therapeutics Inc. |
Purification of chimeric FVIII molecules
|
WO2015023891A2
(en)
|
2013-08-14 |
2015-02-19 |
Biogen Idec Ma Inc. |
Factor viii-xten fusions and uses thereof
|
WO2015035342A2
(en)
|
2013-09-08 |
2015-03-12 |
Oligasis Llc |
Factor viii zwitterionic polymer conjugates
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
ES2967617T3
(es)
|
2013-12-06 |
2024-05-03 |
Bioverativ Therapeutics Inc |
Herramientas de farmacocinética poblacional y sus usos
|
CN106456718A
(zh)
|
2014-01-10 |
2017-02-22 |
比奥根Ma公司 |
因子viii嵌合蛋白及其用途
|
KR102382402B1
(ko)
|
2014-02-04 |
2022-04-01 |
바이오젠 엠에이 인코포레이티드 |
번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
CN104630131B
(zh)
*
|
2015-01-15 |
2017-08-15 |
上海交通大学 |
一种稳定表达人凝血八因子的cho细胞株及其应用
|
EA201890423A1
(ru)
|
2015-08-03 |
2018-07-31 |
Биовератив Терапьютикс Инк. |
Слитые белки фактора ix, способы их получения и применения
|
CA2989966C
(en)
|
2015-08-20 |
2024-04-30 |
Albumedix A/S |
Albumin variants and conjugates
|
EP3167877A1
(en)
|
2015-11-12 |
2017-05-17 |
Bayer Pharma Aktiengesellschaft |
Method for the production of freeze-dried pellets comprising factor viii
|
TWI777175B
(zh)
|
2015-11-13 |
2022-09-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體之病毒載體
|
US10189889B2
(en)
|
2015-11-13 |
2019-01-29 |
Baxalta Incorporated |
Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
|
LT3411478T
(lt)
|
2016-02-01 |
2022-09-26 |
Bioverativ Therapeutics Inc. |
Optimizuoti viii faktoriaus genai
|
CN109790529A
(zh)
|
2016-06-24 |
2019-05-21 |
财团法人牧岩生命科学研究所 |
包含FVIII和vWF因子的嵌合蛋白及其用途
|
BR112019011115A2
(pt)
|
2016-12-02 |
2019-10-01 |
Bioverativ Therapeutics Inc |
métodos para tratar artropatia hemofílica usando fatores de coagulação quiméricos
|
BR112019011198A2
(pt)
|
2016-12-02 |
2019-12-17 |
Bioverativ Therapeutics Inc |
métodos de indução de tolerância imune a fatores de coagulação
|
TW201920255A
(zh)
|
2017-08-09 |
2019-06-01 |
美商生物化學醫療公司 |
核酸分子及其用途
|
JP2020534837A
(ja)
|
2017-09-27 |
2020-12-03 |
シギロン セラピューティクス, インコーポレイテッドSigilon Therapeutics, Inc. |
活性細胞を含む方法、組成物、及び移植可能な要素
|
WO2019152692A1
(en)
|
2018-02-01 |
2019-08-08 |
Bioverativ Therapeutics, Inc. |
Use of lentiviral vectors expressing factor viii
|
US20210145889A1
(en)
|
2018-04-04 |
2021-05-20 |
Sigilon Therapeutics, Inc. |
Methods, compositions, and implantable elements comprising stem cells
|
IL312315A
(en)
|
2018-04-04 |
2024-06-01 |
Sigilon Therapeutics Inc |
Implantable particles and related methods
|
JP2021523878A
(ja)
|
2018-05-18 |
2021-09-09 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病aを処置する方法
|
MX2021000582A
(es)
|
2018-07-16 |
2021-04-12 |
Baxalta Inc |
Terapia genica de hemofilia a mediante el uso de vectores virales que codifican variantes del factor viii (fviii) recombinantes con mayor expresion.
|
BR112021002017A2
(pt)
|
2018-08-09 |
2021-05-11 |
Bioverativ Therapeutics Inc. |
moléculas de ácido nucleico e usos das mesmas para terapia genética não viral
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
TW202039546A
(zh)
|
2019-01-16 |
2020-11-01 |
美商巴克斯歐塔公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
TW202115127A
(zh)
|
2019-06-19 |
2021-04-16 |
美商百歐維拉提夫治療公司 |
治療血友病及低骨質密度之方法及組成物
|
JP2022553640A
(ja)
|
2019-10-10 |
2022-12-26 |
コディアック サイエンシーズ インコーポレイテッド |
眼障害を処置する方法
|
JP2023506171A
(ja)
|
2019-12-12 |
2023-02-15 |
武田薬品工業株式会社 |
発現が上昇した組換えfviiiバリアントをコードするウイルスベクターを使用する、血友病aの遺伝子療法
|
CN117858895A
(zh)
|
2021-06-14 |
2024-04-09 |
武田药品工业株式会社 |
使用表达增强的编码重组fviii变体的病毒载体的血友病a基因疗法
|
TW202323274A
(zh)
|
2021-08-23 |
2023-06-16 |
美商百歐維拉提夫治療公司 |
優化因子viii基因
|
CN118019758A
(zh)
|
2021-09-30 |
2024-05-10 |
比奥维拉迪维治疗股份有限公司 |
编码免疫原性降低的因子viii多肽的核酸
|
WO2024081310A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|