DK56581A - Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf - Google Patents

Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf

Info

Publication number
DK56581A
DK56581A DK56581A DK56581A DK56581A DK 56581 A DK56581 A DK 56581A DK 56581 A DK56581 A DK 56581A DK 56581 A DK56581 A DK 56581A DK 56581 A DK56581 A DK 56581A
Authority
DK
Denmark
Prior art keywords
amino
acceptable salts
procedure
preparation
pharmaceutical acceptable
Prior art date
Application number
DK56581A
Other languages
English (en)
Other versions
DK156400B (da
DK156400C (da
Inventor
R Sargas
R C Schnur
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK56581A publication Critical patent/DK56581A/da
Publication of DK156400B publication Critical patent/DK156400B/da
Application granted granted Critical
Publication of DK156400C publication Critical patent/DK156400C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK056581A 1980-02-12 1981-02-11 Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf DK156400C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12094480 1980-02-12
US06/120,944 US4248882A (en) 1980-02-12 1980-02-12 Treating diabetes-associated complications with hydantoin amines

Publications (3)

Publication Number Publication Date
DK56581A true DK56581A (da) 1981-08-13
DK156400B DK156400B (da) 1989-08-14
DK156400C DK156400C (da) 1990-01-08

Family

ID=22393428

Family Applications (1)

Application Number Title Priority Date Filing Date
DK056581A DK156400C (da) 1980-02-12 1981-02-11 Analogifremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf

Country Status (8)

Country Link
US (1) US4248882A (da)
EP (1) EP0034063B1 (da)
JP (1) JPS56127379A (da)
AT (1) ATE3865T1 (da)
DE (1) DE3160449D1 (da)
DK (1) DK156400C (da)
GR (1) GR73856B (da)
IE (1) IE50895B1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490381A (en) * 1979-11-13 1984-12-25 Imperial Chemical Industries Plc 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones
EP0065393B1 (en) * 1981-05-12 1984-12-27 Imperial Chemical Industries Plc Pyrrole derivatives
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater
EP0172352B1 (en) * 1984-06-22 1990-08-29 Beecham Group Plc Active benzopyran compounds
US4680306A (en) * 1984-07-20 1987-07-14 Pfizer Inc. Sprio-imidazolones for treatment of diabetes complications
ATE37371T1 (de) * 1984-08-20 1988-10-15 Pfizer Verfahren zur herstellung asymmetrischer hydantoine.
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
JPH0772190B2 (ja) * 1985-02-26 1995-08-02 エーザイ株式会社 ヒダントイン誘導体
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63126881A (ja) * 1986-11-14 1988-05-30 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
MX12896A (es) * 1987-09-04 1993-06-01 Pfizer Procedimiento para preparar un compuesto de espiro-heteroazolonas
US4952694A (en) * 1988-07-27 1990-08-28 Pfizer Inc. Novel resolution process for racemic spiro-hydantoins
EP0536119A4 (en) * 1989-02-10 1993-08-04 Washington Research Foundation Immunoregulatory agents
JP2678499B2 (ja) * 1989-08-09 1997-11-17 日本臓器製薬 株式会社 ***毒素低下剤
JPH03215435A (ja) * 1990-01-12 1991-09-20 Sanwa Kagaku Kenkyusho Co Ltd アルドース還元酵素阻害剤を主成分とする潰瘍治療剤
EP1375485B1 (en) * 2001-04-05 2011-04-20 Nissan Chemical Industries, Ltd. Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
US7795203B2 (en) * 2002-09-30 2010-09-14 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3534037A (en) * 1968-05-10 1970-10-13 Smithkline Corp Spiro-(imidazolidine and pyrimidine-quinoline and cyclopropa(c)quinoline) compounds
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4177282A (en) * 1977-05-23 1979-12-04 Pfizer Inc. Hydantoin therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4176185A (en) * 1979-01-22 1979-11-27 Pfizer Inc. Spiro-quinolylhydantoins
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives

Also Published As

Publication number Publication date
DE3160449D1 (en) 1983-07-28
JPS6237636B2 (da) 1987-08-13
EP0034063A1 (en) 1981-08-19
IE810261L (en) 1981-08-12
US4248882A (en) 1981-02-03
ATE3865T1 (de) 1983-07-15
DK156400B (da) 1989-08-14
JPS56127379A (en) 1981-10-06
IE50895B1 (en) 1986-08-06
EP0034063B1 (en) 1983-06-22
DK156400C (da) 1990-01-08
GR73856B (da) 1984-05-08

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