DK521685A - Spergualin-derivater og anvendelse deraf til fremstilling af laegemidler med immunosuppressiv virkning - Google Patents

Spergualin-derivater og anvendelse deraf til fremstilling af laegemidler med immunosuppressiv virkning Download PDF

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Publication number
DK521685A
DK521685A DK521685A DK521685A DK521685A DK 521685 A DK521685 A DK 521685A DK 521685 A DK521685 A DK 521685A DK 521685 A DK521685 A DK 521685A DK 521685 A DK521685 A DK 521685A
Authority
DK
Denmark
Prior art keywords
preparation
medicines
immunosuppressive effect
spergualin
derivatives
Prior art date
Application number
DK521685A
Other languages
English (en)
Other versions
DK173952B1 (da
DK521685D0 (da
Inventor
Hamao Umezawa
Tomio Takeuchi
Masaaki Ishizuka
Fuminori Abe
Akio Fujii
Teruya Nakamura
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of DK521685D0 publication Critical patent/DK521685D0/da
Publication of DK521685A publication Critical patent/DK521685A/da
Application granted granted Critical
Publication of DK173952B1 publication Critical patent/DK173952B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
DK198505216A 1984-11-13 1985-11-12 Anvendelse af spergualinderivater til fremstilling af lægemidler med immunosuppressiv virkning DK173952B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23748084 1984-11-13
JP59237480A JPS61129119A (ja) 1984-11-13 1984-11-13 新規免疫抑制剤

Publications (3)

Publication Number Publication Date
DK521685D0 DK521685D0 (da) 1985-11-12
DK521685A true DK521685A (da) 1986-05-14
DK173952B1 DK173952B1 (da) 2002-03-04

Family

ID=17015948

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198505216A DK173952B1 (da) 1984-11-13 1985-11-12 Anvendelse af spergualinderivater til fremstilling af lægemidler med immunosuppressiv virkning

Country Status (7)

Country Link
EP (1) EP0181592B1 (da)
JP (1) JPS61129119A (da)
AT (1) ATE80613T1 (da)
DE (1) DE3586649T2 (da)
DK (1) DK173952B1 (da)
IE (1) IE59251B1 (da)
ZA (1) ZA858659B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134312A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 移植免疫抑制剤並びに抗アレルギ−剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
DE3626306A1 (de) * 1986-08-02 1988-02-11 Behringwerke Ag Verwendung von 15-deoxyspergualin als arzneimittel
JPH0794424B2 (ja) * 1987-09-30 1995-10-11 財団法人微生物化学研究会 新スパガリン関連化合物およびその製造法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
FR2716451B1 (fr) * 1994-02-24 1996-04-26 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2716452B1 (fr) * 1994-02-24 1996-05-10 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2737891B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Analogues chiraux de la 15-deoxyspergualine, procede de preparation et utilisation en therapeutique
FR2730488B1 (fr) * 1995-02-10 1997-04-30 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
EP0755380B1 (fr) * 1995-02-10 1998-10-14 Fournier Industrie Et Sante Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils
JPS5368730A (en) * 1976-12-01 1978-06-19 Yoshitomi Pharmaceut Ind Ltd Penicillamin derivatives
JPS5419997A (en) * 1977-07-15 1979-02-15 Intorepurinderea De Anteibiote 33formylrifamycin sv derivative
JPS567753A (en) * 1979-07-02 1981-01-27 Takeda Chem Ind Ltd Preparation of aromatic sulfinic acid
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS58198455A (ja) * 1982-05-17 1983-11-18 Microbial Chem Res Found （−）−１５−デオキシスパガリンおよびその製造法並びにその中間体
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS5976046A (ja) * 1982-10-25 1984-04-28 Microbial Chem Res Found スパガリン−１１−ｏ−アルキル誘導体およびその関連化合物並びにそれらの製造法
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法

Also Published As

Publication number Publication date
EP0181592A2 (en) 1986-05-21
DE3586649T2 (de) 1993-03-11
JPS61129119A (ja) 1986-06-17
JPH0414643B2 (da) 1992-03-13
EP0181592A3 (en) 1990-08-29
DE3586649D1 (de) 1992-10-22
IE59251B1 (en) 1994-01-26
DK173952B1 (da) 2002-03-04
IE852823L (en) 1986-05-13
ZA858659B (en) 1986-07-30
DK521685D0 (da) 1985-11-12
EP0181592B1 (en) 1992-09-16
ATE80613T1 (de) 1992-10-15

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B1 Patent granted (law 1993)
PBP Patent lapsed

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