MX9305918A - Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- MX9305918A MX9305918A MX9305918A MX9305918A MX9305918A MX 9305918 A MX9305918 A MX 9305918A MX 9305918 A MX9305918 A MX 9305918A MX 9305918 A MX9305918 A MX 9305918A MX 9305918 A MX9305918 A MX 9305918A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- amino
- oxoetil
- butanodiamide
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 2- (2-pyridinyl) ethyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 102000004881 Angiotensinogen Human genes 0.000 abstract 1
- 108090001067 Angiotensinogen Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Se describen aquí compuestos de fórmula: A-N(R1)C(O)CH2CHR2C(O)-B en donde A es R3R4NC(O)CH2 en donde, por ejemplo, R3 es hidrógeno o alquilo y R4 es hidrógeno, alquilo o un alquilo sustituido, tal como 2-(2-piridinil)etilo, o R3 y R4, junto con el átomo de nitrógeno al que están unidos, forman un grupo pirrolidino, piperidino, morfolino o tiomorfolino; R1 es, por ejemplo, bencilo, alquilo, un alquilo sustituido tal como ciclohexilmetilo; R2 es, por ejemplo, alquilo, cicloalquimetilo, 1H-imidzaol-4-ilmetilo, 4-tiazolilmetilo o (2-amino-4-tiazolil)metilo; y B es una imitación del estado de transición del sustrato de renina, por ejemplo [1(S)-(ciclohexilmetil)-2(R),3(S)-dihidroxi-5-meti lhexil]amino. Los compuestos inhiben la actividad de la renina y están indicados para el tratamiento de la hipertensión y del insuficiencia cardíaca congestiva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147892A | 1992-09-25 | 1992-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9305918A true MX9305918A (es) | 1994-05-31 |
Family
ID=25491725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9305918A MX9305918A (es) | 1992-09-25 | 1993-09-24 | Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5541163A (es) |
| EP (1) | EP0589445B1 (es) |
| JP (1) | JP3490442B2 (es) |
| KR (1) | KR950703520A (es) |
| CN (1) | CN1090278A (es) |
| AT (1) | ATE147720T1 (es) |
| AU (1) | AU680829B2 (es) |
| BG (1) | BG99542A (es) |
| BR (1) | BR9307110A (es) |
| CA (1) | CA2143300C (es) |
| CO (1) | CO4560549A1 (es) |
| CZ (1) | CZ74895A3 (es) |
| DE (1) | DE69307446T2 (es) |
| EE (1) | EE03083B1 (es) |
| FI (1) | FI951398A (es) |
| HU (2) | HUT70432A (es) |
| IL (1) | IL107092A (es) |
| LT (1) | LT3072B (es) |
| LV (1) | LV10945B (es) |
| MX (1) | MX9305918A (es) |
| NO (1) | NO951133L (es) |
| NZ (1) | NZ255301A (es) |
| PH (1) | PH30881A (es) |
| PL (1) | PL174454B1 (es) |
| RU (1) | RU95113586A (es) |
| SK (1) | SK37695A3 (es) |
| TW (1) | TW239117B (es) |
| WO (1) | WO1994007846A1 (es) |
| ZA (1) | ZA937079B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9307111A (pt) * | 1992-09-25 | 1999-06-15 | Boehringer Ingelheim Ca Ltd | Derivados de n-(hidroxietil) butanodiamida como inibidores de renina |
| CA2165996C (en) * | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Stereoselective preparation of 2-substituted succinic derivatives |
| US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| WO2005037317A2 (en) * | 2003-10-17 | 2005-04-28 | Cornell Research Foundation, Inc. | Mast cell-derived renin |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
| EP0278158A3 (en) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| EP0312283A3 (en) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa |
| US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
| US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| CA1329680C (en) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | N-heterocyclic alcohol derivatives |
| NO892728L (no) * | 1988-07-01 | 1990-01-02 | Searle & Co | Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler. |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
| US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| ES2086341T3 (es) * | 1989-09-12 | 1996-07-01 | Hoechst Ag | Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion. |
| JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
-
1993
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Application Discontinuation
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Application Discontinuation
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
-
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
-
1995
- 1995-03-24 FI FI951398A patent/FI951398A/fi not_active Application Discontinuation
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
-
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |