DK407577A - AZABICYCLO COMPOUNDS AND THEIR MANUFACTURE AND USE - Google Patents

AZABICYCLO COMPOUNDS AND THEIR MANUFACTURE AND USE

Info

Publication number
DK407577A
DK407577A DK407577A DK407577A DK407577A DK 407577 A DK407577 A DK 407577A DK 407577 A DK407577 A DK 407577A DK 407577 A DK407577 A DK 407577A DK 407577 A DK407577 A DK 407577A
Authority
DK
Denmark
Prior art keywords
manufacture
azabicyclo compounds
azabicyclo
compounds
Prior art date
Application number
DK407577A
Other languages
Danish (da)
Other versions
DK146245B (en
DK146245C (en
Inventor
W J Fanshawe
J W Epstein
L S Crawley
C M Hofmann
S R Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK407577A publication Critical patent/DK407577A/en
Priority to DK438580A priority Critical patent/DK438580A/en
Priority to DK438480A priority patent/DK438480A/en
Publication of DK146245B publication Critical patent/DK146245B/en
Application granted granted Critical
Publication of DK146245C publication Critical patent/DK146245C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
DK407577A 1976-09-15 1977-09-14 METHOD OF ANALOGUE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE AZABICYCLO COMPOUNDS OR ACID ADDITION SALTS THEREOF DK146245C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK438580A DK438580A (en) 1976-09-15 1980-10-16 INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS
DK438480A DK438480A (en) 1976-09-15 1980-10-16 PROCEDURE FOR PREPARING AN OPTICALLY ACTIVE AZABICYCLO COMPOUND

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US72340276 1976-09-15
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US80933977 1977-06-23
US80934177 1977-06-23
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US80934077 1977-06-23

Publications (3)

Publication Number Publication Date
DK407577A true DK407577A (en) 1978-03-16
DK146245B DK146245B (en) 1983-08-08
DK146245C DK146245C (en) 1984-01-16

Family

ID=27505564

Family Applications (3)

Application Number Title Priority Date Filing Date
DK407577A DK146245C (en) 1976-09-15 1977-09-14 METHOD OF ANALOGUE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE AZABICYCLO COMPOUNDS OR ACID ADDITION SALTS THEREOF
DK438480A DK438480A (en) 1976-09-15 1980-10-16 PROCEDURE FOR PREPARING AN OPTICALLY ACTIVE AZABICYCLO COMPOUND
DK438580A DK438580A (en) 1976-09-15 1980-10-16 INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK438480A DK438480A (en) 1976-09-15 1980-10-16 PROCEDURE FOR PREPARING AN OPTICALLY ACTIVE AZABICYCLO COMPOUND
DK438580A DK438580A (en) 1976-09-15 1980-10-16 INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS

Country Status (16)

Country Link
JP (1) JPS5337656A (en)
AR (2) AR220684A1 (en)
AT (2) AT367036B (en)
AU (1) AU519620B2 (en)
BE (1) BE858683A (en)
CH (2) CH637929A5 (en)
DD (1) DD133943A5 (en)
DE (1) DE2740562A1 (en)
DK (3) DK146245C (en)
FR (1) FR2375212A1 (en)
GR (1) GR72713B (en)
HU (1) HU177531B (en)
NL (1) NL189041C (en)
PL (1) PL115869B1 (en)
SE (2) SE435384B (en)
YU (2) YU39499B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) * 1986-07-25 1988-02-10 東京電力株式会社 Shield excavator
JPH0658037B2 (en) * 1989-09-01 1994-08-03 日本鋼管株式会社 Shield excavator
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
CN101410106A (en) * 2004-07-22 2009-04-15 惠氏公司 Method for treating nervous system disorders and conditions
MX2007000851A (en) * 2004-07-22 2007-03-26 Wyeth Corp Method for treating nervous system disorders and conditions.
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP1915146A4 (en) * 2005-07-27 2010-06-02 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
DK438480A (en) 1980-10-16
SE452610B (en) 1987-12-07
DD133943A5 (en) 1979-01-31
DK146245B (en) 1983-08-08
AT367037B (en) 1982-05-25
NL7709691A (en) 1978-03-17
AU2844177A (en) 1979-03-08
CH637931A5 (en) 1983-08-31
DK146245C (en) 1984-01-16
DE2740562A1 (en) 1978-03-23
NL189041C (en) 1992-12-16
FR2375212B1 (en) 1981-07-31
ATA288280A (en) 1981-10-15
JPS6129341B2 (en) 1986-07-05
JPS5337656A (en) 1978-04-06
HU177531B (en) 1981-11-28
CH637929A5 (en) 1983-08-31
YU43523B (en) 1989-08-31
AU519620B2 (en) 1981-12-17
PL115869B1 (en) 1981-05-30
DK438580A (en) 1980-10-16
DE2740562C2 (en) 1989-05-03
AR227507A1 (en) 1982-11-15
ATA661577A (en) 1981-10-15
SE435384B (en) 1984-09-24
AT367036B (en) 1982-05-25
YU39499B (en) 1984-12-31
YU188582A (en) 1985-03-20
NL189041B (en) 1992-07-16
AR220684A1 (en) 1980-11-28
BE858683A (en) 1978-03-14
SE8203437L (en) 1982-06-03
FR2375212A1 (en) 1978-07-21
GR72713B (en) 1983-12-01
SE7710367L (en) 1978-03-16
PL200831A1 (en) 1980-02-11
YU217477A (en) 1983-01-21

Similar Documents

Publication Publication Date Title
DK120077A (en) CYCLIC SULPHONYLOXIIMIDES AND THEIR PREPARATION AND USE
DK56876A (en) PROSTAGLAND INNALOGUE AND THEIR MANUFACTURE AND USE
DK194377A (en) PYRROLIDONES AND THEIR MANUFACTURE AND USE
DK407577A (en) AZABICYCLO COMPOUNDS AND THEIR MANUFACTURE AND USE
DK358678A (en) 1,4-BIS-AMINO-ANTHRAQUINON COMPOUNDS AND THEIR USE AND MANUFACTURE
DK154877A (en) TRANS-HEXAHYDRO-PYRIDO INDOLES AND THEIR PREPARATION AND USE
DK287476A (en) PYRROLIDONES AND THEIR MANUFACTURE AND USE
DK286676A (en) BICYCLOHEPTEN COMPOUNDS AND THEIR PREPARATION AND USE
DK97179A (en) BICYCLOOCTAN DERIVATIVES AND THEIR MANUFACTURE AND USE
DK83677A (en) PYRROLBENZOXAZALKANES AND THEIR PREPARATION AND USE
DK214577A (en) BENZENESULPHONYLURINE SUBSTANCES MANUFACTURE AND USE
DK318278A (en) BETA-LACTAM COMPOUNDS AND THEIR PREPARATION AND USE
DK581577A (en) DEHYDROOLIGOPEPTIDES AND THEIR PREPARATION AND USE
DK227177A (en) 1-ARYLOXY-2-HYDROXY-3-AMINOPROPANES AND THEIR PREPARATION AND USE
DK299578A (en) BLEOMYCINES AND THEIR MANUFACTURE AND USE
DK279777A (en) CARBOSTYRILES AND THEIR MANUFACTURE AND USE
DK554776A (en) PROSTAGLAND INNALOGUE PYRROLIDONES AND THEIR MANUFACTURE AND USE
DK281476A (en) PYRROLIDONES AND THEIR MANUFACTURE AND USE
DK574976A (en) SUBSTITUTED CYCLOALKANPYRAZOLES AND THEIR PREPARATION AND USE
DK464176A (en) CYCLOALKANPYRAZOLES AND THEIR PREPARATION AND USE
DK426376A (en) 4-HYDROXYMETHYL-2-PYRROLIDINONES AND THEIR PREPARATION AND USE
DK84377A (en) SUBSTITUTED PHENYLGUANIDINES AND THEIR PREPARATION AND USE
DK582378A (en) SIMIPERMEABLE MEMBRANES AND THEIR MANUFACTURE AND USE
DK446078A (en) UREIDONITRILES AND THEIR MANUFACTURE AND USE
DK62277A (en) PHOSPHONED FLOURTELOMERS AND THEIR MANUFACTURE AND USE

Legal Events

Date Code Title Description
PBP Patent lapsed