DK3986890T3 - Benzisoxazol-sulfonamid-derivater - Google Patents

Benzisoxazol-sulfonamid-derivater Download PDF

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Publication number
DK3986890T3
DK3986890T3 DK20743773.2T DK20743773T DK3986890T3 DK 3986890 T3 DK3986890 T3 DK 3986890T3 DK 20743773 T DK20743773 T DK 20743773T DK 3986890 T3 DK3986890 T3 DK 3986890T3
Authority
DK
Denmark
Prior art keywords
sulfonamide derivatives
benzisoxazole
benzisoxazole sulfonamide
derivatives
sulfonamide
Prior art date
Application number
DK20743773.2T
Other languages
English (en)
Inventor
Ylva Elisabet Bergman Bozikis
Oleg Brodsky
Michelle Ang Camerino
Samantha Elizabeth Greasley
Robert Louis Hoffman
Robert Arnold Kumpf
Pei-Pei Kung
Paul Francis Richardson
Paul Anthony Stupple
Scott Channing Sutton
Original Assignee
Pfizer
Ctxt Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Ctxt Pty Ltd filed Critical Pfizer
Application granted granted Critical
Publication of DK3986890T3 publication Critical patent/DK3986890T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK20743773.2T 2019-06-18 2020-06-16 Benzisoxazol-sulfonamid-derivater DK3986890T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962863199P 2019-06-18 2019-06-18
US201962953223P 2019-12-24 2019-12-24
US202063025278P 2020-05-15 2020-05-15
PCT/IB2020/055589 WO2020254946A1 (en) 2019-06-18 2020-06-16 Benzisoxazole sulfonamide derivatives

Publications (1)

Publication Number Publication Date
DK3986890T3 true DK3986890T3 (da) 2023-12-18

Family

ID=71738189

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20743773.2T DK3986890T3 (da) 2019-06-18 2020-06-16 Benzisoxazol-sulfonamid-derivater

Country Status (29)

Country Link
US (2) US11492346B2 (da)
EP (2) EP3986890B1 (da)
JP (2) JP7352662B2 (da)
KR (1) KR20220024671A (da)
CN (1) CN114364672A (da)
AU (2) AU2020296361A1 (da)
BR (1) BR112021025528A2 (da)
CA (1) CA3143666A1 (da)
CL (1) CL2021003372A1 (da)
CO (1) CO2021017504A2 (da)
CR (1) CR20210627A (da)
DK (1) DK3986890T3 (da)
EC (1) ECSP21091615A (da)
ES (1) ES2969616T3 (da)
FI (1) FI3986890T3 (da)
HR (1) HRP20231501T1 (da)
HU (1) HUE064683T2 (da)
IL (1) IL288802A (da)
LT (1) LT3986890T (da)
MD (1) MD3986890T2 (da)
MX (1) MX2021016085A (da)
PE (1) PE20220808A1 (da)
PL (1) PL3986890T3 (da)
PT (1) PT3986890T (da)
RS (1) RS64931B1 (da)
SI (1) SI3986890T1 (da)
TW (1) TWI787620B (da)
UY (1) UY38752A (da)
WO (1) WO2020254946A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201810092D0 (en) * 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
PL3986890T3 (pl) 2019-06-18 2024-03-11 Pfizer Inc. Pochodne benzizoksazolosulfonamidu
MX2023000735A (es) * 2020-07-15 2023-02-13 Pfizer Metodos y combinaciones de inhibidor de kat6 para el tratamiento del cancer.
WO2022187688A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent kras-binding compounds for therapeutic purposes
WO2022187693A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent cdk2-binding compounds for therapeutic purposes
CA3221048A1 (en) * 2021-05-21 2022-11-24 Aurigene Oncology Limited Fused isoxazolyl compounds as kat6a inhibitors
WO2023280182A1 (zh) * 2021-07-05 2023-01-12 杭州英创医药科技有限公司 作为kat6抑制剂的化合物
TW202321263A (zh) 2021-08-10 2023-06-01 大陸商江蘇恆瑞醫藥股份有限公司 磺醯胺衍生物、其製備方法及其在醫藥上的應用
CA3237830A1 (en) * 2021-11-16 2023-05-25 Insilico Medicine Ip Limited Lysine acetyltransferase 6a (kat6a) inhibitors and uses thereof
WO2023114710A1 (en) * 2021-12-13 2023-06-22 Aurigene Oncology Limited Fused benzoisoxazolyl compounds as kat6a inhibitors
TW202400593A (zh) * 2022-03-28 2024-01-01 美商艾索司特瑞克斯公司 Ｍｙｓｔ家族離胺酸乙醯轉移酶之抑制劑
US20230416240A1 (en) * 2022-06-16 2023-12-28 Prelude Therapeutics Incorporated Kat6 targeting compounds
WO2024023703A1 (en) 2022-07-29 2024-02-01 Pfizer Inc. Dosing regimens comprising a kat6 inhibitor for the treatment of cancer

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Also Published As

Publication number Publication date
LT3986890T (lt) 2023-12-11
TW202115048A (zh) 2021-04-16
WO2020254946A1 (en) 2020-12-24
ECSP21091615A (es) 2022-01-31
US20200399258A1 (en) 2020-12-24
HRP20231501T1 (hr) 2024-03-01
PT3986890T (pt) 2024-01-17
JP7352662B2 (ja) 2023-09-28
BR112021025528A2 (pt) 2022-04-19
JP2023175821A (ja) 2023-12-12
CL2021003372A1 (es) 2022-10-07
EP3986890A1 (en) 2022-04-27
MX2021016085A (es) 2022-04-20
TWI787620B (zh) 2022-12-21
PL3986890T3 (pl) 2024-03-11
HUE064683T2 (hu) 2024-04-28
IL288802A (en) 2022-02-01
CN114364672A (zh) 2022-04-15
AU2023274178A1 (en) 2024-02-15
FI3986890T3 (fi) 2024-01-15
CR20210627A (es) 2022-02-08
EP4299135A2 (en) 2024-01-03
AU2020296361A1 (en) 2022-01-06
KR20220024671A (ko) 2022-03-03
PE20220808A1 (es) 2022-05-20
EP3986890B1 (en) 2023-11-15
ES2969616T3 (es) 2024-05-21
RS64931B1 (sr) 2023-12-29
SI3986890T1 (sl) 2024-03-29
CA3143666A1 (en) 2020-12-24
MD3986890T2 (ro) 2024-04-30
CO2021017504A2 (es) 2022-01-17
UY38752A (es) 2021-01-29
EP4299135A3 (en) 2024-02-28
US20230174522A1 (en) 2023-06-08
JP2022537285A (ja) 2022-08-25
US11492346B2 (en) 2022-11-08

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