US5552155A
(en)
*
|
1992-12-04 |
1996-09-03 |
The Liposome Company, Inc. |
Fusogenic lipsomes and methods for making and using same
|
US5776486A
(en)
|
1993-05-28 |
1998-07-07 |
Aphios Corporation |
Methods and apparatus for making liposomes containing hydrophobic drugs
|
US5981501A
(en)
*
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
ATE247971T1
(de)
|
1995-08-01 |
2003-09-15 |
Novartis Erfind Verwalt Gmbh |
Liposomale oligonukleotidzusammensetzungen
|
US6093816A
(en)
|
1996-06-27 |
2000-07-25 |
Isis Pharmaceuticals, Inc. |
Cationic lipids
|
US7262173B2
(en)
|
1997-03-21 |
2007-08-28 |
Georgetown University |
Chemosensitizing with liposomes containing oligonucleotides
|
EP1027033B1
(en)
|
1997-05-14 |
2009-07-22 |
The University Of British Columbia |
High efficiency encapsulation of nucleic acids in lipid vesicles
|
US6110745A
(en)
|
1997-07-24 |
2000-08-29 |
Inex Pharmaceuticals Corp. |
Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
|
US6410328B1
(en)
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
US6693086B1
(en)
|
1998-06-25 |
2004-02-17 |
National Jewish Medical And Research Center |
Systemic immune activation method using nucleic acid-lipid complexes
|
US20030022854A1
(en)
|
1998-06-25 |
2003-01-30 |
Dow Steven W. |
Vaccines using nucleic acid-lipid complexes
|
AU1830200A
(en)
|
1998-11-25 |
2000-06-13 |
Vanderbilt University |
Cationic liposomes for gene transfer
|
WO2001005433A2
(en)
|
1999-07-14 |
2001-01-25 |
Board Of Regents, The University Of Texas System |
Delivery and retention of activity agents to lymph nodes
|
US7094423B1
(en)
|
1999-07-15 |
2006-08-22 |
Inex Pharmaceuticals Corp. |
Methods for preparation of lipid-encapsulated therapeutic agents
|
WO2002028367A1
(fr)
|
2000-10-04 |
2002-04-11 |
Kyowa Hakko Kogyo Co., Ltd. |
Procede de revetement de particules fines avec un film de lipides
|
US7713942B2
(en)
|
2001-04-04 |
2010-05-11 |
Nordic Vaccine Technology A/S |
Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
WO2002088370A2
(en)
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Autogene nucleic acids encoding a secretable rna polymerase
|
JP2005516897A
(ja)
|
2001-11-07 |
2005-06-09 |
イネックス ファーマシューティカルズ コーポレイション |
改善された粘膜のワクチン及びその使用方法
|
US7901708B2
(en)
|
2002-06-28 |
2011-03-08 |
Protiva Biotherapeutics, Inc. |
Liposomal apparatus and manufacturing methods
|
EP1648519B1
(en)
|
2003-07-16 |
2014-10-08 |
Protiva Biotherapeutics Inc. |
Lipid encapsulated interfering rna
|
US7803397B2
(en)
*
|
2003-09-15 |
2010-09-28 |
Protiva Biotherapeutics, Inc. |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
EP1722762A2
(en)
|
2004-03-02 |
2006-11-22 |
Massachusetts Institute of Technology |
Nanocell drug delivery system
|
AU2005252273B2
(en)
|
2004-06-07 |
2011-04-28 |
Arbutus Biopharma Corporation |
Lipid encapsulated interfering RNA
|
AU2005251403B2
(en)
|
2004-06-07 |
2011-09-01 |
Arbutus Biopharma Corporation |
Cationic lipids and methods of use
|
CA2572439A1
(en)
|
2004-07-02 |
2006-01-12 |
Protiva Biotherapeutics, Inc. |
Immunostimulatory sirna molecules and uses therefor
|
WO2006007712A1
(en)
|
2004-07-19 |
2006-01-26 |
Protiva Biotherapeutics, Inc. |
Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
|
WO2006053430A1
(en)
|
2004-11-17 |
2006-05-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of apolipoprotein b
|
WO2006113679A2
(en)
|
2005-04-15 |
2006-10-26 |
Board Of Regents, The University Of Texas System |
Delivery of sirna by neutral lipid compositions
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
US20080088046A1
(en)
|
2006-10-13 |
2008-04-17 |
Steffen Panzner |
Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
|
US20070087045A1
(en)
|
2005-10-14 |
2007-04-19 |
Industrial Technology Research Institute |
Lipid carrier and method of preparing the same
|
US7838658B2
(en)
|
2005-10-20 |
2010-11-23 |
Ian Maclachlan |
siRNA silencing of filovirus gene expression
|
WO2007051303A1
(en)
*
|
2005-11-02 |
2007-05-10 |
Protiva Biotherapeutics, Inc. |
MODIFIED siRNA MOLECULES AND USES THEREOF
|
WO2007056861A1
(en)
|
2005-11-18 |
2007-05-24 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of influenza virus gene expression
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
US20080171716A1
(en)
|
2006-08-16 |
2008-07-17 |
Protiva Biotherapeutics, Inc. |
Nucleic acid modulation of toll-like receptor-mediated immune stimulation
|
EP2086507B1
(en)
*
|
2006-10-06 |
2018-11-07 |
BioNet Pharma GmbH |
A spinal nucleus pulposus implant
|
US20100297242A1
(en)
|
2007-10-17 |
2010-11-25 |
Tae-Gwan Park |
Ldl-like cationic nanoparticles for deliverying nucleic acid gene, method for preparing thereof and method for deliverying nucleic acid gene using the same
|
AU2008342535B2
(en)
*
|
2007-12-27 |
2015-02-05 |
Arbutus Biopharma Corporation |
Silencing of polo-like kinase expression using interfering RNA
|
CN102119217B
(zh)
|
2008-04-15 |
2015-06-03 |
普洛体维生物治疗公司 |
用于核酸递送的新型制剂
|
WO2009158678A1
(en)
|
2008-06-27 |
2009-12-30 |
Children's Hospital & Research Center At Oakland |
Lipophilic nucleic acid delivery vehicle and methods of use therefor
|
WO2010014895A2
(en)
|
2008-07-31 |
2010-02-04 |
Enzon Pharmaceuticals, Inc. |
Nanoparticle compositions for nucleic acids delivery system
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
AU2009307677C1
(en)
|
2008-10-20 |
2022-09-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
KR102344392B1
(ko)
|
2008-11-10 |
2021-12-28 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
CN102216462A
(zh)
|
2008-11-17 |
2011-10-12 |
安龙制药公司 |
用于核酸递送***的支化阳离子脂质
|
CN102231952A
(zh)
|
2008-11-17 |
2011-11-02 |
安龙制药公司 |
用于核酸运载***的可释放阳离子脂质
|
US10292932B2
(en)
|
2008-12-26 |
2019-05-21 |
Samyang Biopharmaceuticals Corporation |
Polymeric micelle particle comprising anionic drugs and method of preparing the same
|
CA2756499A1
(en)
|
2009-03-25 |
2010-09-30 |
Novartis Ag |
Pharmaceutical composition containing a drug and sirna
|
NZ621981A
(en)
|
2009-05-05 |
2015-09-25 |
Tekmira Pharmaceuticals Corp |
Lipid compositions
|
EA201791744A3
(ru)
|
2009-06-10 |
2018-07-31 |
Арбутус Биофарма Корпорэйшн |
Улучшенная липидная композиция
|
CA2767127A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
WO2011020023A2
(en)
*
|
2009-08-14 |
2011-02-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
NZ714887A
(en)
|
2009-09-11 |
2019-07-26 |
Ionis Pharmaceuticals Inc |
Modulation of huntingtin expression
|
CN107028886A
(zh)
|
2009-11-04 |
2017-08-11 |
不列颠哥伦比亚大学 |
含有核酸的脂质粒子及相关的方法
|
NZ700688A
(en)
|
2009-12-01 |
2016-02-26 |
Shire Human Genetic Therapies |
Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
|
WO2011089595A2
(en)
|
2010-01-19 |
2011-07-28 |
Polypid Ltd. |
Sustained-release nucleic acid matrix compositions
|
US10077232B2
(en)
|
2010-05-12 |
2018-09-18 |
Arbutus Biopharma Corporation |
Cyclic cationic lipids and methods of use
|
KR101198715B1
(ko)
|
2010-05-14 |
2012-11-13 |
한국생명공학연구원 |
핵산 및 친수성 음이온 화합물의 고효율 포획을 위한 비대칭 리포솜 및 이의 제조방법
|
US20100239521A1
(en)
|
2010-06-01 |
2010-09-23 |
Mohammad Reza Mozafari |
Method for the preparation of micro- and nano-sized carrier systems for the encapsulation of bioactive substances
|
DK2575764T3
(da)
|
2010-06-03 |
2017-08-07 |
Alnylam Pharmaceuticals Inc |
Biologisk nedbrydelige lipider til fremføring af aktive midler
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
PL2611467T3
(pl)
|
2010-08-31 |
2022-08-16 |
Glaxosmithkline Biologicals Sa |
Małe liposomy do dostarczania rna kodującego immunogen
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
AU2012267578B2
(en)
|
2011-06-08 |
2017-04-20 |
Translate Bio, Inc. |
Cleavable lipids
|
US9011903B2
(en)
|
2011-06-08 |
2015-04-21 |
Nitto Denko Corporation |
Cationic lipids for therapeutic agent delivery formulations
|
JP6184945B2
(ja)
*
|
2011-06-08 |
2017-08-23 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
mRNA送達のための脂質ナノ粒子組成物および方法
|
EP2729127B1
(en)
*
|
2011-07-04 |
2018-05-02 |
Statens Serum Institut |
Methods for producing liposomes
|
MX366055B
(es)
|
2011-08-31 |
2019-06-26 |
Novartis Ag |
Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno.
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
CA2850792A1
(en)
|
2011-10-05 |
2013-04-11 |
Protiva Biotherapeutics Inc. |
Compositions and methods for silencing aldehyde dehydrogenase
|
EP2773328A2
(en)
|
2011-11-04 |
2014-09-10 |
Nitto Denko Corporation |
Method of producing lipid nanoparticles for drug delivery
|
US9579338B2
(en)
|
2011-11-04 |
2017-02-28 |
Nitto Denko Corporation |
Method of producing lipid nanoparticles for drug delivery
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
HUE041494T2
(hu)
|
2012-02-24 |
2019-05-28 |
Arbutus Biopharma Corp |
Trialkil-kationos lipidek és alkalmazási módszereik
|
AU2013225950B2
(en)
|
2012-02-29 |
2018-02-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating huntington's disease
|
BR112014024131A2
(pt)
|
2012-03-29 |
2017-07-25 |
Shire Human Genetic Therapies |
lipídios catiônicos ionizáveis
|
DE18200782T1
(de)
|
2012-04-02 |
2021-10-21 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
|
US9303079B2
(en)
|
2012-04-02 |
2016-04-05 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
US20160289674A1
(en)
|
2012-04-02 |
2016-10-06 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of membrane proteins
|
PT2858974T
(pt)
|
2012-06-08 |
2018-11-29 |
Nitto Denko Corp |
Lípidos para formulações de administração de agentes terapêuticos
|
EA201492055A1
(ru)
|
2012-06-08 |
2015-11-30 |
Шир Хьюман Дженетик Терапис, Инк. |
ИНГАЛЯЦИОННАЯ ДОСТАВКА мРНК В НЕЛЕГОЧНЫЕ КЛЕТКИ-МИШЕНИ
|
HUE055044T2
(hu)
|
2013-03-14 |
2021-10-28 |
Translate Bio Inc |
MRNS-kódolt ellenanyagok bejuttatására szolgáló eljárások és készítmények
|
ES2647832T3
(es)
|
2013-03-14 |
2017-12-26 |
Translate Bio, Inc. |
Ácidos ribonucleicos con nucleótidos modificados con 4-tio y procedimientos relacionados
|
EP2971013B1
(en)
|
2013-03-15 |
2020-08-19 |
The University Of British Columbia |
Lipid nanoparticles for transfection and related methods
|
ES2795249T3
(es)
|
2013-03-15 |
2020-11-23 |
Translate Bio Inc |
Mejora sinérgica de la administración de ácidos nucleicos a través de formulaciones mezcladas
|
KR102109188B1
(ko)
|
2013-04-01 |
2020-05-11 |
삼성전자주식회사 |
양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
|
JP2016528890A
(ja)
*
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いるゲノム編集の治療用の使用
|
JP6620093B2
(ja)
|
2013-07-23 |
2019-12-11 |
アービュートゥス バイオファーマ コーポレイションArbutus Biopharma Corporation |
メッセンジャーrnaを送達するための組成物及び方法
|
US9453060B2
(en)
|
2013-08-09 |
2016-09-27 |
New York University |
Protein engineered systems for delivery of molecules
|
ES2954366T3
(es)
|
2013-10-22 |
2023-11-21 |
Translate Bio Inc |
Terapia de ácido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa
|
CA2928186A1
(en)
|
2013-10-22 |
2015-04-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for phenylketonuria
|
EP4036241A1
(en)
*
|
2013-10-22 |
2022-08-03 |
Translate Bio, Inc. |
Cns delivery of mrna and uses thereof
|
EP3060257B1
(en)
|
2013-10-22 |
2021-02-24 |
Translate Bio, Inc. |
Lipid formulations for delivery of messenger rna
|
KR102541164B1
(ko)
|
2014-01-21 |
2023-06-08 |
안자리움 바이오사이언시스 아게 |
하이브리도좀, 이를 포함하는 조성물, 이의 제조 방법 및 이의 용도
|
DK3116997T3
(da)
|
2014-03-10 |
2019-08-19 |
Editas Medicine Inc |
Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
|
TR201900649T4
(tr)
|
2014-03-24 |
2019-02-21 |
Translate Bio Inc |
Oküler hastalıkların tedavisi için mrna tedavisi.
|
WO2015154002A1
(en)
|
2014-04-04 |
2015-10-08 |
Ohio State Innovation Foundation |
Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
|
PT3134131T
(pt)
*
|
2014-04-23 |
2022-03-24 |
Modernatx Inc |
Vacinas de ácidos nucleicos
|
JP6557722B2
(ja)
|
2014-05-30 |
2019-08-07 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
核酸の送達のための生分解性脂質
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
ES2964588T3
(es)
|
2014-06-24 |
2024-04-08 |
Translate Bio Inc |
Composiciones enriquecidas estereoquímicamente para la administración de ácidos nucleicos
|
US10583084B2
(en)
|
2014-06-26 |
2020-03-10 |
Ramot At Tel-Aviv University Ltd. |
Liposomal formulations for delivery of nucleic acids
|
CN114146063A
(zh)
|
2014-07-02 |
2022-03-08 |
川斯勒佰尔公司 |
信使rna的包封
|
WO2016090262A1
(en)
|
2014-12-05 |
2016-06-09 |
Shire Human Genetic Therapies, Inc. |
Messenger rna therapy for treatment of articular disease
|
CN107530436B
(zh)
*
|
2015-01-21 |
2022-03-29 |
菲泽尔克斯公司 |
用于将治疗剂和诊断剂递送到细胞中的方法、组合物和***
|
WO2016118725A1
(en)
|
2015-01-23 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
WO2016149508A1
(en)
|
2015-03-19 |
2016-09-22 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for pompe disease
|
WO2016189532A1
(en)
|
2015-05-26 |
2016-12-01 |
Ramot At Tel-Aviv University Ltd. |
Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes
|
CA2989884A1
(en)
|
2015-07-09 |
2017-01-12 |
Insmed Incorporated |
Compositions and methods for treating lung diseases and lung injury
|
SI3350157T1
(sl)
|
2015-09-17 |
2022-04-29 |
Modernatx, Inc. |
Sestave za doziranje terapevtskih sredstev v celice
|
WO2017070618A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Cancer vaccines
|
EP3364950A4
(en)
|
2015-10-22 |
2019-10-23 |
ModernaTX, Inc. |
VACCINES AGAINST TROPICAL DISEASES
|
CA3002922A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
WO2017075038A1
(en)
|
2015-10-26 |
2017-05-04 |
Rana Therapeutics, Inc. |
Nanoparticle formulations for delivery of nucleic acid complexes
|
EP3964200A1
(en)
|
2015-12-10 |
2022-03-09 |
ModernaTX, Inc. |
Compositions and methods for delivery of therapeutic agents
|
WO2017105138A1
(ko)
|
2015-12-18 |
2017-06-22 |
주식회사 삼양바이오팜 |
음이온성 약물을 함유하는 고분자 미셀의 제조방법
|
JP7114465B2
(ja)
|
2015-12-22 |
2022-08-08 |
モデルナティエックス インコーポレイテッド |
薬剤の細胞内送達のための化合物および組成物
|
CN107281103A
(zh)
|
2016-04-11 |
2017-10-24 |
百奥迈科生物技术有限公司 |
具有高含量阳性脂质化合物的脂质体制剂及其应用
|
WO2017201332A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
RU2764587C2
(ru)
|
2016-05-18 |
2022-01-18 |
Вояджер Терапьютикс, Инк. |
Способы и композиции для лечения хореи гентингтона
|
CN109312313A
(zh)
|
2016-06-13 |
2019-02-05 |
川斯勒佰尔公司 |
用于治疗鸟氨酸转氨甲酰酶缺乏症的信使rna疗法
|
WO2017218704A1
(en)
|
2016-06-14 |
2017-12-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
EP3519578B1
(en)
|
2016-10-03 |
2021-12-22 |
Precision Nanosystems Inc |
Compositions for transfecting resistant cell types
|
MA46584A
(fr)
|
2016-10-21 |
2019-08-28 |
Modernatx Inc |
Vaccin contre le cytomégalovirus humain
|
KR20190093816A
(ko)
|
2016-10-26 |
2019-08-26 |
큐어백 아게 |
지질 나노입자 mRNA 백신
|
WO2018089540A1
(en)
|
2016-11-08 |
2018-05-17 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
CA3039137A1
(en)
|
2016-11-08 |
2018-05-17 |
Ramot At Tel-Aviv University Ltd. |
Cationic lipids for nucleic acid delivery and preparation thereof
|
CN110114058B
(zh)
|
2016-11-10 |
2023-05-26 |
川斯勒佰尔公司 |
用于递送mrna的改进的基于ice的脂质纳米颗粒制剂
|
MA46762A
(fr)
|
2016-11-10 |
2019-09-18 |
Translate Bio Inc |
Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm
|
CA3045122A1
(en)
|
2016-12-09 |
2018-06-14 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
US11969506B2
(en)
|
2017-03-15 |
2024-04-30 |
Modernatx, Inc. |
Lipid nanoparticle formulation
|
DK3596041T3
(da)
|
2017-03-15 |
2023-01-23 |
Modernatx Inc |
Forbindelse og sammensætninger til intracellulær afgivelse af terapeutiske midler
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
EP3630076A1
(en)
|
2017-05-30 |
2020-04-08 |
GlaxoSmithKline Biologicals SA |
Methods for manufacturing a liposome encapsulated rna
|
US20200131498A1
(en)
|
2017-06-14 |
2020-04-30 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase
|
WO2018232120A1
(en)
|
2017-06-14 |
2018-12-20 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of agents
|
US11786607B2
(en)
|
2017-06-15 |
2023-10-17 |
Modernatx, Inc. |
RNA formulations
|
WO2018236849A1
(en)
|
2017-06-19 |
2018-12-27 |
Translate Bio, Inc. |
MESSENGER RNA THERAPY FOR THE TREATMENT OF FRIEDREICH ATAXIA
|
SG11202000312UA
(en)
|
2017-07-14 |
2020-02-27 |
Oncorus Inc |
Encapsulated polynucleotides and methods of use
|
EP3662913A4
(en)
|
2017-08-04 |
2021-06-30 |
Kyowa Kirin Co., Ltd. |
LIPID NANOPARTICLES CONTAINING NUCLEIC ACID
|
US11639329B2
(en)
|
2017-08-16 |
2023-05-02 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
WO2019036028A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
|
CA3073018A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
US11744801B2
(en)
|
2017-08-31 |
2023-09-05 |
Modernatx, Inc. |
Methods of making lipid nanoparticles
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
WO2019090411A1
(en)
|
2017-11-09 |
2019-05-16 |
Immmunovaccine Technologies Inc. |
Pharmaceutical compositions, methods for preparation comprising sizing of lipid vesicle particles, and uses thereof
|
WO2019118621A1
(en)
|
2017-12-12 |
2019-06-20 |
The Johns Hopkins University |
Methods for making giant vesicles and their use
|
EP3727428A1
(en)
|
2017-12-20 |
2020-10-28 |
Translate Bio, Inc. |
Improved composition and methods for treatment of ornithine transcarbamylase deficiency
|
US20210024928A1
(en)
|
2018-02-16 |
2021-01-28 |
Mina Therapeutics Limited |
C/ebp alpha sarna compositions and methods of use
|
WO2019169203A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|
EP3775202A4
(en)
|
2018-03-27 |
2022-04-06 |
Factor Bioscience Inc. |
NUCLEIC ACID THERAPEUTIC AGENTS
|
US20230149310A1
(en)
|
2018-03-30 |
2023-05-18 |
Arcturus Therapeutics, Inc. |
Lipid particles for nucleic acid delivery
|
BR112020020933A2
(pt)
|
2018-04-17 |
2021-04-06 |
Curevac Ag |
Moléculas de rna de rsv inovadoras e composições para vacinação
|
CA3097203C
(en)
|
2018-04-29 |
2023-09-05 |
Precision Nanosystems Inc. |
Compositions for transfecting resistant cell types
|
AU2019262059A1
(en)
|
2018-05-01 |
2020-12-03 |
Fred Hutchinson Cancer Center |
Nanoparticles for gene expression and uses thereof
|
WO2019217870A1
(en)
|
2018-05-10 |
2019-11-14 |
Northwestern University |
Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology
|
WO2019226650A1
(en)
|
2018-05-23 |
2019-11-28 |
Modernatx, Inc. |
Delivery of dna
|
WO2019226925A1
(en)
|
2018-05-24 |
2019-11-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
EP3823634A4
(en)
|
2018-07-21 |
2022-08-03 |
University of Tennessee Research Foundation |
NEUTRAL LIPOSOMES CONTAINING BIOLOGICAL ACTIVE INGREDIENTS
|
KR20210056331A
(ko)
|
2018-07-23 |
2021-05-18 |
트랜슬레이트 바이오 인코포레이티드 |
전령 rna의 건조 분말 제형
|
WO2020028133A1
(en)
|
2018-07-30 |
2020-02-06 |
Trucode Gene Repair, Inc. |
Lipid nanoparticle formulations comprising nucleic acid mimics
|
WO2020051220A1
(en)
*
|
2018-09-04 |
2020-03-12 |
The Board of the Regents of the University of Texas System |
Compositions and methods for organ specific delivery of nucleic acids
|
WO2020051243A1
(en)
|
2018-09-04 |
2020-03-12 |
Ohio State Innovation Foundation |
Lipid nanoparticles and methods of using thereof
|
WO2020056294A1
(en)
|
2018-09-14 |
2020-03-19 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
CA3113436A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
US20210378980A1
(en)
|
2018-09-20 |
2021-12-09 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|
FI3864163T3
(fi)
|
2018-10-09 |
2024-05-03 |
Univ British Columbia |
Koostumukset ja järjestelmät, joihin sisältyvät transfektiokompetentit vesikkelit, joissa ei ole orgaanisia liuottimia eikä pesuaineita, sekä niihin liittyvät menetelmät
|
EP3877522A4
(en)
|
2018-11-09 |
2022-11-02 |
Arbutus Biopharma Corporation |
LIPID NANOPARTICLE FORMULATIONS
|
US20220072154A1
(en)
|
2018-11-09 |
2022-03-10 |
Arbutus Biopharma Corporation |
Negatively charged peg-lipid conjugates
|
US20220016265A1
(en)
|
2018-11-09 |
2022-01-20 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
CN113286622A
(zh)
|
2018-11-09 |
2021-08-20 |
阿布特斯生物制药公司 |
含硅的阳离子脂质
|
EP3876994A2
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
EP3880174A2
(en)
|
2018-11-12 |
2021-09-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
ES2972334T3
(es)
|
2018-11-16 |
2024-06-12 |
Nitto Denko Corp |
Formulación y métodos de administración de interferencia de ARN para tumores malignos
|
AU2019384557A1
(en)
|
2018-11-21 |
2021-06-10 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR
|
AU2020204989A1
(en)
|
2019-01-04 |
2021-07-08 |
Elevatebio Technologies, Inc. |
Encapsulated RNA polynucleotides and methods of use
|
US20220023214A1
(en)
|
2019-01-24 |
2022-01-27 |
CannaClear Inc. |
Lecithin Vesicles for Oral Delivery
|
EP3914236A4
(en)
|
2019-01-24 |
2022-10-26 |
Northwestern University |
HIGH-DENSITY LIPOPROTEINMIMETIC NANOPARTICLES USING LIPID-CONJUGATED CORE SCAFFOLDINGS
|
WO2020160397A1
(en)
|
2019-01-31 |
2020-08-06 |
Modernatx, Inc. |
Methods of preparing lipid nanoparticles
|
WO2020154774A1
(en)
|
2019-01-31 |
2020-08-06 |
Newsouth Innovations Pty Limited |
Liposomal nanoparticle
|
AU2020241756A1
(en)
|
2019-03-19 |
2021-11-04 |
Arcturus Therapeutics, Inc. |
Method of making lipid-encapsulated RNA nanoparticles
|
WO2020189773A1
(ja)
|
2019-03-20 |
2020-09-24 |
洋文 竹内 |
後眼部送達用組成物
|
AU2020260280B2
(en)
|
2019-04-15 |
2023-06-29 |
Global Life Sciences Solutions Canada Ulc |
Nonviral modification of t cell gene expression
|
AU2020268798A1
(en)
|
2019-05-03 |
2021-11-04 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
CA3139321A1
(en)
|
2019-05-07 |
2020-11-12 |
Modernatx, Inc. |
Polynucleotides for disrupting immune cell activity and methods of use thereof
|
CA3140423A1
(en)
|
2019-05-14 |
2020-11-19 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
JP2022538797A
(ja)
|
2019-06-14 |
2022-09-06 |
ディーエヌエーライト セラピューティクス, インコーポレイテッド |
生物学的送達ビヒクルのための組成物及び方法
|
WO2020254535A1
(en)
|
2019-06-18 |
2020-12-24 |
Curevac Ag |
Rotavirus mrna vaccine
|
CA3143577C
(en)
|
2019-06-20 |
2024-02-20 |
Precision Nanosystems Inc. |
Ionizable lipids for nucleic acid delivery
|
JP7420841B2
(ja)
|
2019-06-29 |
2024-01-23 |
プレシジョン ナノシステムズ ユーエルシー |
核酸送達のためのイオン化可能な脂質
|
KR20220038365A
(ko)
|
2019-07-23 |
2022-03-28 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자의 안정한 조성물 및 제조 방법
|
US20220273566A1
(en)
|
2019-07-29 |
2022-09-01 |
Georgia Tech Research Corporation |
Nanomaterials containing constrained lipids and uses thereof
|
JP2022543046A
(ja)
|
2019-07-30 |
2022-10-07 |
バーンダリ・インコーポレイテッド |
ウイルス様粒子ワクチン
|
AU2020319876A1
(en)
|
2019-07-31 |
2022-02-24 |
Modernatx, Inc. |
Compositions and methods for delivery of RNA interference agents to immune cells
|
WO2021026358A1
(en)
|
2019-08-07 |
2021-02-11 |
Moderna TX, Inc. |
Compositions and methods for enhanced delivery of agents
|
WO2021028439A1
(en)
|
2019-08-14 |
2021-02-18 |
Curevac Ag |
Rna combinations and compositions with decreased immunostimulatory properties
|
BR112022002708A2
(pt)
|
2019-08-14 |
2022-05-31 |
Acuitas Therapeutics Inc |
Nanopartículas lipídicas aperfeiçoadas para a liberação de ácidos nucleicos
|
EP4021407A1
(en)
|
2019-08-30 |
2022-07-06 |
GlaxoSmithKline Biologicals S.A. |
Jet mixing lipid nanoparticle manufacturing process
|
EP4031191A4
(en)
|
2019-09-18 |
2023-10-25 |
The Regents of the University of California |
PROTEIN-PRODUCING NANOLIPOSOMES AND THEIR USES
|
MX2022003269A
(es)
|
2019-09-19 |
2022-07-04 |
Modernatx Inc |
Compuestos lipidicos de cola ramificada y composiciones para la administracion intracelular de agentes terapeuticos.
|
JP2022553375A
(ja)
|
2019-10-22 |
2022-12-22 |
ジェネバント サイエンシズ ゲーエムベーハー |
オルニチントランスカルバミラーゼ(otc)構築物およびそれを使用する方法
|
JP2023502576A
(ja)
|
2019-11-22 |
2023-01-25 |
ジェネレーション バイオ カンパニー |
イオン化可能な脂質およびそれらのナノ粒子組成物
|
WO2021108731A1
(en)
|
2019-11-25 |
2021-06-03 |
The Methodist Hospital |
Aposome compositions and methods of use
|
EP3838266A1
(en)
|
2019-12-20 |
2021-06-23 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Microfluidic production of biofunctionalized giant unilamellar vesicles for targeted intracellular cargo delivery
|
AU2020417305A1
(en)
|
2019-12-31 |
2022-07-21 |
Fred Hutchinson Cancer Center |
Nanoparticle systems to stimulate and maintain immune system responsiveness at treatment sites
|
EP3858332A1
(en)
|
2020-01-31 |
2021-08-04 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Bottom-up assembly of synthetic extracellular vesicles
|
BR112022014970A2
(pt)
|
2020-01-31 |
2022-09-20 |
Modernatx Inc |
Métodos para preparar nanopartículas lipídicas
|
CA3160511A1
(en)
|
2020-02-04 |
2021-08-12 |
Susanne RAUCH |
Coronavirus vaccine
|
CN113186203B
(zh)
|
2020-02-13 |
2022-12-30 |
斯微(上海)生物科技股份有限公司 |
治疗或者预防冠状病毒病的疫苗试剂
|
WO2021173840A1
(en)
|
2020-02-25 |
2021-09-02 |
Translate Bio, Inc. |
Improved processes of preparing mrna-loaded lipid nanoparticles
|
CN113999184A
(zh)
|
2020-02-28 |
2022-02-01 |
深圳深信生物科技有限公司 |
一种胺基脂质化合物、其制备方法和应用
|
JP2023518985A
(ja)
|
2020-03-27 |
2023-05-09 |
ジェネレーション バイオ カンパニー |
新規脂質及びそれらのナノ粒子組成物
|
US11559577B2
(en)
|
2020-03-31 |
2023-01-24 |
Engimata, Inc. |
Immunogenic composition forming a vaccine, and a method for its manufacture
|
CN113456591B
(zh)
|
2020-03-31 |
2022-06-14 |
武汉合生科技有限公司 |
糖基聚醚类化合物脂质体及其制备方法和药物
|
EP4132584A4
(en)
|
2020-04-07 |
2024-05-01 |
The Regents Of The University Of California |
MANUFACTURE OF SYNTHETIC EXOSOMES FOR CNS AND NON-CNS DELIVERY OF THERAPEUTIC AGENTS
|
KR20230004563A
(ko)
|
2020-04-10 |
2023-01-06 |
노오쓰웨스턴 유니버시티 |
강력한 암 면역치료제로서 리포좀성 구형 핵산 내 캡슐화된 산화된 종양 세포 용해물
|
GB202307565D0
(en)
|
2020-04-22 |
2023-07-05 |
BioNTech SE |
Coronavirus vaccine
|
EP4143217A2
(en)
|
2020-05-01 |
2023-03-08 |
Arcturus Therapeutics, Inc. |
Nucleic acids and methods of treatment for cystic fibrosis
|
US20230181619A1
(en)
|
2020-05-07 |
2023-06-15 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
US20230190954A1
(en)
|
2020-05-07 |
2023-06-22 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
JP2023526284A
(ja)
|
2020-05-15 |
2023-06-21 |
トランスレイト バイオ, インコーポレイテッド |
mRNA送達のための脂質ナノ粒子製剤
|
AU2021274481A1
(en)
|
2020-05-18 |
2022-11-03 |
Generation Bio Co. |
Novel lipids and nanoparticle compositions thereof
|
CA3183163A1
(en)
|
2020-05-18 |
2021-11-25 |
Max Biology Co. Ltd. |
Lipid-polymer compositions and methods of use
|
CN116322788A
(zh)
|
2020-05-19 |
2023-06-23 |
奥纳治疗公司 |
环状rna组合物和方法
|
WO2021236763A2
(en)
|
2020-05-20 |
2021-11-25 |
Nitto Denko Corporation |
dsRNA DIRECTED TO CORONAVIRUS PROTEINS
|
BR112022024248A2
(pt)
|
2020-05-29 |
2023-10-10 |
CureVac SE |
Vacinas de combinação à base de ácido nucleico
|
CA3180557A1
(en)
|
2020-05-29 |
2021-12-02 |
Lorena Lerner |
Encapsulated rna replicons and methods of use
|
US20230029453A1
(en)
|
2020-07-06 |
2023-02-02 |
Janssen Biotech, Inc. |
Prostate Neoantigens And Their Uses
|
US20230338288A1
(en)
|
2020-07-14 |
2023-10-26 |
The Research Foundation For The State University Of New York |
Asymmetric charged vesicles and methods of preparing and use thereof
|
MX2023000806A
(es)
|
2020-07-17 |
2023-04-11 |
Generation Bio Co |
Métodos para encapsular polinucleótidos en tamaños reducidos de nanopartículas lipídicas y formulación novedosa de estos.
|
GB202011367D0
(en)
|
2020-07-22 |
2020-09-02 |
Micropore Tech Limited |
Method of preparing liposomes
|
US20230293434A1
(en)
|
2020-07-23 |
2023-09-21 |
The Regents Of The University Of California |
COMPOSITIONS COMPRISING miR-690 AND METHODS THEREFOR
|
JP2023543963A
(ja)
|
2020-08-06 |
2023-10-19 |
モデルナティエックス インコーポレイテッド |
脂質ナノ粒子を調製する方法
|
EP4192433A2
(en)
|
2020-08-06 |
2023-06-14 |
Modernatx, Inc. |
Compositions for the delivery of payload molecules to airway epithelium
|
US20230338495A1
(en)
|
2020-08-19 |
2023-10-26 |
Vitruviae LLC |
Vaccine Compositions and Antibodies For Lyme Disease
|
WO2022046919A2
(en)
|
2020-08-25 |
2022-03-03 |
The Regents Of The University Of California |
Compositions and methods for the treatment of ocular neuroinflammation
|
CA3170743A1
(en)
|
2020-08-31 |
2022-03-03 |
Susanne RAUCH |
Multivalent nucleic acid based coronavirus vaccines
|
US20230310585A1
(en)
|
2020-09-11 |
2023-10-05 |
The University Of British Columbia |
Vaccine for viral pathogens
|