DK382084A - Fremgangsmaade til fremstilling af penemer - Google Patents

Fremgangsmaade til fremstilling af penemer Download PDF

Info

Publication number: DK382084A
Authority: DK; Denmark
Prior art keywords: peneme; procedure; manufacturing; peneme manufacturing
Prior art date: 1983-08-11

Application number

DK382084A

Other languages

English (en)

Other versions

DK167926B1 (da

DK382084D0 (da

Inventor

Carlo Battistini

Maurizio Foglio

Giovanni Franceschi

Cosimo Scarafile

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-11

Filing date

1984-08-08

Publication date

1985-02-12

1984-08-08 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1984-08-08 Publication of DK382084D0 publication Critical patent/DK382084D0/da

1985-02-12 Publication of DK382084A publication Critical patent/DK382084A/da

1994-01-03 Application granted granted Critical

1994-01-03 Publication of DK167926B1 publication Critical patent/DK167926B1/da

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/06—Preparation by forming the ring or condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK382084A 1983-08-11 1984-08-08 Fremgangsmaade til fremstilling af penemer DK167926B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838321677A GB8321677D0 (en)	1983-08-11	1983-08-11	Preparation of penems
GB8321677		1983-08-11

Publications (3)

Publication Number	Publication Date
DK382084D0 DK382084D0 (da)	1984-08-08
DK382084A true DK382084A (da)	1985-02-12
DK167926B1 DK167926B1 (da)	1994-01-03

Family

ID=10547172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK382084A DK167926B1 (da)	1983-08-11	1984-08-08	Fremgangsmaade til fremstilling af penemer

Country Status (20)

Country	Link
US (1)	US4631150A (da)
JP (1)	JPS6058988A (da)
KR (1)	KR910002098B1 (da)
AT (1)	AT383808B (da)
BE (1)	BE900316A (da)
CA (1)	CA1279640C (da)
CH (1)	CH663024A5 (da)
DE (1)	DE3429102A1 (da)
DK (1)	DK167926B1 (da)
ES (1)	ES534892A0 (da)
FI (1)	FI83521C (da)
FR (1)	FR2550533B1 (da)
GB (2)	GB8321677D0 (da)
GR (1)	GR80102B (da)
HU (1)	HU192415B (da)
IL (1)	IL72612A (da)
IT (1)	IT1209578B (da)
NL (1)	NL8402478A (da)
PT (1)	PT79065B (da)
SE (1)	SE463514B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8416651D0 (en) *	1984-06-29	1984-08-01	Erba Farmitalia	Penem derivatives
US5215997A (en) *	1985-09-11	1993-06-01	Ciba-Geigy Corporation	Synthesis of beta-lactam compounds
DE3688960D1 (de) *	1985-09-11	1993-10-07	Ciba Geigy	Synthese von Beta-Lactamverbindungen.
EP0232966B1 (en) *	1986-01-17	1997-10-08	Beecham Group Plc	Process for the preparation of penem compounds and intermediates for this preparation
EP0233155A1 (de) *	1986-02-14	1987-08-19	Ciba-Geigy Ag	Aminoacyloxymethyl-Verbindungen
US5215891A (en) *	1986-10-15	1993-06-01	Farmitalia Carlo Erba	Process for preparing penems
EP0279781A3 (de) *	1987-02-17	1989-07-26	Ciba-Geigy Ag	Verfahren zur Herstellung von 4-Acetoxy-3-hydroxyethyl-azetidinon
US5312914A (en) *	1987-02-17	1994-05-17	Ciba-Geigy Corp	Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone
GB8713515D0 (en) *	1987-06-10	1987-07-15	Erba Farmitalia	Methoxymethyl compounds
GB2206578B (en) *	1987-07-07	1991-07-03	Erba Carlo Spa	Process for the preparation of penems
US5364768A (en) *	1987-07-07	1994-11-15	Farmitalia Carlo Erba S.R.L.	Process for the preparation of penems
US5191075A (en) *	1988-10-19	1993-03-02	Pfizer Inc	Process for the preparation of penems
US4992543A (en) *	1988-10-19	1991-02-12	Pfizer Inc.	Penem derivatives
EP0366189A3 (en) *	1988-10-24	1992-01-02	Norwich Eaton Pharmaceuticals, Inc.	Novel antimicrobial lactam-quinolones
US5273973A (en) *	1988-10-24	1993-12-28	Norwich Eaton Pharmaceuticals, Inc.	Antimicrobial quinolonyl esters
US5180719A (en) *	1988-10-24	1993-01-19	Norwich Eaton Pharmaceuticals, Inc.	Antimicrobial quinolonyl lactam esters
CA2001203C (en) *	1988-10-24	2001-02-13	Thomas P. Demuth, Jr.	Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) *	1988-10-24	1994-07-12	Procter & Gamble Pharmaceuticals, Inc.	Antimicrobial quinolone thioureas
US5491139A (en) *	1988-10-24	1996-02-13	The Procter & Gamble Company	Antimicrobial quinolonyl lactams
EP0399228A1 (de) *	1989-04-29	1990-11-28	Hoechst Aktiengesellschaft	Verfahren zur Herstellung von Penemverbindungen
US5198544A (en) *	1989-04-29	1993-03-30	Hoechst Aktiengesellschaft	Process for the preparation of penem compounds
EP0525057B1 (en) *	1990-04-18	2000-06-14	Procter & Gamble Pharmaceuticals, Inc.	Antimicrobial quinolonyl lactams
US5399679A (en) *	1992-06-16	1995-03-21	Farmitalia Carlo Erba S.R.L.	(1'R,3S,4R)4-acylthio azetidinones
EP0597401A3 (en) *	1992-11-11	1995-07-26	Takeda Chemical Industries Ltd	Preparation of penemes.
IT1286558B1 (it) *	1996-02-27	1998-07-15	Menarini Farma Ind	Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
CN100417654C (zh) *	2004-01-09	2008-09-10	中国医学科学院医药生物技术研究所	2-苯羧酸酯青霉烯类化合物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4500457A (en) *	1977-05-09	1985-02-19	Ciba-Geigy Corporation	Process for preparing thia-aza compounds with a beta-lactam ring
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003960B1 (de) *	1978-02-02	1983-06-29	Ciba-Geigy Ag	6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
EP0013067A1 (en) *	1978-12-22	1980-07-09	Beecham Group Plc	Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
FI75163C (fi) *	1979-02-24	1988-05-09	Erba Farmitalia	Foerfarande foer framstaellning av nya penemkarboxylsyror eller -estrar.
US4269771A (en) *	1979-04-06	1981-05-26	Farmitalia Carlo Erba	Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
ES8300769A1 (es) *	1980-06-06	1982-11-01	Sankyo Co	Un procedimiento para la preparacion de derivados del acido penen-3-carboxilico.
GB2079744A (en) *	1980-07-04	1982-01-27	Erba Farmitalia	6-Alkyl-2-functionalized penems
US4347183A (en) *	1981-02-02	1982-08-31	Schering Corporation	Process for the synthesis of penems and carbapenems
JPS588084A (ja) *	1981-07-08	1983-01-18	Takeda Chem Ind Ltd	（６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
US4411906A (en) *	1981-11-25	1983-10-25	Schering Corporation	(5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
SU1389680A3 (ru) *	1981-12-11	1988-04-15	Фармиталия Карло Эрба С.П.А. (Фирма)	Способ получени оптически активных пенемов или их солей с щелочными металлами
US4443373A (en) *	1982-03-30	1984-04-17	Schering Corporation	Process for the production of antibiotic penems
US4584133A (en) *	1983-11-07	1986-04-22	Schering Corporation	Process for the production of penems

1983
- 1983-08-11 GB GB838321677A patent/GB8321677D0/en active Pending
1984
- 1984-08-03 ES ES534892A patent/ES534892A0/es active Granted
- 1984-08-06 IT IT8422234A patent/IT1209578B/it active
- 1984-08-06 US US06/637,878 patent/US4631150A/en not_active Expired - Lifetime
- 1984-08-07 SE SE8404004A patent/SE463514B/sv not_active IP Right Cessation
- 1984-08-07 FR FR8412466A patent/FR2550533B1/fr not_active Expired
- 1984-08-07 IL IL72612A patent/IL72612A/xx not_active IP Right Cessation
- 1984-08-07 AT AT0255884A patent/AT383808B/de not_active IP Right Cessation
- 1984-08-07 DE DE19843429102 patent/DE3429102A1/de not_active Ceased
- 1984-08-08 BE BE0/213460A patent/BE900316A/fr not_active IP Right Cessation
- 1984-08-08 FI FI843111A patent/FI83521C/fi not_active IP Right Cessation
- 1984-08-08 JP JP59165031A patent/JPS6058988A/ja active Granted
- 1984-08-08 DK DK382084A patent/DK167926B1/da not_active IP Right Cessation
- 1984-08-09 GB GB08420236A patent/GB2144743B/en not_active Expired
- 1984-08-10 CA CA000460795A patent/CA1279640C/en not_active Expired - Fee Related
- 1984-08-10 KR KR1019840004797A patent/KR910002098B1/ko not_active IP Right Cessation
- 1984-08-10 GR GR80102A patent/GR80102B/el unknown
- 1984-08-10 HU HU843056A patent/HU192415B/hu not_active IP Right Cessation
- 1984-08-10 CH CH3855/84A patent/CH663024A5/de not_active IP Right Cessation
- 1984-08-10 PT PT79065A patent/PT79065B/pt not_active IP Right Cessation
- 1984-08-10 NL NL8402478A patent/NL8402478A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
FR2550533A1 (fr)	1985-02-15
PT79065A (en)	1984-09-01
DK167926B1 (da)	1994-01-03
GB2144743A (en)	1985-03-13
FI843111A (fi)	1985-02-12
SE8404004L (sv)	1985-02-12
SE463514B (sv)	1990-12-03
SE8404004D0 (sv)	1984-08-07
US4631150A (en)	1986-12-23
KR850001757A (ko)	1985-04-01
FI843111A0 (fi)	1984-08-08
JPS6058988A (ja)	1985-04-05
CA1279640C (en)	1991-01-29
IT1209578B (it)	1989-08-30
GB8321677D0 (en)	1983-09-14
FI83521C (fi)	1991-07-25
IT8422234A0 (it)	1984-08-06
PT79065B (en)	1986-11-14
HUT34984A (en)	1985-05-28
HU192415B (en)	1987-06-29
FR2550533B1 (fr)	1987-01-30
BE900316A (fr)	1985-02-08
ATA255884A (de)	1987-01-15
GB8420236D0 (en)	1984-09-12
FI83521B (fi)	1991-04-15
ES8600306A1 (es)	1985-09-16
JPH037675B2 (da)	1991-02-04
GB2144743B (en)	1987-01-28
IL72612A0 (en)	1984-11-30
GR80102B (en)	1984-12-14
AT383808B (de)	1987-08-25
DK382084D0 (da)	1984-08-08
KR910002098B1 (ko)	1991-04-03
ES534892A0 (es)	1985-09-16
NL8402478A (nl)	1985-03-01
IL72612A (en)	1988-06-30
DE3429102A1 (de)	1985-02-28
CH663024A5 (de)	1987-11-13

Legal Events

Date	Code	Title	Description
1994-01-03	B1	Patent granted (law 1993)
1997-04-14	PBP	Patent lapsed

Publication	Publication Date	Title
DK382084A (da)	1985-02-12	Fremgangsmaade til fremstilling af penemer
DK162580C (da)	1992-04-06	Fremgangsmaade til fremstilling af mikrokapsler
DK164659C (da)	1992-12-14	Fremgangsmaade til fremstilling af aromatiske carbonhydrider
DK606084D0 (da)	1984-12-18	Fremgangsmaade til fremstilling af 2-fluor-17beta-oestradiol
DK386784D0 (da)	1984-08-10	Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
DK445984D0 (da)	1984-09-19	Fremgangsmaade til fremstilling af cephalosporiner
DK158147C (da)	1990-09-03	Fremgangsmaade til fremstilling af et organolermateriale
DK294584D0 (da)	1984-06-15	Fremgangsmaade til fremstilling af formparter
DK87082A (da)	1982-08-29	Fremgangsmaade til fremstilling af cemnetklinker
DK304185A (da)	1986-01-28	Fremgangsmaade til fremstilling af furanon
DK37890A (da)	1990-02-13	Fremgangsmaade til fremstilling af 6-deoxyanthracycliner
DK614884A (da)	1985-06-24	Fremgangsmaade til fremstilling af koenroeg
DK132084D0 (da)	1984-02-29	Fremgangsmaade til fremstilling af mikrokapsler
DK299083D0 (da)	1983-06-29	Fremgangsmade til fremstilling af cephalosporinforbindelser
DK202983D0 (da)	1983-05-06	Fremgangsmade til fremstilling af l-lysin
DK614784D0 (da)	1984-12-20	Fremgangsmaade til fremstilling af koenroeg
DK535083D0 (da)	1983-11-23	Fremgangsmade til fremstilling af cephalosporinforbindelser
DK156389C (da)	1990-01-08	Fremgangsmaade til fremstilling af nitromethan
DK65883D0 (da)	1983-02-15	Fremgangsmade til fremstilling af elastase
DK573184D0 (da)	1984-12-03	Fremgangsmaade til fremstilling af polyphenylenoxid
DK351883A (da)	1984-02-03	Fremgangsmaade til fremstilling af nitromethan
DK429584D0 (da)	1984-09-07	Fremgangsmaade til fremstilling af carbapenemer
DK575584A (da)	1985-06-06	Fremgangsmaade til fremstilling af polyphenylenoxid
DK235182A (da)	1983-11-26	Fremgangsmaade til fremstilling af chromgaer
DK228182A (da)	1982-11-22	Fremgangsmaade til fremstilling af dimedon