DK3765024T3 - Hidtil ukendt farmaceutisk formulering, som omfatter dobbelte nk-1/nk-3-receptor-antagonister - Google Patents
Hidtil ukendt farmaceutisk formulering, som omfatter dobbelte nk-1/nk-3-receptor-antagonister Download PDFInfo
- Publication number
- DK3765024T3 DK3765024T3 DK19711866.4T DK19711866T DK3765024T3 DK 3765024 T3 DK3765024 T3 DK 3765024T3 DK 19711866 T DK19711866 T DK 19711866T DK 3765024 T3 DK3765024 T3 DK 3765024T3
- Authority
- DK
- Denmark
- Prior art keywords
- dual
- pharmaceutical formulation
- receptor antagonists
- previously unknown
- unknown pharmaceutical
- Prior art date
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862642622P | 2018-03-14 | 2018-03-14 | |
PCT/EP2019/056303 WO2019175253A1 (en) | 2018-03-14 | 2019-03-13 | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3765024T3 true DK3765024T3 (da) | 2024-02-12 |
Family
ID=65817992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19711866.4T DK3765024T3 (da) | 2018-03-14 | 2019-03-13 | Hidtil ukendt farmaceutisk formulering, som omfatter dobbelte nk-1/nk-3-receptor-antagonister |
Country Status (32)
Country | Link |
---|---|
US (5) | US10774091B2 (da) |
EP (1) | EP3765024B1 (da) |
JP (1) | JP7433252B2 (da) |
KR (1) | KR20200139138A (da) |
CN (1) | CN112292132A (da) |
AU (1) | AU2019233606A1 (da) |
BR (1) | BR112020017388A2 (da) |
CA (1) | CA3092238A1 (da) |
CL (1) | CL2020002350A1 (da) |
CO (1) | CO2020011262A2 (da) |
CR (1) | CR20200385A (da) |
DK (1) | DK3765024T3 (da) |
EA (1) | EA202092131A1 (da) |
EC (1) | ECSP20057488A (da) |
ES (1) | ES2974300T3 (da) |
FI (1) | FI3765024T3 (da) |
GE (1) | GEP20237503B (da) |
HR (1) | HRP20240120T1 (da) |
HU (1) | HUE065300T2 (da) |
IL (1) | IL276959B2 (da) |
JO (1) | JOP20200227A1 (da) |
LT (1) | LT3765024T (da) |
MA (1) | MA51999B1 (da) |
MX (2) | MX2020009438A (da) |
PE (1) | PE20210395A1 (da) |
PH (1) | PH12020551457A1 (da) |
PT (1) | PT3765024T (da) |
RS (1) | RS65257B1 (da) |
SG (1) | SG11202008226YA (da) |
SI (1) | SI3765024T1 (da) |
UA (1) | UA128159C2 (da) |
WO (1) | WO2019175253A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6902682B2 (ja) * | 2015-05-18 | 2021-07-14 | カンディー セラピューティクス リミテッド | 性ホルモン依存性疾患を治療するためのnk−1/nk−3受容体デュアルアンタゴニスト |
MX2019003083A (es) | 2016-09-18 | 2019-08-05 | H Lee Moffitt Cancer Ct & Res | Inhibidores de yap1 que dirigen la interacción de yap1 con oct4. |
AU2019233606A1 (en) | 2018-03-14 | 2020-09-17 | KaNDy Therapeutics Limited | Novel pharmaceutical formulation comprising dual NK-1/NK-3 receptor antagonists |
EP3765015A4 (en) | 2018-03-14 | 2021-12-15 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | YAP1 INHIBITORS AGAINST INTERACTION OF YAP1 WITH OCT4 |
CN114728906A (zh) | 2019-11-15 | 2022-07-08 | 康堤医疗有限公司 | 制备nt-814的关键中间体6-氯-4-(4-氟-2-甲基苯基)吡啶-3-胺的新化学方法 |
KR102484687B1 (ko) * | 2022-03-04 | 2023-01-05 | (주)씨앤엘디 | 페노피브레이트를 포함하는 이상지질혈증의 예방 또는 치료용 약학 조성물 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US3097618A (en) | 1960-12-01 | 1963-07-16 | Raymond Bag Corp | Manufacture of multi-wall bag having heat-sealed liner |
DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
GB9907571D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
AU2001275524B2 (en) | 2000-06-12 | 2006-02-02 | University Of Rochester | Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist |
EP1192952A3 (en) | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
AU2002259147A1 (en) | 2001-05-08 | 2002-11-18 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
AU2003298369B2 (en) | 2002-12-23 | 2009-08-27 | Janssen Pharmaceutica N.V. | Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists |
JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
US7525659B2 (en) | 2003-01-15 | 2009-04-28 | Negevtech Ltd. | System for detection of water defects |
CA2530886C (en) | 2003-07-03 | 2013-05-28 | F. Hoffmann-La Roche Ag | Dual nk1/nk3 antagonists for treating schizophrenia |
JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
JO2525B1 (en) | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
MXPA06013162A (es) | 2004-05-12 | 2007-02-13 | Pfizer Prod Inc | Derivados de piperidina como antagonistas de neurocinina 1 y neurocinina 3. |
DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
WO2006013205A1 (en) | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
US20060030600A1 (en) | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
JP5121716B2 (ja) | 2005-09-09 | 2013-01-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | ピリジン誘導体および精神異常の処置におけるそれらの使用 |
JP5203449B2 (ja) | 2007-04-20 | 2013-06-05 | エフ.ホフマン−ラ ロシュ アーゲー | 二重nk1/nk3受容体アンタゴニストとしてのピロリジン誘導体 |
GB0814340D0 (en) | 2008-08-05 | 2008-09-10 | Smithkline Beecham Corp | Anhydrous crystol form fo a pyridine derivative |
US8796269B2 (en) * | 2009-08-27 | 2014-08-05 | Nerre Therapeutics Limited | Crystalline 2-(3,5-Bis(trifluoromethyl)phenyl)-N-(4-(4-fluoro-2-methylphenyl)-6-((7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)pyridin-3-yl)-N,2-dimethyl-propanamide of the formula (I), their use in therapy, and process for the preparation of the same |
US8487102B2 (en) | 2010-04-20 | 2013-07-16 | Hoffmann-La Roche Inc. | Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists |
US9446029B2 (en) | 2010-07-27 | 2016-09-20 | Colorado State University Research Foundation | Use of NK-1 receptor antagonists in management of visceral pain |
ES2376564B1 (es) | 2010-08-12 | 2013-01-24 | Manuel Vicente Salinas Martín | Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer. |
GB2488788B (en) * | 2011-03-07 | 2013-07-10 | Natco Pharma Ltd | Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response |
WO2013082388A1 (en) | 2011-12-02 | 2013-06-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Peptide deformylase inhibitors |
KR101739820B1 (ko) | 2012-03-28 | 2017-05-25 | 주식회사유한양행 | 레바프라잔 또는 그의 염을 함유하는 비수성 액체 형태의 경구투여용 약학 조성물 |
US20150272927A1 (en) | 2012-12-03 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Methods and compositions for treating vasomotor symptoms |
GB201315846D0 (en) | 2013-09-05 | 2013-10-23 | Imp Innovations Ltd | Method for treating or preventing hot flushes |
JP6902682B2 (ja) | 2015-05-18 | 2021-07-14 | カンディー セラピューティクス リミテッド | 性ホルモン依存性疾患を治療するためのnk−1/nk−3受容体デュアルアンタゴニスト |
AU2019233606A1 (en) | 2018-03-14 | 2020-09-17 | KaNDy Therapeutics Limited | Novel pharmaceutical formulation comprising dual NK-1/NK-3 receptor antagonists |
CN114728906A (zh) | 2019-11-15 | 2022-07-08 | 康堤医疗有限公司 | 制备nt-814的关键中间体6-氯-4-(4-氟-2-甲基苯基)吡啶-3-胺的新化学方法 |
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2019
- 2019-03-13 AU AU2019233606A patent/AU2019233606A1/en active Pending
- 2019-03-13 US US16/351,659 patent/US10774091B2/en active Active
- 2019-03-13 IL IL276959A patent/IL276959B2/en unknown
- 2019-03-13 FI FIEP19711866.4T patent/FI3765024T3/fi active
- 2019-03-13 DK DK19711866.4T patent/DK3765024T3/da active
- 2019-03-13 WO PCT/EP2019/056303 patent/WO2019175253A1/en active Application Filing
- 2019-03-13 HU HUE19711866A patent/HUE065300T2/hu unknown
- 2019-03-13 KR KR1020207026436A patent/KR20200139138A/ko unknown
- 2019-03-13 JP JP2020572615A patent/JP7433252B2/ja active Active
- 2019-03-13 ES ES19711866T patent/ES2974300T3/es active Active
- 2019-03-13 GE GEAP201915464A patent/GEP20237503B/en unknown
- 2019-03-13 MA MA51999A patent/MA51999B1/fr unknown
- 2019-03-13 PT PT197118664T patent/PT3765024T/pt unknown
- 2019-03-13 MX MX2020009438A patent/MX2020009438A/es unknown
- 2019-03-13 HR HRP20240120TT patent/HRP20240120T1/hr unknown
- 2019-03-13 LT LTEPPCT/EP2019/056303T patent/LT3765024T/lt unknown
- 2019-03-13 CN CN201980019147.6A patent/CN112292132A/zh active Pending
- 2019-03-13 JO JOP/2020/0227A patent/JOP20200227A1/ar unknown
- 2019-03-13 BR BR112020017388-6A patent/BR112020017388A2/pt unknown
- 2019-03-13 EP EP19711866.4A patent/EP3765024B1/en active Active
- 2019-03-13 CA CA3092238A patent/CA3092238A1/en active Pending
- 2019-03-13 SG SG11202008226YA patent/SG11202008226YA/en unknown
- 2019-03-13 EA EA202092131A patent/EA202092131A1/ru unknown
- 2019-03-13 UA UAA202006478A patent/UA128159C2/uk unknown
- 2019-03-13 SI SI201930698T patent/SI3765024T1/sl unknown
- 2019-03-13 PE PE2020001406A patent/PE20210395A1/es unknown
- 2019-03-13 CR CR20200385A patent/CR20200385A/es unknown
- 2019-03-13 RS RS20240167A patent/RS65257B1/sr unknown
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2020
- 2020-08-04 US US16/985,087 patent/US11787820B2/en active Active
- 2020-08-04 US US16/984,961 patent/US11591346B2/en active Active
- 2020-09-10 MX MX2022005706A patent/MX2022005706A/es unknown
- 2020-09-11 CL CL2020002350A patent/CL2020002350A1/es unknown
- 2020-09-11 PH PH12020551457A patent/PH12020551457A1/en unknown
- 2020-09-11 CO CONC2020/0011262A patent/CO2020011262A2/es unknown
- 2020-09-14 EC ECSENADI202057488A patent/ECSP20057488A/es unknown
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2023
- 2023-01-13 US US18/097,046 patent/US11767328B2/en active Active
- 2023-07-31 US US18/228,593 patent/US20230382922A1/en active Pending
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