DK366684A - Fremgangsmaade til fremstilling af cefuroximaxetil - Google Patents

Fremgangsmaade til fremstilling af cefuroximaxetil Download PDF

Info

Publication number: DK366684A
Authority: DK; Denmark
Prior art keywords: cefuroximaxetil; manufacturing; manufacturing cefuroximaxetil
Prior art date: 1983-07-29

Application number

DK366684A

Other languages

English (en)

Other versions

DK165505B (da

DK165505C (da

DK366684D0 (da

Inventor

Harold Alfred Crisp

Michael Wright

John Peter Turnbull

Francis Oughton John

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-29

Filing date

1984-07-27

Publication date

1985-01-30

1984-07-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1984-07-27 Publication of DK366684D0 publication Critical patent/DK366684D0/da

1985-01-30 Publication of DK366684A publication Critical patent/DK366684A/da

1992-12-07 Publication of DK165505B publication Critical patent/DK165505B/da

1993-04-19 Application granted granted Critical

1993-04-19 Publication of DK165505C publication Critical patent/DK165505C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK366684A 1983-07-29 1984-07-27 Fremgangsmaade til fremstilling af krystallinsk cefuroximaxetil samt denne forbindelse paa hoejren form DK165505C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838320521A GB8320521D0 (en)	1983-07-29	1983-07-29	Chemical process
GB8320521		1983-07-29

Publications (4)

Publication Number	Publication Date
DK366684D0 DK366684D0 (da)	1984-07-27
DK366684A true DK366684A (da)	1985-01-30
DK165505B DK165505B (da)	1992-12-07
DK165505C DK165505C (da)	1993-04-19

Family

ID=10546505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK366684A DK165505C (da)	1983-07-29	1984-07-27	Fremgangsmaade til fremstilling af krystallinsk cefuroximaxetil samt denne forbindelse paa hoejren form

Country Status (21)

Country	Link
JP (1)	JPH0613526B2 (da)
KR (1)	KR910008377B1 (da)
AT (1)	AT392470B (da)
AU (2)	AU582121B2 (da)
BE (1)	BE900241A (da)
CA (1)	CA1265511A (da)
CH (1)	CH662121A5 (da)
DE (1)	DE3427828A1 (da)
DK (1)	DK165505C (da)
ES (1)	ES534695A0 (da)
FI (1)	FI76808C (da)
FR (1)	FR2549837B1 (da)
GB (2)	GB8320521D0 (da)
IE (1)	IE57726B1 (da)
IL (1)	IL72536A (da)
NL (1)	NL8402372A (da)
NO (1)	NO167292C (da)
NZ (1)	NZ209046A (da)
PT (1)	PT78985B (da)
SE (1)	SE463263B (da)
ZA (1)	ZA845830B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8400024D0 (en) *	1984-01-03	1984-02-08	Glaxo Group Ltd	Cephalosporin antibiotics
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
US5063224A (en) *	1990-07-09	1991-11-05	Eli Lilly And Company	R-cefuroxime axetil
IT1277426B1 (it) *	1995-08-03	1997-11-10	Acs Dobfar Spa	Forma cristallina biodisponibile del cefuroxima axetil
CN1111537C (zh) *	1997-05-15	2003-06-18	第一制糖株式会社	高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
KR100228264B1 (ko) *	1997-08-02	1999-11-01	김선진	결정형 세푸록심 악세틸의 제조방법
CA2209868C (en) *	1997-08-15	2001-08-14	Bernard Charles Sherman	Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (da) *	1997-09-29	2001-09-29	Ranbaxy Lab Ltd
EP0937727B1 (de) *	1998-02-20	2002-01-30	Fako Ilaclari A.S.	Verfahren zur Herstellung vom löslichen kristallinen Cefuroxim axetil
IN190849B (da)	2000-07-17	2003-08-23	Ranbaxy Lab Ltd
AT411996B (de)	2000-09-11	2004-08-26	Sandoz Ag	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
ITMI20011763A1 (it) *	2001-08-10	2003-02-10	Antibioticos Spa	Processo di preparazione di cefuroxime axelite ad elevata purezza
ITMI20011925A1 (it) *	2001-09-14	2003-03-14	Antibioticos Spa	Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
TWI328006B (en) *	2003-12-26	2010-08-01	Nissan Chemical Ind Ltd	Crystal form of quinoline compound and process for its production
CN100448879C (zh) *	2004-07-22	2009-01-07	北京化工大学	一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de)	2005-04-25	2006-10-26	Grünenthal GmbH	Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1094545A (en) *	1976-02-16	1981-01-27	Michael Gregson	Cephalosporin antibiotics
GB1571683A (en) *	1976-02-16	1980-07-16	Glaxo Operations Ltd	Ester derivatives of cefuroxime
GB1598568A (en) *	1977-04-19	1981-09-23	Glaxo Lab Ltd	Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
JPS577485A (en) *	1980-06-13	1982-01-14	Takeda Chem Ind Ltd	Cephalosporin
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
GB8400024D0 (en) *	1984-01-03	1984-02-08	Glaxo Group Ltd	Cephalosporin antibiotics

1983
- 1983-07-29 GB GB838320521A patent/GB8320521D0/en active Pending
1984
- 1984-07-27 DE DE19843427828 patent/DE3427828A1/de not_active Ceased
- 1984-07-27 FR FR8412011A patent/FR2549837B1/fr not_active Expired
- 1984-07-27 ES ES534695A patent/ES534695A0/es active Granted
- 1984-07-27 JP JP59155694A patent/JPH0613526B2/ja not_active Expired - Lifetime
- 1984-07-27 CA CA000459929A patent/CA1265511A/en not_active Expired - Fee Related
- 1984-07-27 FI FI843011A patent/FI76808C/fi not_active IP Right Cessation
- 1984-07-27 BE BE0/213398A patent/BE900241A/fr not_active IP Right Cessation
- 1984-07-27 AT AT2444/84A patent/AT392470B/de not_active IP Right Cessation
- 1984-07-27 DK DK366684A patent/DK165505C/da not_active IP Right Cessation
- 1984-07-27 SE SE8403897A patent/SE463263B/sv not_active IP Right Cessation
- 1984-07-27 ZA ZA845830A patent/ZA845830B/xx unknown
- 1984-07-27 AU AU31256/84A patent/AU582121B2/en not_active Ceased
- 1984-07-27 CH CH3672/84A patent/CH662121A5/de not_active IP Right Cessation
- 1984-07-27 PT PT78985A patent/PT78985B/pt unknown
- 1984-07-27 IE IE1938/84A patent/IE57726B1/en not_active IP Right Cessation
- 1984-07-27 KR KR1019840004465A patent/KR910008377B1/ko not_active IP Right Cessation
- 1984-07-27 GB GB08419202A patent/GB2145409B/en not_active Expired
- 1984-07-27 NL NL8402372A patent/NL8402372A/nl not_active Application Discontinuation
- 1984-07-27 NO NO843055A patent/NO167292C/no not_active IP Right Cessation
- 1984-07-29 IL IL72536A patent/IL72536A/xx not_active IP Right Cessation
- 1984-07-30 NZ NZ209046A patent/NZ209046A/en unknown
1989
- 1989-06-16 AU AU36601/89A patent/AU634965B2/en not_active Ceased

Also Published As

Publication number	Publication date
SE8403897L (sv)	1985-01-30
KR850001221A (ko)	1985-03-16
DE3427828A1 (de)	1985-02-14
IL72536A0 (en)	1984-11-30
AU3660189A (en)	1989-10-05
SE463263B (sv)	1990-10-29
GB2145409B (en)	1987-02-18
AT392470B (de)	1991-04-10
CA1265511A (en)	1990-02-06
SE8403897D0 (sv)	1984-07-27
IE841938L (en)	1985-01-29
FI843011A0 (fi)	1984-07-27
JPS6075484A (ja)	1985-04-27
FI843011A (fi)	1985-01-30
ZA845830B (en)	1986-03-26
KR910008377B1 (ko)	1991-10-12
AU582121B2 (en)	1989-03-16
IE57726B1 (en)	1993-03-24
JPH0613526B2 (ja)	1994-02-23
PT78985B (en)	1986-10-23
NO167292B (no)	1991-07-15
IL72536A (en)	1988-01-31
ES8601869A1 (es)	1985-11-01
AU3125684A (en)	1985-01-31
AU634965B2 (en)	1993-03-11
DK165505B (da)	1992-12-07
ATA244484A (de)	1990-09-15
NO843055L (no)	1985-01-30
GB8419202D0 (en)	1984-08-30
NL8402372A (nl)	1985-02-18
NZ209046A (en)	1988-02-29
BE900241A (fr)	1985-01-28
FI76808B (fi)	1988-08-31
GB2145409A (en)	1985-03-27
PT78985A (en)	1984-08-01
FR2549837A1 (fr)	1985-02-01
FI76808C (fi)	1988-12-12
FR2549837B1 (fr)	1986-12-26
NO167292C (no)	1991-10-23
DK165505C (da)	1993-04-19
ES534695A0 (es)	1985-11-01
DK366684D0 (da)	1984-07-27
CH662121A5 (de)	1987-09-15
GB8320521D0 (en)	1983-09-01

Legal Events

Date	Code	Title	Description
2003-03-03	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK350083A (da)	1984-02-11	Fremgangsmaade til fremstilling af phenylethanolaminer
DK382084A (da)	1985-02-12	Fremgangsmaade til fremstilling af penemer
DK366684D0 (da)	1984-07-27	Fremgangsmaade til fremstilling af cefuroximaxetil
DK79684D0 (da)	1984-02-20	Fremgangsmade til fremstilling af jernoxid
DK582883A (da)	1984-06-18	Fremgangsmaade til fremstilling af modelis
DK223587D0 (da)	1987-05-01	Fremgangsmaade til fremstilling af azopigmenter
DK459584A (da)	1984-09-26	Fremgangsmaade til fremstilling af glasgenstande
DK554583D0 (da)	1983-12-01	Fremgangsmade til fremstilling af kompositmaterialer
DK87283D0 (da)	1983-02-24	Fremgangsmade til fremstilling af thioethere
DK355584D0 (da)	1984-07-20	Fremgangsmaade til fremstilling af 3-exomethylen-cephalosporiner
DK223487A (da)	1987-11-04	Fremgangsmaade til fremstilling af azopigmenter
DK424083D0 (da)	1983-09-16	Fremgangsmade til fremstilling af anthracyclinglycosider
DK40883A (da)	1983-08-04	Fremgangsmaade til fremstilling af benzothienylallylaminer
DK23784A (da)	1984-07-22	Fremgangsmaade til fremstilling af beta-lactam
DK202983A (da)	1983-11-18	Fremgangsmaade til fremstilling af l-lysin
DK501084A (da)	1985-04-20	Fremgangsmaade til fremstilling af et metaltellurid
DK33985D0 (da)	1985-01-25	Fremgangsmaade til fremstilling af acetone
DK212884A (da)	1984-10-30	Fremgangsmaade til fremstilling af isoxazolylimidazolidinoner
DK132084A (da)	1985-02-19	Fremgangsmaade til fremstilling af mikrokapsler
DK329685D0 (da)	1985-07-19	Fremgangsmaade til fremstilling af alfa-l-aspartyl-l-phenylalaninalkylestere
DK385983A (da)	1984-02-25	Fremgangsmaade til fremstilling af 1-oxacephamer
DK219483D0 (da)	1983-05-17	Fremgangsmade til fremstilling af anthracyclinglycosider
DK551582A (da)	1983-06-15	Fremgangsmaade til fremstilling af encainid
DK432683A (da)	1984-03-28	Fremgangsmaade til fremstilling af 2-hydroxy-2-phenylethylaminer
DK94487D0 (da)	1987-02-24	Fremgangsmaade til fremstilling af encainid