DK3666771T3 - Lpa-antagonister - Google Patents

Lpa-antagonister Download PDF

Info

Publication number
DK3666771T3
DK3666771T3 DK20154651.2T DK20154651T DK3666771T3 DK 3666771 T3 DK3666771 T3 DK 3666771T3 DK 20154651 T DK20154651 T DK 20154651T DK 3666771 T3 DK3666771 T3 DK 3666771T3
Authority
DK
Denmark
Prior art keywords
lpa antagonists
lpa
antagonists
Prior art date
Application number
DK20154651.2T
Other languages
English (en)
Inventor
Peter Tai Wah Cheng
Jun Shi
Yan Shi
Shiwei Tao
Suresh Dhanusu
Kumaravel Selvakumar
Ramesh Babu Reddigunta
Tianan Fang
Sutjano Jusuf
Robert F Kaltenbach Iii
Jun Li
Hao Zhang
Steven J Walker
Lawrence J Kennedy
James R Corte
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK3666771T3 publication Critical patent/DK3666771T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK20154651.2T 2016-06-21 2017-06-20 Lpa-antagonister DK3666771T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662352792P 2016-06-21 2016-06-21
EP17734594.9A EP3472148B1 (en) 2016-06-21 2017-06-20 Carbamoyloxymethyl triazole cyclohexyl acids as lpa antagonists

Publications (1)

Publication Number Publication Date
DK3666771T3 true DK3666771T3 (da) 2021-11-15

Family

ID=59258388

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20154651.2T DK3666771T3 (da) 2016-06-21 2017-06-20 Lpa-antagonister
DK17734594.9T DK3472148T3 (da) 2016-06-21 2017-06-20 Carbamoyloxymethyltriazolcyclohexylsyrer som lpa-antagonister

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK17734594.9T DK3472148T3 (da) 2016-06-21 2017-06-20 Carbamoyloxymethyltriazolcyclohexylsyrer som lpa-antagonister

Country Status (32)

Country Link
US (7) US10071078B2 (da)
EP (2) EP3666771B1 (da)
JP (2) JP7073281B2 (da)
KR (2) KR102463621B1 (da)
CN (2) CN109963843B (da)
AR (1) AR108838A1 (da)
AU (2) AU2017281439B2 (da)
BR (1) BR112018076558A2 (da)
CA (1) CA3029202C (da)
CL (1) CL2018003708A1 (da)
CO (1) CO2019000471A2 (da)
CY (2) CY1123443T1 (da)
DK (2) DK3666771T3 (da)
EA (1) EA037585B1 (da)
ES (2) ES2895385T3 (da)
HR (2) HRP20211708T8 (da)
HU (2) HUE057211T2 (da)
IL (1) IL263767B (da)
LT (2) LT3472148T (da)
ME (1) ME03804B (da)
MX (1) MX2018015563A (da)
MY (1) MY195782A (da)
PE (1) PE20190211A1 (da)
PL (2) PL3666771T3 (da)
PT (2) PT3666771T (da)
RS (2) RS60347B1 (da)
SG (1) SG11201811321TA (da)
SI (2) SI3666771T1 (da)
TW (2) TWI757128B (da)
UY (1) UY37302A (da)
WO (1) WO2017223016A1 (da)
ZA (1) ZA201808580B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
CN111699180A (zh) * 2017-12-19 2020-09-22 百时美施贵宝公司 作为lpa拮抗剂的吡唑n-连接的氨基甲酰基环己基酸
KR20200101957A (ko) 2017-12-19 2020-08-28 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산
BR112020011965A2 (pt) 2017-12-19 2020-11-17 Bristol-Myers Squibb Company triazol azinas de ácido ciclo-hexílico como antagonistas de lpa
AR113965A1 (es) * 2017-12-19 2020-07-01 Bristol Myers Squibb Co Triazol azoles ciclohexil ácidos como antagonistas de lpa
WO2019126103A1 (en) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azoles as lpa antagonists
KR20200100724A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 n-연결된 카르바모일 시클로헥실 산
KR20200100754A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 이속사졸 아졸
JP7299892B2 (ja) 2017-12-19 2023-06-28 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアジン
CN111479807A (zh) 2017-12-19 2020-07-31 百时美施贵宝公司 作为lpa拮抗剂的环己基酸异噁唑吖嗪
EP3728196B1 (en) 2017-12-19 2023-04-05 Bristol-Myers Squibb Company Pyrazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
CA3085586A1 (en) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Triazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
ES2946657T3 (es) * 2018-09-18 2023-07-24 Bristol Myers Squibb Co Acidos ciclopentílicos como antagonistas de LPA
KR20210060546A (ko) * 2018-09-18 2021-05-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 옥사비시클로 산
CN112702998A (zh) 2018-09-18 2021-04-23 百时美施贵宝公司 作为lpa拮抗剂的环庚酸
CN113260310A (zh) * 2018-10-15 2021-08-13 百时美施贵宝公司 用于成像lpa1受体的放射性配体
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
CN111434653A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 三氮唑类化合物及其制备方法与用途
BR112021020399A2 (pt) 2019-04-16 2021-12-07 Bristol Myers Squibb Co Processo para preparação de compostos de ácido carbamoiloximetil triazol ciclo-hexílico
JP7465898B2 (ja) 2019-06-18 2024-04-11 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのトリアゾールカルボン酸
JP7422788B2 (ja) 2019-06-18 2024-01-26 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのイソキサゾールカルボン酸
US20220235027A1 (en) 2019-06-18 2022-07-28 Bristol-Myers Squibb Company Cyclobutyl carboxylic acids as lpa antagonists
CN114206832A (zh) 2019-07-30 2022-03-18 大正制药株式会社 拮抗lpa1受体的脲化合物
EP4058144A1 (en) * 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
JPWO2021107125A1 (da) * 2019-11-29 2021-06-03
EP4073069B1 (en) 2019-12-12 2023-12-06 Chiesi Farmaceutici S.p.A. Aromatic amido derivatives as lpa receptor 2 inhibitors
WO2021116260A1 (en) 2019-12-12 2021-06-17 Chiesi Farmaceutici S.P.A. Quinazoline derivatives as lpa receptor 2 inhibitors
WO2021116257A1 (en) 2019-12-12 2021-06-17 Chiesi Farmaceutici S.P.A. Thienopyrimidine derivatives as lpa receptor 2 inhibitors
CN111195254B (zh) * 2020-02-25 2021-03-16 中国医学科学院阜外医院 Lpa2及其激动剂的应用
KR102393079B1 (ko) 2020-02-28 2022-04-29 한국화학연구원 가축 호흡기 질환의 예방 또는 치료용 조성물
CA3183097A1 (en) * 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20230019880A (ko) 2020-06-03 2023-02-09 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
JP2023533851A (ja) 2020-07-16 2023-08-04 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｌｐａ受容体阻害剤としてのアミドシクロヘキサン酸誘導体
EP4232431A1 (en) * 2020-10-22 2023-08-30 Lhotse Bio, Inc. Compounds and compositions for treating conditions associated with lpa receptor activity
CN114456159A (zh) * 2020-11-10 2022-05-10 武汉人福创新药物研发中心有限公司 氮取代杂环噻吩类化合物及其用途
CN114456157A (zh) * 2020-11-10 2022-05-10 武汉人福创新药物研发中心有限公司 氮取代氨基碳酸酯噻吩类化合物及其用途
CN114456147A (zh) * 2020-11-10 2022-05-10 武汉人福创新药物研发中心有限公司 氧取代氨基碳酸酯噻吩类化合物
CN114621135B (zh) * 2020-12-11 2024-01-30 上海拓界生物医药科技有限公司 一种lpa1小分子拮抗剂
CN112778187B (zh) * 2021-01-06 2022-10-28 烟台舜康生物科技有限公司 一种海那替尼中间体的合成方法及所得的海纳替尼中间体
WO2022174882A1 (en) 2021-02-16 2022-08-25 Chiesi Farmaceutici S.P.A. 5-membered heterocyclyl carbamate derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
WO2022174883A1 (en) 2021-02-16 2022-08-25 Chiesi Farmaceutici S.P.A. 5-membered heterocyclyl derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
CA3212918A1 (en) 2021-03-24 2022-09-29 Gabriele Amari 8-cyclo-substituted quinazoline derivatives as lpa receptor 2 inhibitors
CA3218917A1 (en) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2022270621A1 (ja) * 2021-06-25 2022-12-29 公益財団法人がん研究会 骨肉腫及び神経膠腫の転移と増殖を抑制する新規治療薬
EP4375277A1 (en) 2021-07-20 2024-05-29 Tuojie Biotech (Shanghai) Co., Ltd. Lpa1 small molecule antagonist
WO2023066359A1 (en) * 2021-10-21 2023-04-27 Lhotse Bio, Inc. Compounds and compositions for treating conditions associated with lpa receptor activity
WO2023107938A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
CN116640117A (zh) * 2021-12-15 2023-08-25 武汉人福创新药物研发中心有限公司 三氮唑类lpar1拮抗剂及其用途
WO2023118253A1 (en) 2021-12-23 2023-06-29 Chiesi Farmaceutici S.P.A. Cyclohexane acid derivatives as lpa receptor inhibitors
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物
WO2023170025A1 (en) 2022-03-08 2023-09-14 Chiesi Farmaceutici S.P.A. Amido cyclopropyl derivatives as lpa receptor inhibitors
WO2023178061A1 (en) 2022-03-15 2023-09-21 Bristol-Myers Squibb Company Biocatalytic synthesis of (1s,3s)-3-hydroxycyclohexane-1-carboxylic acid compounds
CN117024409A (zh) * 2023-10-10 2023-11-10 药康众拓(北京)医药科技有限公司 氘代lpa1抑制剂化合物及其用途

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1695422A (en) 1928-12-18 A cobpobation
US1695432A (en) 1924-03-18 1928-12-18 Arthur W Lovejoy Toilet-paper holder
US1695455A (en) 1925-12-07 1928-12-18 Delpech Jacques Apparatus for the manufacture of artificial filaments
US1677284A (en) 1926-04-23 1928-07-17 Goodrich Co B F Sheet material and method of making and mounting the same
US1695431A (en) 1926-10-05 1928-12-18 Fred H Linley Combustion control in steam-boiler furnaces
GB267434A (en) 1926-11-12 1927-03-17 Thomas Whyte Guthrie An improved billiard-cue tip
US1695454A (en) 1927-05-23 1928-12-18 Edward J Coyne Door spring
IT1237793B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
EP1364659B1 (en) 2001-02-08 2009-11-11 Ono Pharmaceutical Co., Ltd. Remedies for urinary diseases comprising lpa receptor controlling agents
RU2006127575A (ru) 2004-02-18 2008-03-27 Астразенека Аб (Se) Соединение триазола и их применение в качестве антагонистов метаботропного рецептора глутамата
DE102004038403B4 (de) 2004-08-07 2006-08-31 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten
US20080186971A1 (en) 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
GB0806794D0 (en) 2008-04-15 2008-05-14 Ludwig Inst Cancer Res Therapeutic compounds
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2012062623A1 (en) * 2010-11-09 2012-05-18 F. Hoffmann-La Roche Ag Triazole derivatives as ligands for gaba receptors
US8742097B2 (en) * 2010-11-09 2014-06-03 Hoffmann-La Roche Inc. Triazole compounds I
PE20140879A1 (es) 2010-12-07 2014-08-06 Amira Pharmaceuticals Inc Antagonistas del receptor de acido lisofosfatidico para el tratamiento de fibrosis
CN103443098B (zh) * 2011-01-30 2016-03-16 广州源生医药科技有限公司 作为溶血磷脂酸受体的拮抗剂的化合物、组合物及其应用
US9527807B2 (en) 2011-04-05 2016-12-27 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
WO2013085824A1 (en) * 2011-12-04 2013-06-13 Angion Biomedica Corp. Small molecule anti-fibrotic compounds and uses thereof
EP2864301A1 (en) 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG N-aryltriazole compounds as lpar antagonists
CA2869541A1 (en) * 2012-06-20 2013-12-27 F. Hoffmann-La Roche Ag N-alkyltriazole compounds as lpar antagonists
WO2014001279A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
AR108745A1 (es) 2016-06-21 2018-09-19 Syngenta Participations Ag Derivados de oxadiazol microbiocidas
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
CA3085586A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Triazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
CN111479807A (zh) 2017-12-19 2020-07-31 百时美施贵宝公司 作为lpa拮抗剂的环己基酸异噁唑吖嗪
EP3728196B1 (en) 2017-12-19 2023-04-05 Bristol-Myers Squibb Company Pyrazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
CN111699180A (zh) 2017-12-19 2020-09-22 百时美施贵宝公司 作为lpa拮抗剂的吡唑n-连接的氨基甲酰基环己基酸
JP7299892B2 (ja) 2017-12-19 2023-06-28 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアジン
WO2019126103A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azoles as lpa antagonists
KR20200100724A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 n-연결된 카르바모일 시클로헥실 산
KR20200100754A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 이속사졸 아졸
BR112020011965A2 (pt) 2017-12-19 2020-11-17 Bristol-Myers Squibb Company triazol azinas de ácido ciclo-hexílico como antagonistas de lpa
KR20200101957A (ko) 2017-12-19 2020-08-28 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산

Also Published As

Publication number Publication date
JP7073281B2 (ja) 2022-05-23
SI3472148T1 (sl) 2020-07-31
TW202126629A (zh) 2021-07-16
TW201808919A (zh) 2018-03-16
DK3472148T3 (da) 2020-04-27
TWI725200B (zh) 2021-04-21
USRE49352E1 (en) 2023-01-03
PT3472148T (pt) 2020-05-08
HUE057211T2 (hu) 2022-04-28
LT3472148T (lt) 2020-05-25
CA3029202A1 (en) 2017-12-28
PT3666771T (pt) 2021-10-27
ES2785951T3 (es) 2020-10-08
PL3666771T3 (pl) 2021-12-27
US20170360759A1 (en) 2017-12-21
CL2018003708A1 (es) 2019-02-08
RS62524B1 (sr) 2021-11-30
US10071078B2 (en) 2018-09-11
KR20190020049A (ko) 2019-02-27
PL3472148T3 (pl) 2020-12-14
UY37302A (es) 2018-01-02
EP3472148B1 (en) 2020-03-11
RS60347B1 (sr) 2020-07-31
EP3666771B1 (en) 2021-09-29
KR102463621B1 (ko) 2022-11-03
CA3029202C (en) 2022-03-01
EP3666771A1 (en) 2020-06-17
US20200138789A1 (en) 2020-05-07
HRP20211708T1 (hr) 2022-02-04
IL263767A (en) 2019-01-31
LT3666771T (lt) 2021-12-10
EA201892710A1 (ru) 2019-05-31
PE20190211A1 (es) 2019-02-07
CY1123443T1 (el) 2021-12-31
EP3472148A1 (en) 2019-04-24
AU2021209334A1 (en) 2021-08-26
HRP20211708T8 (hr) 2022-03-04
CN109963843A (zh) 2019-07-02
CO2019000471A2 (es) 2019-02-08
KR102377340B1 (ko) 2022-03-21
AU2021209334B2 (en) 2023-06-01
HUE049944T2 (hu) 2020-11-30
ME03804B (me) 2021-04-20
MY195782A (en) 2023-02-13
BR112018076558A2 (pt) 2019-04-02
NZ750013A (en) 2022-03-25
CN114601830A (zh) 2022-06-10
WO2017223016A1 (en) 2017-12-28
JP2019518766A (ja) 2019-07-04
CN109963843B (zh) 2022-03-11
JP7312295B2 (ja) 2023-07-20
TWI757128B (zh) 2022-03-01
US20220249443A1 (en) 2022-08-11
US11007180B2 (en) 2021-05-18
HRP20200586T1 (hr) 2020-07-10
SG11201811321TA (en) 2019-01-30
ZA201808580B (en) 2020-08-26
CY1124737T1 (el) 2022-07-22
JP2022106974A (ja) 2022-07-20
US20180333395A1 (en) 2018-11-22
KR20220038537A (ko) 2022-03-28
US20230390249A1 (en) 2023-12-07
EA037585B1 (ru) 2021-04-19
AU2017281439B2 (en) 2021-07-01
ES2895385T3 (es) 2022-02-21
AR108838A1 (es) 2018-10-03
SI3666771T1 (sl) 2021-12-31
US10576062B2 (en) 2020-03-03
AU2017281439A1 (en) 2019-02-07
IL263767B (en) 2021-08-31
US20210244711A1 (en) 2021-08-12
MX2018015563A (es) 2019-06-06

Similar Documents

Publication Publication Date Title
DK3666771T3 (da) Lpa-antagonister
DK3405050T3 (da) Børnesikret snusbeholder
DK3436823T3 (da) Antigen-array
FI20160137A (fi) Vikavirtaindikaattori
DK3335532T3 (da) Tandharve
DK3445708T3 (da) Stigbøjle
DK3402792T3 (da) Quinolin-2-on-derivater
DK3509963T3 (da) Pallecontainer
FI20165164A (fi) Kellukekone
DK3528829T3 (da) Bacitracin-alginat-oligomer-konjugater
DK3575238T3 (da) Pallecontainer
DE112017006386A5 (de) Schraubarbeitszylinder
DE112017000734A5 (de) Glycolsensor
DK3310756T3 (da) Thromboxanreceptorantagonister
DK3471535T3 (da) Dyrelift
DK3323708T3 (da) Bovfender
DK3452587T3 (da) Penicillin-g-acylaser
DK3452590T3 (da) Plademagnet
DK3295800T3 (da) Sandwichkiksindretning
DE112017006474A5 (de) Gargerätevorrichtung
DK3551954T3 (da) Rekuperator
DE112017005767A5 (de) Nasslaufende lamellenkupplung
DK3468607T3 (da) Resveratrolsolubilisat
DK3430609T3 (da) Smartflag
DE112017000296A5 (de) Radgeschwindigkeitssensorvorrichtung