CY1124737T1 - Ανταγωνιστες lpa - Google Patents

Ανταγωνιστες lpa

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Publication number
CY1124737T1
CY1124737T1 CY20211101007T CY211101007T CY1124737T1 CY 1124737 T1 CY1124737 T1 CY 1124737T1 CY 20211101007 T CY20211101007 T CY 20211101007T CY 211101007 T CY211101007 T CY 211101007T CY 1124737 T1 CY1124737 T1 CY 1124737T1
Authority
CY
Cyprus
Prior art keywords
lpa
competitors
compounds
salts
tautomers
Prior art date
Application number
CY20211101007T
Other languages
English (en)
Inventor
Peter Tai Wah CHENG
Robert F. Kaltenbach, Iii
Jun Li
Jun Shi
Yan Shi
Shiwei Tao
Hao Zhang
Suresh Dhanusu
Kumaravel Selvakumar
Ramesh Babu Reddigunta
Steven J. Walker
Lawrence J. Kennedy
James R. Corte
Tianan Fang
Sutjano JUSUF
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1124737T1 publication Critical patent/CY1124737T1/el

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
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    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/061,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του Χημικού Τύπου (Ι): ή στερεοϊσομερή, ταυτομερή, φαρμακευτικώς αποδεκτά άλατα, επιδιαλυτωμένα άλατα ή προφάρμακα εξ αυτών, όπου όλες οι μεταβλητές καθορίζονται ως εις το παρόν. Αυτές οι ενώσεις είναι επιλεκτικοί αναστολείς υποδοχέων LPA.
CY20211101007T 2016-06-21 2021-11-19 Ανταγωνιστες lpa CY1124737T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662352792P 2016-06-21 2016-06-21
EP20154651.2A EP3666771B1 (en) 2016-06-21 2017-06-20 Lpa antagonists

Publications (1)

Publication Number Publication Date
CY1124737T1 true CY1124737T1 (el) 2022-07-22

Family

ID=59258388

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20201100531T CY1123443T1 (el) 2016-06-21 2020-06-10 Οξεα καρβαμοϋλοξυμεθυλ-τριαζολ-κυκλοεξυλιου ως ανταγωνιστες lpa
CY20211101007T CY1124737T1 (el) 2016-06-21 2021-11-19 Ανταγωνιστες lpa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20201100531T CY1123443T1 (el) 2016-06-21 2020-06-10 Οξεα καρβαμοϋλοξυμεθυλ-τριαζολ-κυκλοεξυλιου ως ανταγωνιστες lpa

Country Status (32)

Country Link
US (7) US10071078B2 (el)
EP (2) EP3472148B1 (el)
JP (2) JP7073281B2 (el)
KR (2) KR102463621B1 (el)
CN (2) CN109963843B (el)
AR (1) AR108838A1 (el)
AU (2) AU2017281439B2 (el)
BR (1) BR112018076558A2 (el)
CA (1) CA3029202C (el)
CL (1) CL2018003708A1 (el)
CO (1) CO2019000471A2 (el)
CY (2) CY1123443T1 (el)
DK (2) DK3472148T3 (el)
EA (1) EA037585B1 (el)
ES (2) ES2785951T3 (el)
HR (2) HRP20211708T8 (el)
HU (2) HUE057211T2 (el)
IL (1) IL263767B (el)
LT (2) LT3472148T (el)
ME (1) ME03804B (el)
MX (1) MX2018015563A (el)
MY (1) MY195782A (el)
PE (1) PE20190211A1 (el)
PL (2) PL3666771T3 (el)
PT (2) PT3666771T (el)
RS (2) RS60347B1 (el)
SG (1) SG11201811321TA (el)
SI (2) SI3666771T1 (el)
TW (2) TWI757128B (el)
UY (1) UY37302A (el)
WO (1) WO2017223016A1 (el)
ZA (1) ZA201808580B (el)

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