DK3642331T3 - Fremgangsmåde til udvidelse af T-celler og anvendelser deraf - Google Patents

Fremgangsmåde til udvidelse af T-celler og anvendelser deraf Download PDF

Info

Publication number
DK3642331T3
DK3642331T3 DK18735229.9T DK18735229T DK3642331T3 DK 3642331 T3 DK3642331 T3 DK 3642331T3 DK 18735229 T DK18735229 T DK 18735229T DK 3642331 T3 DK3642331 T3 DK 3642331T3
Authority
DK
Denmark
Prior art keywords
expanding
cells
Prior art date
Application number
DK18735229.9T
Other languages
English (en)
Inventor
Hans Grönlund
Original Assignee
Neogap Therapeutics Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1710023.1A external-priority patent/GB201710023D0/en
Priority claimed from GBGB1716978.0A external-priority patent/GB201716978D0/en
Application filed by Neogap Therapeutics Ab filed Critical Neogap Therapeutics Ab
Application granted granted Critical
Publication of DK3642331T3 publication Critical patent/DK3642331T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464401—Neoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121—Dendritic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fuel Cell (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK18735229.9T 2017-06-22 2018-06-21 Fremgangsmåde til udvidelse af T-celler og anvendelser deraf DK3642331T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1710023.1A GB201710023D0 (en) 2017-06-22 2017-06-22 T-cell expansion method and uses
GBGB1716978.0A GB201716978D0 (en) 2017-10-16 2017-10-16 T-cell expansion method and uses
PCT/EP2018/066690 WO2018234516A2 (en) 2017-06-22 2018-06-21 METHOD AND APPARATUS FOR EXPANSION OF T CELLULOCYTES

Publications (1)

Publication Number Publication Date
DK3642331T3 true DK3642331T3 (da) 2023-07-31

Family

ID=62784126

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18735229.9T DK3642331T3 (da) 2017-06-22 2018-06-21 Fremgangsmåde til udvidelse af T-celler og anvendelser deraf

Country Status (11)

Country Link
US (1) US20200140813A1 (da)
EP (2) EP4248980A3 (da)
JP (1) JP7218309B2 (da)
KR (1) KR20200020904A (da)
CN (1) CN110785487A (da)
AU (1) AU2018287169A1 (da)
CA (1) CA3068103A1 (da)
DK (1) DK3642331T3 (da)
ES (1) ES2950653T3 (da)
FI (1) FI3642331T3 (da)
WO (1) WO2018234516A2 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111638329B (zh) * 2020-06-09 2021-06-01 南方医科大学 一种用于检测布鲁氏菌病elispot检测试剂盒及其应用
EP4032973B1 (en) 2021-01-21 2023-07-19 Guizhou Sinorda Biotechnology CO., Ltd. Modified t cells for adoptive immunotherapy
AU2021395504A1 (en) 2020-12-08 2023-06-29 Guizhou Sinorda Biotechnology Co. Ltd. Modified t cells for adoptive immunotherapy
US20230092508A1 (en) * 2021-09-20 2023-03-23 Droplet Biosciences, Inc. Methods for disease assessment using drain fluid

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200502391A (en) * 2003-05-08 2005-01-16 Xcyte Therapies Inc Generation and isolation of antigen-specific t cells
US20080171059A1 (en) * 2006-08-07 2008-07-17 Shanshan Wu Howland Methods and compositions for increased priming of t-cells through cross-presentation of exogenous antigens
US9107858B2 (en) * 2007-12-05 2015-08-18 Wisconsin Alumni Research Foundation Dendritic cell targeting compositions and uses thereof
CA2779601A1 (en) * 2009-11-02 2011-05-05 Orbis Health Solutions Llc Vaccine compositions and methods of use
WO2012159643A1 (en) * 2011-05-24 2012-11-29 Biontech Ag Individualized vaccines for cancer
AU2013351542B2 (en) * 2012-11-28 2018-08-09 BioNTech SE Individualized vaccines for cancer
EP2983702A2 (en) * 2013-04-07 2016-02-17 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
AU2015314776A1 (en) * 2014-09-14 2017-04-06 Washington University Personalized cancer vaccines and methods therefor
JP6599450B2 (ja) * 2014-10-02 2019-10-30 アメリカ合衆国 がん特異的突然変異に対し抗原特異性を有するｔ細胞を単離する方法
WO2016077215A2 (en) * 2014-11-10 2016-05-19 Yale University Modular nanodevices for smart adaptable vaccines
MY190974A (en) * 2015-05-20 2022-05-25 Massachusetts Gen Hospital Shared neoantigens
US11446390B2 (en) * 2015-11-18 2022-09-20 The University Of North Carolina At Chapel Hill Antigen capturing nanoparticles for use in cancer immunotherapy
ES2902477T3 (es) 2015-12-04 2022-03-28 Univ Texas Péptidos SLC45A2 para inmunoterapia
EP3182125A1 (en) * 2015-12-16 2017-06-21 Ab Tcer T-cell reactivity platform

Also Published As

Publication number Publication date
US20200140813A1 (en) 2020-05-07
CA3068103A1 (en) 2018-12-27
EP4248980A3 (en) 2023-12-06
JP2020524514A (ja) 2020-08-20
EP3642331B1 (en) 2023-05-24
FI3642331T3 (fi) 2023-07-24
WO2018234516A3 (en) 2019-02-14
WO2018234516A2 (en) 2018-12-27
AU2018287169A1 (en) 2020-01-16
EP4248980A2 (en) 2023-09-27
EP3642331A2 (en) 2020-04-29
KR20200020904A (ko) 2020-02-26
JP7218309B2 (ja) 2023-02-06
CN110785487A (zh) 2020-02-11
ES2950653T3 (es) 2023-10-11

Similar Documents

Publication Publication Date Title
DK3568494T3 (da) Fremgangsmåder og sammensætninger til markering af celler
DK3630761T3 (da) Kras-g12c-inhibitorer og fremgangsmåder til anvendelse af disse
DK3750418T3 (da) Aerosolgenereringsenhed og fremgangsmåde til styring af samme
DK3398022T3 (da) Systemer og fremgangsmåder til tilpasning af uav-bane
DK3402483T3 (da) Fremgangsmåder og sammensætninger til aktivering af gamma-delta-T-celler
DK3259386T3 (da) Systemer og fremgangsmåder til udførelse af immunoassays
DK3132247T3 (da) Fremgangsmåder, kits og apparat til udvidelse af en cellepopulation
DK3536008T3 (da) System og fremgangsmåde til udløsning af strålegenopretning
DK3426109T3 (da) Samling og fremgangsmåde til opskumning af fluid
DK3444334T3 (da) Fremgangsmåde til inducering af CD8+ T-celler
DK3701973T3 (da) Plasmabaseret film og fremgangsmåder til fremstilling og anvendelse af samme
DK3294762T3 (da) Ekspressionskonstruktioner og fremgangsmåder til genmanipulering af methylotrof gær
DK3230044T3 (da) Transplantationsstøttestruktur til bruskreparation og fremgangsmåde til fremstilling af denne
DK3519572T3 (da) Forbindelser og fremgangsmåder til reduktion af tau-ekspression
DK3753301T3 (da) Fremgangsmåde og indretning til opnåelse af celleoplysninger
DK3175588T3 (da) Systemer og fremgangsmåder til beskedredigering
DK3717851T3 (da) Fremgangsmåde og anordning til tørring af plader
DK3393688T3 (da) Fremgangsmåde og indretning til genindvinding af salt
DK3265555T3 (da) T-celle-ekspansion
DK3441381T3 (da) Fremgangsmåde til fremstilling af methanol og indretning til fremstilling af methanol
DK3394259T3 (da) Sammensætninger og fremgangsmåder til reducering af tau-ekspression
DK3642331T3 (da) Fremgangsmåde til udvidelse af T-celler og anvendelser deraf
DK3188051T3 (da) Systemer og fremgangsmåder til generering af søgeskabeloner
DK3541947T3 (da) Fremgangsmåde til fremstilling af elektrokompetente gærceller og fremgangsmåde til anvendelse af cellerne
DK3332940T3 (da) Silikoneekstruderingsanlæg og fremgangsmåde til silikoneekstrudering