DK3585910T3 - Sammensætninger og fremgangsmåder til forøget proteinproduktion i bacillus licheniformis - Google Patents
Sammensætninger og fremgangsmåder til forøget proteinproduktion i bacillus licheniformis Download PDFInfo
- Publication number
- DK3585910T3 DK3585910T3 DK18708867.9T DK18708867T DK3585910T3 DK 3585910 T3 DK3585910 T3 DK 3585910T3 DK 18708867 T DK18708867 T DK 18708867T DK 3585910 T3 DK3585910 T3 DK 3585910T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- methods
- bacillus licheniformis
- protein production
- increased protein
- Prior art date
Links
- 241000194108 Bacillus licheniformis Species 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000014616 translation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463268P | 2017-02-24 | 2017-02-24 | |
| PCT/US2018/019140 WO2018156705A1 (en) | 2017-02-24 | 2018-02-22 | Compositions and methods for increased protein production in bacillus licheniformis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585910T3 true DK3585910T3 (da) | 2024-06-17 |
Family
ID=61563545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18708867.9T DK3585910T3 (da) | 2017-02-24 | 2018-02-22 | Sammensætninger og fremgangsmåder til forøget proteinproduktion i bacillus licheniformis |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11866713B2 (da) |
| EP (2) | EP4353828A3 (da) |
| JP (1) | JP7231228B2 (da) |
| KR (1) | KR102375732B1 (da) |
| CN (1) | CN110520520B (da) |
| DK (1) | DK3585910T3 (da) |
| FI (1) | FI3585910T3 (da) |
| WO (1) | WO2018156705A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111670244B (zh) * | 2018-01-03 | 2023-08-01 | 丹尼斯科美国公司 | 突变的和遗传修饰的芽孢杆菌属细胞及其用于增加蛋白质产生的方法 |
| US11781147B2 (en) | 2018-11-28 | 2023-10-10 | Danisco Us Inc. | Promoter sequences and methods thereof for enhanced protein production in Bacillus cells |
| CA3136113A1 (en) | 2019-04-05 | 2020-10-08 | Danisco Us Inc. | Methods for polynucleotide integration into the genome of bacillus using dual circular recombinant dna constructs and compositions thereof |
| CA3136114A1 (en) | 2019-04-05 | 2020-10-08 | Danisco Us Inc. | Methods for integrating a donor dna sequence into the genome of bacillus using linear recombinant dna constructs and compositions thereof |
| WO2021030267A1 (en) | 2019-08-14 | 2021-02-18 | Danisco Us Inc | Compositions and methods for increased protein production in bacillus licheniformis |
| CN112980755B (zh) * | 2019-12-13 | 2023-05-12 | 中国科学院天津工业生物技术研究所 | 高效分泌异淀粉酶的基因工程菌 |
| CN114945665A (zh) | 2020-01-15 | 2022-08-26 | 丹尼斯科美国公司 | 用于增强地衣芽孢杆菌中蛋白产生的组合物和方法 |
| GB202001211D0 (en) * | 2020-01-29 | 2020-03-11 | Imperial College Innovations Ltd | Methods |
| CN115176018A (zh) * | 2020-03-04 | 2022-10-11 | 巴斯夫欧洲公司 | 用于大肠杆菌和芽孢杆菌中表达的穿梭载体 |
| CN112062822B (zh) * | 2020-09-24 | 2022-02-01 | 江南大学 | 一种碳分解代谢调控蛋白CcpA突变体I42A |
| CN112062821B (zh) * | 2020-09-24 | 2022-02-01 | 江南大学 | 一种碳分解代谢调控蛋白CcpA突变体K31A |
| EP4294823A1 (en) | 2021-02-22 | 2023-12-27 | Danisco US Inc. | Methods and compositions for producing proteins of interest in pigment deficient bacillus cells |
| CN117769597A (zh) | 2021-05-24 | 2024-03-26 | 丹尼斯科美国公司 | 用于增强芽孢杆菌属细胞中蛋白质产生的组合物和方法 |
| CN113430179B (zh) * | 2021-06-28 | 2022-05-20 | 济宁医学院 | 具有越膜能力的、高稳定型的超氧化物歧化酶的制备方法 |
| CN117836315A (zh) | 2021-08-20 | 2024-04-05 | 丹尼斯科美国公司 | 用于增强芽孢杆菌属细胞中蛋白质产生的方法和组合物 |
| WO2023091878A1 (en) | 2021-11-16 | 2023-05-25 | Danisco Us Inc. | Compositions and methods for enhanced protein production in bacillus cells |
| CA3238467A1 (en) | 2021-11-18 | 2023-05-25 | Veli Alkan | High performance alpha-amylases for starch liquefaction |
| WO2024118882A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative multiplex genome engineering in microbial cells using a selection marker swapping system |
| WO2024118876A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system |
| WO2024118881A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5310675A (en) | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
| US5700676A (en) | 1984-05-29 | 1997-12-23 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| JP2599946B2 (ja) | 1986-01-15 | 1997-04-16 | アムジェン，インコーポレイテツド | ズブチリシン類似体 |
| US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
| US4914031A (en) | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
| DE3909096A1 (de) | 1989-03-20 | 1990-09-27 | Garabed Antranikian | Alpha-amylase |
| US5665587A (en) | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
| US5482849A (en) | 1990-12-21 | 1996-01-09 | Novo Nordisk A/S | Subtilisin mutants |
| KR100258460B1 (ko) | 1991-05-01 | 2000-06-01 | 한센 핀 베네드 | 안정화 효소 및 세제 조성물 |
| PL310326A1 (en) | 1993-02-11 | 1995-12-11 | Genencor Int | Novel oxidation-stable mutants of alpha-amylase as well as detergent and starch liquefaction compositions containing them |
| DE4411223A1 (de) | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren |
| JP4358431B2 (ja) | 1997-10-13 | 2009-11-04 | ノボザイムス アクティーゼルスカブ | α−アミラーゼ変異体 |
| AR015977A1 (es) | 1997-10-23 | 2001-05-30 | Genencor Int | Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes |
| CN103352033B (zh) | 1998-02-27 | 2016-05-11 | 诺维信公司 | 麦芽α淀粉酶变体 |
| US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6197565B1 (en) | 1998-11-16 | 2001-03-06 | Novo-Nordisk A/S | α-Amylase variants |
| CN1252256C (zh) | 1999-03-30 | 2006-04-19 | 诺维信公司 | α－淀粉酶变体 |
| MXPA01012179A (es) | 1999-05-28 | 2002-07-22 | Novozymes As | Nuevas endo-beta-1,4-glucanasas. |
| US6509185B1 (en) | 2000-01-07 | 2003-01-21 | Genencor International, Inc. | Mutant aprE promotor |
| DE60134752D1 (de) | 2000-08-11 | 2008-08-21 | Genencor Int | Transformation von bacillus, transformanten und mutanten-bibliotheken |
| WO2002029113A2 (en) | 2000-10-06 | 2002-04-11 | Novozymes Biotech, Inc. | Methods for monitoring multiple gene expression |
| DK2339016T3 (da) | 2002-03-29 | 2017-01-23 | Danisco Us Inc | Øget produktion af subtilisiner |
| EP1576094B1 (en) | 2002-04-22 | 2011-09-28 | Danisco US Inc. | Methods of creating modified promoters resulting in varying levels of gene expression |
| DE102004030938A1 (de) | 2004-06-26 | 2006-01-12 | Henkel Kgaa | Neue, Polyaminosäuren bildende oder abbauende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| DE102004047777B4 (de) | 2004-10-01 | 2018-05-09 | Basf Se | Alpha-Amylase-Varianten mit erhöhter Lösungsmittelstabilität, Verfahren zu deren Herstellung sowie deren Verwendung |
| DE102004047776B4 (de) | 2004-10-01 | 2018-05-09 | Basf Se | Gegen Di- und/oder Multimerisierung stabilisierte Alpha-Amylase-Varianten, Verfahren zu deren Herstellung sowie deren Verwendung |
| ZA200706858B (en) | 2005-02-18 | 2008-10-29 | Genencor Int | Polypeptides having alpha-amylase and granular starch hydrolyzing activity |
| US7968691B2 (en) | 2006-08-23 | 2011-06-28 | Danisco Us Inc. | Pullulanase variants with increased productivity |
| EP2099818A2 (en) | 2006-11-29 | 2009-09-16 | Novozymes Inc. | Bacillus licheniformis chromosome |
| CN101679987A (zh) | 2007-03-09 | 2010-03-24 | 丹尼斯科美国公司 | 嗜碱芽孢杆菌物种α-淀粉酶变体、包括α-淀粉酶变体的组合物以及使用方法 |
| RU2009149405A (ru) | 2007-05-30 | 2011-07-10 | ДАНИСКО ЮЭс, ИНК., ДЖЕНЕНКОР ДИВИЖН (US) | Улучшенные варианты альфа-амилазы bacillus licheniformis |
| CN101679960B (zh) | 2007-05-30 | 2013-01-16 | 丹尼斯科美国公司 | 在发酵过程中具有改良生产水平的α-淀粉酶的变体 |
| PL2447361T3 (pl) | 2008-06-06 | 2015-03-31 | Danisco Us Inc | Warianty alfa-amylazy (AMYS) z Geobacillus stearothermophilus o poprawionych właściwościach |
| ES2604666T3 (es) | 2009-05-19 | 2017-03-08 | Dupont Nutrition Biosciences Aps | Polipéptidos de amilasa |
| JP5687566B2 (ja) | 2011-06-01 | 2015-03-18 | 日東電工株式会社 | 防水通音部材 |
| EP2788491B1 (en) | 2011-12-09 | 2019-01-23 | Danisco US Inc. | Ribosomal promotors from b. subtilis for protein production in microorganisms |
| US20160017305A1 (en) | 2013-03-11 | 2016-01-21 | Danisco Us Inc. | Alpha-amylase combinatorial variants |
-
2018
- 2018-02-22 WO PCT/US2018/019140 patent/WO2018156705A1/en unknown
- 2018-02-22 US US16/486,892 patent/US11866713B2/en active Active
- 2018-02-22 DK DK18708867.9T patent/DK3585910T3/da active
- 2018-02-22 EP EP24152366.1A patent/EP4353828A3/en active Pending
- 2018-02-22 JP JP2019546341A patent/JP7231228B2/ja active Active
- 2018-02-22 EP EP18708867.9A patent/EP3585910B1/en active Active
- 2018-02-22 KR KR1020197027398A patent/KR102375732B1/ko active IP Right Grant
- 2018-02-22 FI FIEP18708867.9T patent/FI3585910T3/fi active
- 2018-02-22 CN CN201880024359.9A patent/CN110520520B/zh active Active
-
2023
- 2023-11-30 US US18/524,856 patent/US20240182914A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240182914A1 (en) | 2024-06-06 |
| EP3585910A1 (en) | 2020-01-01 |
| CN110520520B (zh) | 2024-03-22 |
| WO2018156705A1 (en) | 2018-08-30 |
| EP4353828A3 (en) | 2024-07-24 |
| EP3585910B1 (en) | 2024-03-20 |
| KR20190121331A (ko) | 2019-10-25 |
| US11866713B2 (en) | 2024-01-09 |
| JP7231228B2 (ja) | 2023-03-01 |
| US20200056193A1 (en) | 2020-02-20 |
| JP2020508072A (ja) | 2020-03-19 |
| FI3585910T3 (fi) | 2024-06-19 |
| EP4353828A2 (en) | 2024-04-17 |
| CN110520520A (zh) | 2019-11-29 |
| KR102375732B1 (ko) | 2022-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3585910T3 (da) | Sammensætninger og fremgangsmåder til forøget proteinproduktion i bacillus licheniformis | |
| DK3658557T3 (da) | Tyk2-inhibitorer og anvendelser deraf | |
| IL262321A (en) | Preparations and methods for selective protein expression | |
| DK3601533T3 (da) | Fremgangsmåder til frembringelse af tumorinfiltrerende lymfocytter og anvendelser af samme i immunoterapi | |
| KR20180084895A (ko) | 효소 내재화 조성물 및 방법 | |
| DK3453707T3 (da) | Benzazepinderivat, fremgangsmåde til fremstilling, farmaceutisk sammensætning og anvendelse deraf | |
| DK3581190T3 (da) | Manipulerede naturlige dræberceller og anvendelser deraf | |
| DK3524603T3 (da) | Fgfr4-hæmmer, fremgangsmåde til fremstilling deraf og farmaceutisk anvendelse deraf | |
| DK3580561T3 (da) | Hla-baserede metoder, sammensætninger og anvendelse heraf | |
| DK3471755T3 (da) | Pegyleret svineinterferon og fremgangsmåder til anvendelse deraf | |
| DK3368655T3 (da) | Forbedret proteinekspression og fremgangsmåder dertil | |
| DK3268470T3 (da) | Transposasepolypeptider og anvendelser deraf | |
| DK3247393T3 (da) | Matrixmetalloproteasespaltelige og serinproteasespaltelige substrater og fremgangsmåder til anvendelse deraf | |
| DK3240895T3 (da) | Sammensætninger og fremgangsmåder til proteinglykosylering | |
| DK3235830T3 (da) | Interleukin-15-proteinkompleks og anvendelse deraf | |
| DK3402483T3 (da) | Fremgangsmåder og sammensætninger til aktivering af gamma-delta-T-celler | |
| DK3484865T3 (da) | Somatostatinmodulatorer og anvendelser deraf | |
| DK3565579T3 (da) | Pd1-41bbl-fusionsprotein og fremgangsmåder til anvendelse deraf | |
| DK3368571T3 (da) | Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf | |
| ZA201900209B (en) | Novel natural protein and application thereof | |
| DK3240436T3 (da) | Sammensætning indeholdende kitin og fordøjelige proteiner | |
| DK3621694T3 (da) | Lrrc33-inhibitorer og anvendelse heraf | |
| DK3380496T3 (da) | Forbedret proteinproduktion og fremgangsmåder hertil | |
| DK3142659T3 (da) | Hiv-1 proteasehæmmere og anvendelser deraf | |
| DK3325618T3 (da) | Hidtil ukendte trypsin-isoformer og anvendelse deraf |