DK3563156T3 - Fremgangsmåde til separering af biomolekyler - Google Patents

Fremgangsmåde til separering af biomolekyler Download PDF

Info

Publication number: DK3563156T3
Authority: DK; Denmark
Prior art keywords: biomolecules; separation; procedure
Prior art date: 2016-12-28

Application number

DK17840481.0T

Other languages

English (en)

Inventor

Ola Lind

Johan Avallin

Andreas Lundin

Nils Norrman

Ronnie Palmgren

Gustav Rodrigo

Original Assignee

Cytiva Sweden Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-12-28

Filing date

2017-12-27

Publication date

2021-11-08

2016-12-28 Priority claimed from GBGB1622305.9A external-priority patent/GB201622305D0/en

2016-12-28 Priority claimed from GBGB1622304.2A external-priority patent/GB201622304D0/en

2016-12-28 Priority claimed from GBGB1622307.5A external-priority patent/GB201622307D0/en

2017-12-27 Application filed by Cytiva Sweden Ab filed Critical Cytiva Sweden Ab

2021-11-08 Application granted granted Critical

2021-11-08 Publication of DK3563156T3 publication Critical patent/DK3563156T3/da

Links

238000000034 method Methods 0.000 title 1
238000000926 separation method Methods 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0009—Settling tanks making use of electricity or magnetism
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/30—Combinations with other devices, not otherwise provided for
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/07—Means for pre-treatment of biological substances by electrical or electromagnetic forces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
- G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Sustainable Development (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Clinical Laboratory Science (AREA)
Electromagnetism (AREA)
Chemical Kinetics & Catalysis (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Peptides Or Proteins (AREA)

DK17840481.0T 2016-12-28 2017-12-27 Fremgangsmåde til separering af biomolekyler DK3563156T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB1622305.9A GB201622305D0 (en)	2016-12-28	2016-12-28	Magnetic immunoglobulin-binding particles
GBGB1622304.2A GB201622304D0 (en)	2016-12-28	2016-12-28	Magnetic immunoglobulin-binding particles
GBGB1622307.5A GB201622307D0 (en)	2016-12-28	2016-12-28	A method and system for separating biomolecules
PCT/EP2017/084620 WO2018122246A1 (en)	2016-12-28	2017-12-27	A method and system for separating biomolecules

Publications (1)

Publication Number	Publication Date
DK3563156T3 true DK3563156T3 (da)	2021-11-08

Family

ID=60943003

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK17826229.1T DK3563154T3 (da)	2016-12-28	2017-12-21	Magnetiske immunoglobulin-bindende partikler
DK17840481.0T DK3563156T3 (da)	2016-12-28	2017-12-27	Fremgangsmåde til separering af biomolekyler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK17826229.1T DK3563154T3 (da)	2016-12-28	2017-12-21	Magnetiske immunoglobulin-bindende partikler

Country Status (8)

Country	Link
US (3)	US11846635B2 (da)
EP (2)	EP3563154B1 (da)
JP (1)	JP7072968B2 (da)
CN (2)	CN110121646B (da)
DK (2)	DK3563154T3 (da)
ES (2)	ES2886173T3 (da)
SI (1)	SI3563156T1 (da)
WO (2)	WO2018122089A1 (da)

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US11214789B2 (en)	2016-05-03	2022-01-04	Flodesign Sonics, Inc.	Concentration and washing of particles with acoustics
CN111100780A (zh) *	2018-10-26	2020-05-05	南京金斯瑞生物科技有限公司	一种半连续流的磁珠纯化***
AU2020246969A1 (en)	2019-03-27	2021-09-16	Cytiva Sweden Ab	A method for separating biomolecules
WO2021064244A1 (en) *	2019-10-05	2021-04-08	Lab-On-A-Bead Ab	Purification process based on magnetic beads
US20210260600A1 (en) *	2020-02-01	2021-08-26	Sunil Mehta	Automated device and method to purify biomaterials from a mixture by using magnetic particles and disposable product-contact materials
EP4226163A1 (en) *	2020-10-12	2023-08-16	Life Technologies AS	Magnetic particle processing systems for use with biological cells and related methods
US20220169991A1 (en) *	2020-12-01	2022-06-02	Global Life Sciences Solutions Usa Llc	Viral vector purification apparatus and method
CN113721015B (zh) *	2021-09-08	2023-03-21	中国农业大学	微生物自动化检测装置、***及方法
CN113583865A (zh) *	2021-10-08	2021-11-02	深圳市瑞沃德生命科技有限公司	分选柱的制备方法及分选柱
CA3237161A1 (en) *	2021-11-15	2023-05-19	Mcmaster University	Magnetic microgel beads, methods of making and uses thereof
GB202206123D0 (en)	2022-04-27	2022-06-08	Cytiva Bioprocess R & D Ab	A pre-screening method and a method for separating adeno-associated virus capsids
CN115524482A (zh) *	2022-09-27	2022-12-27	深圳赛桥生物创新技术有限公司	磁珠分选方法、设备及存储介质
GB202214280D0 (en)	2022-09-29	2022-11-16	Cytiva Vioprocess R&D Ab	Chromatography ligand and chromatography material, and uses thereof

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US20040146855A1 (en)	2003-01-27	2004-07-29	Marchessault Robert H.	Formation of superparamagnetic particles
EP1621890A1 (en)	2004-07-26	2006-02-01	bioMerieux B.V.	Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
US7897257B2 (en)	2005-04-18	2011-03-01	Ge Healthcare Bio-Sciences Ab	Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof
US20080283792A1 (en)	2005-10-28	2008-11-20	Ge Healthcare Bio-Sciences Ab	Separation Medium with Various Functionalities
WO2009102258A1 (en)	2008-02-15	2009-08-20	Ge Healthcare Bio-Sciences Ab	Separation of biomolecules
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JP5691161B2 (ja)	2009-11-19	2015-04-01	Jnc株式会社	タンパク質の精製方法
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CN102586225B (zh) *	2011-01-14	2014-07-09	博奥生物集团有限公司	一种操纵磁珠分离目标分子的方法
US8668886B2 (en)	2011-04-24	2014-03-11	Therapeutic Proteins International, LLC	Separative bioreactor
WO2013081540A1 (en) *	2011-11-30	2013-06-06	Ge Healthcare Bio-Sciences Ab	Affinity chromatography matrix
EP2639294A1 (fr) *	2012-03-15	2013-09-18	CellProthera	Automate et procédé automatisé de culture cellulaire
CN102838674A (zh) *	2012-09-20	2012-12-26	海狸纳米科技（苏州）有限公司	一种利用蛋白a的高密度包被磁珠纯化抗体的方法
JP5540291B1 (ja)	2013-02-27	2014-07-02	仁木工芸株式会社	磁気分離装置及び磁気分離装置を使用した生物由来物質精製システム
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CN104475041A (zh) *	2014-10-22	2015-04-01	哈尔滨工业大学	制备琼脂糖磁性微球的新方法及其在分离纯化IgG抗体中的用途
CN105418730A (zh)	2015-11-13	2016-03-23	洛阳惠尔纳米科技有限公司	一种基于磁珠法的抗体纯化方法

2017
- 2017-12-21 ES ES17826229T patent/ES2886173T3/es active Active
- 2017-12-21 CN CN201780081112.6A patent/CN110121646B/zh active Active
- 2017-12-21 EP EP17826229.1A patent/EP3563154B1/en active Active
- 2017-12-21 WO PCT/EP2017/084033 patent/WO2018122089A1/en unknown
- 2017-12-21 US US16/470,677 patent/US11846635B2/en active Active
- 2017-12-21 DK DK17826229.1T patent/DK3563154T3/da active
- 2017-12-27 SI SI201730950T patent/SI3563156T1/sl unknown
- 2017-12-27 US US16/470,607 patent/US11686726B2/en active Active
- 2017-12-27 WO PCT/EP2017/084620 patent/WO2018122246A1/en unknown
- 2017-12-27 EP EP17840481.0A patent/EP3563156B1/en active Active
- 2017-12-27 ES ES17840481T patent/ES2896939T3/es active Active
- 2017-12-27 DK DK17840481.0T patent/DK3563156T3/da active
- 2017-12-27 CN CN201780081042.4A patent/CN110088626B/zh active Active
- 2017-12-27 JP JP2019535894A patent/JP7072968B2/ja active Active
2023
- 2023-05-15 US US18/317,411 patent/US20230333098A1/en active Pending

Also Published As

Publication number	Publication date
US20190339261A1 (en)	2019-11-07
US11686726B2 (en)	2023-06-27
ES2896939T3 (es)	2022-02-28
DK3563154T3 (da)	2021-09-20
US11846635B2 (en)	2023-12-19
CN110088626A (zh)	2019-08-02
ES2886173T3 (es)	2021-12-16
JP7072968B2 (ja)	2022-05-23
EP3563156B1 (en)	2021-10-13
CN110121646B (zh)	2023-06-20
EP3563154B1 (en)	2021-07-28
EP3563156A1 (en)	2019-11-06
JP2020503865A (ja)	2020-02-06
US20230333098A1 (en)	2023-10-19
SI3563156T1 (sl)	2021-12-31
US20200087614A1 (en)	2020-03-19
CN110088626B (zh)	2023-06-20
EP3563154A1 (en)	2019-11-06
CN110121646A (zh)	2019-08-13
WO2018122246A1 (en)	2018-07-05
WO2018122089A1 (en)	2018-07-05

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