DK3395354T3 - Plasminogen til anvendelse i behandling af diabetisk nefropati - Google Patents
Plasminogen til anvendelse i behandling af diabetisk nefropati Download PDFInfo
- Publication number
- DK3395354T3 DK3395354T3 DK16874925.7T DK16874925T DK3395354T3 DK 3395354 T3 DK3395354 T3 DK 3395354T3 DK 16874925 T DK16874925 T DK 16874925T DK 3395354 T3 DK3395354 T3 DK 3395354T3
- Authority
- DK
- Denmark
- Prior art keywords
- plasminogen
- treatment
- diabetic nephropathy
- nephropathy
- diabetic
- Prior art date
Links
- 208000007342 Diabetic Nephropathies Diseases 0.000 title 1
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 208000033679 diabetic kidney disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2015097944 | 2015-12-18 | ||
PCT/CN2016/110450 WO2017101868A1 (zh) | 2015-12-18 | 2016-12-16 | 一种预防和治疗糖尿病肾病的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3395354T3 true DK3395354T3 (da) | 2024-06-03 |
Family
ID=59055777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16874925.7T DK3395354T3 (da) | 2015-12-18 | 2016-12-16 | Plasminogen til anvendelse i behandling af diabetisk nefropati |
Country Status (8)
Country | Link |
---|---|
US (1) | US11090372B2 (da) |
EP (1) | EP3395354B1 (da) |
JP (1) | JP6682008B2 (da) |
CN (1) | CN108778307A (da) |
CA (1) | CA3008686C (da) |
DK (1) | DK3395354T3 (da) |
TW (1) | TWI725092B (da) |
WO (1) | WO2017101868A1 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017101868A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
CN108472342B (zh) | 2015-12-18 | 2022-11-15 | 泰伦基国际有限公司 | 一种用于预防或治疗急性及慢性血栓的方法 |
TWI624267B (zh) | 2015-12-18 | 2018-05-21 | Talengen Institute Of Life Sciences Co Ltd | 纖溶酶原在製備預防或治療糖尿病性視網膜病變的藥劑上的用途及包括纖溶酶原用於預防或治療糖尿病性視網膜病變之藥劑 |
CA3008466C (en) | 2015-12-18 | 2023-06-20 | Talengen International Limited | Method for preventing or treating radiation and chemical damage |
CN108463235A (zh) | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种用于预防和治疗***的方法 |
TWI653981B (zh) | 2015-12-18 | 2019-03-21 | 深圳瑞健生命科學硏究院有限公司 | Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury |
JP7194440B2 (ja) | 2016-12-15 | 2022-12-22 | タレンゲン インターナショナル リミテッド | 心臓病変を改善するための方法 |
CN110114082A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种预防和治疗脂肪代谢紊乱及其相关病症的方法 |
TW201829448A (zh) | 2016-12-15 | 2018-08-16 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途 |
DK3556383T3 (da) | 2016-12-15 | 2024-05-13 | Talengen Int Ltd | Plasminogen til anvendelse ved behandling af diabetes |
WO2018233604A1 (zh) | 2017-06-19 | 2018-12-27 | 泰伦基国际有限公司 | 一种调控glp-1/glp-1r的方法和药物 |
JP7487970B2 (ja) * | 2020-02-06 | 2024-05-21 | タレンゲン インターナショナル リミテッド | 多発性硬化症を予防及び治療する方法並びに薬剤 |
KR20220137946A (ko) * | 2020-02-11 | 2022-10-12 | 탈렌젠 인터내셔널 리미티드 | 바이러스성 폐렴의 치료 방법 및 약물 |
WO2021170099A1 (zh) * | 2020-02-26 | 2021-09-02 | 泰伦基国际有限公司 | 一种预防和治疗血压异常病症的方法和药物 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1195375A (zh) | 1995-04-26 | 1998-10-07 | 儿童医学中心公司 | 血管抑制素片段和集合血管抑制素及其使用方法 |
CA2295925A1 (en) | 1997-06-26 | 1999-01-07 | Karolinska Innovations Ab | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
CA2344317C (en) | 1998-09-29 | 2012-01-24 | Leuven Research & Development Vzw | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
WO2000044391A2 (en) | 1999-01-28 | 2000-08-03 | The Children's Medical Center Corporation | Plasminogen kringle 4 region fragments and methods of use |
US6899877B2 (en) | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
WO2001024815A1 (en) | 1999-10-07 | 2001-04-12 | Human Genome Sciences, Inc. | Plasminogen-like polynucleotides, polypeptides, and antibodies |
TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
US7067492B2 (en) | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
US7202066B2 (en) | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
AU2003210137A1 (en) | 2002-02-06 | 2003-09-02 | N-Zyme Biotec Gmbh | Method for producing recombinant proteins in micro-organisms |
US6787135B2 (en) | 2002-03-13 | 2004-09-07 | William Beaumont Hospital | Modification of vitreal matrix metalloproteinase activity |
EP2322201A3 (en) | 2002-10-29 | 2011-07-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
CN1451746A (zh) | 2003-03-20 | 2003-10-29 | 广州市启源生物科技有限公司 | 人纤溶酶原Kringle 5缺失突变重组多肽 |
US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
CN1946352A (zh) | 2004-04-09 | 2007-04-11 | 狄科特康坦特公司 | 递送药物至眼以治疗后段疾病的方法和物品 |
MX2007002177A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de pirrolo-naftilo como inhibidores de pai-1. |
US7754747B2 (en) | 2004-08-23 | 2010-07-13 | Wyeth Llc | Oxazolo-naphthyl acids |
CN101227918A (zh) | 2005-04-29 | 2008-07-23 | 加州大学评议会 | 治疗以炎症反应为特征的病理的肽和肽模拟物 |
JP2008539235A (ja) | 2005-04-29 | 2008-11-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 炎症反応によって特徴付けられる病状を処置するためのペプチドおよびペプチド模倣物 |
US20060257391A1 (en) | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
WO2007022321A2 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
WO2007051314A1 (en) | 2005-11-07 | 2007-05-10 | American Diagnostica Inc. | Curcuminoid compounds for inhibiting plasminogen activator inhibitor-1 |
CN100529085C (zh) | 2005-12-30 | 2009-08-19 | 上海新生源医药研究有限公司 | 重组人纤溶酶原Kringle 5(hk5)生产方法 |
CN101002888A (zh) | 2006-01-16 | 2007-07-25 | 陈维森 | 复方糖尿康 |
US20070196350A1 (en) | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
ES2451015T3 (es) | 2006-08-28 | 2014-03-26 | Omnio Healer Ab | Candidatos contra la infección |
CA2703494A1 (en) | 2007-10-23 | 2009-04-30 | Institute Of Medicinal Molecular Design, Inc. | Inhibitor of pai-1 production |
KR101529743B1 (ko) | 2007-11-29 | 2015-06-17 | 그리폴스 테라퓨틱스 인코포레이티드 | 재조합적으로 변형된 플라스민 |
JP2009196927A (ja) | 2008-02-21 | 2009-09-03 | Chemo Sero Therapeut Res Inst | 血管障害に起因する網膜障害の進展阻害または治療剤 |
EP2566514A4 (en) | 2010-05-03 | 2013-11-27 | Abbvie Inc | METHODS OF INHIBITING FIBROSIS WITH ANTI-PAI-1 ANTIBODIES |
CN102250210B (zh) | 2010-05-21 | 2014-05-28 | 厦门大学 | 人纤溶酶原Kringle 5短肽、其药物组合物、用途和编码该种短肽的多核苷酸 |
CN102121023B (zh) * | 2010-12-22 | 2012-07-04 | 中山大学 | 突变型人纤溶酶原kringle5及其制备方法及应用 |
JP6085568B2 (ja) * | 2011-01-05 | 2017-02-22 | スロンボジェニックス・ナムローゼ・フェンノートシャップThromboGenics NV | プラスミノーゲンおよびプラスミンの変異体 |
CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
EP2741767A1 (en) | 2011-08-12 | 2014-06-18 | ThromboGenics N.V. | Plasminogen and plasmin variants |
EP2914575B1 (en) | 2012-10-31 | 2020-10-14 | The Regents Of The University Of Michigan | Plasminogen activator-1 inhibitors and methods of use thereof |
US9079739B2 (en) | 2012-11-02 | 2015-07-14 | The Procter & Gamble Company | Apparatus for controlling the nip force/pressure between two rotating cylinders |
ES2770507T3 (es) | 2013-08-13 | 2020-07-01 | Sanofi Sa | Anticuerpos dirigidos contra el inhibidor de los activadores del plasminógeno de tipo 1 (PAI-1) y usos de los mismos |
TW201722994A (zh) | 2013-08-13 | 2017-07-01 | 賽諾菲公司 | 胞漿素原活化素抑制劑-1(pai-1)之抗體及其用途 |
CN104789544B (zh) | 2014-01-16 | 2019-11-26 | 中国科学院福建物质结构研究所 | 重组pai-1抑制剂、包含其的组合物及其用于治疗和检测用途 |
BR112017012972A2 (pt) | 2014-12-19 | 2018-02-27 | Prometic Biotherapeutics Inc | composição farmacêutica que compreende plasminogênio e seus usos |
TWI801331B (zh) | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
TWI624267B (zh) | 2015-12-18 | 2018-05-21 | Talengen Institute Of Life Sciences Co Ltd | 纖溶酶原在製備預防或治療糖尿病性視網膜病變的藥劑上的用途及包括纖溶酶原用於預防或治療糖尿病性視網膜病變之藥劑 |
CN108472342B (zh) | 2015-12-18 | 2022-11-15 | 泰伦基国际有限公司 | 一种用于预防或治疗急性及慢性血栓的方法 |
TWI653981B (zh) | 2015-12-18 | 2019-03-21 | 深圳瑞健生命科學硏究院有限公司 | Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury |
WO2017101868A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
DK3556383T3 (da) | 2016-12-15 | 2024-05-13 | Talengen Int Ltd | Plasminogen til anvendelse ved behandling af diabetes |
-
2016
- 2016-12-16 WO PCT/CN2016/110450 patent/WO2017101868A1/zh active Application Filing
- 2016-12-16 CN CN201680073672.2A patent/CN108778307A/zh active Pending
- 2016-12-16 CA CA3008686A patent/CA3008686C/en active Active
- 2016-12-16 EP EP16874925.7A patent/EP3395354B1/en active Active
- 2016-12-16 DK DK16874925.7T patent/DK3395354T3/da active
- 2016-12-16 TW TW105141898A patent/TWI725092B/zh active
- 2016-12-16 JP JP2018550635A patent/JP6682008B2/ja active Active
- 2016-12-16 US US16/062,049 patent/US11090372B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN108778307A (zh) | 2018-11-09 |
CA3008686A1 (en) | 2017-06-22 |
EP3395354A1 (en) | 2018-10-31 |
CA3008686C (en) | 2023-03-14 |
JP6682008B2 (ja) | 2020-04-15 |
TW201722466A (zh) | 2017-07-01 |
TWI725092B (zh) | 2021-04-21 |
EP3395354B1 (en) | 2024-05-22 |
US20190015485A1 (en) | 2019-01-17 |
WO2017101868A1 (zh) | 2017-06-22 |
JP2019500424A (ja) | 2019-01-10 |
EP3395354A4 (en) | 2019-06-12 |
US11090372B2 (en) | 2021-08-17 |
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