DK3212789T3 - Massiv parallel kombinatorisk genetik til crispr - Google Patents
Massiv parallel kombinatorisk genetik til crispr Download PDFInfo
- Publication number
- DK3212789T3 DK3212789T3 DK15813148.2T DK15813148T DK3212789T3 DK 3212789 T3 DK3212789 T3 DK 3212789T3 DK 15813148 T DK15813148 T DK 15813148T DK 3212789 T3 DK3212789 T3 DK 3212789T3
- Authority
- DK
- Denmark
- Prior art keywords
- crispr
- genetics
- massive parallel
- parallel combinatory
- combinatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073126P | 2014-10-31 | 2014-10-31 | |
| US201562166302P | 2015-05-26 | 2015-05-26 | |
| PCT/US2015/058304 WO2016070037A2 (en) | 2014-10-31 | 2015-10-30 | Massively parallel combinatorial genetics for crispr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3212789T3 true DK3212789T3 (da) | 2020-07-27 |
Family
ID=54884363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15813148.2T DK3212789T3 (da) | 2014-10-31 | 2015-10-30 | Massiv parallel kombinatorisk genetik til crispr |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190100769A1 (da) |
| EP (2) | EP3708155A1 (da) |
| JP (1) | JP6788584B2 (da) |
| CN (1) | CN107429246B (da) |
| DK (1) | DK3212789T3 (da) |
| HK (1) | HK1243456A1 (da) |
| TW (1) | TWI716367B (da) |
| WO (1) | WO2016070037A2 (da) |
Families Citing this family (53)
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|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| EP3690044B1 (en) | 2014-02-11 | 2024-01-10 | The Regents of the University of Colorado, a body corporate | Crispr enabled multiplexed genome engineering |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
| KR102648489B1 (ko) | 2015-04-06 | 2024-03-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| JP7012645B2 (ja) | 2016-01-11 | 2022-01-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | キメラタンパク質および免疫治療の方法 |
| EA201891619A1 (ru) | 2016-01-11 | 2019-02-28 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Химерные белки и способы регулирования экспрессии генов |
| JP2019514377A (ja) * | 2016-04-26 | 2019-06-06 | マサチューセッツ インスティテュート オブ テクノロジー | 拡張可能なリコンビナーゼカスケード |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN109688820B (zh) | 2016-06-24 | 2023-01-10 | 科罗拉多州立大学董事会（法人团体） | 用于生成条形码化组合文库的方法 |
| US11913017B2 (en) * | 2016-06-29 | 2024-02-27 | The Regents Of The University Of California | Efficient genetic screening method |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3510152A4 (en) * | 2016-09-07 | 2020-04-29 | Flagship Pioneering, Inc. | METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US20190330616A1 (en) * | 2016-12-29 | 2019-10-31 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Method for generating higher order genome editing libraries |
| EP3565891B1 (en) | 2017-01-09 | 2023-04-12 | Whitehead Institute for Biomedical Research | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
| WO2018145041A1 (en) * | 2017-02-06 | 2018-08-09 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| MX2020001178A (es) | 2017-07-31 | 2020-09-25 | Regeneron Pharma | Celulas madre embrionarias de raton transgenico con cas y ratones y usos de los mismos. |
| JP2020533957A (ja) | 2017-07-31 | 2020-11-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｃｒｉｓｐｒリポーター非ヒト動物およびその使用 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US11547614B2 (en) | 2017-10-31 | 2023-01-10 | The Broad Institute, Inc. | Methods and compositions for studying cell evolution |
| WO2020033585A1 (en) * | 2018-08-07 | 2020-02-13 | The Broad Institute, Inc. | Methods for combinatorial screening and use of therapeutic targets thereof |
| EP3853363A4 (en) * | 2018-09-19 | 2022-12-14 | The University of Hong Kong | ENHANCED HIGH THROUGHPUT COMBINATORY GENE MODIFICATION SYSTEM AND OPTIMIZED CAS9 ENZYME VARIANTS |
| CN113646434B (zh) * | 2018-12-20 | 2023-05-30 | 北京大学 | 使用加标签的向导rna构建体进行高效基因筛选的组合物和方法 |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| CN110652589A (zh) * | 2019-10-12 | 2020-01-07 | 中国人民解放军陆军军医大学 | Gasc1抑制剂在制备治疗肝癌的药物中的应用 |
| US20230002756A1 (en) * | 2019-12-12 | 2023-01-05 | The Trustees Of The University Of Pennsylvania | High Performance Platform for Combinatorial Genetic Screening |
| EP4136238A1 (en) * | 2020-04-16 | 2023-02-22 | The University of Hong Kong | A system for three-way combinatorial crispr screens for analysing target interactions and methods thereof |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| WO2022159402A1 (en) * | 2021-01-19 | 2022-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for high-multiplexed genome engineering using synthetic crispr arrays |
| WO2022195582A1 (en) * | 2021-03-15 | 2022-09-22 | G.T.A.I Innovation Ltd. | A method and apparatus for lab tests |
| CN113599522B (zh) * | 2021-08-03 | 2022-09-20 | 深圳市北科生物科技有限公司 | Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用 |
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| CN116019811B (zh) * | 2023-02-07 | 2024-04-12 | 华中科技大学协和深圳医院 | Gsk-j4用于制备抗革兰氏阳性菌感染药物中的应用 |
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| WO2005108568A1 (en) * | 2004-05-10 | 2005-11-17 | Basf Plant Science Gmbh | Methods for assembling multiple expression constructs |
| EP2239264A4 (en) * | 2007-12-28 | 2012-01-11 | Mitsubishi Tanabe Pharma Corp | ANTITUMOR AGENT |
| WO2011143660A2 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| EA038924B1 (ru) | 2012-05-25 | 2021-11-10 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Способы и композиции рнк-специфической модификации днк-мишени и рнк-специфической модуляции транскрипции |
| CN103516916B (zh) | 2012-06-28 | 2018-03-27 | 中兴通讯股份有限公司 | 拨号方法及装置 |
| CA2877962C (en) * | 2012-06-29 | 2018-06-05 | Massachusetts Institute Of Technology | Massively parallel combinatorial genetics |
| MD20150043A2 (ro) * | 2012-10-02 | 2015-08-31 | Epitherapeutics Aps | Inhibitori ai histon-demetilazelor |
| US9073878B2 (en) * | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| CN103833671B (zh) * | 2012-11-27 | 2016-12-21 | 中国科学院上海药物研究所 | 一类二氢噻唑酮类化合物及其药物组合物和用途 |
| KR102531576B1 (ko) * | 2012-12-06 | 2023-05-11 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
| ES2883590T3 (es) * | 2012-12-12 | 2021-12-09 | Broad Inst Inc | Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas |
| US20140310830A1 (en) * | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| AU2014235794A1 (en) * | 2013-03-14 | 2015-10-22 | Caribou Biosciences, Inc. | Compositions and methods of nucleic acid-targeting nucleic acids |
| JP6370368B2 (ja) | 2013-03-27 | 2018-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｒｄ４阻害剤としてのインドリノン類似体 |
| RU2725502C2 (ru) * | 2013-06-17 | 2020-07-02 | Те Брод Инститьют Инк. | Доставка, конструирование и оптимизация систем, способы и композиции для целенаправленного воздействия и моделирования заболеваний и нарушений постмитотических клеток |
| MX2016007327A (es) * | 2013-12-12 | 2017-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para dirigirlos a trastornos y enfermedades usando componentes para suministro de particulas. |
| AU2014361781B2 (en) * | 2013-12-12 | 2021-04-01 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing |
| BR112016013207A2 (pt) * | 2013-12-12 | 2017-09-26 | Massachusetts Inst Technology | administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais |
| US20170022499A1 (en) * | 2014-04-03 | 2017-01-26 | Massachusetts Institute Of Techology | Methods and compositions for the production of guide rna |
| EP3137079A1 (en) * | 2014-04-28 | 2017-03-08 | The J. David Gladstone Institutes | Inhibitors of jmjd2c as anticancer agents |
| US20170232030A1 (en) * | 2014-08-13 | 2017-08-17 | Epizyme, Inc. | Combination therapy for treating cancer |
| WO2016049024A2 (en) * | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo |
-
2015
- 2015-10-30 JP JP2017523864A patent/JP6788584B2/ja active Active
- 2015-10-30 CN CN201580065962.8A patent/CN107429246B/zh active Active
- 2015-10-30 EP EP20167714.3A patent/EP3708155A1/en not_active Withdrawn
- 2015-10-30 EP EP15813148.2A patent/EP3212789B1/en active Active
- 2015-10-30 WO PCT/US2015/058304 patent/WO2016070037A2/en active Application Filing
- 2015-10-30 DK DK15813148.2T patent/DK3212789T3/da active
- 2015-10-30 TW TW104135960A patent/TWI716367B/zh active
- 2015-10-30 US US15/521,931 patent/US20190100769A1/en not_active Abandoned
-
2018
- 2018-02-28 HK HK18102856.9A patent/HK1243456A1/zh unknown
-
2021
- 2021-06-03 US US17/338,027 patent/US20210310022A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3212789A2 (en) | 2017-09-06 |
| WO2016070037A8 (en) | 2017-03-02 |
| US20210310022A1 (en) | 2021-10-07 |
| CN107429246A (zh) | 2017-12-01 |
| JP6788584B2 (ja) | 2020-11-25 |
| WO2016070037A2 (en) | 2016-05-06 |
| WO2016070037A3 (en) | 2016-06-23 |
| TW201631155A (zh) | 2016-09-01 |
| TWI716367B (zh) | 2021-01-21 |
| EP3708155A1 (en) | 2020-09-16 |
| EP3212789B1 (en) | 2020-04-22 |
| US20190100769A1 (en) | 2019-04-04 |
| CN107429246B (zh) | 2021-06-01 |
| JP2017534285A (ja) | 2017-11-24 |
| HK1243456A1 (zh) | 2018-07-13 |
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