DK3194373T3 - Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin - Google Patents

Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin Download PDF

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Publication number
DK3194373T3
DK3194373T3 DK15841956.4T DK15841956T DK3194373T3 DK 3194373 T3 DK3194373 T3 DK 3194373T3 DK 15841956 T DK15841956 T DK 15841956T DK 3194373 T3 DK3194373 T3 DK 3194373T3
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vitability
electrochemic
pyocyanin
biofilm
monitoring
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DK15841956.4T
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English (en)
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Edgar D Goluch
Hunter J Sismaet
Thaddaeus A Webster
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Univ Northeastern
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/12Nitrate to nitrite reducing bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
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    • G01N33/48735Investigating suspensions of cells, e.g. measuring microbe concentration
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    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
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    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means

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  • Engineering & Computer Science (AREA)
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DK15841956.4T 2014-09-16 2015-09-16 Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin DK3194373T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051099P 2014-09-16 2014-09-16
US201562215379P 2015-09-08 2015-09-08
PCT/US2015/050412 WO2016044417A2 (en) 2014-09-16 2015-09-16 Diagnostic system and process for rapid bacterial infection diagnosis

Publications (1)

Publication Number Publication Date
DK3194373T3 true DK3194373T3 (da) 2021-04-26

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DK15841956.4T DK3194373T3 (da) 2014-09-16 2015-09-16 Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin

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US (2) US10316348B2 (da)
EP (1) EP3194373B1 (da)
JP (1) JP6914838B2 (da)
DK (1) DK3194373T3 (da)
WO (1) WO2016044417A2 (da)

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JP6978408B2 (ja) 2015-08-25 2021-12-08 アバイルズ メディカル,インコーポレイテッド 流体試料中の生存微生物を検出する装置、システムおよび方法
US10044630B2 (en) * 2015-12-15 2018-08-07 Software Ag Systems and/or methods for remote application introspection in cloud-based integration scenarios
WO2017209839A1 (en) 2016-05-31 2017-12-07 Avails Medical, Inc. Detecting viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
US20210172000A1 (en) * 2017-04-19 2021-06-10 CAP Diagnostics, LLC, dba Pathnostics Methods and systems for preparing therapeutic solutions for polymicrobial infections
WO2019005296A1 (en) 2017-06-27 2019-01-03 Avails Medical, Inc. APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS
CA3077052A1 (en) 2017-10-03 2019-04-11 Avails Medical, Inc. Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to anti-infectives based on redox reactions
CN107976577B (zh) * 2017-10-31 2019-07-23 中国农业大学 一种生物存活率的检测方法及装置
CA3085018A1 (en) * 2017-12-05 2019-06-13 Avails Medical, Inc. Systems and methods for preparing an output sample comprising a defined concentration of an infectious agent for downstream testing
GB201900605D0 (en) 2019-01-16 2019-03-06 Univ Durham An electrochemical capacitor device for use with a biofilm
WO2020190549A1 (en) 2019-03-18 2020-09-24 Purdue Research Foundation Omniphobic paper-based smart bandage devices
EP3963317A4 (en) * 2019-04-29 2022-07-06 Siemens Healthcare Diagnostics Inc. SENSOR ASSEMBLIES FOR LIQUIDS, DEVICE AND PROCESSES
CN111381023A (zh) * 2020-03-16 2020-07-07 廖世奇 一种适配体快速筛查呼气中病原体的方法及***
SG10202103157SA (en) * 2020-03-30 2021-10-28 Helios Bioelectronics Inc Method for pathogen detection
CN111662949A (zh) * 2020-07-13 2020-09-15 北京海关技术中心 口罩中铜绿假单胞菌定性检测能力验证样品及其制备方法
CN112362711B (zh) * 2020-11-11 2021-08-17 重庆大学 一种微生物检测装置及检测方法

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6245735B1 (en) * 1996-07-29 2001-06-12 The Brigham And Women's Hospital, Inc. Methods and products for treating pseudomonas infection
WO2012149058A2 (en) * 2011-04-25 2012-11-01 California Institute Of Technology Methods and system for interfering with viability of bacteria and related compounds and compositions
US20150071904A1 (en) * 2012-01-06 2015-03-12 Trustees Of Boston University Compositions and methods to boost endogenous ros production from bacteria
EP2875343B1 (en) * 2012-07-20 2018-03-14 Northeastern University Microfluidic-nanofluidic devices for detection and measurement of redox active substances
CN105050686B (zh) * 2013-03-18 2019-08-06 恩弗里德***公司 清洁运输车辆中的车厢空气的***和方法
WO2015031798A1 (en) * 2013-08-29 2015-03-05 Northeastern University Matrix-enhanced electrochemical detector for pathogenic bacteria

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Publication number Publication date
EP3194373A4 (en) 2018-04-04
WO2016044417A3 (en) 2016-09-09
WO2016044417A2 (en) 2016-03-24
JP6914838B2 (ja) 2021-08-04
EP3194373A2 (en) 2017-07-26
JP2017529874A (ja) 2017-10-12
EP3194373B1 (en) 2021-03-31
US10316348B2 (en) 2019-06-11
US20190323056A1 (en) 2019-10-24
US20170247739A1 (en) 2017-08-31

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