DK3194373T3 - Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin - Google Patents
Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin Download PDFInfo
- Publication number
- DK3194373T3 DK3194373T3 DK15841956.4T DK15841956T DK3194373T3 DK 3194373 T3 DK3194373 T3 DK 3194373T3 DK 15841956 T DK15841956 T DK 15841956T DK 3194373 T3 DK3194373 T3 DK 3194373T3
- Authority
- DK
- Denmark
- Prior art keywords
- vitability
- electrochemic
- pyocyanin
- biofilm
- monitoring
- Prior art date
Links
- YNCMLFHHXWETLD-UHFFFAOYSA-N pyocyanin Chemical compound CN1C2=CC=CC=C2N=C2C1=CC=CC2=O YNCMLFHHXWETLD-UHFFFAOYSA-N 0.000 title 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/12—Nitrate to nitrite reducing bacteria
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/22—Testing for sterility conditions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48735—Investigating suspensions of cells, e.g. measuring microbe concentration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Sustainable Development (AREA)
- Urology & Nephrology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462051099P | 2014-09-16 | 2014-09-16 | |
US201562215379P | 2015-09-08 | 2015-09-08 | |
PCT/US2015/050412 WO2016044417A2 (en) | 2014-09-16 | 2015-09-16 | Diagnostic system and process for rapid bacterial infection diagnosis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3194373T3 true DK3194373T3 (da) | 2021-04-26 |
Family
ID=55534007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15841956.4T DK3194373T3 (da) | 2014-09-16 | 2015-09-16 | Fremgangsmåde til monitorering af levedygtighed for en biofilm af pseudomonas aeruginosa baseret på elektrokemisk detektering af pyocyanin |
Country Status (5)
Country | Link |
---|---|
US (2) | US10316348B2 (da) |
EP (1) | EP3194373B1 (da) |
JP (1) | JP6914838B2 (da) |
DK (1) | DK3194373T3 (da) |
WO (1) | WO2016044417A2 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6978408B2 (ja) | 2015-08-25 | 2021-12-08 | アバイルズ メディカル,インコーポレイテッド | 流体試料中の生存微生物を検出する装置、システムおよび方法 |
US10044630B2 (en) * | 2015-12-15 | 2018-08-07 | Software Ag | Systems and/or methods for remote application introspection in cloud-based integration scenarios |
WO2017209839A1 (en) | 2016-05-31 | 2017-12-07 | Avails Medical, Inc. | Detecting viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives |
US20210172000A1 (en) * | 2017-04-19 | 2021-06-10 | CAP Diagnostics, LLC, dba Pathnostics | Methods and systems for preparing therapeutic solutions for polymicrobial infections |
WO2019005296A1 (en) | 2017-06-27 | 2019-01-03 | Avails Medical, Inc. | APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS |
CA3077052A1 (en) | 2017-10-03 | 2019-04-11 | Avails Medical, Inc. | Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to anti-infectives based on redox reactions |
CN107976577B (zh) * | 2017-10-31 | 2019-07-23 | 中国农业大学 | 一种生物存活率的检测方法及装置 |
CA3085018A1 (en) * | 2017-12-05 | 2019-06-13 | Avails Medical, Inc. | Systems and methods for preparing an output sample comprising a defined concentration of an infectious agent for downstream testing |
GB201900605D0 (en) | 2019-01-16 | 2019-03-06 | Univ Durham | An electrochemical capacitor device for use with a biofilm |
WO2020190549A1 (en) | 2019-03-18 | 2020-09-24 | Purdue Research Foundation | Omniphobic paper-based smart bandage devices |
EP3963317A4 (en) * | 2019-04-29 | 2022-07-06 | Siemens Healthcare Diagnostics Inc. | SENSOR ASSEMBLIES FOR LIQUIDS, DEVICE AND PROCESSES |
CN111381023A (zh) * | 2020-03-16 | 2020-07-07 | 廖世奇 | 一种适配体快速筛查呼气中病原体的方法及*** |
SG10202103157SA (en) * | 2020-03-30 | 2021-10-28 | Helios Bioelectronics Inc | Method for pathogen detection |
CN111662949A (zh) * | 2020-07-13 | 2020-09-15 | 北京海关技术中心 | 口罩中铜绿假单胞菌定性检测能力验证样品及其制备方法 |
CN112362711B (zh) * | 2020-11-11 | 2021-08-17 | 重庆大学 | 一种微生物检测装置及检测方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245735B1 (en) * | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
WO2012149058A2 (en) * | 2011-04-25 | 2012-11-01 | California Institute Of Technology | Methods and system for interfering with viability of bacteria and related compounds and compositions |
US20150071904A1 (en) * | 2012-01-06 | 2015-03-12 | Trustees Of Boston University | Compositions and methods to boost endogenous ros production from bacteria |
EP2875343B1 (en) * | 2012-07-20 | 2018-03-14 | Northeastern University | Microfluidic-nanofluidic devices for detection and measurement of redox active substances |
CN105050686B (zh) * | 2013-03-18 | 2019-08-06 | 恩弗里德***公司 | 清洁运输车辆中的车厢空气的***和方法 |
WO2015031798A1 (en) * | 2013-08-29 | 2015-03-05 | Northeastern University | Matrix-enhanced electrochemical detector for pathogenic bacteria |
-
2015
- 2015-09-16 EP EP15841956.4A patent/EP3194373B1/en active Active
- 2015-09-16 DK DK15841956.4T patent/DK3194373T3/da active
- 2015-09-16 JP JP2017533750A patent/JP6914838B2/ja active Active
- 2015-09-16 WO PCT/US2015/050412 patent/WO2016044417A2/en active Application Filing
- 2015-09-16 US US15/511,735 patent/US10316348B2/en active Active
-
2019
- 2019-06-11 US US16/437,624 patent/US20190323056A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3194373A4 (en) | 2018-04-04 |
WO2016044417A3 (en) | 2016-09-09 |
WO2016044417A2 (en) | 2016-03-24 |
JP6914838B2 (ja) | 2021-08-04 |
EP3194373A2 (en) | 2017-07-26 |
JP2017529874A (ja) | 2017-10-12 |
EP3194373B1 (en) | 2021-03-31 |
US10316348B2 (en) | 2019-06-11 |
US20190323056A1 (en) | 2019-10-24 |
US20170247739A1 (en) | 2017-08-31 |
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