DK3182996T3 - Fremgangsmåder til behandling af myelomatose med immunmodulatoriske forbindelser i kombination med antistoffer - Google Patents
Fremgangsmåder til behandling af myelomatose med immunmodulatoriske forbindelser i kombination med antistoffer Download PDFInfo
- Publication number
- DK3182996T3 DK3182996T3 DK15757389.0T DK15757389T DK3182996T3 DK 3182996 T3 DK3182996 T3 DK 3182996T3 DK 15757389 T DK15757389 T DK 15757389T DK 3182996 T3 DK3182996 T3 DK 3182996T3
- Authority
- DK
- Denmark
- Prior art keywords
- myelomatosis
- antibodies
- treatment
- methods
- combination
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462040918P | 2014-08-22 | 2014-08-22 | |
PCT/US2015/046091 WO2016029004A1 (en) | 2014-08-22 | 2015-08-20 | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3182996T3 true DK3182996T3 (da) | 2023-03-13 |
Family
ID=54035318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15757389.0T DK3182996T3 (da) | 2014-08-22 | 2015-08-20 | Fremgangsmåder til behandling af myelomatose med immunmodulatoriske forbindelser i kombination med antistoffer |
Country Status (23)
Country | Link |
---|---|
US (1) | US10034872B2 (da) |
EP (2) | EP3925609A1 (da) |
JP (2) | JP7120763B2 (da) |
KR (1) | KR20170042598A (da) |
CN (1) | CN107073115A (da) |
AU (2) | AU2015305449B2 (da) |
BR (1) | BR112017003620A2 (da) |
CA (1) | CA2958867A1 (da) |
CL (1) | CL2017000416A1 (da) |
DK (1) | DK3182996T3 (da) |
EA (1) | EA201790439A1 (da) |
ES (1) | ES2940302T3 (da) |
FI (1) | FI3182996T3 (da) |
HR (1) | HRP20230265T1 (da) |
HU (1) | HUE061382T2 (da) |
IL (1) | IL250724A0 (da) |
LT (1) | LT3182996T (da) |
MX (1) | MX2017002382A (da) |
PL (1) | PL3182996T3 (da) |
PT (1) | PT3182996T (da) |
RS (1) | RS64038B1 (da) |
SI (1) | SI3182996T1 (da) |
WO (1) | WO2016029004A1 (da) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3313528B1 (en) * | 2015-06-29 | 2021-08-04 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens comprising pomalidomide and an anti-cs1 antibody for treating cancer |
CN110099907A (zh) * | 2016-12-21 | 2019-08-06 | 拜欧赛里克斯公司 | 靶向蛋白质的噻吩并吡咯衍生物、组合物、方法及其用途 |
CN111132696B (zh) * | 2017-10-13 | 2023-05-16 | 江苏恒瑞医药股份有限公司 | Pd-1抗体和表观遗传调节剂联合在制备***的药物中的用途 |
US11191769B2 (en) * | 2018-06-13 | 2021-12-07 | Biotheryx, Inc. | Fused thiophene compounds |
AU2019351811A1 (en) * | 2018-10-01 | 2021-05-06 | Celgene Corporation | Combination therapy for the treatment of cancer |
US20220257649A1 (en) * | 2018-11-13 | 2022-08-18 | Nantcell, Inc. | Combination therapies for multiple myeloma |
US20230028293A1 (en) * | 2019-12-08 | 2023-01-26 | The Regents Of The University Of Colorado, A Body Corporate | Multiple myeloma combination therapies based on protein translation inhibitors and immunomodulators |
EP4073517A1 (en) * | 2019-12-11 | 2022-10-19 | Erasmus University Rotterdam Medical Center | Method for monitoring of deep remissions in multiple myeloma and other plasma cell dyscrasias |
WO2022072538A1 (en) * | 2020-09-30 | 2022-04-07 | Biotheryx, Inc. | Antibody-drug conjugates, pharmaceutical compositions thereof, and their therapeutic applications |
CA3208313A1 (en) | 2021-01-13 | 2022-07-21 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
WO2023014082A1 (ko) * | 2021-08-04 | 2023-02-09 | 주식회사 아이비스바이오 | 물질 특성이 개선된 면역조절아마이드 유도체 |
KR102362871B1 (ko) * | 2021-11-19 | 2022-02-15 | 케이블루바이오 주식회사 | 신규한 사환구조 트리테르펜 화합물을 유효성분으로 포함하는 다발성골수종의 예방 또는 치료용 조성물 |
Family Cites Families (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE634184A (da) | 1961-04-26 | |||
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4994443A (en) | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
US5001116A (en) | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
US4551177A (en) | 1984-04-23 | 1985-11-05 | National Starch And Chemical Corporation | Compressible starches as binders for tablets or capsules |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするdna |
US5974203A (en) | 1988-04-11 | 1999-10-26 | Canon Kabushiki Kaisha | Pattern recognition communication apparatus for transmitting and receiving image data |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
EP0505552A4 (en) | 1990-10-12 | 1994-06-08 | Amgen Inc | Megakaryocyte maturation factors |
US5387421A (en) | 1991-01-31 | 1995-02-07 | Tsrl, Inc. | Multi stage drug delivery system |
WO1992014455A1 (en) | 1991-02-14 | 1992-09-03 | The Rockefeller University | METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5358941A (en) | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
US5360352A (en) | 1992-12-24 | 1994-11-01 | The Whitaker Corporation | Wire retainer for current mode coupler |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
US20010056114A1 (en) | 2000-11-01 | 2001-12-27 | D'amato Robert | Methods for the inhibition of angiogenesis with 3-amino thalidomide |
US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US6114355A (en) | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
US5594637A (en) | 1993-05-26 | 1997-01-14 | Base Ten Systems, Inc. | System and method for assessing medical risk |
US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
US5641758A (en) | 1993-11-10 | 1997-06-24 | Kluge; Michael | Cytarabine derivatives, the preparation and use thereof |
US6432924B1 (en) | 1993-12-26 | 2002-08-13 | East Carolina University | Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase |
GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
JPH10508131A (ja) | 1994-10-28 | 1998-08-04 | アドバンスド・ヘルス・メド・イー・システムズ コーポレーション | 処方箋管理システム |
US5593696A (en) | 1994-11-21 | 1997-01-14 | Mcneil-Ppc, Inc. | Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders |
US5619991A (en) | 1995-04-26 | 1997-04-15 | Lucent Technologies Inc. | Delivery of medical services using electronic data communications |
US5643915A (en) | 1995-06-06 | 1997-07-01 | Andrulis Pharmaceuticals Corp. | Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies |
US5731325A (en) | 1995-06-06 | 1998-03-24 | Andrulis Pharmaceuticals Corp. | Treatment of melanomas with thalidomide alone or in combination with other anti-melanoma agents |
US5832449A (en) | 1995-11-13 | 1998-11-03 | Cunningham; David W. | Method and system for dispensing, tracking and managing pharmaceutical trial products |
US6063026A (en) | 1995-12-07 | 2000-05-16 | Carbon Based Corporation | Medical diagnostic analysis system |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
CA2261762C (en) | 1996-07-24 | 2008-06-17 | Celgene Corporation | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
ATE236872T1 (de) | 1996-08-12 | 2003-04-15 | Celgene Corp | Immunotherapeutische mittel und ihre anwendung in der reduzierung der cytokininwerte |
US5924074A (en) | 1996-09-27 | 1999-07-13 | Azron Incorporated | Electronic medical records system |
DE69734290T2 (de) | 1996-11-05 | 2006-07-06 | The Children's Medical Center Corp., Boston | Mittel zur hemmung von angiogenese enthaltend thalodomid und einen nsaid |
US6131090A (en) | 1997-03-04 | 2000-10-10 | Pitney Bowes Inc. | Method and system for providing controlled access to information stored on a portable recording medium |
US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
PT998271E (pt) | 1997-06-06 | 2005-10-31 | Depomed Inc | Formas de dosagem oral de farmacos com retencao gastrica para a libertacao controlada de farmacos altamente soluveis |
AU8909898A (en) | 1997-08-22 | 1999-03-16 | Deka Products Limited Partnership | Health care system and method for physician order entry |
US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
US5874448A (en) | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
US6096757A (en) | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
KR20070040423A (ko) | 1998-03-16 | 2007-04-16 | 셀진 코포레이션 | 염증성 사이토카인 억제제용2-(2,6-디옥소피페리딘-3-일)이소인돌린 유도체, 그제조방법 및 그 용도 |
JPH11286455A (ja) | 1998-03-31 | 1999-10-19 | Kanebo Ltd | 骨髄異形成症候群治療薬 |
US6673828B1 (en) | 1998-05-11 | 2004-01-06 | Children's Medical Center Corporation | Analogs of 2-Phthalimidinoglutaric acid |
US6045501A (en) | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
US6020358A (en) | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
US20030013739A1 (en) | 1998-12-23 | 2003-01-16 | Pharmacia Corporation | Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia |
GB9904585D0 (en) | 1999-02-26 | 1999-04-21 | Gemini Research Limited | Clinical and diagnostic database |
AU771015B2 (en) | 1999-03-18 | 2004-03-11 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
US20010021380A1 (en) | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
US7629360B2 (en) | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
US6890547B1 (en) | 1999-07-16 | 2005-05-10 | Amato Pharmaceutical Products, Ltd. | Glycyrrhizin preparations for transmucosal absorption |
US6202923B1 (en) | 1999-08-23 | 2001-03-20 | Innovation Associates, Inc. | Automated pharmacy |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
US6326388B1 (en) | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
CA2319872C (en) | 2000-02-02 | 2012-06-19 | Chun-Ying Huang | Pharmaceutical composition for the treatment of hepatocellular carcinoma |
PT1251832E (pt) | 2000-02-04 | 2007-01-31 | Depomed Inc | Forma de dosagem constituída por invólucro-e-núcleo que conduz a uma libertação do fármaco de ordem zero |
CA2402643A1 (en) | 2000-03-17 | 2001-09-27 | Cell Therapeutics, Inc. | Polyglutamic acid-camptothecin conjugates and methods of preparation |
AU2001249755A1 (en) | 2000-03-31 | 2001-10-15 | Celgene Corporation | Inhibition of cyclooxygenase-2 activity |
JP4679028B2 (ja) | 2000-05-15 | 2011-04-27 | セルジーン コーポレイション | 結腸直腸癌を治療するための組成物および方法 |
MXPA02011218A (es) | 2000-05-15 | 2004-08-19 | Celgene Corp | Composiciones y metodos para el tratamiento de cancer. |
AU2001280161A1 (en) | 2000-08-24 | 2002-03-04 | Kirin Beer Kabushiki Kaisha | C-mpl ligand-containing medicinal compositions for increasing platelets and erythrocytes |
US6315720B1 (en) | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
DK1353672T3 (da) | 2000-11-30 | 2008-01-21 | Childrens Medical Center | Syntese af 4-amino-thalidomidenantiomerer |
US20020128228A1 (en) | 2000-12-01 | 2002-09-12 | Wen-Jen Hwu | Compositions and methods for the treatment of cancer |
US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
DE60234585D1 (da) | 2001-02-27 | 2010-01-14 | Us Government | |
PT1423115E (pt) | 2001-08-06 | 2009-07-21 | Childrens Medical Center | Actividade antiangiogénica de análogos da talidomida substituídos com nitrogénio |
US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
JP4027693B2 (ja) | 2002-03-20 | 2007-12-26 | トリニティ工業株式会社 | 塗料送給装置及びバルブユニット |
US20030220254A1 (en) | 2002-03-29 | 2003-11-27 | Texas Tech University System | Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CN1658848A (zh) | 2002-04-12 | 2005-08-24 | 细胞基因公司 | 血管生成调节剂的鉴定方法,由此发现的化合物和使用该化合物的治疗方法 |
US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
CA2794060C (en) | 2002-05-17 | 2017-08-22 | Celgene Corporation | Methods and compositions using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione for treatment and management of multiple myeloma |
US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
MXPA04011310A (es) | 2002-05-17 | 2005-02-14 | Celgene Corp | Metodo y composiciones que utilizan farmacos inhibidores selectivos de citocinas para el tratamiento y el manejo de canceres y otras enfermedades. |
US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
US8404717B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
US20040091455A1 (en) | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
EP1556010A4 (en) | 2002-10-31 | 2007-12-05 | Supergen Inc | PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US20040152632A1 (en) | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
CL2004001004A1 (es) | 2003-05-19 | 2005-03-18 | Upjohn Co | Combinacion farmaceutica que comprende irinotecan y revimid para tratar el mieloma multiple. |
UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
EA014429B1 (ru) | 2004-04-14 | 2010-12-30 | Селджин Корпорейшн | Композиции, содержащие иммуномодулирующие соединения для лечения и управления течением миелодиспластических синдромов, и способы с их использованием |
CN1972686A (zh) | 2004-04-14 | 2007-05-30 | 细胞基因公司 | 选择性细胞因子抑制药在髓发育不良综合征中的用途 |
US20060128654A1 (en) | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of cytidine analogs and derivatives |
US20070155791A1 (en) | 2005-12-29 | 2007-07-05 | Zeldis Jerome B | Methods for treating cutaneous lupus using aminoisoindoline compounds |
US8058260B2 (en) | 2006-05-22 | 2011-11-15 | Xenoport, Inc. | 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof |
CN101686971B (zh) * | 2006-08-07 | 2013-09-11 | 艾伯特生物治疗学公司 | 用于治疗多发性骨髓瘤的药物产品及其用途 |
CA2661983C (en) | 2006-08-30 | 2015-05-05 | Mount Sinai School Of Medicine Of New York University | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
US20080057086A1 (en) | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
CN107445940A (zh) | 2006-09-26 | 2017-12-08 | 细胞基因公司 | 作为抗肿瘤剂的5‑取代的喹唑酮衍生物 |
MX347987B (es) | 2007-09-26 | 2017-05-22 | Celgene Corp * | Derivados de quinazolinona 6-,7-, u 8-sustituidos y composiciones que los comprenden y metodos para usar los mismos. |
JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain vehicles, installations and methods |
WO2009058394A1 (en) | 2007-11-01 | 2009-05-07 | Celgene Corporation | Cytidine analogs for treatment of myelodysplastic syndromes |
SG193206A1 (en) | 2008-05-15 | 2013-09-30 | Celgene Corp | Oral formulations of cytidine analogs and methods of use thereof |
PE20110547A1 (es) | 2008-10-29 | 2011-08-04 | Celgene Corp | Compuestos de isoindolina con actividad anticancerigena |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
LT3351240T (lt) | 2009-05-19 | 2019-06-10 | Celgene Corporation | 4-amino-2-(2,6-dioksopiperidin-3-il)izoindolin-1,3-diono kompozicijos |
SI3202461T1 (sl) | 2010-02-11 | 2019-05-31 | Celgene Corporation | Derivati arilmetoksi izoindolina in sestavki, ki jih vsebujejo in metode uporabe le teh |
EA201391319A1 (ru) | 2011-03-11 | 2014-03-31 | Селджин Корпорейшн | Способ лечения рака с использованием 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона |
US20140142128A1 (en) | 2012-11-20 | 2014-05-22 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with bruton's tyrosine kinase |
EP3240551A4 (en) * | 2014-12-31 | 2018-08-08 | Anthrogenesis Corporation | Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells |
US9713375B1 (en) | 2015-02-26 | 2017-07-25 | Brett Einar Rahm | Collapsible portable table |
EP3313528B1 (en) * | 2015-06-29 | 2021-08-04 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens comprising pomalidomide and an anti-cs1 antibody for treating cancer |
-
2015
- 2015-08-20 BR BR112017003620A patent/BR112017003620A2/pt not_active Application Discontinuation
- 2015-08-20 AU AU2015305449A patent/AU2015305449B2/en active Active
- 2015-08-20 HR HRP20230265TT patent/HRP20230265T1/hr unknown
- 2015-08-20 EP EP21172501.5A patent/EP3925609A1/en active Pending
- 2015-08-20 KR KR1020177004321A patent/KR20170042598A/ko not_active Application Discontinuation
- 2015-08-20 EA EA201790439A patent/EA201790439A1/ru unknown
- 2015-08-20 MX MX2017002382A patent/MX2017002382A/es unknown
- 2015-08-20 CA CA2958867A patent/CA2958867A1/en not_active Abandoned
- 2015-08-20 PT PT157573890T patent/PT3182996T/pt unknown
- 2015-08-20 PL PL15757389.0T patent/PL3182996T3/pl unknown
- 2015-08-20 JP JP2017510546A patent/JP7120763B2/ja active Active
- 2015-08-20 ES ES15757389T patent/ES2940302T3/es active Active
- 2015-08-20 US US14/831,616 patent/US10034872B2/en active Active
- 2015-08-20 CN CN201580056904.9A patent/CN107073115A/zh not_active Withdrawn
- 2015-08-20 FI FIEP15757389.0T patent/FI3182996T3/fi active
- 2015-08-20 WO PCT/US2015/046091 patent/WO2016029004A1/en active Application Filing
- 2015-08-20 LT LTEPPCT/US2015/046091T patent/LT3182996T/lt unknown
- 2015-08-20 DK DK15757389.0T patent/DK3182996T3/da active
- 2015-08-20 EP EP15757389.0A patent/EP3182996B1/en active Active
- 2015-08-20 SI SI201531929T patent/SI3182996T1/sl unknown
- 2015-08-20 HU HUE15757389A patent/HUE061382T2/hu unknown
- 2015-08-20 RS RS20230191A patent/RS64038B1/sr unknown
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2017
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2020
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Publication number | Publication date |
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LT3182996T (lt) | 2023-03-10 |
CN107073115A (zh) | 2017-08-18 |
ES2940302T3 (es) | 2023-05-05 |
WO2016029004A1 (en) | 2016-02-25 |
SI3182996T1 (sl) | 2023-04-28 |
KR20170042598A (ko) | 2017-04-19 |
IL250724A0 (en) | 2017-04-30 |
CL2017000416A1 (es) | 2017-09-08 |
PT3182996T (pt) | 2023-03-21 |
FI3182996T3 (fi) | 2023-03-28 |
JP7120763B2 (ja) | 2022-08-17 |
US10034872B2 (en) | 2018-07-31 |
AU2021209158A1 (en) | 2021-08-19 |
RS64038B1 (sr) | 2023-04-28 |
HUE061382T2 (hu) | 2023-06-28 |
JP2017525713A (ja) | 2017-09-07 |
CA2958867A1 (en) | 2016-02-25 |
AU2015305449A1 (en) | 2017-03-16 |
EP3925609A1 (en) | 2021-12-22 |
MX2017002382A (es) | 2017-05-17 |
JP2021006557A (ja) | 2021-01-21 |
EA201790439A1 (ru) | 2017-07-31 |
EP3182996A1 (en) | 2017-06-28 |
AU2015305449B2 (en) | 2021-05-06 |
HRP20230265T1 (hr) | 2023-04-14 |
BR112017003620A2 (pt) | 2017-12-05 |
US20160051530A1 (en) | 2016-02-25 |
EP3182996B1 (en) | 2022-12-28 |
PL3182996T3 (pl) | 2023-04-17 |
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