DK307883A - Carbostyrilderivater samt fremgangsmaade til fremstilling deraf - Google Patents

Carbostyrilderivater samt fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK307883A
DK307883A DK307883A DK307883A DK307883A DK 307883 A DK307883 A DK 307883A DK 307883 A DK307883 A DK 307883A DK 307883 A DK307883 A DK 307883A DK 307883 A DK307883 A DK 307883A
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DK
Denmark
Prior art keywords
carbostyl
procedures
derivatives
preparing
carbostyl derivatives
Prior art date
Application number
DK307883A
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English (en)
Other versions
DK168288B1 (da
DK307883D0 (da
Inventor
Minoru Uchida
Makoto Komastu
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57117311A external-priority patent/JPS597168A/ja
Priority claimed from JP57117312A external-priority patent/JPS597169A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK307883D0 publication Critical patent/DK307883D0/da
Publication of DK307883A publication Critical patent/DK307883A/da
Application granted granted Critical
Publication of DK168288B1 publication Critical patent/DK168288B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK307883A 1982-07-05 1983-07-04 Analogifremgangsmåde til fremstilling af carbostyrilderivater DK168288B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11731282 1982-07-05
JP57117311A JPS597168A (ja) 1982-07-05 1982-07-05 カルボスチリル誘導体
JP11731182 1982-07-05
JP57117312A JPS597169A (ja) 1982-07-05 1982-07-05 カルボスチリル誘導体

Publications (3)

Publication Number Publication Date
DK307883D0 DK307883D0 (da) 1983-07-04
DK307883A true DK307883A (da) 1984-01-06
DK168288B1 DK168288B1 (da) 1994-03-07

Family

ID=26455454

Family Applications (1)

Application Number Title Priority Date Filing Date
DK307883A DK168288B1 (da) 1982-07-05 1983-07-04 Analogifremgangsmåde til fremstilling af carbostyrilderivater

Country Status (17)

Country Link
US (2) US4578381A (da)
AT (1) AT385506B (da)
AU (1) AU552717B2 (da)
CA (1) CA1247624A (da)
CH (1) CH654578A5 (da)
DE (1) DE3324034A1 (da)
DK (1) DK168288B1 (da)
ES (4) ES523838A0 (da)
FI (1) FI80022C (da)
FR (1) FR2530626B1 (da)
GB (1) GB2123825B (da)
IT (1) IT1203676B (da)
NL (1) NL194165C (da)
NO (1) NO164835C (da)
PH (1) PH21650A (da)
PT (1) PT76980B (da)
SE (1) SE462848B (da)

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US4677112A (en) * 1984-02-02 1987-06-30 Warner-Lambert Company 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
WO1991014677A1 (fr) * 1990-03-28 1991-10-03 Otsuka Pharmaceutical Co., Ltd. Derive de quinoline, medicament anti-ulcereux contenant ce derive et production de ce derive
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5200524A (en) * 1990-12-20 1993-04-06 North Carolina State University Camptothecin intermediates and method of making same
US5258516A (en) * 1990-12-20 1993-11-02 Nc State University Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs
US5264579A (en) * 1990-12-20 1993-11-23 North Carolina State University D ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5315007A (en) * 1990-12-20 1994-05-24 North Carolina State University Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5212317A (en) * 1990-12-20 1993-05-18 North Carolina State University Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs
US5254690A (en) * 1990-12-20 1993-10-19 North Carolina State University Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs
DE69207560T2 (de) * 1991-06-07 1996-06-27 Otsuka Pharma Co Ltd Antidiabetikum
TW227558B (da) * 1992-05-14 1994-08-01 Otsuka Pharma Co Ltd
US5428166A (en) * 1992-06-18 1995-06-27 North Carolina State University Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
JP2872546B2 (ja) * 1992-11-26 1999-03-17 大塚製薬株式会社 腸粘膜障害保護剤
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
WO1995011026A1 (en) * 1993-10-21 1995-04-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative for inhibiting production of interleukin-8
WO1995012579A1 (en) * 1993-11-05 1995-05-11 Otsuka Pharmaceutical Company, Limited Bismuth salt of carbostyril derivatives for the treatment of peptic ulcers
US5496952A (en) * 1995-02-07 1996-03-05 North Carolina State University Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
ATE275132T1 (de) * 1995-06-27 2004-09-15 Takeda Chemical Industries Ltd 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
IL125378A0 (en) * 1996-01-23 1999-03-12 Shionogi & Co Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
EP0920319A4 (en) * 1996-05-20 2002-05-02 Merck & Co Inc GONADOLIBERIN ANTAGONISTS
KR100669823B1 (ko) * 2001-02-20 2007-01-17 경동제약 주식회사 2-(4-클로로벤조일아미노)-3-[2(1ｈ)-퀴놀리논-4-일]프로피온산의 제조방법 및 그 중간체
JP4394686B2 (ja) * 2003-07-30 2010-01-06 大塚製薬株式会社 唾液分泌促進用医薬組成物およびその使用
TWI340650B (en) * 2004-01-21 2011-04-21 Otsuka Pharma Co Ltd Amine saly of carbostyril derivative
KR101098116B1 (ko) * 2004-12-01 2011-12-26 오츠카 세이야쿠 가부시키가이샤 레바미피드의 개선된 제조 방법
JP3892894B2 (ja) * 2005-04-28 2007-03-14 大塚製薬株式会社 カルボスチリル化合物の製造法
CN101870674B (zh) * 2009-04-21 2012-04-18 陕西大生化学科技有限公司 改进的瑞巴派特中间体的制备方法
CN103476753B (zh) * 2011-02-25 2015-12-09 诺弗米克斯有限公司 新的瑞巴派特复合物和共晶体
CN102153512B (zh) * 2011-03-07 2013-03-27 江西同和药业有限责任公司 瑞巴派特中间体的制备方法
SA113340675B1 (ar) * 2012-06-26 2015-08-16 استيش. كو.، ليمتد أدوية ريباميبايد تحضيرية جديدة، طريقة تحضيرها واستخدامها
CN108341775B (zh) * 2017-01-25 2021-03-16 重庆常捷医药有限公司 一种瑞巴派特中间体的合成方法
KR102190019B1 (ko) 2018-10-23 2020-12-15 삼진제약주식회사 쇼그렌 증후군 예방 또는 치료용 조성물
CN111057001A (zh) * 2019-12-23 2020-04-24 巨化集团公司制药厂 一种喹诺酮丙二酸酯化合物的制备方法

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JPS5535018A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Alkaneamide derivative
JPS5583749A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
JPS5585520A (en) * 1978-12-22 1980-06-27 Otsuka Pharmaceut Co Ltd Remedy for peptic ulcer
DE2927534A1 (de) * 1979-07-07 1981-01-08 Bayer Ag Optisch reine heterocyclische aminosaeuren, verfahren zu ihrer herstellung und ihre verwendung
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FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
CH654578A5 (de) 1986-02-28
CA1247624A (en) 1988-12-28
PT76980A (en) 1983-08-01
GB2123825A (en) 1984-02-08
NO164835C (no) 1990-11-21
SE8303813L (sv) 1984-01-06
AT385506B (de) 1988-04-11
ATA245183A (de) 1987-09-15
SE462848B (sv) 1990-09-10
ES8500906A1 (es) 1984-11-01
DE3324034A1 (de) 1984-01-05
DK168288B1 (da) 1994-03-07
AU552717B2 (en) 1986-06-19
FR2530626B1 (fr) 1986-12-05
GB8318174D0 (en) 1983-08-03
PT76980B (en) 1986-01-09
FI80022B (fi) 1989-12-29
FR2530626A1 (fr) 1984-01-27
FI832425L (fi) 1984-01-06
IT1203676B (it) 1989-02-15
ES530716A0 (es) 1985-05-01
NO164835B (no) 1990-08-13
ES8505348A1 (es) 1985-05-16
USRE34722E (en) 1994-09-06
ES8504724A1 (es) 1985-05-01
DK307883D0 (da) 1983-07-04
NO832431L (no) 1984-01-06
ES530715A0 (es) 1985-05-16
FI80022C (fi) 1990-04-10
AU1653683A (en) 1984-01-12
ES523838A0 (es) 1984-11-01
PH21650A (en) 1988-01-13
US4578381A (en) 1986-03-25
SE8303813D0 (sv) 1983-07-04
NL8302390A (nl) 1984-02-01
NL194165C (nl) 2001-08-03
ES8505347A1 (es) 1985-05-16
DE3324034C2 (da) 1993-07-01
ES530714A0 (es) 1985-05-16
GB2123825B (en) 1985-09-18
FI832425A0 (fi) 1983-07-01
NL194165B (nl) 2001-04-02
IT8367731A0 (it) 1983-07-05

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