DK2860251T3 - Aptapmer-lægemidler nyttige ved behandling af komplement-relaterede lidelser - Google Patents

Aptapmer-lægemidler nyttige ved behandling af komplement-relaterede lidelser Download PDF

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DK2860251T3
DK2860251T3 DK14194459.5T DK14194459T DK2860251T3 DK 2860251 T3 DK2860251 T3 DK 2860251T3 DK 14194459 T DK14194459 T DK 14194459T DK 2860251 T3 DK2860251 T3 DK 2860251T3
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aptamer
seq
nucleotides
complement
disease
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DK14194459.5T
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Claude Benedict
John Deiner
Dilara Grate
Sara Chesworth Keene
Jeffrey Kurz
Thomas Green Mccauley
James Rottman
Kristin Thompson
Charles Wilson
Anna J Zoltoski
Markus Kurz
David Epstein
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Archemix Llc
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/16—Aptamers
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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Claims (16)

1. Aptamer eller et salt deraf, hvor aptameren er: fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfC fCfUmGfCmG-3T (SEQ ID NO: 4), hvor fC og fU = 2'-fluor-nukleotider, mG og mA = 2'-OMe-nukleotider, og alle andre nukleotider er 2'-OH, og 3T angiver en inverteret deoxythymidin.
2. Sammensætning omfattende en terapeutisk virkningsfuld mængde af aptameren eller saltet deraf ifølge krav 1 og en farmaceutisk acceptabel bærer eller et farmaceutisk acceptabelt fortyndingsmiddel.
3. Anvendelse af aptamer eller salt deraf ifølge krav 1 til fremstilling af et lægemiddel til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein hos et pattedyr.
4. Aptamer eller salt deraf ifølge krav 1 til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein hos et pattedyr.
5. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor pattedyret er et menneske.
6. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor sygdommen er en akut iskæmisk sygdom, en akut inflammatorisk sygdom eller en kronisk inflammatorisk eller immun-medieret sygdom.
7. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor sygdommen er myokardieinfarkt, slagtilfælde, iskæmi/reperfusionsskade, infektionssygdom, septikæmi, chok, akut transplantatafvisning, hyperakut transplantatafvisning, allergi, astma, reumato-id arthritis eller anden reumatologisk sygdom, multipel sklerose eller anden neurologisk sygdom, psoriasis eller anden dermatologisk sygdom, myastheni gravis, systemisk lupus erythematosus (SLE), subakut transplantatafvisning, kronisk transplantatafvisning eller glomerulonefritis eller anden nyresygdom.
8. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor sygdommen er myokardieskade relateret til koronararterie bypass (CABG-) kirurgi, myokardieskade relateret til ballonangioplastik eller myokardieskade relateret til restenose.
9. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor sygdommen, der skal behandles, er en C5-, C5a- og/eller C5b-9-komplementprotein-medieret komplikation relateret til CABG-kirurg i.
10. Anvendelse ifølge krav 8 eller 9, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 8 eller 9, hvor forbindelsen indgives forud for kirurgi og indgives kontinuerligt i mindst 24 timer.
11. Anvendelse ifølge krav 3, eller aptameren eller saltet deraf til anvendelse i en fremgangsmåde til behandling, forebyggelse eller lindring af en sygdom medieret af C5-, C5a- og/eller C5b-9-komplementprotein i et pattedyr ifølge krav 4, hvor forbindelsen indgives intravenøst.
12. In v/'tro-diagnostisk fremgangsmåde omfattende at kontakte aptameren eller saltet deraf ifølge krav 1 med en sammensætning, der mistænkes for at omfatte C5-komplementprotein eller en variant deraf, og detektere tilstedeværelsen eller fraværet af C5-komplementproteinet eller en variant deraf.
13. Diagnostisk fremgangsmåde ifølge krav 12, hvor C5-komplementproteinet eller varianten deraf er et humant C5-komplementprotein eller en variant deraf.
14. Aptamer eller et salt ifølge krav 1 til anvendelse som in v/tro-diagnostik.
15. Aptamer eller et salt ifølge krav 1 til anvendelse som in v/Vo-diagnostisk middel.
16. Aptamer eller salt ifølge krav 1 til anvendelse ved behandling, forebyggelse eller lindring af sygdommen in vivo.
DK14194459.5T 2004-02-12 2005-02-14 Aptapmer-lægemidler nyttige ved behandling af komplement-relaterede lidelser DK2860251T3 (da)

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US54454204P 2004-02-12 2004-02-12
US54774704P 2004-02-25 2004-02-25
US58168504P 2004-06-21 2004-06-21
US60804804P 2004-09-07 2004-09-07
EP13150168.6A EP2578683B9 (en) 2004-02-12 2005-02-14 Aptamer therapeutics useful in the treatment of complement-related disorders

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DK05713496.7T DK1727567T3 (da) 2004-02-12 2005-02-14 Aptamer-terapeutiske midler nyttige i behandling af komplementrelaterede forstyrrelser
DK18156968.2T DK3385384T3 (da) 2004-02-12 2005-02-14 Aptamer-lægemidler nyttige ved behandlingen af komplement-relaterede lidelser
DK14194459.5T DK2860251T3 (da) 2004-02-12 2005-02-14 Aptapmer-lægemidler nyttige ved behandling af komplement-relaterede lidelser

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US (2) US7538211B2 (da)
EP (5) EP1727567B1 (da)
JP (1) JP5242918B2 (da)
CY (3) CY1114443T1 (da)
DK (3) DK1727567T3 (da)
ES (4) ES2674129T3 (da)
HK (2) HK1183896A1 (da)
HU (2) HUE050481T2 (da)
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PT (3) PT3385384T (da)
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