DK2758074T3 - Bakteriestammer der udtrykker methylasegener og anvendelser deraf - Google Patents
Bakteriestammer der udtrykker methylasegener og anvendelser deraf Download PDFInfo
- Publication number
- DK2758074T3 DK2758074T3 DK12834027.0T DK12834027T DK2758074T3 DK 2758074 T3 DK2758074 T3 DK 2758074T3 DK 12834027 T DK12834027 T DK 12834027T DK 2758074 T3 DK2758074 T3 DK 2758074T3
- Authority
- DK
- Denmark
- Prior art keywords
- starms
- bacteria
- methylase genes
- expressing
- expressing methylase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161538682P | 2011-09-23 | 2011-09-23 | |
| PCT/US2012/056761 WO2013044177A2 (en) | 2011-09-23 | 2012-09-21 | Bacterial strains expressing methylase genes and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2758074T3 true DK2758074T3 (da) | 2020-07-27 |
Family
ID=47915109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12834027.0T DK2758074T3 (da) | 2011-09-23 | 2012-09-21 | Bakteriestammer der udtrykker methylasegener og anvendelser deraf |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10813987B2 (da) |
| EP (2) | EP3760226A1 (da) |
| DK (1) | DK2758074T3 (da) |
| ES (1) | ES2806605T3 (da) |
| HK (1) | HK1201041A1 (da) |
| WO (1) | WO2013044177A2 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11680273B2 (en) | 2011-09-23 | 2023-06-20 | Loma Linda University | Treatment of autoimmune diseases |
| DK2758074T3 (da) | 2011-09-23 | 2020-07-27 | Univ Loma Linda | Bakteriestammer der udtrykker methylasegener og anvendelser deraf |
| WO2014145042A1 (en) * | 2013-03-15 | 2014-09-18 | Loma Linda University | Treatment of autoimmune diseases |
| JP2023516684A (ja) * | 2020-03-03 | 2023-04-20 | アディテックス，インコーポレイテッド | 高血糖症を治療するおよび１型糖尿病の開始を抑制する方法 |
| CA3229923A1 (en) * | 2021-08-30 | 2023-03-09 | Aditxt, Inc. | Enzymatically methylated dna and methods of production and therapeutic use |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5695976A (en) | 1989-12-18 | 1997-12-09 | Novo Nordisk A/S | Stable integration of DNA in bacterial genomes |
| US5314695A (en) | 1990-11-13 | 1994-05-24 | Corvas International, Inc. | Tissue factor based prothrombin time reagent |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| ATE256749T1 (de) | 1995-01-23 | 2004-01-15 | Novozymes As | Dna-integration durch transposition |
| FR2750704B1 (fr) | 1996-07-04 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de production d'adn therapeutique |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| AU2797399A (en) | 1998-03-02 | 1999-09-20 | Vanderbilt University | Improved eukaryotic expression vector |
| US7026155B2 (en) * | 1999-02-02 | 2006-04-11 | Regents Of The University Of California | Method of reducing bacterial proliferation |
| KR20070053815A (ko) | 1999-03-03 | 2007-05-25 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 백신 및 유전자요법 조성물 및 이들의 제조 및 사용방법 |
| WO2000059538A2 (en) | 1999-04-08 | 2000-10-12 | The John Hopkins University | Antigen-specific induction of peripheral immune tolerance |
| WO2001032857A1 (en) | 1999-10-29 | 2001-05-10 | The Hospital For Sick Children | Methylation of unstable sequences |
| ATE424893T1 (de) | 2001-06-08 | 2009-03-15 | Novartis Pharma Gmbh | Behandlung und vorbeugung von insulin- produzierende zelltransplantatabstossung |
| US7381711B2 (en) | 2002-08-06 | 2008-06-03 | Loma Linda University | Substances for preventing and treating autoimmune diseases |
| US8183026B2 (en) | 2003-01-14 | 2012-05-22 | Mississippi State University | Methods of preparation of live attenuated bacterial vaccine by alteration of DNA adenine methylase (Dam) activity in those bacteria |
| EP1890606A1 (en) | 2005-04-25 | 2008-02-27 | Koninklijke Philips Electronics N.V. | Method and apparatus for continuous imaging by ultrasound transducer system |
| US20090191218A1 (en) | 2005-05-11 | 2009-07-30 | Fengchun Li | DNA Vaccines And Methods For The Prevention Of Transplantation Rejection |
| US8778327B2 (en) | 2005-05-11 | 2014-07-15 | Loma Linda University | Substances, compositions and methods for preventing and treating immune-mediated inflammatory disorders |
| WO2009114735A1 (en) | 2008-03-12 | 2009-09-17 | Loma Linda University | Dna vaccines and methods for the prevention of transplantation rejection |
| ES2537406T3 (es) | 2006-09-28 | 2015-06-08 | Loma Linda University | Transfección mediada por células apoptóticas de células de mamífero con ARN de interferencia |
| EP1921149A1 (en) | 2006-11-13 | 2008-05-14 | AEterna Zentaris GmbH | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| CA2736877A1 (en) | 2008-09-12 | 2010-03-18 | Scarab Genomics, Llc | Clean genome bactofection |
| DK2758074T3 (da) | 2011-09-23 | 2020-07-27 | Univ Loma Linda | Bakteriestammer der udtrykker methylasegener og anvendelser deraf |
-
2012
- 2012-09-21 DK DK12834027.0T patent/DK2758074T3/da active
- 2012-09-21 ES ES12834027T patent/ES2806605T3/es active Active
- 2012-09-21 EP EP20170511.8A patent/EP3760226A1/en active Pending
- 2012-09-21 WO PCT/US2012/056761 patent/WO2013044177A2/en active Application Filing
- 2012-09-21 US US14/346,706 patent/US10813987B2/en active Active
- 2012-09-21 EP EP12834027.0A patent/EP2758074B1/en active Active
-
2015
- 2015-01-29 HK HK15100990.3A patent/HK1201041A1/xx unknown
-
2020
- 2020-09-09 US US17/015,947 patent/US20210085771A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10813987B2 (en) | 2020-10-27 |
| EP3760226A1 (en) | 2021-01-06 |
| US20140286871A1 (en) | 2014-09-25 |
| EP2758074B1 (en) | 2020-04-22 |
| EP2758074A4 (en) | 2015-09-23 |
| US20210085771A1 (en) | 2021-03-25 |
| ES2806605T3 (es) | 2021-02-18 |
| WO2013044177A3 (en) | 2013-07-11 |
| HK1201041A1 (en) | 2015-08-21 |
| EP2758074A2 (en) | 2014-07-30 |
| WO2013044177A2 (en) | 2013-03-28 |
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