DK2642992T3 - Forbindelser og anvendelse deraf - Google Patents

Forbindelser og anvendelse deraf Download PDF

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Publication number
DK2642992T3
DK2642992T3 DK11820847.9T DK11820847T DK2642992T3 DK 2642992 T3 DK2642992 T3 DK 2642992T3 DK 11820847 T DK11820847 T DK 11820847T DK 2642992 T3 DK2642992 T3 DK 2642992T3
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DK
Denmark
Prior art keywords
compounds
Prior art date
Application number
DK11820847.9T
Other languages
English (en)
Inventor
Palanisamy Senthilkumar Udayampalayam
Maneesh Paul-Satyaseela
Shridhar Narayanan
Gopalan Balasubramanian
Aravind Appu
Senthilnathan Manickam
Hariharan Periasamy
Original Assignee
Allecra Therapeutics Gmbh
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45757037&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2642992(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allecra Therapeutics Gmbh filed Critical Allecra Therapeutics Gmbh
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Publication of DK2642992T3 publication Critical patent/DK2642992T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/87Compounds being unsubstituted in position 3 or with substituents other than only two methyl radicals attached in position 3, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/883Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a substituted hydrocarbon radical attached in position 3
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
DK11820847.9T 2010-11-25 2011-11-25 Forbindelser og anvendelse deraf DK2642992T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3555CH2010 2010-11-25
IN3096CH2011 2011-09-09
PCT/IN2011/000813 WO2012070071A1 (en) 2010-11-25 2011-11-25 Compounds and their use

Publications (1)

Publication Number Publication Date
DK2642992T3 true DK2642992T3 (da) 2021-03-01

Family

ID=45757037

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11820847.9T DK2642992T3 (da) 2010-11-25 2011-11-25 Forbindelser og anvendelse deraf

Country Status (28)

Country Link
US (1) US10201532B2 (da)
EP (1) EP2642992B1 (da)
JP (1) JP5961177B2 (da)
KR (1) KR101933084B1 (da)
CN (2) CN107260729B (da)
AP (1) AP2013006947A0 (da)
AU (1) AU2011333305B2 (da)
BR (1) BR112013012735B1 (da)
CA (1) CA2818100C (da)
CL (1) CL2013001482A1 (da)
CO (1) CO6781486A2 (da)
CR (1) CR20130306A (da)
DK (1) DK2642992T3 (da)
EA (1) EA030662B1 (da)
EC (1) ECSP13012716A (da)
ES (1) ES2859639T3 (da)
HU (1) HUE053623T2 (da)
IL (1) IL226538A (da)
MA (1) MA34760B1 (da)
MX (1) MX353447B (da)
MY (1) MY170435A (da)
NZ (1) NZ610247A (da)
PE (1) PE20140716A1 (da)
SG (1) SG190877A1 (da)
SV (1) SV2013004451A (da)
UA (1) UA115966C2 (da)
WO (1) WO2012070071A1 (da)
ZA (1) ZA201303773B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2993900B1 (fr) * 2012-07-27 2016-03-25 Biomerieux Sa Procede de detection de bacteries productrices de carbapenemases de type oxa-48
TWI595007B (zh) * 2012-09-10 2017-08-11 Neotope Biosciences Ltd 抗mcam抗體及相關使用方法
US20140128364A1 (en) * 2012-11-05 2014-05-08 Rempex Pharmaceuticals Therapeutic uses of tigemonam and carumonam
GB201319776D0 (en) * 2013-11-08 2013-12-25 Allecra Therapeutics Sas Compound
GB201408649D0 (en) 2014-05-15 2014-07-02 Allecra Therapeutics Sas Method
JP2016010399A (ja) * 2014-06-03 2016-01-21 日水製薬株式会社 カルバペネマーゼ産生耐性菌検出用組成物
FR3024465B1 (fr) * 2014-07-30 2018-03-23 Biomerieux Caracterisation de micro-organismes par maldi-tof
EP3372587A1 (en) * 2017-03-09 2018-09-12 Centre National de la Recherche Scientifique (CNRS) 3-imidazolines as carbapenemases inhibitors
SI25892A (sl) * 2019-09-05 2021-03-31 Gorenje Gospodinjski Aparati, D.O.O. Pralni stroj, ki se polni s sprednje strani, z električnim svetlobnim telesom
US11040987B2 (en) 2019-09-11 2021-06-22 Tennor Therapeutics Limited Penam derivatives for treating bacterial infections
CN110840897B (zh) * 2019-11-28 2023-08-08 河北旺发生物科技有限公司 金属β-内酰胺酶抑制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118790A (ja) * 1982-12-24 1984-07-09 Taiho Yakuhin Kogyo Kk ペニシリン誘導体
US4562073A (en) 1982-12-24 1985-12-31 Taiho Pharmaceutical Company Limited Penicillin derivatives
JPS60215688A (ja) * 1984-04-09 1985-10-29 Taiho Yakuhin Kogyo Kk ペニシリン誘導体
JP2599595B2 (ja) * 1987-06-26 1997-04-09 大鵬薬品工業株式会社 2β−置換メチルペニシラン酸誘導体、その塩及びエステル
US4891369A (en) 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
JP2648750B2 (ja) * 1988-03-02 1997-09-03 大塚化学株式会社 β−ラクタム誘導体の製造方法
DE602004010862T2 (de) 2003-04-14 2009-01-02 Wyeth Holdings Corp. Zusammensetzungen enthaltend Piperacillin und Tazobactam zur Injektion
MX2007004490A (es) 2004-10-14 2007-05-08 Wyeth Corp Composiciones que contienen piperacilina, tazobactam y un acido aminocarboxilico en un diluyente de lactato de sodio.
EP2046802B1 (en) * 2006-07-12 2013-08-21 Allecra Therapeutics GmbH 2-substituted methyl penam derivatives
FR2936951B1 (fr) 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments

Also Published As

Publication number Publication date
JP5961177B2 (ja) 2016-08-02
MX2013005907A (es) 2013-12-06
AU2011333305B2 (en) 2017-06-22
EP2642992B1 (en) 2020-11-25
US10201532B2 (en) 2019-02-12
KR20140052927A (ko) 2014-05-07
CO6781486A2 (es) 2013-10-31
EA201300617A1 (ru) 2014-03-31
CN103347515B (zh) 2017-06-06
AU2011333305A1 (en) 2013-07-11
CA2818100C (en) 2019-07-09
MX353447B (es) 2018-01-11
EP2642992A1 (en) 2013-10-02
ECSP13012716A (es) 2013-08-30
WO2012070071A1 (en) 2012-05-31
UA115966C2 (uk) 2018-01-25
MA34760B1 (fr) 2013-12-03
PE20140716A1 (es) 2014-07-12
CL2013001482A1 (es) 2014-04-04
US20140057888A1 (en) 2014-02-27
CA2818100A1 (en) 2012-05-31
JP2014504279A (ja) 2014-02-20
CN103347515A (zh) 2013-10-09
EA030662B1 (ru) 2018-09-28
MY170435A (en) 2019-07-31
BR112013012735A8 (pt) 2021-10-26
ES2859639T3 (es) 2021-10-04
SG190877A1 (en) 2013-07-31
HUE053623T2 (hu) 2021-07-28
AP2013006947A0 (en) 2013-06-30
WO2012070071A9 (en) 2012-08-16
CN107260729A (zh) 2017-10-20
IL226538A (en) 2017-07-31
SV2013004451A (es) 2017-12-01
CN107260729B (zh) 2020-03-31
NZ610247A (en) 2014-09-26
ZA201303773B (en) 2014-11-26
CR20130306A (es) 2013-09-18
KR101933084B1 (ko) 2018-12-28
BR112013012735A2 (pt) 2017-11-07
BR112013012735B1 (pt) 2021-11-23

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