DK267489A - 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler - Google Patents
1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler Download PDFInfo
- Publication number
- DK267489A DK267489A DK267489A DK267489A DK267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A
- Authority
- DK
- Denmark
- Prior art keywords
- deoxy
- preparation
- medicinal products
- nojirimycin derivatives
- nojirimycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88401340A EP0344383A1 (en) | 1988-06-02 | 1988-06-02 | Novel alpha-Glucosidase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DK267489D0 DK267489D0 (da) | 1989-06-01 |
DK267489A true DK267489A (da) | 1989-12-03 |
Family
ID=8200392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK267489A DK267489A (da) | 1988-06-02 | 1989-06-01 | 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler |
Country Status (22)
Country | Link |
---|---|
US (1) | US5157116A (no) |
EP (1) | EP0344383A1 (no) |
JP (1) | JP2791419B2 (no) |
KR (1) | KR0155541B1 (no) |
CN (1) | CN1023803C (no) |
AR (1) | AR247890A1 (no) |
AT (1) | ATE129716T1 (no) |
AU (1) | AU608711B2 (no) |
CA (1) | CA1339740C (no) |
DE (1) | DE68924670T2 (no) |
DK (1) | DK267489A (no) |
ES (1) | ES2081857T3 (no) |
FI (1) | FI92934C (no) |
GR (1) | GR3018354T3 (no) |
HU (1) | HU203559B (no) |
IE (1) | IE68455B1 (no) |
IL (1) | IL90463A0 (no) |
NO (1) | NO170023C (no) |
NZ (1) | NZ229337A (no) |
PH (1) | PH25908A (no) |
PT (1) | PT90713B (no) |
ZA (1) | ZA894068B (no) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
JP3580900B2 (ja) * | 1995-04-20 | 2004-10-27 | ホクレン農業協同組合連合会 | α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料 |
US5981720A (en) * | 1996-09-09 | 1999-11-09 | Wisconsin Alumni Res Found | Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity |
SK141899A3 (en) * | 1997-04-15 | 2000-09-12 | Csir Corporate Building | Pharmaceutical compositions having appetite suppressant activity |
HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
GB2396815B (en) * | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
JP4486792B2 (ja) * | 2003-06-12 | 2010-06-23 | 学校法人近畿大学 | 環状オニウム化合物およびグルコシダーゼ阻害剤 |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
EP1746992A2 (en) * | 2004-03-25 | 2007-01-31 | United Therapeutics | Use of n-substituted imino sugars for appetite suppression |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
ES2328384T3 (es) * | 2004-11-23 | 2009-11-12 | Warner-Lambert Company Llc | Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia. |
DK2027137T3 (en) * | 2005-06-08 | 2015-05-18 | Amicus Therapeutics Inc | Imino and aminosugar PURIFICATION |
US20060293508A1 (en) * | 2005-06-08 | 2006-12-28 | Michael Major | Stabilization of triflated compounds |
EP1888612A1 (en) * | 2005-06-08 | 2008-02-20 | Amicus Therapeutics, Inc. | Crystalline sugar compositions and method of making |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
US8877717B2 (en) | 2007-03-12 | 2014-11-04 | Zadec Aps | Anti-diabetic extract of rooibos |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
JP2013528172A (ja) | 2010-05-21 | 2013-07-08 | ファイザー・インク | 2−フェニルベンゾイルアミド |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP2014513923A (ja) | 2011-03-04 | 2014-06-19 | ファイザー・インク | Edn3様ペプチドおよびその使用 |
US20150050371A1 (en) | 2012-03-09 | 2015-02-19 | Biotropics Malaysia Berhad | Extract Formulations of Rhodamnia Cinerea And Uses Thereof |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体 |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
BR112019007543A2 (pt) | 2016-10-14 | 2019-07-02 | Tes Pharma S R L | inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase |
AU2019385644A1 (en) | 2018-11-20 | 2021-06-03 | Tes Pharma S.R.L. | Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase |
JOP20210193A1 (ar) | 2019-01-18 | 2023-01-30 | Astrazeneca Ab | مثبطات pcsk9 وطرق استخدامها |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2922760A1 (de) * | 1979-06-05 | 1980-12-11 | Bayer Ag | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
GB2064527B (en) * | 1979-12-08 | 1984-05-02 | Nippon Shinyaku Co Ltd | Moranoline derivatives and process for preparation thereof |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
JPS61115093A (ja) * | 1984-11-09 | 1986-06-02 | Nippon Shinyaku Co Ltd | モラノリン誘導体の製法 |
US4634765A (en) * | 1984-12-18 | 1987-01-06 | Merrell Dow Pharmaceuticals Inc. | Homodisaccharide hypoglycemic agents |
GB2181729B (en) * | 1985-10-12 | 1990-04-04 | Nippon Shinyaku Co Ltd | Glucosylmoranoline derivatives and production thereof |
DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
-
1988
- 1988-06-02 EP EP88401340A patent/EP0344383A1/en not_active Withdrawn
-
1989
- 1989-04-28 AT AT89401227T patent/ATE129716T1/de not_active IP Right Cessation
- 1989-04-28 DE DE68924670T patent/DE68924670T2/de not_active Expired - Fee Related
- 1989-04-28 ES ES89401227T patent/ES2081857T3/es not_active Expired - Lifetime
- 1989-05-29 ZA ZA894068A patent/ZA894068B/xx unknown
- 1989-05-29 AR AR89314032A patent/AR247890A1/es active
- 1989-05-30 NZ NZ229337A patent/NZ229337A/en unknown
- 1989-05-30 IL IL90463A patent/IL90463A0/xx not_active IP Right Cessation
- 1989-05-30 CA CA000601196A patent/CA1339740C/en not_active Expired - Fee Related
- 1989-05-30 AU AU35801/89A patent/AU608711B2/en not_active Ceased
- 1989-05-31 HU HU892791A patent/HU203559B/hu not_active IP Right Cessation
- 1989-06-01 PH PH38729A patent/PH25908A/en unknown
- 1989-06-01 NO NO892230A patent/NO170023C/no not_active IP Right Cessation
- 1989-06-01 KR KR1019890007498A patent/KR0155541B1/ko not_active IP Right Cessation
- 1989-06-01 CN CN89103723A patent/CN1023803C/zh not_active Expired - Fee Related
- 1989-06-01 DK DK267489A patent/DK267489A/da not_active Application Discontinuation
- 1989-06-01 PT PT90713A patent/PT90713B/pt not_active IP Right Cessation
- 1989-06-01 FI FI892682A patent/FI92934C/fi not_active IP Right Cessation
- 1989-06-02 JP JP1139401A patent/JP2791419B2/ja not_active Expired - Fee Related
- 1989-06-12 IE IE179889A patent/IE68455B1/en not_active IP Right Cessation
-
1992
- 1992-02-18 US US07/839,014 patent/US5157116A/en not_active Expired - Fee Related
-
1995
- 1995-12-08 GR GR950403473T patent/GR3018354T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0225498A (ja) | 1990-01-26 |
NO170023B (no) | 1992-05-25 |
DE68924670D1 (de) | 1995-12-07 |
JP2791419B2 (ja) | 1998-08-27 |
CA1339740C (en) | 1998-03-17 |
FI892682A (fi) | 1989-12-03 |
ZA894068B (en) | 1990-09-26 |
KR0155541B1 (ko) | 1998-10-15 |
DK267489D0 (da) | 1989-06-01 |
NZ229337A (en) | 1990-12-21 |
PT90713A (pt) | 1989-12-29 |
PT90713B (pt) | 1993-09-30 |
IE891798L (en) | 1989-12-02 |
FI92934B (fi) | 1994-10-14 |
FI892682A0 (fi) | 1989-06-01 |
CN1040032A (zh) | 1990-02-28 |
NO892230L (no) | 1989-12-04 |
FI92934C (fi) | 1995-01-25 |
CN1023803C (zh) | 1994-02-16 |
IL90463A0 (en) | 1990-01-18 |
ATE129716T1 (de) | 1995-11-15 |
AR247890A1 (es) | 1995-04-28 |
NO892230D0 (no) | 1989-06-01 |
GR3018354T3 (en) | 1996-03-31 |
NO170023C (no) | 1992-09-02 |
AU608711B2 (en) | 1991-04-11 |
PH25908A (en) | 1991-12-19 |
KR910000776A (ko) | 1991-01-30 |
US5157116A (en) | 1992-10-20 |
DE68924670T2 (de) | 1996-05-23 |
IE68455B1 (en) | 1996-06-26 |
EP0344383A1 (en) | 1989-12-06 |
HU203559B (en) | 1991-08-28 |
AU3580189A (en) | 1990-02-01 |
HUT50191A (en) | 1989-12-28 |
ES2081857T3 (es) | 1996-03-16 |
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Legal Events
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AHS | Application shelved for other reasons than non-payment |