DK2566861T3 - Modulatorer af fedtsyreamidhydrolase - Google Patents

Modulatorer af fedtsyreamidhydrolase

Info

Publication number
DK2566861T3
DK2566861T3 DK11719136.1T DK11719136T DK2566861T3 DK 2566861 T3 DK2566861 T3 DK 2566861T3 DK 11719136 T DK11719136 T DK 11719136T DK 2566861 T3 DK2566861 T3 DK 2566861T3
Authority
DK
Denmark
Prior art keywords
modulators
fatty acid
acid amide
amide hydrolase
hydrolase
Prior art date
Application number
DK11719136.1T
Other languages
English (en)
Inventor
John M Keith
Jing Liu
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK2566861T3 publication Critical patent/DK2566861T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
DK11719136.1T 2010-05-03 2011-05-02 Modulatorer af fedtsyreamidhydrolase DK2566861T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33052210P 2010-05-03 2010-05-03
PCT/US2011/034755 WO2011139951A1 (en) 2010-05-03 2011-05-02 Modulators of fatty acid amide hydrolase

Publications (1)

Publication Number Publication Date
DK2566861T3 true DK2566861T3 (da) 2014-06-02

Family

ID=44080143

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11719136.1T DK2566861T3 (da) 2010-05-03 2011-05-02 Modulatorer af fedtsyreamidhydrolase

Country Status (26)

Country Link
US (2) US8940745B2 (da)
EP (1) EP2566861B1 (da)
JP (1) JP5841128B2 (da)
KR (1) KR101770619B1 (da)
CN (1) CN102869658B (da)
AU (1) AU2011248407B2 (da)
BR (1) BR112012028179A2 (da)
CA (1) CA2797100C (da)
CL (1) CL2012003071A1 (da)
DK (1) DK2566861T3 (da)
EA (1) EA022158B1 (da)
ES (1) ES2483242T3 (da)
HR (1) HRP20140724T1 (da)
IL (1) IL222631A (da)
ME (1) ME01912B (da)
MX (1) MX2012012759A (da)
NZ (1) NZ603175A (da)
PL (1) PL2566861T3 (da)
PT (1) PT2566861E (da)
RS (1) RS53376B (da)
SG (1) SG185411A1 (da)
SI (1) SI2566861T1 (da)
SM (1) SMT201400067B (da)
UA (1) UA108233C2 (da)
WO (1) WO2011139951A1 (da)
ZA (1) ZA201209042B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180296521A1 (en) * 2015-10-16 2018-10-18 Scythian Biosciences Inc. Methods and compositions for treating gastrointestinal inflammation
MA43001A (fr) * 2015-10-16 2021-04-07 Impact Biosciences Corp Cannabidiol et hu-211 pour le traitement d'une lésion cérébrale traumatique
CN111743864B (zh) * 2020-08-05 2022-04-01 牡丹江医学院 一种体育外伤喷雾剂及其制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4810160Y1 (da) 1969-10-14 1973-03-16
GB1292410A (en) 1970-05-13 1972-10-11 Yoshitomi Pharmaceutical Thienobenzothiazepine derivatives
JPS5515456A (en) 1978-07-19 1980-02-02 Morishita Seiyaku Kk 2-substituted-piperazinomethyl-1,4-benzodioxane
NZ223847A (en) 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions
JPH07502014A (ja) 1991-06-21 1995-03-02 ベーリンガー　マンハイム　イタリア　エス．ピー．エイ． 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール
US5612380A (en) 1994-09-27 1997-03-18 The Scripps Research Institute Method for sleep induction
HUP9602489A3 (en) * 1995-01-11 1998-01-28 Samjin Pharm Co Ltd Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
EP0896590A1 (en) 1996-05-03 1999-02-17 Warner-Lambert Company Rapid purification by polymer supported quench
US5856537A (en) 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
EP0968200A1 (en) * 1997-02-24 2000-01-05 ZymoGenetics, Inc. Calcitonin mimetics
JPH11139969A (ja) 1997-08-07 1999-05-25 Tanabe Seiyaku Co Ltd 医薬組成物
HUP0102662A3 (en) 1997-11-07 2003-01-28 Schering Corp Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
AU740588B2 (en) 1997-11-24 2001-11-08 Scripps Research Institute, The Inhibitors of gap junction communication
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
CN1303376A (zh) 1998-03-31 2001-07-11 阿卡蒂亚药品公司 对毒蕈碱性受体具有活性的化合物
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
GB9823873D0 (en) 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
US6100279A (en) 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
AU1413301A (en) 1999-11-17 2001-05-30 Sumitomo Pharmaceuticals Company, Limited Diabetic remedy containing dipiperazine derivative
US6462054B1 (en) 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
EP1301484A2 (en) 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
US20020183316A1 (en) 2000-10-27 2002-12-05 Kevin Pan Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders
JP2004532229A (ja) 2001-04-27 2004-10-21 ブリストル−マイヤーズ　スクイブ　カンパニー 脂肪酸アミド加水分解酵素阻害剤
CN100509797C (zh) 2001-06-11 2009-07-08 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
AU2002363236A1 (en) 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
WO2003047569A1 (en) 2001-12-03 2003-06-12 Gpc Biotech, Inc. Compositions and methods for inhibiting prenyltransferases
US6727247B2 (en) 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
US6949574B2 (en) 2002-02-08 2005-09-27 Bristol-Myers Squibb Company (Oxime)carbamoyl fatty acid amide hydrolase inhibitors
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
WO2004033652A2 (en) 2002-10-08 2004-04-22 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
FR2850377B1 (fr) 2003-01-23 2009-02-20 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2385040A1 (en) 2003-03-14 2011-11-09 ONO Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
US20040191155A1 (en) 2003-03-25 2004-09-30 Mahler Barry Asher Thermal process for reducing the concentration of dinitrogen difluoride and dinitrogen tetrafluoride in nitrogen trifluoride
FR2854633B1 (fr) 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
US20080070924A1 (en) 2003-06-10 2008-03-20 Frans Eduard Janssens Novel Formulations For Opioid-Based Treatments Of Pain Comprising 1-(1,2-Disubstituted Piperidinyl)-4-Substituted Piperazine Derivatives
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
FR2864080B1 (fr) 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
SE0401971D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
AR055831A1 (es) * 2004-12-30 2007-09-12 Janssen Pharmaceutica Nv Pepirazinilureas y piperidinilureas como moduladores de hidrolasa de amida de acidos grasos
GB0503056D0 (en) 2005-02-14 2005-03-23 Smithkline Beecham Corp Chemical compounds
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
ITRM20060090A1 (it) 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
ATE481409T1 (de) 2006-05-18 2010-10-15 Hoffmann La Roche Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor
WO2008024139A2 (en) 2006-08-18 2008-02-28 N.V. Organon Inhibitors of fatty acid amide hydrolase
US20110172230A1 (en) 2006-08-23 2011-07-14 Takahiro Ishii Urea compound or salt thereof
NZ575624A (en) 2006-10-18 2012-02-24 Pfizer Prod Inc Biaryl ether urea compounds
AU2008263166A1 (en) 2007-05-25 2008-12-18 Janssen Pharmaceutica N.V. Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
JPWO2009048101A1 (ja) 2007-10-10 2011-02-24 武田薬品工業株式会社 アミド化合物
US8461159B2 (en) 2008-11-25 2013-06-11 Jannsen Pharmaceutica BV Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
US8598356B2 (en) 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase

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US20150099761A1 (en) 2015-04-09
EA201291155A1 (ru) 2013-08-30
KR101770619B1 (ko) 2017-08-23
EP2566861B1 (en) 2014-05-14
BR112012028179A2 (pt) 2016-08-02
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AU2011248407A1 (en) 2012-11-22
KR20130096639A (ko) 2013-08-30
PL2566861T3 (pl) 2014-09-30
ME01912B (me) 2014-12-20
WO2011139951A1 (en) 2011-11-10
UA108233C2 (uk) 2015-04-10
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