DK2413899T3 - Dentalt anæstetikum omfattende tetracain og en vasokonstriktor til intranasal indgivelse - Google Patents

Dentalt anæstetikum omfattende tetracain og en vasokonstriktor til intranasal indgivelse Download PDF

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Publication number
DK2413899T3
DK2413899T3 DK10714119.4T DK10714119T DK2413899T3 DK 2413899 T3 DK2413899 T3 DK 2413899T3 DK 10714119 T DK10714119 T DK 10714119T DK 2413899 T3 DK2413899 T3 DK 2413899T3
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DK
Denmark
Prior art keywords
vasoconstrictor
tetracaine
intranasal administration
dental anesthetic
anesthetic
Prior art date
Application number
DK10714119.4T
Other languages
English (en)
Inventor
Mark David Kollar
Original Assignee
St Renatus Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Renatus Llc filed Critical St Renatus Llc
Application granted granted Critical
Publication of DK2413899T3 publication Critical patent/DK2413899T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00Local anaesthesia; Hypothermia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK10714119.4T 2009-04-03 2010-04-02 Dentalt anæstetikum omfattende tetracain og en vasokonstriktor til intranasal indgivelse DK2413899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16668009P 2009-04-03 2009-04-03
PCT/US2010/001002 WO2010114622A1 (en) 2009-04-03 2010-04-02 Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration

Publications (1)

Publication Number Publication Date
DK2413899T3 true DK2413899T3 (da) 2021-04-19

Family

ID=42164462

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10714119.4T DK2413899T3 (da) 2009-04-03 2010-04-02 Dentalt anæstetikum omfattende tetracain og en vasokonstriktor til intranasal indgivelse

Country Status (18)

Country Link
US (7) US8580282B2 (da)
EP (1) EP2413899B1 (da)
JP (3) JP5788864B2 (da)
KR (2) KR101747979B1 (da)
CN (2) CN102421416B (da)
AU (2) AU2010232995C1 (da)
BR (1) BRPI1010303A2 (da)
CA (1) CA2757032C (da)
DK (1) DK2413899T3 (da)
EA (1) EA024184B1 (da)
ES (1) ES2861064T3 (da)
IL (1) IL215489A0 (da)
MX (1) MX2011010445A (da)
NZ (2) NZ612063A (da)
PL (1) PL2413899T3 (da)
PT (1) PT2413899T (da)
WO (1) WO2010114622A1 (da)
ZA (2) ZA201107011B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2413899T3 (pl) 2009-04-03 2021-09-20 St. Renatus, Llc Dentystyczny środek znieczulający zawierający tetrakainę i środek zwężający naczynia krwionośne do podawania donosowego
EP2903604A1 (en) 2012-09-28 2015-08-12 St. Renatus, LLC Pharmaceutical composition comprising benzyl alcohol for the treatment of migraines
WO2015103450A1 (en) * 2014-01-01 2015-07-09 Real Time Imaging Technologies, Llc Improved local anesthetic solution for dental and/or contrast media use
WO2015195708A1 (en) * 2014-06-16 2015-12-23 Loewi LLC Methods of anesthetizing nerve tissue in the trigeminal nerve pathway and medical uses thereof
AU2015371291A1 (en) * 2014-12-23 2017-08-03 St. Renatus, Llc Tetracaine-based anesthetic
WO2016115117A1 (en) 2015-01-12 2016-07-21 Real Time Imaging Technologies, Llc Low-dose x-ray imaging system
US10039830B2 (en) * 2016-03-04 2018-08-07 Cetylite Industries, Inc. Topical anesthetic composition
WO2017210390A1 (en) * 2016-06-01 2017-12-07 St. Renatus, Llc Intranasal dental anesthetic
EA202191506A1 (ru) 2018-12-19 2021-10-08 Нортик Холдингз Инк. Терапевтическая композиция интраназального лидокаина
CN111494310A (zh) * 2020-04-29 2020-08-07 周晓玲 一种局部***物的制备及使用方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
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US3832460A (en) * 1971-03-19 1974-08-27 C Kosti Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue
US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
BR9306816A (pt) 1992-07-28 1998-12-08 Procter & Gamble Composição farmaceutica para uso tópico contendo um polímero catiônico reticulado e um eter alcoxilado
WO1995013810A1 (en) 1993-11-19 1995-05-26 Schering-Plough Healthcare Products Incorporated Nasal spray compositions containing oxymetazoline
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US6075059A (en) 1999-02-24 2000-06-13 The Ohio State University Compositions for dental anesthesia
US20040131665A1 (en) * 1999-10-22 2004-07-08 Wepfer Scott T. Topical anesthetic formulation
US6413499B1 (en) * 2000-01-06 2002-07-02 Bryan M. Clay Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
JP4591746B2 (ja) 2002-12-03 2010-12-01 大正製薬株式会社 難溶性抗ウイルス成分含有水溶性外用剤組成物
ES2223277B1 (es) * 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
PT1628673E (pt) 2004-01-01 2007-03-30 Panacea Biotec Ltd Composições farmacêuticas compreendendo um extracto de euphorbia prostrata
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
WO2007050543A2 (en) 2005-10-24 2007-05-03 Collegium Pharmaceutical, Inc. Topical pharmaceutical foam composition
US9252862B2 (en) 2008-09-17 2016-02-02 Qualcomm Incorporated MIMO preamble for initial access with an unknown number of transmit antennas
PL2413899T3 (pl) * 2009-04-03 2021-09-20 St. Renatus, Llc Dentystyczny środek znieczulający zawierający tetrakainę i środek zwężający naczynia krwionośne do podawania donosowego

Also Published As

Publication number Publication date
ZA201309321B (en) 2016-07-27
US20170326112A1 (en) 2017-11-16
EP2413899A1 (en) 2012-02-08
EP2413899B1 (en) 2021-01-27
CN103932973B (zh) 2017-08-11
PT2413899T (pt) 2021-03-30
US20200268715A1 (en) 2020-08-27
NZ612063A (en) 2015-02-27
CA2757032C (en) 2022-06-07
JP2012522783A (ja) 2012-09-27
CN103932973A (zh) 2014-07-23
NZ595376A (en) 2013-09-27
AU2015242984B2 (en) 2017-09-14
US20170319547A1 (en) 2017-11-09
EA201171215A1 (ru) 2012-07-30
AU2010232995C1 (en) 2016-01-28
JP2017031226A (ja) 2017-02-09
AU2015242984A1 (en) 2015-11-05
AU2010232995B2 (en) 2015-07-16
ES2861064T3 (es) 2021-10-05
US20140234421A1 (en) 2014-08-21
US20120039960A1 (en) 2012-02-16
US9855247B2 (en) 2018-01-02
US10420750B2 (en) 2019-09-24
MX2011010445A (es) 2012-01-19
CN102421416B (zh) 2014-05-28
KR101747979B1 (ko) 2017-06-15
CA2757032A1 (en) 2010-10-07
CN102421416A (zh) 2012-04-18
JP5788864B2 (ja) 2015-10-07
IL215489A0 (en) 2011-12-29
KR20170026639A (ko) 2017-03-08
BRPI1010303A2 (pt) 2016-03-15
US9308191B2 (en) 2016-04-12
KR20120042729A (ko) 2012-05-03
AU2010232995A1 (en) 2011-10-20
PL2413899T3 (pl) 2021-09-20
US8580282B2 (en) 2013-11-12
US10456377B2 (en) 2019-10-29
US20160184269A1 (en) 2016-06-30
WO2010114622A1 (en) 2010-10-07
JP2015034167A (ja) 2015-02-19
EA024184B1 (ru) 2016-08-31
ZA201107011B (en) 2014-03-26
US20170326111A1 (en) 2017-11-16

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